ES2174220T3 - Uso de derivados de 4-fenil-3,6-dihidro-2h-piridilo como agentes bloqueantes de subtipos de receptores nmda. - Google Patents
Uso de derivados de 4-fenil-3,6-dihidro-2h-piridilo como agentes bloqueantes de subtipos de receptores nmda.Info
- Publication number
- ES2174220T3 ES2174220T3 ES97905107T ES97905107T ES2174220T3 ES 2174220 T3 ES2174220 T3 ES 2174220T3 ES 97905107 T ES97905107 T ES 97905107T ES 97905107 T ES97905107 T ES 97905107T ES 2174220 T3 ES2174220 T3 ES 2174220T3
- Authority
- ES
- Spain
- Prior art keywords
- nmda receptor
- hydrogen
- subtipos
- piridilo
- dihidro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE AL USO DE COMPUESTOS DE FORMULA GENERAL (I), EN LA QUE R 1 ES HIDROGENO, HALOGENO, ALQUILO INFERIOR O ALCOXI INFERIOR; R 2 ES HIDROGENO; R SUP,3 ES HIDROGENO, AMINO, UREIDO, ALQUILCARBONILO INFERIOR, ALQUILSULFONILAMINO INFERIOR, ALQUILCARBAMOILO INFERIOR, CARBAMOILO, ALQUILOXICARBAMOILO INFERIOR, ALQUILAMINO INFERIOR O R SUP,2 Y R 3 CUANDO SE UNEN SON -(CH 2 ) M -, X ES METILENO, HIDROXIMETILENO, ALCOXIMETILENO INFERIOR O CARBONILO, N ES 1 O 2 Y M ES 3 O 4; ASI COMO LAS SALES FARMACEUTICAMENTE ACEPTABLES PARA LA FABRICACION DE MEDICAMENTOS PARA EL CONTROL O TRATAMIENTO DE ENFERMEDADES QUE REPRESENTAN INDICACIONES TERAPEUTICAS PARA LOS BLOQUEANTES ESPECIFICOS DE UN SUBTIPO DE RECEPTOR NMDA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP96103636 | 1996-03-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2174220T3 true ES2174220T3 (es) | 2002-11-01 |
Family
ID=8222541
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97905107T Expired - Lifetime ES2174220T3 (es) | 1996-03-08 | 1997-02-27 | Uso de derivados de 4-fenil-3,6-dihidro-2h-piridilo como agentes bloqueantes de subtipos de receptores nmda. |
Country Status (15)
Country | Link |
---|---|
US (1) | US5962472A (es) |
EP (1) | EP0885004B1 (es) |
JP (1) | JP3248917B2 (es) |
KR (1) | KR100352358B1 (es) |
CN (1) | CN1131031C (es) |
AT (1) | ATE216883T1 (es) |
AU (1) | AU717140B2 (es) |
BR (1) | BR9708171A (es) |
CA (1) | CA2248134A1 (es) |
DE (1) | DE69712325T2 (es) |
DK (1) | DK0885004T3 (es) |
ES (1) | ES2174220T3 (es) |
PT (1) | PT885004E (es) |
TR (1) | TR199801774T2 (es) |
WO (1) | WO1997032581A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1674087A1 (en) | 2000-10-02 | 2006-06-28 | Pfizer Products Inc. | Prophylactic use of n-methyl-d-aspartate (NMDA) antagonists |
US7375136B2 (en) * | 2001-03-08 | 2008-05-20 | Emory University | pH-dependent NMDA receptor antagonists |
US6951875B2 (en) * | 2001-10-29 | 2005-10-04 | Hoffmann-La Roche Inc. | Conjugated aromatic compounds with a pyridine substituent |
US7005432B2 (en) * | 2002-05-16 | 2006-02-28 | Hoffman-La Roche Inc. | Substituted imidazol-pyridazine derivatives |
EP1689721B1 (en) * | 2003-11-26 | 2010-07-14 | Pfizer Products Inc. | Aminopyrazole derivatives as gsk-3 inhibitors |
AU2008272964A1 (en) * | 2007-06-29 | 2009-01-08 | Emory University | NMDA receptor antagonists for neuroprotection |
JP2011516417A (ja) * | 2008-03-27 | 2011-05-26 | エヴォテック・ノイロサイエンシーズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Nmdanr2b−サブタイプ選択的アンタゴニストを使用する障害の処置方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH506525A (de) * | 1968-12-24 | 1971-04-30 | Hoffmann La Roche | Verfahren zur Herstellung von aromatischen Äthern |
CH558354A (de) * | 1970-06-17 | 1975-01-31 | Hoffmann La Roche | Verfahren zur herstellung von aromatischen aethern. |
CH547802A (de) * | 1970-06-19 | 1974-04-11 | Hoffmann La Roche | Verfahren zur herstellung von tetrahydropyridinderivaten. |
US3879405A (en) * | 1970-06-19 | 1975-04-22 | Hoffmann La Roche | Tetrahydropyridine derivatives |
US5149817A (en) * | 1990-03-05 | 1992-09-22 | Shionogi & Co., Ltd. | Teirahydropyridine derivatives |
DE4325885A1 (de) * | 1993-08-02 | 1995-02-09 | Basf Ag | Elektrolumineszierende Anordnung |
DE4325855A1 (de) * | 1993-08-02 | 1995-02-09 | Boehringer Ingelheim Kg | Neue Benzoesäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
DE4410822A1 (de) * | 1994-03-24 | 1995-09-28 | Schering Ag | Neue Piperidin-Derivate |
US5698565A (en) * | 1995-06-09 | 1997-12-16 | Hoffmann-La Roche Inc. | Use of phenoxy-pyridine derivatives |
-
1997
- 1997-02-27 EP EP97905107A patent/EP0885004B1/en not_active Expired - Lifetime
- 1997-02-27 CN CN97192889A patent/CN1131031C/zh not_active Expired - Fee Related
- 1997-02-27 CA CA002248134A patent/CA2248134A1/en not_active Abandoned
- 1997-02-27 WO PCT/EP1997/000951 patent/WO1997032581A1/en active IP Right Grant
- 1997-02-27 ES ES97905107T patent/ES2174220T3/es not_active Expired - Lifetime
- 1997-02-27 KR KR10-1998-0706936A patent/KR100352358B1/ko not_active IP Right Cessation
- 1997-02-27 TR TR1998/01774T patent/TR199801774T2/xx unknown
- 1997-02-27 PT PT97905107T patent/PT885004E/pt unknown
- 1997-02-27 AU AU18782/97A patent/AU717140B2/en not_active Ceased
- 1997-02-27 BR BR9708171A patent/BR9708171A/pt not_active Application Discontinuation
- 1997-02-27 JP JP53141697A patent/JP3248917B2/ja not_active Expired - Fee Related
- 1997-02-27 DK DK97905107T patent/DK0885004T3/da active
- 1997-02-27 DE DE69712325T patent/DE69712325T2/de not_active Expired - Fee Related
- 1997-02-27 AT AT97905107T patent/ATE216883T1/de not_active IP Right Cessation
- 1997-03-07 US US08/813,523 patent/US5962472A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP3248917B2 (ja) | 2002-01-21 |
EP0885004A1 (en) | 1998-12-23 |
CN1131031C (zh) | 2003-12-17 |
US5962472A (en) | 1999-10-05 |
ATE216883T1 (de) | 2002-05-15 |
CN1213304A (zh) | 1999-04-07 |
EP0885004B1 (en) | 2002-05-02 |
WO1997032581A1 (en) | 1997-09-12 |
DE69712325D1 (de) | 2002-06-06 |
KR19990087505A (ko) | 1999-12-27 |
PT885004E (pt) | 2002-08-30 |
BR9708171A (pt) | 1999-07-27 |
KR100352358B1 (ko) | 2003-03-10 |
AU717140B2 (en) | 2000-03-16 |
DK0885004T3 (da) | 2002-08-19 |
JP2000507542A (ja) | 2000-06-20 |
AU1878297A (en) | 1997-09-22 |
DE69712325T2 (de) | 2002-11-28 |
TR199801774T2 (xx) | 1998-12-21 |
CA2248134A1 (en) | 1997-09-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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