JP2008517631A5 - - Google Patents
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- Publication number
- JP2008517631A5 JP2008517631A5 JP2007539228A JP2007539228A JP2008517631A5 JP 2008517631 A5 JP2008517631 A5 JP 2008517631A5 JP 2007539228 A JP2007539228 A JP 2007539228A JP 2007539228 A JP2007539228 A JP 2007539228A JP 2008517631 A5 JP2008517631 A5 JP 2008517631A5
- Authority
- JP
- Japan
- Prior art keywords
- trna
- amino acid
- providing
- translation system
- host cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62273804P | 2004-10-27 | 2004-10-27 | |
| US60/622,738 | 2004-10-27 | ||
| PCT/US2005/039210 WO2006110182A2 (en) | 2004-10-27 | 2005-10-27 | Orthogonal translation components for the in vivo incorporation of unnatural amino acids |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011255180A Division JP5539948B2 (ja) | 2004-10-27 | 2011-11-22 | 非天然アミノ酸のインビボ組込み用直交翻訳成分 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008517631A JP2008517631A (ja) | 2008-05-29 |
| JP2008517631A5 true JP2008517631A5 (enExample) | 2008-12-04 |
| JP5135504B2 JP5135504B2 (ja) | 2013-02-06 |
Family
ID=37087466
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007539228A Expired - Fee Related JP5135504B2 (ja) | 2004-10-27 | 2005-10-27 | 非天然アミノ酸のインビボ組込み用直交翻訳成分 |
| JP2011255180A Expired - Fee Related JP5539948B2 (ja) | 2004-10-27 | 2011-11-22 | 非天然アミノ酸のインビボ組込み用直交翻訳成分 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011255180A Expired - Fee Related JP5539948B2 (ja) | 2004-10-27 | 2011-11-22 | 非天然アミノ酸のインビボ組込み用直交翻訳成分 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US8216804B2 (enExample) |
| EP (3) | EP1807515A4 (enExample) |
| JP (2) | JP5135504B2 (enExample) |
| CN (2) | CN102827827B (enExample) |
| AU (1) | AU2005330514B2 (enExample) |
| BR (1) | BRPI0517381A (enExample) |
| CA (1) | CA2583735A1 (enExample) |
| IL (2) | IL182495A0 (enExample) |
| MX (1) | MX2007004892A (enExample) |
| WO (1) | WO2006110182A2 (enExample) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1490483B1 (en) * | 2001-04-19 | 2015-06-03 | The Scripps Research Institute | In vivo incorporation of unnatural amino acids |
| KR20050073559A (ko) * | 2002-10-16 | 2005-07-14 | 더 스크립스 리서치 인스티튜트 | 당단백질 합성 |
| CN103289960B (zh) | 2003-04-17 | 2017-04-26 | 斯克利普斯研究院 | 扩展真核生物遗传密码 |
| DE602004011789T2 (de) * | 2003-07-07 | 2009-02-12 | The Scripps Research Institute, La Jolla | Zusammensetzungen der orthogonalen Lysyl-tRNA und Aminoacyl-tRNA Synthetase Paaren und ihre Verwendungen |
| EP1794323B1 (en) | 2004-09-21 | 2014-08-06 | The Scripps Research Institute | In vivo incorporation of alkynyl amino acids into proteins in eubacteria |
| WO2006136197A1 (en) * | 2005-06-21 | 2006-12-28 | V. Mane Fils | Smoking device incorporating a breakable capsule, breakable capsule and process for manufacturing said capsule |
| CA2624290A1 (en) | 2005-10-12 | 2007-04-26 | Scripps Research Institute | Selective posttranslational modification of phage-displayed polypeptides |
| CA2638763A1 (en) * | 2006-03-09 | 2007-09-13 | The Scripps Research Institute | System for the expression of orthogonal translation components in eubacterial host cells |
| JP5249194B2 (ja) | 2006-03-16 | 2013-07-31 | ザ スクリプス リサーチ インスティチュート | 非天然アミノ酸フェニルセレノシステインを含有するタンパク質の遺伝的にプログラムされた発現 |
| BRPI0711811A2 (pt) | 2006-05-23 | 2011-12-06 | Scripps Research Inst | aminoácidos de cumarina fluorescente geneticamente codificados |
| CA2663052A1 (en) | 2006-09-21 | 2008-03-27 | The Scripps Research Institute | Genetically programmed expression of selectively sulfated proteins in eubacteria |
| US20080166766A1 (en) | 2006-10-18 | 2008-07-10 | The Scripps Research Institute | Genetic incorporation of unnatural amino acids into proteins in mammalian cells |
| WO2009049223A2 (en) * | 2007-10-10 | 2009-04-16 | Irm Llc | Methods and compositions for the site-selective incorporation of fluorinated amino acids into polypeptides |
| KR20100088618A (ko) | 2007-10-25 | 2010-08-09 | 더 스크립스 리서치 인스티튜트 | 리덕타제 내로의 3-아미노티로신의 유전적 도입 |
| WO2009117726A2 (en) | 2008-03-21 | 2009-09-24 | The Regents Of The University Of California | High-sensitive fluorescent energy transfer assay using fluorescent amino acids and fluoresent proteins |
| US8637306B2 (en) | 2008-12-10 | 2014-01-28 | The Scripps Research Institute | Production of carrier-peptide conjugates using chemically reactive unnatural amino acids |
| JP5725467B2 (ja) * | 2010-08-27 | 2015-05-27 | 国立大学法人 東京大学 | 新規人工翻訳合成系 |
| US8658394B2 (en) * | 2011-02-02 | 2014-02-25 | Waterstone Pharmaceuticals | Methods, cells and systems for incorporating non-canonical amino acids into proteins |
| CN102888387B (zh) * | 2011-07-21 | 2015-03-18 | 中国科学院生物物理研究所 | 3-氯代酪氨酸翻译系统及其应用 |
| CN103215235B (zh) * | 2012-01-18 | 2014-11-05 | 中国科学院生物物理研究所 | 3-咪唑基酪氨酸翻译系统及其应用 |
| JP6343604B2 (ja) | 2012-05-18 | 2018-06-13 | メディカル リサーチ カウンシル | BCN基を含むアミノ酸をコードする直交性コドンと、直交性PylRS合成酵素とを使用して、BCN基を含むアミノ酸をポリペプチドに取り込む方法 |
| SG11201408161RA (en) | 2012-06-08 | 2015-01-29 | Sutro Biopharma Inc | Antibodies comprising site-specific non-natural amino acid residues, methods of their preparation and methods of their use |
| EP3135690A1 (en) | 2012-06-26 | 2017-03-01 | Sutro Biopharma, Inc. | Modified fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use |
| CN103571804B (zh) * | 2012-08-10 | 2015-08-12 | 中国科学院生物物理研究所 | 3-吡唑基酪氨酸翻译系统及其应用 |
| ES2728864T3 (es) | 2012-08-31 | 2019-10-29 | Sutro Biopharma Inc | Aminoácidos modificados que comprenden un grupo azido |
| CN104004723B (zh) * | 2013-02-22 | 2016-08-17 | 中国科学院生物物理研究所 | 3,5-二氟代酪氨酸翻译系统及其应用 |
| UY35368A (es) | 2013-03-08 | 2014-10-31 | Irm Llc | Péptidos y composiciones para el tratamiento de daño articular |
| CN106047846B (zh) * | 2013-03-22 | 2020-02-04 | 中国科学院生物物理研究所 | 8-羟基喹啉丙氨酸翻译系统及其应用 |
| ES2658039T3 (es) | 2013-07-10 | 2018-03-08 | Sutro Biopharma, Inc. | Anticuerpos que comprenden múltiples residuos de aminoácidos no naturales sitio-específicos, métodos para su preparación y métodos de uso |
| EP3021942A4 (en) | 2013-07-19 | 2017-04-19 | The Regents of The University of California | Milk fat globule epidermal growth factor 8 regulates fatty acid uptake |
| ES2697778T3 (es) | 2013-10-11 | 2019-01-28 | Sutro Biopharma Inc | ARNt sintetasas de aminoácidos no naturales para para-metilazido-L-fenilalanina |
| EP3055298B1 (en) | 2013-10-11 | 2020-04-29 | Sutro Biopharma, Inc. | Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use |
| EP3055320B1 (en) | 2013-10-11 | 2018-10-03 | Sutro Biopharma, Inc. | NON-NATURAL AMINO ACID tRNA SYNTHETASES FOR PYRIDYL TETRAZINE |
| GB2528227A (en) | 2014-03-14 | 2016-01-20 | Medical Res Council | Cyclopropene amino acids and methods |
| GB201419109D0 (en) | 2014-10-27 | 2014-12-10 | Medical Res Council | Incorporation of unnatural amino acids into proteins |
| US12091391B2 (en) * | 2015-04-30 | 2024-09-17 | Oregon State University | Reagents and methods for bioorthogonal labeling of biomolecules in living cells |
| US11708413B2 (en) | 2016-01-27 | 2023-07-25 | Sutro Biopharma, Inc. | Anti-CD74 antibody conjugates, compositions comprising anti-CD74 antibody conjugates and methods of using anti-CD74 antibody conjugates |
| WO2018031531A1 (en) * | 2016-08-08 | 2018-02-15 | President And Fellows Of Harvard College | Engineered bacteria for non-invasive imaging and therapeutic applications |
| IL266361B2 (en) | 2016-11-14 | 2024-02-01 | Novartis Ag | Methods and preparations for the treatment of cartilage damage and arthritis |
| US11339209B2 (en) | 2016-11-14 | 2022-05-24 | Novartis Ag | Compositions, methods, and therapeutic uses related to fusogenic protein minion |
| WO2019005973A1 (en) * | 2017-06-30 | 2019-01-03 | President And Fellows Of Harvard College | SYNTHASE VARIANTS FOR INCORPORATING BIPHENYLALANINE INTO A PEPTIDE |
| CA3071836A1 (en) * | 2017-08-04 | 2019-02-07 | Bioventures, Llc | Linear lipopeptide paenipeptins and methods of using the same |
| US20210356377A1 (en) * | 2018-09-07 | 2021-11-18 | Medimmune, Llc | Methods Of Cell Selection |
| GB201817444D0 (en) | 2018-10-26 | 2018-12-12 | Res & Innovation Uk | Methods and compositions |
| CN113454211A (zh) * | 2019-02-20 | 2021-09-28 | 诺和诺德股份有限公司 | 氨酰基-tRNA合成酶及其用途 |
| CA3143506A1 (en) * | 2019-06-21 | 2020-12-24 | Trustees Of Boston College | Enhanced platforms for unnatural amino acid incorporation in mammalian cells |
| US20220325269A1 (en) * | 2019-08-08 | 2022-10-13 | Brickbio, Inc. | Aminoacyl-trna synthetases and cell lines for site-specific incorporation of unnatural amino acids |
| US20220403438A1 (en) * | 2019-10-08 | 2022-12-22 | Trustees Of Boston College | Proteins containing multiple, different unnatural amino acids and methods of making and using such proteins |
| JP2022552137A (ja) * | 2019-10-15 | 2022-12-15 | トラスティーズ オブ ボストン カレッジ | 非天然アミノ酸組み込み増強のためのキメラ耐熱性アミノアシルtRNAシンテターゼ |
| WO2021117848A1 (ja) * | 2019-12-12 | 2021-06-17 | 中外製薬株式会社 | 非天然アミノ酸を含むペプチドの製造方法 |
| WO2021165968A1 (en) * | 2020-02-20 | 2021-08-26 | B. G. Negev Technologies And Applications Ltd., At Ben-Gurion University | Mutant aminoacyl-trna synthetases |
| EP4146665A1 (en) | 2020-05-05 | 2023-03-15 | Genentech, Inc. | Systems and methods for tyrosinase-mediated site-specific protein conjugation |
| AU2021320894A1 (en) * | 2020-08-07 | 2023-03-02 | Brickbio, Inc. | Stable cell lines for site-specific incorporation of unnatural amino acids |
| CN114250243B (zh) * | 2020-09-24 | 2024-05-03 | 深圳华大生命科学研究院 | 一种检测极端嗜盐生物中氨酰-tRNA合成酶和tRNA活性的系统及方法 |
| CN113481218B (zh) * | 2021-06-13 | 2024-06-14 | 中国药科大学 | 巨型病毒或巨型噬菌体来源氨酰tRNA合成酶/tRNA正交体系构建方法及正交体系 |
| WO2023069816A2 (en) | 2021-09-20 | 2023-04-27 | The Broad Institute, Inc. | Compositions and methods for multiplex decoding of quadruplet codons |
| US20250129132A1 (en) * | 2021-09-21 | 2025-04-24 | University Of Washington | Genetically encoded and exogenously triggered protein-protein ligation |
| CN114134141B (zh) * | 2021-11-03 | 2024-01-30 | 杭州嵌化合生医药科技有限公司 | 一种引入非天然氨基酸的嵌合体苯丙氨酸翻译系统及其构建方法 |
| CN115717130B (zh) * | 2022-09-02 | 2024-10-15 | 凯莱英医药集团(天津)股份有限公司 | 氨酰-tRNA合酶突变体及烯基酪氨酰-tRNA的制备方法 |
| WO2024091824A1 (en) | 2022-10-26 | 2024-05-02 | Ada Forsyth Institute, Inc. | Differentiation and reprogramming of chondrocyte |
| WO2024147130A1 (en) * | 2023-01-02 | 2024-07-11 | B. G. Negev Technologies And Applications Ltd., At Ben-Gurion University | Mutant aminoacyl trna synthetase, compositions comprising same, and use thereof |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5580953A (en) * | 1991-08-14 | 1996-12-03 | Amylin Pharmaceuticals, Inc. | Amylin antagonist peptides and uses therefor |
| US5635608A (en) | 1994-11-08 | 1997-06-03 | Molecular Probes, Inc. | α-carboxy caged compounds |
| JPH11504218A (ja) | 1995-04-24 | 1999-04-20 | クロマゾーム コーポレーション | 新規代謝経路の生成およびスクリーニングのための方法 |
| US5958672A (en) | 1995-07-18 | 1999-09-28 | Diversa Corporation | Protein activity screening of clones having DNA from uncultivated microorganisms |
| CN1156180A (zh) * | 1995-09-05 | 1997-08-06 | 底古萨股份公司 | 用大肠杆菌生产色氨酸 |
| US5998580A (en) | 1995-10-13 | 1999-12-07 | Fay; Frederick F. | Photosensitive caged macromolecules |
| US5756316A (en) | 1995-11-02 | 1998-05-26 | Genencor International, Inc. | Molecular cloning by multimerization of plasmids |
| US6238884B1 (en) | 1995-12-07 | 2001-05-29 | Diversa Corporation | End selection in directed evolution |
| US6171820B1 (en) | 1995-12-07 | 2001-01-09 | Diversa Corporation | Saturation mutagenesis in directed evolution |
| US5783431A (en) | 1996-04-24 | 1998-07-21 | Chromaxome Corporation | Methods for generating and screening novel metabolic pathways |
| JP2000301808A (ja) * | 1999-04-19 | 2000-10-31 | Canon Inc | テストパターン記録方法、情報処理装置および記録装置 |
| CN1297999A (zh) * | 1999-11-24 | 2001-06-06 | 上海博容基因开发有限公司 | 一种新的多肽——人谷氨酰转移核糖核酸合成酶58和编码这种多肽的多核苷酸 |
| JP2003530365A (ja) * | 2000-04-10 | 2003-10-14 | ザ スクリプス リサーチ インスティチュート | プロテオミック分析 |
| EP1490483B1 (en) | 2001-04-19 | 2015-06-03 | The Scripps Research Institute | In vivo incorporation of unnatural amino acids |
| AU2003250559A1 (en) | 2002-07-23 | 2004-02-09 | Yong-Seok Jeong | Beverage can |
| DK1578949T3 (da) | 2002-10-16 | 2009-07-27 | Scripps Research Inst | Stedspecifik optagelse af keto-aminnosyrer hos proteiner |
| KR20050073559A (ko) | 2002-10-16 | 2005-07-14 | 더 스크립스 리서치 인스티튜트 | 당단백질 합성 |
| EP1583816A4 (en) | 2002-12-22 | 2007-06-13 | Scripps Research Inst | PROTEIN ARRAYS |
| CN103289960B (zh) | 2003-04-17 | 2017-04-26 | 斯克利普斯研究院 | 扩展真核生物遗传密码 |
| WO2005003294A2 (en) | 2003-06-18 | 2005-01-13 | The Scripps Research Institute | Unnatural reactive amino acid genetic code additions |
| WO2005007624A2 (en) | 2003-07-07 | 2005-01-27 | The Scripps Research Institute | Compositions of orthogonal glutamyl-trna and aminoacyl trna synthetase pairs and uses thereof |
| DE602004011789T2 (de) | 2003-07-07 | 2009-02-12 | The Scripps Research Institute, La Jolla | Zusammensetzungen der orthogonalen Lysyl-tRNA und Aminoacyl-tRNA Synthetase Paaren und ihre Verwendungen |
| WO2005007870A2 (en) | 2003-07-07 | 2005-01-27 | The Scripps Research Institute | COMPOSITIONS OF ORTHOGONAL LEUCYL-tRNA AND AMINOACYL-tRNA SYNTHETASE PAIRS AND USES THEREOF |
| US7134031B2 (en) | 2003-08-04 | 2006-11-07 | Arm Limited | Performance control within a multi-processor system |
| WO2005038002A2 (en) * | 2003-10-14 | 2005-04-28 | The Scripps Research Institute | Site-specific incorporation of redox active amino acids into proteins |
| BRPI0417801A (pt) | 2003-12-18 | 2007-04-10 | Scripps Research Inst | incorporação seletiva de 5-hidroxitriptofano em proteìnas de células mamìferas |
| JP2005322288A (ja) * | 2004-05-07 | 2005-11-17 | Sony Corp | ディスク記録及び/又は再生装置 |
| JP2005321568A (ja) * | 2004-05-07 | 2005-11-17 | Canon Inc | 画像形成装置 |
| AU2005248392A1 (en) | 2004-05-25 | 2005-12-08 | Irm, Llc | Site specific incorporation of heavy atom-containing unnatural amino acids into proteins for crystal structure determination |
| EP1797177A4 (en) | 2004-09-21 | 2008-07-09 | Scripps Research Inst | ADDITION OF PHOTOREGULATED AMINO ACIDS TO THE GENETIC CODE |
| EP1794323B1 (en) | 2004-09-21 | 2014-08-06 | The Scripps Research Institute | In vivo incorporation of alkynyl amino acids into proteins in eubacteria |
| JP2008513806A (ja) | 2004-09-22 | 2008-05-01 | ザ スクリップス リサーチ インスティテュート | Nmr試験のための蛋白質の部位特異的標識 |
| EP1809758A4 (en) | 2004-10-20 | 2009-04-01 | Scripps Research Inst | LOCAL IN VIVO INSTALLATION OF N-ACETYLGALACTOSAMINE AMINO ACIDS IN EU BACTERIA |
| CA2624290A1 (en) | 2005-10-12 | 2007-04-26 | Scripps Research Institute | Selective posttranslational modification of phage-displayed polypeptides |
| CA2638763A1 (en) | 2006-03-09 | 2007-09-13 | The Scripps Research Institute | System for the expression of orthogonal translation components in eubacterial host cells |
| JP5249194B2 (ja) | 2006-03-16 | 2013-07-31 | ザ スクリプス リサーチ インスティチュート | 非天然アミノ酸フェニルセレノシステインを含有するタンパク質の遺伝的にプログラムされた発現 |
-
2005
- 2005-10-27 AU AU2005330514A patent/AU2005330514B2/en not_active Ceased
- 2005-10-27 BR BRPI0517381-7A patent/BRPI0517381A/pt not_active Application Discontinuation
- 2005-10-27 CN CN201210216741.4A patent/CN102827827B/zh not_active Expired - Fee Related
- 2005-10-27 MX MX2007004892A patent/MX2007004892A/es active IP Right Grant
- 2005-10-27 EP EP05857733A patent/EP1807515A4/en not_active Ceased
- 2005-10-27 WO PCT/US2005/039210 patent/WO2006110182A2/en not_active Ceased
- 2005-10-27 US US11/665,083 patent/US8216804B2/en active Active
- 2005-10-27 CA CA002583735A patent/CA2583735A1/en not_active Abandoned
- 2005-10-27 EP EP11165007.3A patent/EP2383340B1/en not_active Expired - Lifetime
- 2005-10-27 EP EP11164983.6A patent/EP2380982B1/en not_active Expired - Lifetime
- 2005-10-27 CN CN2005800369829A patent/CN101048506B/zh not_active Expired - Fee Related
- 2005-10-27 JP JP2007539228A patent/JP5135504B2/ja not_active Expired - Fee Related
-
2007
- 2007-04-12 IL IL182495A patent/IL182495A0/en unknown
-
2011
- 2011-02-15 IL IL211229A patent/IL211229A0/en unknown
- 2011-11-22 JP JP2011255180A patent/JP5539948B2/ja not_active Expired - Fee Related
-
2012
- 2012-06-08 US US13/492,296 patent/US9102932B2/en active Active
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