ATE216883T1 - Verwendung von 4-phenyl-3,6-dihydro-2h-pyridyl derivaten als nmda rezeptor subtyp blocker - Google Patents

Verwendung von 4-phenyl-3,6-dihydro-2h-pyridyl derivaten als nmda rezeptor subtyp blocker

Info

Publication number
ATE216883T1
ATE216883T1 AT97905107T AT97905107T ATE216883T1 AT E216883 T1 ATE216883 T1 AT E216883T1 AT 97905107 T AT97905107 T AT 97905107T AT 97905107 T AT97905107 T AT 97905107T AT E216883 T1 ATE216883 T1 AT E216883T1
Authority
AT
Austria
Prior art keywords
nmda receptor
receptor subtype
hydrogen
dihydro
phenyl
Prior art date
Application number
AT97905107T
Other languages
English (en)
Inventor
Anne Bourson
Guenther Fischer
Neidhart Marie-Paule Heitz
Vincent Mutel
Gerhard Trube
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE216883T1 publication Critical patent/ATE216883T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT97905107T 1996-03-08 1997-02-27 Verwendung von 4-phenyl-3,6-dihydro-2h-pyridyl derivaten als nmda rezeptor subtyp blocker ATE216883T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96103636 1996-03-08
PCT/EP1997/000951 WO1997032581A1 (en) 1996-03-08 1997-02-27 Use of 4-phenyl-3,6-dihydro-2h-pyridyl derivatives as nmda receptor subtype blockers

Publications (1)

Publication Number Publication Date
ATE216883T1 true ATE216883T1 (de) 2002-05-15

Family

ID=8222541

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97905107T ATE216883T1 (de) 1996-03-08 1997-02-27 Verwendung von 4-phenyl-3,6-dihydro-2h-pyridyl derivaten als nmda rezeptor subtyp blocker

Country Status (15)

Country Link
US (1) US5962472A (de)
EP (1) EP0885004B1 (de)
JP (1) JP3248917B2 (de)
KR (1) KR100352358B1 (de)
CN (1) CN1131031C (de)
AT (1) ATE216883T1 (de)
AU (1) AU717140B2 (de)
BR (1) BR9708171A (de)
CA (1) CA2248134A1 (de)
DE (1) DE69712325T2 (de)
DK (1) DK0885004T3 (de)
ES (1) ES2174220T3 (de)
PT (1) PT885004E (de)
TR (1) TR199801774T2 (de)
WO (1) WO1997032581A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1674087A1 (de) 2000-10-02 2006-06-28 Pfizer Products Inc. Prophylaktische Verwendung von N-Methyl-D-Aspartat Rezeptor (NMDA) Antagonisten
EP1436258A4 (de) * 2001-03-08 2005-03-23 Univ Emory Ph-wert-abhängige nmda-rezeptorantagonisten
US6951875B2 (en) * 2001-10-29 2005-10-04 Hoffmann-La Roche Inc. Conjugated aromatic compounds with a pyridine substituent
US7005432B2 (en) * 2002-05-16 2006-02-28 Hoffman-La Roche Inc. Substituted imidazol-pyridazine derivatives
WO2005051919A1 (en) * 2003-11-26 2005-06-09 Pfizer Products Inc. Aminopyrazole derivatives as gsk-3 inhibitors
EA201070077A1 (ru) * 2007-06-29 2010-08-30 Эмори Юниверсити Антагонисты nmda-рецепторов с нейропротективным действием
JP2011516417A (ja) * 2008-03-27 2011-05-26 エヴォテック・ノイロサイエンシーズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Ｎｍｄａｎｒ２ｂ−サブタイプ選択的アンタゴニストを使用する障害の処置方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH506525A (de) * 1968-12-24 1971-04-30 Hoffmann La Roche Verfahren zur Herstellung von aromatischen Äthern
CH558354A (de) * 1970-06-17 1975-01-31 Hoffmann La Roche Verfahren zur herstellung von aromatischen aethern.
US3879405A (en) * 1970-06-19 1975-04-22 Hoffmann La Roche Tetrahydropyridine derivatives
CH547802A (de) * 1970-06-19 1974-04-11 Hoffmann La Roche Verfahren zur herstellung von tetrahydropyridinderivaten.
US5149817A (en) * 1990-03-05 1992-09-22 Shionogi & Co., Ltd. Teirahydropyridine derivatives
DE4325855A1 (de) * 1993-08-02 1995-02-09 Boehringer Ingelheim Kg Neue Benzoesäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE4325885A1 (de) * 1993-08-02 1995-02-09 Basf Ag Elektrolumineszierende Anordnung
DE4410822A1 (de) * 1994-03-24 1995-09-28 Schering Ag Neue Piperidin-Derivate
US5698565A (en) * 1995-06-09 1997-12-16 Hoffmann-La Roche Inc. Use of phenoxy-pyridine derivatives

Also Published As

Publication number Publication date
KR100352358B1 (ko) 2003-03-10
EP0885004B1 (de) 2002-05-02
DE69712325D1 (de) 2002-06-06
US5962472A (en) 1999-10-05
DK0885004T3 (da) 2002-08-19
TR199801774T2 (xx) 1998-12-21
JP2000507542A (ja) 2000-06-20
PT885004E (pt) 2002-08-30
CN1131031C (zh) 2003-12-17
WO1997032581A1 (en) 1997-09-12
CN1213304A (zh) 1999-04-07
AU1878297A (en) 1997-09-22
CA2248134A1 (en) 1997-09-12
AU717140B2 (en) 2000-03-16
DE69712325T2 (de) 2002-11-28
EP0885004A1 (de) 1998-12-23
ES2174220T3 (es) 2002-11-01
KR19990087505A (ko) 1999-12-27
JP3248917B2 (ja) 2002-01-21
BR9708171A (pt) 1999-07-27

Similar Documents

Publication Publication Date Title
EA200700232A1 (ru) Высокоселективные ингибиторы обратного захвата норэпинефрина и способы их применения
DK0687268T3 (da) Spiroazacykliske derivater som substans P-antagonister
HUP0402236A2 (hu) Heterociklusos vegyületek, az ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
MX9705590A (es) Compuestos heterociclicos sustituidos, procedimiento para su preparacion y composiciones que los contienen.
ATE139233T1 (de) Annelierte thiophen-derivate, ihre herstellung und verwendung
HUP0001192A2 (hu) Topiramát és származékainak alkalmazása elhízás kezelésére használható gyógyszerkészítmények előállítására
DK0533280T4 (da) Ny medicinsk anvendelse af tachykininantagonister
NO954694L (no) Doseringsform for antidepressiva
DE69523169D1 (de) Verwendung von Mangiferin oder seinen Derivaten zur kosmetischen Anwendung
DE69616480D1 (de) Piperidinderivate als neurokininantagonisten
ES2176204T3 (es) Antidepresivos que contienen un derivado de xantina.
TW336939B (en) Lipopeptide derivatives, a process for their preparation and their use
JO2321B1 (en) 4-phenyl-pyridine derivatives
WO1999024022A3 (en) Isoquinoline derivatives for treating disorders associated with 5ht7 receptors
IL119828A (en) 6-(disubstituted amino)-2,4-¬(bis(hydroxyaryl)¾-1,3,5-triazine derivatives their preparation and cosmetic light-screening agents containing them
NO20001514L (no) Vitronectin-reseptor-antagonist
ATE216883T1 (de) Verwendung von 4-phenyl-3,6-dihydro-2h-pyridyl derivaten als nmda rezeptor subtyp blocker
ES2073258T3 (es) Nuevos derivados de la urea, su preparacion y su aplicacion en terapeutica.
DE69412073D1 (de) Xanthinderivate als adenosin-a1 rezeptor antagonisten
HUP0002929A2 (hu) Tachikinin receptor antagonista hatású 2-acilamino-propán-aminok és az ezeket tartalmazó gyógyszerkészítmények
NO973241L (no) Anvendelse av 3,4-difenylkromaner til fremstilling av et farmasöytisk preparat for behandling eller profylakse av hyperlipoproteinemi, hypertriglyceridemi, hyperlipidemi eller hyperkolesterolemi, eller arteriosklerose, eller for antikoagulativ b
NO20023041L (no) Fremgangsmåte for fremstilling av pyrazolopyridazinderivater
ES2162078T3 (es) Compuestos terapeuticos.
YU61096A (sh) Novi intermedijari, njihova primena u sintezi n,n'-premoštenih bisindolilmaleimida i farmaceutske formulacije
NO992316L (no) Benzensulfonamidderivater og legemidler inneholdende disse

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee