JP2009529328A5 - - Google Patents

Info

Publication number

JP2009529328A5

JP2009529328A5 JP2008558393A JP2008558393A JP2009529328A5 JP 2009529328 A5 JP2009529328 A5 JP 2009529328A5 JP 2008558393 A JP2008558393 A JP 2008558393A JP 2008558393 A JP2008558393 A JP 2008558393A JP 2009529328 A5 JP2009529328 A5 JP 2009529328A5

Authority

JP

Japan

Prior art keywords

trna

nucleotide sequence

amino acid

unnatural amino

promoter

Prior art date

2007-03-07

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 239000002773 nucleotide Substances 0.000 claims 44
• 125000003729 nucleotide group Chemical group 0.000 claims 44
• 108091033319 polynucleotide Proteins 0.000 claims 31
• 102000040430 polynucleotide Human genes 0.000 claims 31
• 239000002157 polynucleotide Substances 0.000 claims 31
• 150000001413 amino acids Chemical class 0.000 claims 29
• 235000001014 amino acid Nutrition 0.000 claims 28
• 108090000765 processed proteins & peptides Proteins 0.000 claims 26
• 229920001184 polypeptide Polymers 0.000 claims 24
• 102000004196 processed proteins & peptides Human genes 0.000 claims 24
• 108020004566 Transfer RNA Proteins 0.000 claims 23
• 241000588724 Escherichia coli Species 0.000 claims 20
• 108020004705 Codon Proteins 0.000 claims 10
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 10
• ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 9
• 102000039446 nucleic acids Human genes 0.000 claims 9
• 108020004707 nucleic acids Proteins 0.000 claims 9
• 150000007523 nucleic acids Chemical class 0.000 claims 9
• 108090000623 proteins and genes Proteins 0.000 claims 8
• 102000052866 Amino Acyl-tRNA Synthetases Human genes 0.000 claims 7
• 108700028939 Amino Acyl-tRNA Synthetases Proteins 0.000 claims 7
• 108700007698 Genetic Terminator Regions Proteins 0.000 claims 7
• ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 7
• 101150024902 glnS gene Proteins 0.000 claims 6
• 101100489185 Bacillus subtilis (strain 168) yugH gene Proteins 0.000 claims 4
• IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical group O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 claims 4
• OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine group Chemical group [C@@H]1([C@H](O)[C@H](O)[C@@H](CO)O1)N1C=NC=2C(N)=NC=NC12 OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 4
• 238000000034 method Methods 0.000 claims 4
• 241000203407 Methanocaldococcus jannaschii Species 0.000 claims 3
• 238000004519 manufacturing process Methods 0.000 claims 3
• ZPEZUAAEBBHXBT-WCCKRBBISA-N (2s)-2-amino-3-methylbutanoic acid;2-amino-3-methylbutanoic acid Chemical compound CC(C)C(N)C(O)=O.CC(C)[C@H](N)C(O)=O ZPEZUAAEBBHXBT-WCCKRBBISA-N 0.000 claims 2
• 206010011732 Cyst Diseases 0.000 claims 2
• 101100312053 Lactococcus lactis subsp. lactis (strain IL1403) glyS gene Proteins 0.000 claims 2
• 101100322930 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) alaXM gene Proteins 0.000 claims 2
• 101710146427 Probable tyrosine-tRNA ligase, cytoplasmic Proteins 0.000 claims 2
• 102000018378 Tyrosine-tRNA ligase Human genes 0.000 claims 2
• 101710107268 Tyrosine-tRNA ligase, mitochondrial Proteins 0.000 claims 2
• 101150068393 argx gene Proteins 0.000 claims 2
• 208000031513 cyst Diseases 0.000 claims 2
• HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 239000004475 Arginine Substances 0.000 claims 1
• 241001112695 Clostridiales Species 0.000 claims 1
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
• 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 1
• 235000003704 aspartic acid Nutrition 0.000 claims 1
• OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
• 238000006467 substitution reaction Methods 0.000 claims 1