MX9709211A - Derivados de 2-(1h-4(5)-imidazoil) ciclopropilo. - Google Patents
Derivados de 2-(1h-4(5)-imidazoil) ciclopropilo.Info
- Publication number
- MX9709211A MX9709211A MX9709211A MX9709211A MX9709211A MX 9709211 A MX9709211 A MX 9709211A MX 9709211 A MX9709211 A MX 9709211A MX 9709211 A MX9709211 A MX 9709211A MX 9709211 A MX9709211 A MX 9709211A
- Authority
- MX
- Mexico
- Prior art keywords
- formula
- coch2
- ch2ch2
- methyl
- hydrogen
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Paints Or Removers (AREA)
- Silver Salt Photography Or Processing Solution Therefor (AREA)
- Photoreceptors In Electrophotography (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invencion proporciona compuestos que tienen actividad antagonista del receptor de histamina H3 de la formula: (1.0) r2 es un hidrogeno o un grupo de metilo o etilo; R3 es un hidrogeno o un grupo de metilo o etilo; n es 0, 1, 2, 3, 4, 5 o 6; y R1 se selecciona del grupo que consiste de (a) cicloalquilo de 3 a 8 átomos de carbono; (b) fenilo o fenilo substituido; (C) alquilo; (d) u heterociclico; (e) decahidronaftaleno y (f) octahidroindeno; con las salvedades de que cuando X es H, A puede ser -CH2CH2-, -COCH2-, CONH-, -CON(CH3)-, -CH=CH, -C=C, -CH2-NH-, -CH2-N(CH3)-, -CH(OH)CH2-, -NH-CH2-, -N(CH3)-CH2-, -CH2O-, -CH2S-, Y NHCOO; cuando X es NH2, NH(CH3), N(CH3)2, OH, OCH3, CH3 SH Y SCH3; A puede ser -N(CH3)-CO-, -NHCH2-, -N(CH3)-CH2, -CH=CH, -COCH2-, -CH2CH2-, -CH(OH)CH2-, o C = C -; y cuando R1 y X tomados juntos representan una estructura de anillo bicíclico 5,6, o 6,6 saturada, x puede ser NH, O o S. las sales farmacéuticamente aceptables, y estereoisomeros individuales de los compuestos de la formula estructura (1.0) anteriormente citada, así como las mezclas de los mismos, también se proponen como quedando dentro del alcance de la presente invencion. Esta invencion proporciona asimismo compuestos farmacéuticos que comprenden un portador farmacéuticamente aceptable en combinacion con una cantidad efectiva de un compuesto de la formula anteriormente citada y un método para tratar condiciones en donde el antagonismo de los receptores de histamina H3 pueden ser de importancia terapéutica tales como alergia, inflamacion, enfermedad cardivascular (es decir hiper- o hipo-tension). trastornos gastrointestinales (secrecion de ácido, movilidad) y trastornos de CNS que tienen trastornos de atencion o consentimiento, (es decir, Trastorno Hiperactivo de Déficit de Atencion de Alzheimer, funcion anormal de la memoria racionada con la edad, ataque fulminante, etc.), trastornos psiquiátricos y de motor de CNS (es decir, depresion, esquizofrenia, trastornos obsesivo-compulsivo, de tourette, etc.) trastornos del sueño (es decir, narcolepsia, apnea del sueño, insomnio, ritmos biologicos y circadiano alterados, hiper- e hipo-somnolencia y trastornos del sueño relacionados), epilepsia, funcion anormal hipotalámica (es decir, desordenes al comer, tales como obesidad, anorexia/bulimia, termorregulacion, liberacion de hormona) que comprende administrar una cantidad efectiva de un compuesto de lo anterior a un paciente que necesita de este tratamiento.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/453,359 US5652258A (en) | 1995-05-30 | 1995-05-30 | 2-(4-imidazoyl) cyclopropyl derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9709211A true MX9709211A (es) | 1998-07-31 |
Family
ID=23800267
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9709211A MX9709211A (es) | 1995-05-30 | 1997-11-27 | Derivados de 2-(1h-4(5)-imidazoil) ciclopropilo. |
Country Status (17)
Country | Link |
---|---|
US (2) | US5652258A (es) |
EP (1) | EP0837679B1 (es) |
JP (1) | JP2001503013A (es) |
KR (1) | KR19990022137A (es) |
CN (1) | CN1100534C (es) |
AT (1) | ATE207354T1 (es) |
AU (1) | AU713767B2 (es) |
CA (1) | CA2222101A1 (es) |
DE (1) | DE69616328T2 (es) |
DK (1) | DK0837679T3 (es) |
ES (1) | ES2163019T3 (es) |
FI (1) | FI974363A (es) |
MX (1) | MX9709211A (es) |
NO (1) | NO975484D0 (es) |
NZ (1) | NZ308410A (es) |
PT (1) | PT837679E (es) |
WO (1) | WO1996038141A1 (es) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5652258A (en) * | 1995-05-30 | 1997-07-29 | Gliatech, Inc. | 2-(4-imidazoyl) cyclopropyl derivatives |
US6008240A (en) * | 1997-12-15 | 1999-12-28 | Gliatech, Inc. | 2-(1H-4(5)-imidazoyl) cyclopropyl derivatives |
JP2002534511A (ja) | 1999-01-18 | 2002-10-15 | ノボ ノルディスク アクティーゼルスカブ | 置換型イミダゾール、それらの調製及び使用 |
US7265115B2 (en) | 1999-01-29 | 2007-09-04 | Abbott Laboratories | Diazabicyclic CNS active agents |
US6908926B1 (en) | 1999-04-16 | 2005-06-21 | Novo Nordisk A/S | Substituted imidazoles, their preparation and use |
US6114350A (en) * | 1999-04-19 | 2000-09-05 | Nen Life Science Products, Inc. | Cyanine dyes and synthesis methods thereof |
US6610721B2 (en) | 2000-03-17 | 2003-08-26 | Novo Nordisk A/S | Imidazo heterocyclic compounds |
US6437147B1 (en) | 2000-03-17 | 2002-08-20 | Novo Nordisk | Imidazole compounds |
US6794405B2 (en) | 2000-08-17 | 2004-09-21 | Merck & Co., Inc. | Alicyclic imidazoles as H3 agents |
JP2004506685A (ja) * | 2000-08-21 | 2004-03-04 | グリアテツク・インコーポレイテツド | 食欲の制御と肥満の治療のためのヒスタミンh3受容体逆アゴニストの使用 |
WO2002067938A2 (en) * | 2000-10-30 | 2002-09-06 | Schering Corporation | Treating or reducing the risk of cardiovascular disease |
MXPA04005557A (es) * | 2002-03-01 | 2005-05-17 | Warner Lambert Co | Metodo para tratar la osteoartritis. |
CA2555071A1 (en) * | 2004-02-02 | 2005-09-01 | Pfizer Products Inc. | Histamine-3 receptor modulators |
EP1720861A2 (en) | 2004-02-25 | 2006-11-15 | Eli Lilly And Company | Histamine h3 receptor antagonists, preparation and therapeutic uses |
MXPA06011167A (es) | 2004-04-01 | 2007-01-25 | Eli Lilli And Company | Agentes del receptor h3 de histamina, preparacion y usos terapeuticos. |
US7696234B2 (en) | 2004-06-02 | 2010-04-13 | Eli Lilly And Company | Histamine H3 receptor agents, preparation and therapeutic uses |
JP4942654B2 (ja) | 2004-08-23 | 2012-05-30 | イーライ リリー アンド カンパニー | ヒスタミンh3受容体薬剤、製剤及び治療的使用 |
JP5057982B2 (ja) | 2004-10-18 | 2012-10-24 | イーライ リリー アンド カンパニー | ヒスタミンh3受容体阻害剤、製造及び治療的使用 |
US7951826B2 (en) * | 2005-03-17 | 2011-05-31 | Eli Lilly And Company | Pyrrolidine derivatives as histamine H3 receptor antagonists |
EP1868991B1 (en) | 2005-04-01 | 2014-07-30 | Eli Lilly And Company | Histamine h3 receptor agents, preparation and therapeutic uses |
EP1707203A1 (en) | 2005-04-01 | 2006-10-04 | Bioprojet | Treatment of parkinson's disease obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine H3- receptor ligands |
EP1717233A1 (en) * | 2005-04-29 | 2006-11-02 | Bioprojet | Histamine H3-receptor ligands and their therapeutic application |
EP1717235A3 (en) | 2005-04-29 | 2007-02-28 | Bioprojet | Phenoxypropylpiperidines and -pyrrolidines and their use as histamine H3-receptor ligands |
WO2007032536A1 (ja) * | 2005-09-15 | 2007-03-22 | Banyu Pharmaceutical Co., Ltd. | 脂質・糖代謝性疾患の治療剤としてのヒスタミンh3アゴニスト |
EP1942104A1 (en) | 2006-12-20 | 2008-07-09 | sanofi-aventis | Heteroarylcyclopropanecarboxamides and their use as pharmaceuticals |
US8993808B2 (en) | 2009-01-21 | 2015-03-31 | Oryzon Genomics, S.A. | Phenylcyclopropylamine derivatives and their medical use |
MX338041B (es) | 2009-09-25 | 2016-03-30 | Oryzon Genomics Sa | Inhibidores de demetilasa-1 especificos de lisina y su uso. |
US8946296B2 (en) | 2009-10-09 | 2015-02-03 | Oryzon Genomics S.A. | Substituted heteroaryl- and aryl-cyclopropylamine acetamides and their use |
US9186337B2 (en) | 2010-02-24 | 2015-11-17 | Oryzon Genomics S.A. | Lysine demethylase inhibitors for diseases and disorders associated with Hepadnaviridae |
WO2011106574A2 (en) | 2010-02-24 | 2011-09-01 | Oryzon Genomics, S.A. | Inhibitors for antiviral use |
ES2607081T3 (es) | 2010-04-19 | 2017-03-29 | Oryzon Genomics, S.A. | Inhibidores de desmetilasa específica de lisina-1 y su uso |
EP2598480B1 (en) | 2010-07-29 | 2019-04-24 | Oryzon Genomics, S.A. | Cyclopropylamine derivatives useful as lsd1 inhibitors |
LT2598482T (lt) | 2010-07-29 | 2018-07-10 | Oryzon Genomics, S.A. | Demetilazės lsd1 inhibitoriai arilciklopropilamino pagrindu ir jų medicininis panaudojimas |
WO2012045883A1 (en) | 2010-10-08 | 2012-04-12 | Oryzon Genomics S.A. | Cyclopropylamine inhibitors of oxidases |
WO2012072713A2 (en) | 2010-11-30 | 2012-06-07 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for diseases and disorders associated with flaviviridae |
WO2012107498A1 (en) | 2011-02-08 | 2012-08-16 | Oryzon Genomics S.A. | Lysine demethylase inhibitors for myeloproliferative disorders |
CA2849564C (en) | 2011-10-20 | 2020-10-20 | Oryzon Genomics, S.A. | (hetero)aryl cyclopropylamine compounds as lsd1 inhibitors |
BR112014009306B1 (pt) | 2011-10-20 | 2021-07-20 | Oryzon Genomics S.A. | Compostos de (hetero)aril ciclopropilamina como inibidores de lsd1 |
WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2579596B1 (fr) * | 1985-03-26 | 1987-11-20 | Inst Nat Sante Rech Med | (imidazolyl-4) piperidines, leur preparation et leur application en therapeutique |
FR2671083B1 (fr) * | 1990-12-31 | 1994-12-23 | Inst Nat Sante Rech Med | Nouvelles 4-(4-imidazolyl) piperidines substituees en 1, leur preparation ainsi que leurs applications therapeutiques. |
EP0573542B1 (en) * | 1991-02-27 | 1997-10-15 | Seed Capital Investments( Sci) B.V. | Imidazole-derivatives having antagonistic activity on the histamine h3-receptor |
FR2686084B1 (fr) * | 1992-01-10 | 1995-12-22 | Bioprojet Soc Civ | Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques. |
US5217986A (en) * | 1992-03-26 | 1993-06-08 | Harbor Branch Oceanographic Institution, Inc. | Anti-allergy agent |
US5652258A (en) * | 1995-05-30 | 1997-07-29 | Gliatech, Inc. | 2-(4-imidazoyl) cyclopropyl derivatives |
-
1995
- 1995-05-30 US US08/453,359 patent/US5652258A/en not_active Expired - Fee Related
-
1996
- 1996-05-29 JP JP08536597A patent/JP2001503013A/ja not_active Ceased
- 1996-05-29 CA CA002222101A patent/CA2222101A1/en not_active Abandoned
- 1996-05-29 DK DK96914788T patent/DK0837679T3/da active
- 1996-05-29 AU AU58047/96A patent/AU713767B2/en not_active Ceased
- 1996-05-29 CN CN96195925A patent/CN1100534C/zh not_active Expired - Fee Related
- 1996-05-29 PT PT96914788T patent/PT837679E/pt unknown
- 1996-05-29 ES ES96914788T patent/ES2163019T3/es not_active Expired - Lifetime
- 1996-05-29 NZ NZ308410A patent/NZ308410A/en unknown
- 1996-05-29 WO PCT/US1996/007833 patent/WO1996038141A1/en not_active Application Discontinuation
- 1996-05-29 KR KR1019970708616A patent/KR19990022137A/ko not_active Application Discontinuation
- 1996-05-29 US US08/945,915 patent/US5990317A/en not_active Expired - Fee Related
- 1996-05-29 EP EP96914788A patent/EP0837679B1/en not_active Expired - Lifetime
- 1996-05-29 DE DE69616328T patent/DE69616328T2/de not_active Expired - Fee Related
- 1996-05-29 AT AT96914788T patent/ATE207354T1/de not_active IP Right Cessation
-
1997
- 1997-11-27 MX MX9709211A patent/MX9709211A/es not_active IP Right Cessation
- 1997-11-28 NO NO975484A patent/NO975484D0/no unknown
- 1997-11-28 FI FI974363A patent/FI974363A/fi not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR19990022137A (ko) | 1999-03-25 |
EP0837679A4 (en) | 1999-03-03 |
WO1996038141A1 (en) | 1996-12-05 |
JP2001503013A (ja) | 2001-03-06 |
EP0837679B1 (en) | 2001-10-24 |
FI974363A0 (fi) | 1997-11-28 |
EP0837679A1 (en) | 1998-04-29 |
ATE207354T1 (de) | 2001-11-15 |
NZ308410A (en) | 2001-06-29 |
CN1192143A (zh) | 1998-09-02 |
DK0837679T3 (da) | 2002-02-11 |
CN1100534C (zh) | 2003-02-05 |
AU5804796A (en) | 1996-12-18 |
NO975484D0 (no) | 1997-11-28 |
PT837679E (pt) | 2002-03-28 |
US5990317A (en) | 1999-11-23 |
CA2222101A1 (en) | 1996-12-05 |
DE69616328D1 (de) | 2001-11-29 |
US5652258A (en) | 1997-07-29 |
ES2163019T3 (es) | 2002-01-16 |
FI974363A (fi) | 1997-11-28 |
DE69616328T2 (de) | 2002-07-04 |
AU713767B2 (en) | 1999-12-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration | ||
MM | Annulment or lapse due to non-payment of fees |