DK1863487T4 - Behandling af symptomer på Parkinsons sygdom med alkylaminer uden imidazol som histamin H3-receptorligander - Google Patents

Behandling af symptomer på Parkinsons sygdom med alkylaminer uden imidazol som histamin H3-receptorligander Download PDF

Info

Publication number
DK1863487T4
DK1863487T4 DK06744466.1T DK06744466T DK1863487T4 DK 1863487 T4 DK1863487 T4 DK 1863487T4 DK 06744466 T DK06744466 T DK 06744466T DK 1863487 T4 DK1863487 T4 DK 1863487T4
Authority
DK
Denmark
Prior art keywords
alkylamines
histamine
parkinson
imidazole
treatment
Prior art date
Application number
DK06744466.1T
Other languages
Danish (da)
English (en)
Other versions
DK1863487T3 (da
Inventor
Jean-Charles Schwartz
Jeanne-Marie Lecomte
Original Assignee
Bioprojet Soc Civ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35169680&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1863487(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bioprojet Soc Civ filed Critical Bioprojet Soc Civ
Application granted granted Critical
Publication of DK1863487T3 publication Critical patent/DK1863487T3/da
Publication of DK1863487T4 publication Critical patent/DK1863487T4/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4453Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK06744466.1T 2005-04-01 2006-03-30 Behandling af symptomer på Parkinsons sygdom med alkylaminer uden imidazol som histamin H3-receptorligander DK1863487T4 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05290727A EP1707203A1 (en) 2005-04-01 2005-04-01 Treatment of parkinson's disease obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine H3- receptor ligands
US66861805P 2005-04-06 2005-04-06
PCT/IB2006/000739 WO2006103546A2 (en) 2005-04-01 2006-03-30 Treatment of parkinson's disease, obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine h3-receptor ligands

Publications (2)

Publication Number Publication Date
DK1863487T3 DK1863487T3 (da) 2013-08-12
DK1863487T4 true DK1863487T4 (da) 2019-10-14

Family

ID=35169680

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06744466.1T DK1863487T4 (da) 2005-04-01 2006-03-30 Behandling af symptomer på Parkinsons sygdom med alkylaminer uden imidazol som histamin H3-receptorligander

Country Status (27)

Country Link
US (1) US8486947B2 (https=)
EP (2) EP1707203A1 (https=)
JP (3) JP5546761B2 (https=)
KR (1) KR101308527B1 (https=)
CN (1) CN101171009B (https=)
AU (1) AU2006228413C1 (https=)
BR (1) BRPI0612216B1 (https=)
CA (1) CA2603656C (https=)
CY (1) CY1114636T1 (https=)
DK (1) DK1863487T4 (https=)
EA (1) EA016007B1 (https=)
ES (1) ES2426008T5 (https=)
HR (1) HRP20130748T4 (https=)
MA (1) MA29353B1 (https=)
ME (1) ME01713B (https=)
MX (1) MX2007012162A (https=)
NO (1) NO343603B1 (https=)
NZ (1) NZ561940A (https=)
PL (1) PL1863487T5 (https=)
PT (1) PT1863487E (https=)
RS (1) RS52911B2 (https=)
SG (1) SG147415A1 (https=)
SI (1) SI1863487T2 (https=)
TN (1) TNSN07365A1 (https=)
UA (1) UA94902C2 (https=)
WO (1) WO2006103546A2 (https=)
ZA (1) ZA200708086B (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103382174A (zh) 2006-06-23 2013-11-06 雅培制药有限公司 作为组胺h3受体调节物的环丙胺衍生物
US9108948B2 (en) 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
FR2903904A1 (fr) * 2006-07-21 2008-01-25 Bioprojet Soc Civ Ile Association de modafinil et d'un antagoniste ou agoniste inverse du recepteur h3
UA95644C2 (ru) 2006-07-25 2011-08-25 Сефалон, Инк. Пиридазиноновые производные, фармацевтическая композиция и способ лечения заболеваний
US8153813B2 (en) 2007-12-20 2012-04-10 Abbott Laboratories Benzothiazole and benzooxazole derivatives and methods of use
MX2010008375A (es) 2008-01-30 2011-03-04 Cephalon Inc Star Derivados de piperidina espirocíclicos substituidos como ligandos de receptores de histamina-3 (h3).
FR2932479A1 (fr) * 2008-06-13 2009-12-18 Servier Lab Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US9186353B2 (en) 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
US8853390B2 (en) 2010-09-16 2014-10-07 Abbvie Inc. Processes for preparing 1,2-substituted cyclopropyl derivatives
US9181275B2 (en) 2011-08-11 2015-11-10 Abbvie Inc. Mercaptoamidine derivatives and methods of use
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
HK1207004A1 (zh) * 2012-10-05 2016-01-22 Vtv治疗有限责任公司 治療輕度和中度阿爾茨海默病的方法
EP3391886A1 (en) 2017-04-19 2018-10-24 Novartis AG The use of a h3r inverse agonist for the treatment of shift work disorder
US11654283B2 (en) 2019-03-06 2023-05-23 Medtronic Xomed, Inc. Obstructive sleep apnea patient programmer for implantable devices
EP4248969A1 (en) 2022-03-23 2023-09-27 Bioprojet Use of pitolisant for treating severe fatigue
CN121175294A (zh) 2023-03-31 2025-12-19 生物计划制药公司 盐酸替洛利生的多晶型形式
WO2025082972A1 (en) * 2023-10-16 2025-04-24 Bioprojet Pharma Enteric coated pitolisant formulations and methods of use

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5815945A (ja) * 1981-07-21 1983-01-29 Teikoku Hormone Mfg Co Ltd 新規なフエノキシアルキルアミン誘導体
FR2579596B1 (fr) 1985-03-26 1987-11-20 Inst Nat Sante Rech Med (imidazolyl-4) piperidines, leur preparation et leur application en therapeutique
FR2671083B1 (fr) 1990-12-31 1994-12-23 Inst Nat Sante Rech Med Nouvelles 4-(4-imidazolyl) piperidines substituees en 1, leur preparation ainsi que leurs applications therapeutiques.
JPH06505265A (ja) 1991-02-27 1994-06-16 シード・キャピタル・インベストメント・(エス・シー・アイ)・ベスローテン・フェンノートシャップ ヒスタミンh↓3受容体に対する作動的または拮抗的活性を有するイミダゾール誘導体
DE69212164T2 (de) 1991-12-18 1996-12-05 Schering Corp., Kenilworth, N.J. Imidolylalkyl-derivate substituiert mit einem stickstoffenthaltende-6 gliedrigen ring
MX9207393A (es) 1991-12-18 1994-06-30 Schering Corp Imidazoil o alquilo de imidazoil susbtituido con una cadena heterociclica de cuatro o cinco miembros que contienen nitrogeno.
FR2686084B1 (fr) 1992-01-10 1995-12-22 Bioprojet Soc Civ Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques.
US5639775A (en) 1992-04-01 1997-06-17 The University Of Toledo 4-[4'-piperodinyl or 3'-pirrolidinyl] substituted imidazoles as H3 -receptor antagonists and therapeutic uses thereof
US5380858A (en) 1992-04-01 1995-01-10 The University Of Toledo Process for the preparation of intermediates useful for the synthesis of histamine receptor antagonists
US5486526A (en) * 1992-04-01 1996-01-23 The University Of Toledo Histamine H3 -receptor antagonists and therapeutic uses thereof
WO1994017058A1 (fr) 1993-01-25 1994-08-04 The Green Cross Corporation Compose d'imidazole
JP3522790B2 (ja) 1993-06-08 2004-04-26 花王株式会社 H3−レセプター刺激薬
WO1995006037A1 (en) 1993-08-27 1995-03-02 Vrije Universiteit New imidazole derivatives having agonistic or antagonistic activity on the histamine h3 receptor
GB9319534D0 (en) * 1993-09-22 1993-11-10 Boots Co Plc Therapeutic agents
ATE234290T1 (de) 1993-11-15 2003-03-15 Schering Corp Phenylalkyl-imidazole als h3-rezeptor- antagonisten
GB9411045D0 (en) * 1994-06-02 1994-07-20 Smithkline Beecham Plc Compounds and use
FR2732017B1 (fr) 1995-03-21 2000-09-22 Inst Nat Sante Rech Med Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques
DK0841922T3 (da) 1995-05-30 2002-06-03 Gliatech Inc 1H-4(5)-substituerede imidazolderivater
US5652258A (en) 1995-05-30 1997-07-29 Gliatech, Inc. 2-(4-imidazoyl) cyclopropyl derivatives
DK0841923T3 (da) 1995-06-07 2003-01-27 Gliatech Inc 1H-4(5)-substituerede imidazolderivater
RU2182904C2 (ru) 1996-02-09 2002-05-27 Джеймс Блэк Фаундейшн Лимитед Сульфонамиды и способы их получения
JP3925579B2 (ja) * 1998-02-03 2007-06-06 日本精工株式会社 潤滑剤供給体、並びに前記潤滑剤供給体を備える転がり軸受、リニアガイド装置及びボールねじ装置
EP0982300A3 (en) 1998-07-29 2000-03-08 Societe Civile Bioprojet Non-imidazole alkylamines as histamine H3 - receptor ligands and their therapeutic applications
US6136559A (en) * 1998-10-07 2000-10-24 Ortho Pharmaceutical Corporation DNA encoding as human histamine receptor of the H3 subtype
WO2000076957A1 (en) * 1999-06-11 2000-12-21 Toyama Chemical Co., Ltd. N-alkoxyalkyl-n,n-dialkylamine derivatives or salts thereof, and remedies for nerve degeneration diseases containing the same
GB9924941D0 (en) * 1999-10-22 1999-12-22 Univ Manchester Treatment of dyskinesia
US6620839B2 (en) * 2000-07-13 2003-09-16 Abbott Laboratories 1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications
ATE319696T1 (de) * 2000-08-08 2006-03-15 Ortho Mcneil Pharm Inc Nicht-imidazol aryloxyalkylamine als h3 rezeptor liganden
WO2002013821A1 (en) * 2000-08-17 2002-02-21 Gliatech, Inc. Novel alicyclic imidazoles as h3 agents
AU2001283573A1 (en) * 2000-08-21 2002-03-04 Gliatech, Inc. The use of histamine H3 receptor inverse agonists for the control of appetite and treatment of obesity
EP1373218B9 (en) * 2001-03-29 2008-12-03 Ortho-McNeil-Janssen Pharmaceuticals, Inc. Imidazolyl derivatives useful as histamine h3 receptor ligands
EP1451225A1 (en) * 2001-11-15 2004-09-01 Ortho-McNeil Pharmaceutical, Inc. Agonists of recombinant human histamine h3 receptor
PT1451167E (pt) * 2001-12-10 2006-07-31 Ortho Mcneil Pharm Inc Fenilalcinos
US7279491B2 (en) * 2002-10-23 2007-10-09 Janssen Pharmaceutica N.V. Phenylpiperidines and phenylpyrrolidines
EP1642898B1 (en) * 2003-06-27 2013-03-27 Msd K.K. Heteroaryloxy nitrogenous saturated heterocyclic derivative
FR2856596B1 (fr) * 2003-06-27 2007-04-27 Bioprojet Soc Civ Nouvelle association medicamenteuse psychiatrique et utilisation d'une antagoniste ou agoniste inverse du recepteur h3 de l'histamine pour preparer un medicament prevenant des effets indesirables de psychotropes.
SE0302116D0 (sv) * 2003-07-21 2003-07-21 Astrazeneca Ab Novel compounds
AU2004274309B2 (en) * 2003-09-22 2010-04-08 Msd K.K. Novel piperidine derivative

Also Published As

Publication number Publication date
CN101171009B (zh) 2012-11-07
SI1863487T2 (sl) 2019-11-29
CY1114636T1 (el) 2016-10-05
EP1707203A1 (en) 2006-10-04
PL1863487T5 (pl) 2021-08-09
US8486947B2 (en) 2013-07-16
KR101308527B1 (ko) 2013-09-17
SI1863487T1 (sl) 2013-09-30
MX2007012162A (es) 2007-11-22
RS52911B2 (sr) 2019-11-29
CA2603656C (en) 2015-06-16
ES2426008T3 (es) 2013-10-18
MA29353B1 (fr) 2008-03-03
UA94902C2 (ru) 2011-06-25
CN101171009A (zh) 2008-04-30
JP2014062126A (ja) 2014-04-10
DK1863487T3 (da) 2013-08-12
ME01713B (me) 2014-09-20
EP1863487B2 (en) 2019-07-17
BRPI0612216B1 (pt) 2022-04-19
US20090318433A1 (en) 2009-12-24
SG147415A1 (en) 2008-11-28
BRPI0612216A2 (pt) 2010-10-26
WO2006103546A2 (en) 2006-10-05
HRP20130748T4 (hr) 2019-11-15
PT1863487E (pt) 2013-08-29
NZ561940A (en) 2010-06-25
JP5955872B2 (ja) 2016-07-20
HRP20130748T1 (en) 2013-10-11
EA200702135A1 (ru) 2008-04-28
ES2426008T5 (es) 2020-03-20
AU2006228413C1 (en) 2012-02-02
RS52911B (sr) 2014-02-28
JP5546761B2 (ja) 2014-07-09
EP1863487A2 (en) 2007-12-12
AU2006228413B2 (en) 2011-09-15
PL1863487T3 (pl) 2014-10-31
WO2006103546A3 (en) 2007-03-01
AU2006228413A1 (en) 2006-10-05
EA016007B1 (ru) 2012-01-30
NO343603B1 (no) 2019-04-08
JP2016106142A (ja) 2016-06-16
CA2603656A1 (en) 2006-10-05
KR20080002904A (ko) 2008-01-04
JP2008534572A (ja) 2008-08-28
TNSN07365A1 (fr) 2008-12-31
NO20075086L (no) 2007-12-27
EP1863487B1 (en) 2013-05-29
ZA200708086B (en) 2008-10-29

Similar Documents

Publication Publication Date Title
DK1863487T4 (da) Behandling af symptomer på Parkinsons sygdom med alkylaminer uden imidazol som histamin H3-receptorligander
SI1778234T1 (sl) Pimobendan za uporabo za zmanjšanje velikosti srca pri sesalcih, ki trpijo zaradi srčne insuficience
EP2320904A4 (en) AMINOPYRIMIDINE HEMMER OF HISTAMINE RECEPTORS FOR DISEASE TREATMENT
ATE463486T1 (de) Enantiomerenreine aminoheteroaryl-verbindungen als proteinkinasehemmer
ATE491707T1 (de) Als liganden des histamin-h3-rezeptors geeignete tetrahydronaphthyridinderivate
DK1951660T3 (da) Histamin-3-receptorantagonister
ZA200700679B (en) Novel piperidine derivatives as histamine H3 receptor ligands for treatment of depression
PT2570128T (pt) Antagonistas do receptor muscarínico de acetilcolina
EP1790650B1 (en) NEW SUBSTITUTED IMIDAZOLE DERIVATIVES
ATE508119T1 (de) Ä4,5'ü-bipyrimidinyl-6,4'-diaminderivate als proteinkinase-hemmer
EP2324029A4 (en) HETEROCYCLIC HEMMER OF HISTAMINE RECEPTORS FOR DISEASE TREATMENT
EP2112947A4 (en) IN A STEP FOLDABLE ELLIPTIC TRAINING DEVICE
BRPI0814510A2 (pt) Derivados de 6-cicloamino-3-(piridazin-4-il)imidazol[1,2-b]-piridazina, sua preparação e sua aplicação em terapêutica
IL195514A0 (en) Substituted pyridiyl amide compounds as modulators of the histamine h3 receptor
EP2171592A4 (en) PARALLELIZATION OF SEQUENCIAL FRAMEWORK CONDITIONS USING TRANSACTIONS
DK1761519T3 (da) Indolderivater som histaminreceptorantagonister
DK2041093T3 (da) Til behandling af GPR38-receptor medierede sygdomme anvendelige piperazinylderivativer
PL1708991T3 (pl) Pochodne sulfonoamidu do leczenia chorób
ATE463481T1 (de) Cyclopropylamine als modulatoren des histamin-h3- rezeptors
CY2013037I2 (el) Ανταγωνιστης, υποδοχεα της αγγειοτενσινης ιι για τη θεραπευτικη αγωγη συστημικων νοσων σε γατες
DK2235012T3 (da) 4-Aminpyrimidinderivater som histamin H4-receptorantagonister
LT3456340T (lt) Glp-1 receptoriaus antagonistas, skirtas įgimto hiperinsulinizmo gydymui
ATE377008T1 (de) Imidazolderivate als glutamatrezeptorantagonisten
ITMO20050195A1 (it) Macchina per il trattamento extracorporeo di sangue
NO20075383A (no) Regulering av tyngre maskiner