JP2008534572A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008534572A5 JP2008534572A5 JP2008503613A JP2008503613A JP2008534572A5 JP 2008534572 A5 JP2008534572 A5 JP 2008534572A5 JP 2008503613 A JP2008503613 A JP 2008503613A JP 2008503613 A JP2008503613 A JP 2008503613A JP 2008534572 A5 JP2008534572 A5 JP 2008534572A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- use according
- group
- propyl
- ether
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05290727A EP1707203A1 (en) | 2005-04-01 | 2005-04-01 | Treatment of parkinson's disease obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine H3- receptor ligands |
| EP05290727.6 | 2005-04-01 | ||
| US66861805P | 2005-04-06 | 2005-04-06 | |
| US60/668,618 | 2005-04-06 | ||
| PCT/IB2006/000739 WO2006103546A2 (en) | 2005-04-01 | 2006-03-30 | Treatment of parkinson's disease, obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine h3-receptor ligands |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014000383A Division JP5955872B2 (ja) | 2005-04-01 | 2014-01-06 | 非イミダゾールアルキルアミンヒスタミンｈ３−受容体リガンドによるパーキンソン病、閉塞性睡眠時無呼吸、レビー小体型認知症、血管性認知症の治療 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008534572A JP2008534572A (ja) | 2008-08-28 |
| JP2008534572A5 true JP2008534572A5 (https=) | 2010-11-25 |
| JP5546761B2 JP5546761B2 (ja) | 2014-07-09 |
Family
ID=35169680
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008503613A Expired - Lifetime JP5546761B2 (ja) | 2005-04-01 | 2006-03-30 | 非イミダゾールアルキルアミンヒスタミンｈ３−受容体リガンドによるパーキンソン病、閉塞性睡眠時無呼吸、レビー小体型認知症、血管性認知症の治療 |
| JP2014000383A Expired - Lifetime JP5955872B2 (ja) | 2005-04-01 | 2014-01-06 | 非イミダゾールアルキルアミンヒスタミンｈ３−受容体リガンドによるパーキンソン病、閉塞性睡眠時無呼吸、レビー小体型認知症、血管性認知症の治療 |
| JP2016045424A Pending JP2016106142A (ja) | 2005-04-01 | 2016-03-09 | 非イミダゾールアルキルアミンヒスタミンｈ３−受容体リガンドによるパーキンソン病、閉塞性睡眠時無呼吸、レビー小体型認知症、血管性認知症の治療 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014000383A Expired - Lifetime JP5955872B2 (ja) | 2005-04-01 | 2014-01-06 | 非イミダゾールアルキルアミンヒスタミンｈ３−受容体リガンドによるパーキンソン病、閉塞性睡眠時無呼吸、レビー小体型認知症、血管性認知症の治療 |
| JP2016045424A Pending JP2016106142A (ja) | 2005-04-01 | 2016-03-09 | 非イミダゾールアルキルアミンヒスタミンｈ３−受容体リガンドによるパーキンソン病、閉塞性睡眠時無呼吸、レビー小体型認知症、血管性認知症の治療 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US8486947B2 (https=) |
| EP (2) | EP1707203A1 (https=) |
| JP (3) | JP5546761B2 (https=) |
| KR (1) | KR101308527B1 (https=) |
| CN (1) | CN101171009B (https=) |
| AU (1) | AU2006228413C1 (https=) |
| BR (1) | BRPI0612216B1 (https=) |
| CA (1) | CA2603656C (https=) |
| CY (1) | CY1114636T1 (https=) |
| DK (1) | DK1863487T4 (https=) |
| EA (1) | EA016007B1 (https=) |
| ES (1) | ES2426008T5 (https=) |
| HR (1) | HRP20130748T4 (https=) |
| MA (1) | MA29353B1 (https=) |
| ME (1) | ME01713B (https=) |
| MX (1) | MX2007012162A (https=) |
| NO (1) | NO343603B1 (https=) |
| NZ (1) | NZ561940A (https=) |
| PL (1) | PL1863487T5 (https=) |
| PT (1) | PT1863487E (https=) |
| RS (1) | RS52911B2 (https=) |
| SG (1) | SG147415A1 (https=) |
| SI (1) | SI1863487T2 (https=) |
| TN (1) | TNSN07365A1 (https=) |
| UA (1) | UA94902C2 (https=) |
| WO (1) | WO2006103546A2 (https=) |
| ZA (1) | ZA200708086B (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103382174A (zh) | 2006-06-23 | 2013-11-06 | 雅培制药有限公司 | 作为组胺h3受体调节物的环丙胺衍生物 |
| US9108948B2 (en) | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
| FR2903904A1 (fr) * | 2006-07-21 | 2008-01-25 | Bioprojet Soc Civ Ile | Association de modafinil et d'un antagoniste ou agoniste inverse du recepteur h3 |
| UA95644C2 (ru) | 2006-07-25 | 2011-08-25 | Сефалон, Инк. | Пиридазиноновые производные, фармацевтическая композиция и способ лечения заболеваний |
| US8153813B2 (en) | 2007-12-20 | 2012-04-10 | Abbott Laboratories | Benzothiazole and benzooxazole derivatives and methods of use |
| MX2010008375A (es) | 2008-01-30 | 2011-03-04 | Cephalon Inc Star | Derivados de piperidina espirocíclicos substituidos como ligandos de receptores de histamina-3 (h3). |
| FR2932479A1 (fr) * | 2008-06-13 | 2009-12-18 | Servier Lab | Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US9186353B2 (en) | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
| US8853390B2 (en) | 2010-09-16 | 2014-10-07 | Abbvie Inc. | Processes for preparing 1,2-substituted cyclopropyl derivatives |
| US9181275B2 (en) | 2011-08-11 | 2015-11-10 | Abbvie Inc. | Mercaptoamidine derivatives and methods of use |
| WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
| HK1207004A1 (zh) * | 2012-10-05 | 2016-01-22 | Vtv治疗有限责任公司 | 治療輕度和中度阿爾茨海默病的方法 |
| EP3391886A1 (en) | 2017-04-19 | 2018-10-24 | Novartis AG | The use of a h3r inverse agonist for the treatment of shift work disorder |
| US11654283B2 (en) | 2019-03-06 | 2023-05-23 | Medtronic Xomed, Inc. | Obstructive sleep apnea patient programmer for implantable devices |
| EP4248969A1 (en) | 2022-03-23 | 2023-09-27 | Bioprojet | Use of pitolisant for treating severe fatigue |
| CN121175294A (zh) | 2023-03-31 | 2025-12-19 | 生物计划制药公司 | 盐酸替洛利生的多晶型形式 |
| WO2025082972A1 (en) * | 2023-10-16 | 2025-04-24 | Bioprojet Pharma | Enteric coated pitolisant formulations and methods of use |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5815945A (ja) * | 1981-07-21 | 1983-01-29 | Teikoku Hormone Mfg Co Ltd | 新規なフエノキシアルキルアミン誘導体 |
| FR2579596B1 (fr) | 1985-03-26 | 1987-11-20 | Inst Nat Sante Rech Med | (imidazolyl-4) piperidines, leur preparation et leur application en therapeutique |
| FR2671083B1 (fr) | 1990-12-31 | 1994-12-23 | Inst Nat Sante Rech Med | Nouvelles 4-(4-imidazolyl) piperidines substituees en 1, leur preparation ainsi que leurs applications therapeutiques. |
| JPH06505265A (ja) | 1991-02-27 | 1994-06-16 | シード・キャピタル・インベストメント・（エス・シー・アイ）・ベスローテン・フェンノートシャップ | ヒスタミンｈ↓３受容体に対する作動的または拮抗的活性を有するイミダゾール誘導体 |
| DE69212164T2 (de) | 1991-12-18 | 1996-12-05 | Schering Corp., Kenilworth, N.J. | Imidolylalkyl-derivate substituiert mit einem stickstoffenthaltende-6 gliedrigen ring |
| MX9207393A (es) | 1991-12-18 | 1994-06-30 | Schering Corp | Imidazoil o alquilo de imidazoil susbtituido con una cadena heterociclica de cuatro o cinco miembros que contienen nitrogeno. |
| FR2686084B1 (fr) | 1992-01-10 | 1995-12-22 | Bioprojet Soc Civ | Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques. |
| US5639775A (en) | 1992-04-01 | 1997-06-17 | The University Of Toledo | 4-[4'-piperodinyl or 3'-pirrolidinyl] substituted imidazoles as H3 -receptor antagonists and therapeutic uses thereof |
| US5380858A (en) | 1992-04-01 | 1995-01-10 | The University Of Toledo | Process for the preparation of intermediates useful for the synthesis of histamine receptor antagonists |
| US5486526A (en) * | 1992-04-01 | 1996-01-23 | The University Of Toledo | Histamine H3 -receptor antagonists and therapeutic uses thereof |
| WO1994017058A1 (fr) | 1993-01-25 | 1994-08-04 | The Green Cross Corporation | Compose d'imidazole |
| JP3522790B2 (ja) | 1993-06-08 | 2004-04-26 | 花王株式会社 | Ｈ３−レセプター刺激薬 |
| WO1995006037A1 (en) | 1993-08-27 | 1995-03-02 | Vrije Universiteit | New imidazole derivatives having agonistic or antagonistic activity on the histamine h3 receptor |
| GB9319534D0 (en) * | 1993-09-22 | 1993-11-10 | Boots Co Plc | Therapeutic agents |
| ATE234290T1 (de) | 1993-11-15 | 2003-03-15 | Schering Corp | Phenylalkyl-imidazole als h3-rezeptor- antagonisten |
| GB9411045D0 (en) * | 1994-06-02 | 1994-07-20 | Smithkline Beecham Plc | Compounds and use |
| FR2732017B1 (fr) | 1995-03-21 | 2000-09-22 | Inst Nat Sante Rech Med | Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques |
| DK0841922T3 (da) | 1995-05-30 | 2002-06-03 | Gliatech Inc | 1H-4(5)-substituerede imidazolderivater |
| US5652258A (en) | 1995-05-30 | 1997-07-29 | Gliatech, Inc. | 2-(4-imidazoyl) cyclopropyl derivatives |
| DK0841923T3 (da) | 1995-06-07 | 2003-01-27 | Gliatech Inc | 1H-4(5)-substituerede imidazolderivater |
| RU2182904C2 (ru) | 1996-02-09 | 2002-05-27 | Джеймс Блэк Фаундейшн Лимитед | Сульфонамиды и способы их получения |
| JP3925579B2 (ja) * | 1998-02-03 | 2007-06-06 | 日本精工株式会社 | 潤滑剤供給体、並びに前記潤滑剤供給体を備える転がり軸受、リニアガイド装置及びボールねじ装置 |
| EP0982300A3 (en) | 1998-07-29 | 2000-03-08 | Societe Civile Bioprojet | Non-imidazole alkylamines as histamine H3 - receptor ligands and their therapeutic applications |
| US6136559A (en) * | 1998-10-07 | 2000-10-24 | Ortho Pharmaceutical Corporation | DNA encoding as human histamine receptor of the H3 subtype |
| WO2000076957A1 (en) * | 1999-06-11 | 2000-12-21 | Toyama Chemical Co., Ltd. | N-alkoxyalkyl-n,n-dialkylamine derivatives or salts thereof, and remedies for nerve degeneration diseases containing the same |
| GB9924941D0 (en) * | 1999-10-22 | 1999-12-22 | Univ Manchester | Treatment of dyskinesia |
| US6620839B2 (en) * | 2000-07-13 | 2003-09-16 | Abbott Laboratories | 1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications |
| ATE319696T1 (de) * | 2000-08-08 | 2006-03-15 | Ortho Mcneil Pharm Inc | Nicht-imidazol aryloxyalkylamine als h3 rezeptor liganden |
| WO2002013821A1 (en) * | 2000-08-17 | 2002-02-21 | Gliatech, Inc. | Novel alicyclic imidazoles as h3 agents |
| AU2001283573A1 (en) * | 2000-08-21 | 2002-03-04 | Gliatech, Inc. | The use of histamine H3 receptor inverse agonists for the control of appetite and treatment of obesity |
| EP1373218B9 (en) * | 2001-03-29 | 2008-12-03 | Ortho-McNeil-Janssen Pharmaceuticals, Inc. | Imidazolyl derivatives useful as histamine h3 receptor ligands |
| EP1451225A1 (en) * | 2001-11-15 | 2004-09-01 | Ortho-McNeil Pharmaceutical, Inc. | Agonists of recombinant human histamine h3 receptor |
| PT1451167E (pt) * | 2001-12-10 | 2006-07-31 | Ortho Mcneil Pharm Inc | Fenilalcinos |
| US7279491B2 (en) * | 2002-10-23 | 2007-10-09 | Janssen Pharmaceutica N.V. | Phenylpiperidines and phenylpyrrolidines |
| EP1642898B1 (en) * | 2003-06-27 | 2013-03-27 | Msd K.K. | Heteroaryloxy nitrogenous saturated heterocyclic derivative |
| FR2856596B1 (fr) * | 2003-06-27 | 2007-04-27 | Bioprojet Soc Civ | Nouvelle association medicamenteuse psychiatrique et utilisation d'une antagoniste ou agoniste inverse du recepteur h3 de l'histamine pour preparer un medicament prevenant des effets indesirables de psychotropes. |
| SE0302116D0 (sv) * | 2003-07-21 | 2003-07-21 | Astrazeneca Ab | Novel compounds |
| AU2004274309B2 (en) * | 2003-09-22 | 2010-04-08 | Msd K.K. | Novel piperidine derivative |
-
2005
- 2005-04-01 EP EP05290727A patent/EP1707203A1/en not_active Withdrawn
-
2006
- 2006-03-29 AU AU2006228413A patent/AU2006228413C1/en not_active Expired
- 2006-03-30 SG SG200807447-8A patent/SG147415A1/en unknown
- 2006-03-30 RS RS20130359 patent/RS52911B2/sr unknown
- 2006-03-30 MX MX2007012162A patent/MX2007012162A/es active IP Right Grant
- 2006-03-30 CA CA2603656A patent/CA2603656C/en not_active Expired - Lifetime
- 2006-03-30 ES ES06744466T patent/ES2426008T5/es not_active Expired - Lifetime
- 2006-03-30 CN CN2006800157656A patent/CN101171009B/zh not_active Expired - Lifetime
- 2006-03-30 PL PL06744466T patent/PL1863487T5/pl unknown
- 2006-03-30 EP EP06744466.1A patent/EP1863487B2/en not_active Expired - Lifetime
- 2006-03-30 HR HRP20130748T patent/HRP20130748T4/hr unknown
- 2006-03-30 DK DK06744466.1T patent/DK1863487T4/da active
- 2006-03-30 US US11/909,778 patent/US8486947B2/en active Active
- 2006-03-30 UA UAA200710712A patent/UA94902C2/ru unknown
- 2006-03-30 SI SI200631636T patent/SI1863487T2/sl unknown
- 2006-03-30 KR KR1020077025126A patent/KR101308527B1/ko not_active Expired - Lifetime
- 2006-03-30 PT PT67444661T patent/PT1863487E/pt unknown
- 2006-03-30 EA EA200702135A patent/EA016007B1/ru not_active IP Right Cessation
- 2006-03-30 ME MEP-2013-98A patent/ME01713B/me unknown
- 2006-03-30 BR BRPI0612216-7A patent/BRPI0612216B1/pt active IP Right Grant
- 2006-03-30 JP JP2008503613A patent/JP5546761B2/ja not_active Expired - Lifetime
- 2006-03-30 NZ NZ561940A patent/NZ561940A/en unknown
- 2006-03-30 WO PCT/IB2006/000739 patent/WO2006103546A2/en not_active Ceased
-
2007
- 2007-09-20 ZA ZA200708086A patent/ZA200708086B/xx unknown
- 2007-09-26 TN TNP2007000365A patent/TNSN07365A1/fr unknown
- 2007-09-27 MA MA30254A patent/MA29353B1/fr unknown
- 2007-10-09 NO NO20075086A patent/NO343603B1/no unknown
-
2013
- 2013-08-14 CY CY20131100705T patent/CY1114636T1/el unknown
-
2014
- 2014-01-06 JP JP2014000383A patent/JP5955872B2/ja not_active Expired - Lifetime
-
2016
- 2016-03-09 JP JP2016045424A patent/JP2016106142A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008534572A5 (https=) | ||
| JP2010500293A5 (https=) | ||
| JP2007508360A5 (https=) | ||
| JP2019034943A5 (https=) | ||
| JP2004516314A5 (https=) | ||
| JP2008514732A5 (https=) | ||
| JP2005502635A5 (https=) | ||
| JP2005523922A5 (https=) | ||
| JP2009519226A5 (https=) | ||
| JP2015505296A5 (https=) | ||
| KR940013555A (ko) | 알킬 치환된 헤테로사이클릭 화합물 | |
| JP2012505234A5 (https=) | ||
| JP2002513793A5 (https=) | ||
| JP2008512408A5 (https=) | ||
| RU2004100302A (ru) | Амиды антраниловой кислоты с гетероарилсульфонильной боковой цепью, способ их получения, их применение в качестве лекарственного или диагностического средства, а также содержащие их фармацевтические композиции | |
| JP2005536503A5 (https=) | ||
| RU2015121043A (ru) | Производные фенилэтилпиридина в качестве ингибиторов PDE-4 | |
| JP2005529965A5 (https=) | ||
| JP2007532627A5 (https=) | ||
| JP2021520415A5 (https=) | ||
| JP2005538974A5 (https=) | ||
| JP2006516626A5 (https=) | ||
| JP2005526773A5 (https=) | ||
| JP2005532397A5 (https=) | ||
| JP2012521353A5 (https=) |