ES2184876T3 - Derivados de imidazol sustituidos en 1h-4(5). - Google Patents
Derivados de imidazol sustituidos en 1h-4(5).Info
- Publication number
- ES2184876T3 ES2184876T3 ES96921378T ES96921378T ES2184876T3 ES 2184876 T3 ES2184876 T3 ES 2184876T3 ES 96921378 T ES96921378 T ES 96921378T ES 96921378 T ES96921378 T ES 96921378T ES 2184876 T3 ES2184876 T3 ES 2184876T3
- Authority
- ES
- Spain
- Prior art keywords
- formula
- present
- lower alkyl
- disorders
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Obesity (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Luminescent Compositions (AREA)
- Liquid Crystal Substances (AREA)
Abstract
LA PRESENTE INVENCION ESTA DIRIGIDA A DERIVADOS DE IMIDAZOL 1H (B); O (C) EN LAS CUALES R SUB,1} ES ALQUILO INFERIOR O ALCOXI INFERIOR; R SUB,2}, R SUB,3}, R SUB,4}, R SUB,5}, R SUB,7} Y R SUB,8} SON CADA UNO INDEPENDIENTEMENTE HIDROGENO O ALQUILO INFERIOR; R SUB,6} ES HIDROGENO, ALQUILO INFERIOR O ALCOXI INFERIOR, Y R SUB,5} Y R SUB,6} PUEDEN TOMARSE CONJUNTAMENTE PARA FORMAR UN ANILLO DE 4, 5 O 6 ESLABONES. LOS COMPUESTOS DE FORMULA (I) PRESENTAN ACTIVIDAD AGONISTA DEL RECEPTOR DE HISTAMINA H SUB,3}. TAMBIEN SE CONTEMPLA QUE LAS SALES FARMACEUTICAMENTE ACEPTABLES Y LOS ESTEREOISOMEROS INDIVIDUALES DE LOS COMPUESTOS DE FORMULA (I) ANTERIOR, ASI COMO LAS MEZCLAS DE LOS MISMOS, SE ENCUENTRAN DENTRO DEL ALCANCE DE LA PRESENTE INVENCION. LA PRESENTE INVENCION TAMBIEN DESCRIBE COMPOSICIONES FARMACEUTICAS QUE INCLUYEN UN VEHICULO FARMACEUTICAMENTE ACEPTABLE JUNTO CON UNA CANTIDAD EFICAZ DE UN COMPUESTO DE FORMULA (I). LA PRESENTE INVENCION TAMBIEN DESCRIBE UN PROCEDIMIENTO PARA TRATAR TRASTORNOSEN LOS CUALES LA ACTIVACION DE LOS RECEPTORES H SUB,3} DE HISTAMINA PUEDE PRESENTAR IMPORTANCIA TERAPEUTICA, TALES COMO ALERGIA, INFLAMACION, ENFERMEDAD CARDIO (ES DECIR, HIPER ASCULAR, MIGRAÑA), TRASTORNOS GASTROINTESTINALES (SECRECION DE ACIDOS, MOTILIDAD) Y TRASTORNOS DE SNC QUE IMPLICAN TRASTORNOS PSIQUIATRICOS (ES DECIR, QUE INCLUYEN ANSIEDAD, TRASTORNOS MANIACO/DEPRESIVO, ESQUIZOFRENIA, TRASTORNOS OBSESIVO OS, ETC.).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47992595A | 1995-06-07 | 1995-06-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2184876T3 true ES2184876T3 (es) | 2003-04-16 |
Family
ID=23905996
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96921378T Expired - Lifetime ES2184876T3 (es) | 1995-06-07 | 1996-06-06 | Derivados de imidazol sustituidos en 1h-4(5). |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0841923B1 (es) |
| JP (1) | JPH11507631A (es) |
| AT (1) | ATE224193T1 (es) |
| AU (1) | AU713166B2 (es) |
| CA (1) | CA2222652A1 (es) |
| DE (1) | DE69623784T2 (es) |
| DK (1) | DK0841923T3 (es) |
| ES (1) | ES2184876T3 (es) |
| NZ (1) | NZ311318A (es) |
| PT (1) | PT841923E (es) |
| WO (1) | WO1996040126A1 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6133291A (en) * | 1998-10-16 | 2000-10-17 | Schering Corporation | N-(imidazolylalkyl)substituted cyclic amines as histamine-H3 agonists or antagonists |
| AU3033100A (en) * | 1999-01-18 | 2000-08-01 | Boehringer Ingelheim International Gmbh | Substituted imidazoles, their preparation and use |
| US6908926B1 (en) | 1999-04-16 | 2005-06-21 | Novo Nordisk A/S | Substituted imidazoles, their preparation and use |
| US6610721B2 (en) | 2000-03-17 | 2003-08-26 | Novo Nordisk A/S | Imidazo heterocyclic compounds |
| US6437147B1 (en) | 2000-03-17 | 2002-08-20 | Novo Nordisk | Imidazole compounds |
| WO2002013821A1 (en) | 2000-08-17 | 2002-02-21 | Gliatech, Inc. | Novel alicyclic imidazoles as h3 agents |
| CN1960977B (zh) * | 2004-05-31 | 2010-07-21 | 万有制药株式会社 | 喹唑啉衍生物 |
| EP1707203A1 (en) | 2005-04-01 | 2006-10-04 | Bioprojet | Treatment of parkinson's disease obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine H3- receptor ligands |
| EP1717233A1 (en) | 2005-04-29 | 2006-11-02 | Bioprojet | Histamine H3-receptor ligands and their therapeutic application |
| EP1717235A3 (en) | 2005-04-29 | 2007-02-28 | Bioprojet | Phenoxypropylpiperidines and -pyrrolidines and their use as histamine H3-receptor ligands |
| WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
| EP2740474A1 (en) | 2012-12-05 | 2014-06-11 | Instituto Europeo di Oncologia S.r.l. | Cyclopropylamine derivatives useful as inhibitors of histone demethylases kdm1a |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2586562B1 (fr) * | 1985-09-02 | 1989-03-10 | Inst Nat Sante Rech Med | Composition pharmaceutique contenant de l'a-methylhistamine |
| WO1993012093A1 (en) * | 1991-12-18 | 1993-06-24 | Schering Corporation | Imidazolyl-alkyl-piperazine and -diazepine derivatives as histamine h3 agonists/antagonists |
-
1996
- 1996-06-06 DE DE69623784T patent/DE69623784T2/de not_active Expired - Fee Related
- 1996-06-06 EP EP96921378A patent/EP0841923B1/en not_active Expired - Lifetime
- 1996-06-06 CA CA002222652A patent/CA2222652A1/en not_active Abandoned
- 1996-06-06 JP JP9501805A patent/JPH11507631A/ja not_active Ceased
- 1996-06-06 PT PT96921378T patent/PT841923E/pt unknown
- 1996-06-06 DK DK96921378T patent/DK0841923T3/da active
- 1996-06-06 AU AU62482/96A patent/AU713166B2/en not_active Ceased
- 1996-06-06 ES ES96921378T patent/ES2184876T3/es not_active Expired - Lifetime
- 1996-06-06 WO PCT/US1996/009498 patent/WO1996040126A1/en active IP Right Grant
- 1996-06-06 AT AT96921378T patent/ATE224193T1/de not_active IP Right Cessation
- 1996-06-06 NZ NZ311318A patent/NZ311318A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0841923B1 (en) | 2002-09-18 |
| EP0841923A4 (en) | 1999-04-28 |
| CA2222652A1 (en) | 1996-12-19 |
| DE69623784T2 (de) | 2003-05-15 |
| AU713166B2 (en) | 1999-11-25 |
| JPH11507631A (ja) | 1999-07-06 |
| ATE224193T1 (de) | 2002-10-15 |
| EP0841923A1 (en) | 1998-05-20 |
| AU6248296A (en) | 1996-12-30 |
| DK0841923T3 (da) | 2003-01-27 |
| DE69623784D1 (de) | 2002-10-24 |
| PT841923E (pt) | 2003-01-31 |
| WO1996040126A1 (en) | 1996-12-19 |
| NZ311318A (en) | 2000-08-25 |
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