JP2008517631A5 - - Google Patents
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- Publication number
- JP2008517631A5 JP2008517631A5 JP2007539228A JP2007539228A JP2008517631A5 JP 2008517631 A5 JP2008517631 A5 JP 2008517631A5 JP 2007539228 A JP2007539228 A JP 2007539228A JP 2007539228 A JP2007539228 A JP 2007539228A JP 2008517631 A5 JP2008517631 A5 JP 2008517631A5
- Authority
- JP
- Japan
- Prior art keywords
- trna
- amino acid
- providing
- translation system
- host cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62273804P | 2004-10-27 | 2004-10-27 | |
| US60/622,738 | 2004-10-27 | ||
| PCT/US2005/039210 WO2006110182A2 (en) | 2004-10-27 | 2005-10-27 | Orthogonal translation components for the in vivo incorporation of unnatural amino acids |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011255180A Division JP5539948B2 (ja) | 2004-10-27 | 2011-11-22 | 非天然アミノ酸のインビボ組込み用直交翻訳成分 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008517631A JP2008517631A (ja) | 2008-05-29 |
| JP2008517631A5 true JP2008517631A5 (enExample) | 2008-12-04 |
| JP5135504B2 JP5135504B2 (ja) | 2013-02-06 |
Family
ID=37087466
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007539228A Expired - Fee Related JP5135504B2 (ja) | 2004-10-27 | 2005-10-27 | 非天然アミノ酸のインビボ組込み用直交翻訳成分 |
| JP2011255180A Expired - Fee Related JP5539948B2 (ja) | 2004-10-27 | 2011-11-22 | 非天然アミノ酸のインビボ組込み用直交翻訳成分 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011255180A Expired - Fee Related JP5539948B2 (ja) | 2004-10-27 | 2011-11-22 | 非天然アミノ酸のインビボ組込み用直交翻訳成分 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US8216804B2 (enExample) |
| EP (3) | EP2380982B1 (enExample) |
| JP (2) | JP5135504B2 (enExample) |
| CN (2) | CN102827827B (enExample) |
| AU (1) | AU2005330514B2 (enExample) |
| BR (1) | BRPI0517381A (enExample) |
| CA (1) | CA2583735A1 (enExample) |
| IL (2) | IL182495A0 (enExample) |
| MX (1) | MX2007004892A (enExample) |
| WO (1) | WO2006110182A2 (enExample) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2464532T3 (es) * | 2001-04-19 | 2014-06-03 | The Scripps Research Institute | Métodos y composiciones para la producción de pares ortogonales de ARNt-aminoacil-ARNt sintetasa |
| EP1558747B1 (en) * | 2002-10-16 | 2009-10-14 | The Scripps Research Institute | Glycoprotein synthesis |
| JP5642916B2 (ja) | 2003-04-17 | 2014-12-17 | ザ スクリプス リサーチ インスティテュート | 真核遺伝コードの拡張 |
| WO2005019415A2 (en) | 2003-07-07 | 2005-03-03 | The Scripps Research Institute | Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof |
| MX2007003142A (es) | 2004-09-21 | 2007-07-04 | Scripps Research Inst | Incorporacion in vivo de alquinil aminoacidos a proteinas en eubacterias. |
| WO2006136197A1 (en) * | 2005-06-21 | 2006-12-28 | V. Mane Fils | Smoking device incorporating a breakable capsule, breakable capsule and process for manufacturing said capsule |
| CA2624290A1 (en) | 2005-10-12 | 2007-04-26 | Scripps Research Institute | Selective posttranslational modification of phage-displayed polypeptides |
| MX2008011470A (es) * | 2006-03-09 | 2008-09-24 | Scripps Research Inst | Sistemas para la expresion de componentes de traduccion ortogonales en celulas huesped eubacterianas. |
| US7790847B2 (en) | 2006-03-16 | 2010-09-07 | The Scripps Research Institute | Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine |
| US7807411B2 (en) | 2006-05-23 | 2010-10-05 | The Scripps Research Institute | Genetically encoded fluorescent coumarin amino acids |
| US8114627B2 (en) | 2006-09-21 | 2012-02-14 | The Scripps Research Institute | Genetically programmed expression of selectively sulfated proteins in eubacteria |
| CN101535338A (zh) | 2006-10-18 | 2009-09-16 | 斯克利普斯研究院 | 在哺乳动物细胞中将非天然氨基酸遗传掺入蛋白质 |
| WO2009049223A2 (en) * | 2007-10-10 | 2009-04-16 | Irm Llc | Methods and compositions for the site-selective incorporation of fluorinated amino acids into polypeptides |
| EP2217707B1 (en) | 2007-10-25 | 2014-10-15 | The Scripps Research Institute | Genetic incorporation of 3-aminotyrosine into reductases |
| WO2009117726A2 (en) | 2008-03-21 | 2009-09-24 | The Regents Of The University Of California | High-sensitive fluorescent energy transfer assay using fluorescent amino acids and fluoresent proteins |
| EP2370473B1 (en) | 2008-12-10 | 2016-05-11 | The Scripps Research Institute | Production of carrier-peptide conjugates using chemically reactive unnatural amino acids |
| JP5725467B2 (ja) * | 2010-08-27 | 2015-05-27 | 国立大学法人 東京大学 | 新規人工翻訳合成系 |
| US8658394B2 (en) * | 2011-02-02 | 2014-02-25 | Waterstone Pharmaceuticals | Methods, cells and systems for incorporating non-canonical amino acids into proteins |
| CN102888387B (zh) * | 2011-07-21 | 2015-03-18 | 中国科学院生物物理研究所 | 3-氯代酪氨酸翻译系统及其应用 |
| CN103215235B (zh) * | 2012-01-18 | 2014-11-05 | 中国科学院生物物理研究所 | 3-咪唑基酪氨酸翻译系统及其应用 |
| EP2852664B1 (en) | 2012-05-18 | 2017-09-06 | Medical Research Council | Methods of incorporating an amino acid comprising a bcn group into a polypeptide using an orthogonal codon encoding it and an orthorgonal pylrs synthase. |
| US9738724B2 (en) | 2012-06-08 | 2017-08-22 | Sutro Biopharma, Inc. | Antibodies comprising site-specific non-natural amino acid residues, methods of their preparation and methods of their use |
| EP3135690A1 (en) | 2012-06-26 | 2017-03-01 | Sutro Biopharma, Inc. | Modified fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use |
| CN103571804B (zh) * | 2012-08-10 | 2015-08-12 | 中国科学院生物物理研究所 | 3-吡唑基酪氨酸翻译系统及其应用 |
| SI2890402T1 (sl) | 2012-08-31 | 2019-07-31 | Sutro Biopharma, Inc. | Modificirane aminokisline vsebujoče acido skupino |
| CN104004723B (zh) * | 2013-02-22 | 2016-08-17 | 中国科学院生物物理研究所 | 3,5-二氟代酪氨酸翻译系统及其应用 |
| UY35368A (es) | 2013-03-08 | 2014-10-31 | Irm Llc | Péptidos y composiciones para el tratamiento de daño articular |
| CN106047846B (zh) * | 2013-03-22 | 2020-02-04 | 中国科学院生物物理研究所 | 8-羟基喹啉丙氨酸翻译系统及其应用 |
| WO2015006555A2 (en) | 2013-07-10 | 2015-01-15 | Sutro Biopharma, Inc. | Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use |
| US10005838B2 (en) | 2013-07-19 | 2018-06-26 | The Regents Of The University Of California | Milk fat globule epidermal growth factor 8 regulates fatty acid uptake |
| US9988619B2 (en) | 2013-10-11 | 2018-06-05 | Sutro Biopharma, Inc. | Non-natural amino acid tRNA synthetases for pyridyl tetrazine |
| WO2015054658A1 (en) | 2013-10-11 | 2015-04-16 | Sutro Biopharma, Inc. | Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use |
| PL3055321T3 (pl) | 2013-10-11 | 2019-02-28 | Sutro Biopharma, Inc. | SYNTETAZY tRNA DOŁĄCZAJĄCE AMINOKWAS NIENATURALNY DLA PARA-METYLOAZYDO-L-FENYLOALANINY |
| GB2528227A (en) | 2014-03-14 | 2016-01-20 | Medical Res Council | Cyclopropene amino acids and methods |
| GB201419109D0 (en) * | 2014-10-27 | 2014-12-10 | Medical Res Council | Incorporation of unnatural amino acids into proteins |
| US12091391B2 (en) * | 2015-04-30 | 2024-09-17 | Oregon State University | Reagents and methods for bioorthogonal labeling of biomolecules in living cells |
| AU2017212739B2 (en) | 2016-01-27 | 2024-03-21 | Sutro Biopharma, Inc. | Anti-CD74 antibody conjugates, compositions comprising anti-CD74 antibody conjugates and methods of using anti-CD74 antibody conjugates |
| WO2018031531A1 (en) * | 2016-08-08 | 2018-02-15 | President And Fellows Of Harvard College | Engineered bacteria for non-invasive imaging and therapeutic applications |
| CN109996809A (zh) | 2016-11-14 | 2019-07-09 | 诺华股份有限公司 | 与促融合蛋白minion相关的组合物、方法和治疗用途 |
| CN109963579A (zh) | 2016-11-14 | 2019-07-02 | 诺华股份有限公司 | 用于治疗软骨损伤和关节炎的方法和组合物 |
| WO2019005973A1 (en) * | 2017-06-30 | 2019-01-03 | President And Fellows Of Harvard College | SYNTHASE VARIANTS FOR INCORPORATING BIPHENYLALANINE INTO A PEPTIDE |
| WO2019028463A1 (en) * | 2017-08-04 | 2019-02-07 | Bioventures, Llc | LINEAR LIPOPEPTIDE PAENIPEPTINS AND METHODS OF USE |
| US20210356377A1 (en) * | 2018-09-07 | 2021-11-18 | Medimmune, Llc | Methods Of Cell Selection |
| GB201817444D0 (en) | 2018-10-26 | 2018-12-12 | Res & Innovation Uk | Methods and compositions |
| US12509675B2 (en) | 2019-02-20 | 2025-12-30 | Novo Nordisk A/S | Aminoacyl-tRNA synthetases and uses hereof |
| US12565646B2 (en) | 2019-06-21 | 2026-03-03 | Trustees Of Boston College | Enhanced platforms for unnatural amino acid incorporation in mammalian cells |
| CA3150276A1 (en) * | 2019-08-08 | 2021-02-11 | Brickbio, Inc. | Aminoacyl-trna synthetases and cell lines for site-specific incorporation of unnatural amino acids |
| US12680122B2 (en) | 2019-10-08 | 2026-07-14 | Trustees Of Boston College | Proteins containing multiple, different unnatural amino acids and methods of making and using such proteins |
| EP4045639A1 (en) * | 2019-10-15 | 2022-08-24 | Trustees of Boston College | Chimeric thermostable aminoacyl-trna synthetase for enhanced unnatural amino acid incorporation |
| CN114787359A (zh) * | 2019-12-12 | 2022-07-22 | 中外制药株式会社 | 产生含有非天然氨基酸的肽的方法 |
| EP4107258A4 (en) * | 2020-02-20 | 2024-04-17 | B.G. Negev Technologies and Applications Ltd., at Ben-Gurion University | MUTANT AMINOACYL-ARNT SYNTHETASES |
| AR122020A1 (es) | 2020-05-05 | 2022-08-03 | Genentech Inc | Sistemas y métodos para la conjugación específica de sitio de proteínas mediada por tirosinasa |
| US20230313129A1 (en) * | 2020-08-07 | 2023-10-05 | Brickbio, Inc. | Stable cell lines for site-specific incorporation of unnatural amino acids |
| CN114250243B (zh) * | 2020-09-24 | 2024-05-03 | 深圳华大生命科学研究院 | 一种检测极端嗜盐生物中氨酰-tRNA合成酶和tRNA活性的系统及方法 |
| CN113481218B (zh) * | 2021-06-13 | 2024-06-14 | 中国药科大学 | 巨型病毒或巨型噬菌体来源氨酰tRNA合成酶/tRNA正交体系构建方法及正交体系 |
| WO2023069816A2 (en) | 2021-09-20 | 2023-04-27 | The Broad Institute, Inc. | Compositions and methods for multiplex decoding of quadruplet codons |
| WO2023049774A1 (en) * | 2021-09-21 | 2023-03-30 | University Of Washington | Genetically encoded and exogenously triggered protein-protein ligation |
| CN114134141B (zh) * | 2021-11-03 | 2024-01-30 | 杭州嵌化合生医药科技有限公司 | 一种引入非天然氨基酸的嵌合体苯丙氨酸翻译系统及其构建方法 |
| CN116376947A (zh) * | 2021-12-24 | 2023-07-04 | 北京理工大学 | 一种适用于筛选高产非蛋白质氨基酸的菌株的方法 |
| CN115717130B (zh) * | 2022-09-02 | 2024-10-15 | 凯莱英医药集团(天津)股份有限公司 | 氨酰-tRNA合酶突变体及烯基酪氨酰-tRNA的制备方法 |
| US20260151538A1 (en) | 2022-10-26 | 2026-06-04 | Ada Forsyth Institute, Inc. | Differentiation and reprogramming of chondrocyte |
| US20260218158A1 (en) * | 2023-01-02 | 2026-07-30 | B. G. Negev Technologies And Applications Ltd., At Ben-Gurion University | Mutant aminoacyl trna synthetase, compositions comprising same, and use thereof |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5580953A (en) * | 1991-08-14 | 1996-12-03 | Amylin Pharmaceuticals, Inc. | Amylin antagonist peptides and uses therefor |
| US5635608A (en) | 1994-11-08 | 1997-06-03 | Molecular Probes, Inc. | α-carboxy caged compounds |
| US5824485A (en) | 1995-04-24 | 1998-10-20 | Chromaxome Corporation | Methods for generating and screening novel metabolic pathways |
| US5958672A (en) | 1995-07-18 | 1999-09-28 | Diversa Corporation | Protein activity screening of clones having DNA from uncultivated microorganisms |
| CN1156180A (zh) * | 1995-09-05 | 1997-08-06 | 底古萨股份公司 | 用大肠杆菌生产色氨酸 |
| US5998580A (en) | 1995-10-13 | 1999-12-07 | Fay; Frederick F. | Photosensitive caged macromolecules |
| US5756316A (en) | 1995-11-02 | 1998-05-26 | Genencor International, Inc. | Molecular cloning by multimerization of plasmids |
| US6238884B1 (en) | 1995-12-07 | 2001-05-29 | Diversa Corporation | End selection in directed evolution |
| US6171820B1 (en) | 1995-12-07 | 2001-01-09 | Diversa Corporation | Saturation mutagenesis in directed evolution |
| US5783431A (en) | 1996-04-24 | 1998-07-21 | Chromaxome Corporation | Methods for generating and screening novel metabolic pathways |
| JP2000301808A (ja) * | 1999-04-19 | 2000-10-31 | Canon Inc | テストパターン記録方法、情報処理装置および記録装置 |
| CN1297999A (zh) * | 1999-11-24 | 2001-06-06 | 上海博容基因开发有限公司 | 一种新的多肽——人谷氨酰转移核糖核酸合成酶58和编码这种多肽的多核苷酸 |
| AU2001227280A1 (en) * | 2000-04-10 | 2001-10-23 | The Scripps Research Institute | Proteomic analysis using activity-based probe libraries |
| ES2464532T3 (es) * | 2001-04-19 | 2014-06-03 | The Scripps Research Institute | Métodos y composiciones para la producción de pares ortogonales de ARNt-aminoacil-ARNt sintetasa |
| WO2004009459A1 (en) | 2002-07-23 | 2004-01-29 | Yong-Seok Jeong | Beverage can |
| EP1558747B1 (en) | 2002-10-16 | 2009-10-14 | The Scripps Research Institute | Glycoprotein synthesis |
| MXPA05003983A (es) * | 2002-10-16 | 2005-06-22 | Scripps Research Inst | Incorporacion en sitio especifico de cetoaminoacidos en proteinas. |
| EP1583816A4 (en) | 2002-12-22 | 2007-06-13 | Scripps Research Inst | PROTEIN ARRAYS |
| JP5642916B2 (ja) * | 2003-04-17 | 2014-12-17 | ザ スクリプス リサーチ インスティテュート | 真核遺伝コードの拡張 |
| JP5275566B2 (ja) * | 2003-06-18 | 2013-08-28 | ザ スクリプス リサーチ インスティチュート | 反応性非天然アミノ酸遺伝コード付加 |
| WO2005007624A2 (en) | 2003-07-07 | 2005-01-27 | The Scripps Research Institute | Compositions of orthogonal glutamyl-trna and aminoacyl trna synthetase pairs and uses thereof |
| WO2005019415A2 (en) * | 2003-07-07 | 2005-03-03 | The Scripps Research Institute | Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof |
| EP1704242A4 (en) * | 2003-07-07 | 2008-06-18 | Scripps Research Inst | COMPOSITIONS WITH PAIRS OF ORTHOGONAL LEUCYL-TRNA AND AMINOACYL-TRNA-SYNTHETASE AND USES THEREOF |
| US7134031B2 (en) | 2003-08-04 | 2006-11-07 | Arm Limited | Performance control within a multi-processor system |
| CN101532046A (zh) * | 2003-10-14 | 2009-09-16 | 斯克利普斯研究院 | 将氧化还原活性氨基酸位点特异地掺入蛋白质 |
| CA2549830A1 (en) * | 2003-12-18 | 2006-01-05 | The Scripps Research Institute | Selective incorporation of 5-hyroxytryptophan into proteins in mammalian cells |
| JP2005321568A (ja) * | 2004-05-07 | 2005-11-17 | Canon Inc | 画像形成装置 |
| JP2005322288A (ja) * | 2004-05-07 | 2005-11-17 | Sony Corp | ディスク記録及び/又は再生装置 |
| CA2567624A1 (en) * | 2004-05-25 | 2005-12-08 | The Scripps Research Institute | Site specific incorporation of heavy atom-containing unnatural amino acids into proteins for crystal structure determination |
| MX2007003142A (es) * | 2004-09-21 | 2007-07-04 | Scripps Research Inst | Incorporacion in vivo de alquinil aminoacidos a proteinas en eubacterias. |
| US20090181858A1 (en) * | 2004-09-21 | 2009-07-16 | The Scripps Research Institute | Adding photoregulated amino acids to the genetic code |
| EP1794312A4 (en) * | 2004-09-22 | 2009-08-12 | Scripps Research Inst | LOCAL LABELING OF PROTEINS FOR NMR STUDIES |
| WO2006045116A2 (en) * | 2004-10-20 | 2006-04-27 | The Scripps Research Institute | In vivo site-specific incorporation of n-acetyl-galactosamine amino acids in eubacteria |
| CA2624290A1 (en) * | 2005-10-12 | 2007-04-26 | Scripps Research Institute | Selective posttranslational modification of phage-displayed polypeptides |
| MX2008011470A (es) | 2006-03-09 | 2008-09-24 | Scripps Research Inst | Sistemas para la expresion de componentes de traduccion ortogonales en celulas huesped eubacterianas. |
| US7790847B2 (en) * | 2006-03-16 | 2010-09-07 | The Scripps Research Institute | Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine |
-
2005
- 2005-10-27 MX MX2007004892A patent/MX2007004892A/es active IP Right Grant
- 2005-10-27 JP JP2007539228A patent/JP5135504B2/ja not_active Expired - Fee Related
- 2005-10-27 WO PCT/US2005/039210 patent/WO2006110182A2/en not_active Ceased
- 2005-10-27 BR BRPI0517381-7A patent/BRPI0517381A/pt not_active Application Discontinuation
- 2005-10-27 AU AU2005330514A patent/AU2005330514B2/en not_active Ceased
- 2005-10-27 CN CN201210216741.4A patent/CN102827827B/zh not_active Expired - Fee Related
- 2005-10-27 CN CN2005800369829A patent/CN101048506B/zh not_active Expired - Fee Related
- 2005-10-27 EP EP11164983.6A patent/EP2380982B1/en not_active Expired - Lifetime
- 2005-10-27 EP EP11165007.3A patent/EP2383340B1/en not_active Expired - Lifetime
- 2005-10-27 EP EP05857733A patent/EP1807515A4/en not_active Ceased
- 2005-10-27 US US11/665,083 patent/US8216804B2/en active Active
- 2005-10-27 CA CA002583735A patent/CA2583735A1/en not_active Abandoned
-
2007
- 2007-04-12 IL IL182495A patent/IL182495A0/en unknown
-
2011
- 2011-02-15 IL IL211229A patent/IL211229A0/en unknown
- 2011-11-22 JP JP2011255180A patent/JP5539948B2/ja not_active Expired - Fee Related
-
2012
- 2012-06-08 US US13/492,296 patent/US9102932B2/en not_active Expired - Lifetime
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