JP2009529877A5 - - Google Patents
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- Publication number
- JP2009529877A5 JP2009529877A5 JP2009500449A JP2009500449A JP2009529877A5 JP 2009529877 A5 JP2009529877 A5 JP 2009529877A5 JP 2009500449 A JP2009500449 A JP 2009500449A JP 2009500449 A JP2009500449 A JP 2009500449A JP 2009529877 A5 JP2009529877 A5 JP 2009529877A5
- Authority
- JP
- Japan
- Prior art keywords
- trna
- amino acid
- protein
- phenylselenocysteine
- translation system
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001413 amino acids Chemical class 0.000 claims 30
- 108090000623 proteins and genes Proteins 0.000 claims 29
- 102000004169 proteins and genes Human genes 0.000 claims 29
- FXTLFZWJXBBXGX-QMMMGPOBSA-N (2R)-2-anilino-3-selanylpropanoic acid Chemical compound OC(=O)[C@H](C[SeH])NC1=CC=CC=C1 FXTLFZWJXBBXGX-QMMMGPOBSA-N 0.000 claims 24
- 238000000034 method Methods 0.000 claims 15
- 108020004705 Codon Proteins 0.000 claims 13
- 102000039446 nucleic acids Human genes 0.000 claims 13
- 108020004707 nucleic acids Proteins 0.000 claims 13
- 150000007523 nucleic acids Chemical class 0.000 claims 13
- 108091033319 polynucleotide Proteins 0.000 claims 12
- 102000040430 polynucleotide Human genes 0.000 claims 12
- 239000002157 polynucleotide Substances 0.000 claims 12
- 102000052866 Amino Acyl-tRNA Synthetases Human genes 0.000 claims 10
- 108700028939 Amino Acyl-tRNA Synthetases Proteins 0.000 claims 10
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims 6
- UQBOJOOOTLPNST-UHFFFAOYSA-N Dehydroalanine Chemical compound NC(=C)C(O)=O UQBOJOOOTLPNST-UHFFFAOYSA-N 0.000 claims 5
- 241000588724 Escherichia coli Species 0.000 claims 3
- 125000003473 lipid group Chemical group 0.000 claims 3
- 238000007248 oxidative elimination reaction Methods 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 241001112695 Clostridiales Species 0.000 claims 2
- 108700025695 Suppressor Genes Proteins 0.000 claims 2
- 230000000689 aminoacylating effect Effects 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 238000002741 site-directed mutagenesis Methods 0.000 claims 2
- CJWPDADGDASKGI-YFVJMOTDSA-N (2e,6e)-3,7,11-trimethyldodeca-2,6,10-triene-1-thiol Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CS CJWPDADGDASKGI-YFVJMOTDSA-N 0.000 claims 1
- CFISTOPZXSTQOS-SFHVURJKSA-N (2r)-2-amino-3-hexadecylsulfanylpropanoic acid Chemical compound CCCCCCCCCCCCCCCCSC[C@H](N)C(O)=O CFISTOPZXSTQOS-SFHVURJKSA-N 0.000 claims 1
- 238000006845 Michael addition reaction Methods 0.000 claims 1
- YYHOQQKJSHXDEN-KRWDZBQOSA-N N-palmitoyl-L-cysteine Chemical compound CCCCCCCCCCCCCCCC(=O)N[C@@H](CS)C(O)=O YYHOQQKJSHXDEN-KRWDZBQOSA-N 0.000 claims 1
- SYSLNQMKLROGCL-BCYUYYMPSA-N S-[(2E,6E)-farnesyl]-L-cysteine zwitterion Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CSC[C@H](N)C(O)=O SYSLNQMKLROGCL-BCYUYYMPSA-N 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- ORTRWBYBJVGVQC-UHFFFAOYSA-N hexadecane-1-thiol Chemical compound CCCCCCCCCCCCCCCCS ORTRWBYBJVGVQC-UHFFFAOYSA-N 0.000 claims 1
- KPUXJBYSYFEKKB-UHFFFAOYSA-N hexadecanethioic s-acid Chemical compound CCCCCCCCCCCCCCCC(S)=O KPUXJBYSYFEKKB-UHFFFAOYSA-N 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78327206P | 2006-03-16 | 2006-03-16 | |
| US60/783,272 | 2006-03-16 | ||
| US86145606P | 2006-11-28 | 2006-11-28 | |
| US60/861,456 | 2006-11-28 | ||
| PCT/US2007/006382 WO2007109035A2 (en) | 2006-03-16 | 2007-03-13 | Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009529877A JP2009529877A (ja) | 2009-08-27 |
| JP2009529877A5 true JP2009529877A5 (enExample) | 2010-04-30 |
| JP5249194B2 JP5249194B2 (ja) | 2013-07-31 |
Family
ID=38522926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009500449A Expired - Fee Related JP5249194B2 (ja) | 2006-03-16 | 2007-03-13 | 非天然アミノ酸フェニルセレノシステインを含有するタンパク質の遺伝的にプログラムされた発現 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US7790847B2 (enExample) |
| EP (1) | EP1994165B1 (enExample) |
| JP (1) | JP5249194B2 (enExample) |
| KR (1) | KR20080113226A (enExample) |
| CN (1) | CN101405401B (enExample) |
| AU (1) | AU2007227592B2 (enExample) |
| BR (1) | BRPI0709603A2 (enExample) |
| CA (1) | CA2638772A1 (enExample) |
| IL (1) | IL193722A0 (enExample) |
| MX (1) | MX2008011669A (enExample) |
| RU (1) | RU2464315C2 (enExample) |
| WO (1) | WO2007109035A2 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1490483B1 (en) * | 2001-04-19 | 2015-06-03 | The Scripps Research Institute | In vivo incorporation of unnatural amino acids |
| KR20050073559A (ko) * | 2002-10-16 | 2005-07-14 | 더 스크립스 리서치 인스티튜트 | 당단백질 합성 |
| CN103289960B (zh) | 2003-04-17 | 2017-04-26 | 斯克利普斯研究院 | 扩展真核生物遗传密码 |
| DE602004011789T2 (de) * | 2003-07-07 | 2009-02-12 | The Scripps Research Institute, La Jolla | Zusammensetzungen der orthogonalen Lysyl-tRNA und Aminoacyl-tRNA Synthetase Paaren und ihre Verwendungen |
| AU2005330514B2 (en) | 2004-10-27 | 2011-05-12 | The Scripps Research Institute | Orthogonal translation components for the in vivo incorporation of unnatural amino acids |
| CA2638763A1 (en) * | 2006-03-09 | 2007-09-13 | The Scripps Research Institute | System for the expression of orthogonal translation components in eubacterial host cells |
| JP5249194B2 (ja) | 2006-03-16 | 2013-07-31 | ザ スクリプス リサーチ インスティチュート | 非天然アミノ酸フェニルセレノシステインを含有するタンパク質の遺伝的にプログラムされた発現 |
| BRPI0711811A2 (pt) * | 2006-05-23 | 2011-12-06 | Scripps Research Inst | aminoácidos de cumarina fluorescente geneticamente codificados |
| CA2663052A1 (en) * | 2006-09-21 | 2008-03-27 | The Scripps Research Institute | Genetically programmed expression of selectively sulfated proteins in eubacteria |
| US20080166766A1 (en) | 2006-10-18 | 2008-07-10 | The Scripps Research Institute | Genetic incorporation of unnatural amino acids into proteins in mammalian cells |
| KR20100088618A (ko) * | 2007-10-25 | 2010-08-09 | 더 스크립스 리서치 인스티튜트 | 리덕타제 내로의 3-아미노티로신의 유전적 도입 |
| US20090148887A1 (en) * | 2007-11-02 | 2009-06-11 | The Scripps Research Institute | Genetically encoded boronate amino acid |
| BRPI0819092A2 (pt) | 2007-11-02 | 2014-10-14 | Scripps Research Inst | Evolução direcionada usando proteínas que compreendem aminoácidos não naturais. |
| CN105647824A (zh) * | 2007-12-11 | 2016-06-08 | 斯克利普斯研究院 | 甲基营养酵母菌巴斯德毕赤酵母中的体内非天然氨基酸表达 |
| WO2009086497A2 (en) * | 2007-12-28 | 2009-07-09 | Ardell David H | Genetic encryption |
| WO2009088949A1 (en) | 2008-01-03 | 2009-07-16 | Verenium Corporation | Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them |
| KR20100125290A (ko) * | 2008-02-08 | 2010-11-30 | 더 스크립스 리서치 인스티튜트 | 유전적으로 코딩된 비천연 아미노산에 의한 면역 내성의 파괴 |
| US8637306B2 (en) * | 2008-12-10 | 2014-01-28 | The Scripps Research Institute | Production of carrier-peptide conjugates using chemically reactive unnatural amino acids |
| US20090197339A1 (en) * | 2008-12-10 | 2009-08-06 | The Scripps Research Institute | In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris |
| US8658394B2 (en) * | 2011-02-02 | 2014-02-25 | Waterstone Pharmaceuticals | Methods, cells and systems for incorporating non-canonical amino acids into proteins |
| CN103215235B (zh) * | 2012-01-18 | 2014-11-05 | 中国科学院生物物理研究所 | 3-咪唑基酪氨酸翻译系统及其应用 |
| CN103571804B (zh) * | 2012-08-10 | 2015-08-12 | 中国科学院生物物理研究所 | 3-吡唑基酪氨酸翻译系统及其应用 |
| KR102018863B1 (ko) | 2012-10-12 | 2019-09-05 | 서트로 바이오파마, 인크. | 개선된 발현을 위해 박테리아 추출물 중 선택 단백질의 단백질분해 불활성화 |
| CN103820410B (zh) * | 2012-11-16 | 2016-03-30 | 中国科学院生物物理研究所 | 3-甲硫酪氨酸翻译系统及其应用 |
| CN104004723B (zh) * | 2013-02-22 | 2016-08-17 | 中国科学院生物物理研究所 | 3,5-二氟代酪氨酸翻译系统及其应用 |
| CN106047846B (zh) * | 2013-03-22 | 2020-02-04 | 中国科学院生物物理研究所 | 8-羟基喹啉丙氨酸翻译系统及其应用 |
| CN105792851B (zh) * | 2013-09-13 | 2023-10-10 | 斯克利普斯研究所 | 修饰的治疗剂及其组合物 |
| AU2014364589B2 (en) | 2013-12-18 | 2020-02-27 | The California Institute For Biomedical Research | Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof |
| CN109414451B (zh) * | 2016-05-16 | 2022-08-12 | 德克萨斯大学系统董事会 | 用于作为纳米粒递送tRNA的组合物及其使用方法 |
| EP3565904A1 (en) | 2016-12-29 | 2019-11-13 | Illumina, Inc. | Analysis system for orthogonal access to and tagging of biomolecules in cellular compartments |
| CN114644581B (zh) * | 2021-01-04 | 2024-07-16 | 北京惠大生物科技有限公司 | 含芳基硫酚或芳基硒酚经修饰的氨基酸、重组蛋白及其生物合成方法及应用 |
| AU2022289610A1 (en) | 2021-06-09 | 2024-01-25 | The Scripps Research Institute | Long-acting dual gip/glp-1 peptide conjugates and methods of use |
| CN118389493B (zh) * | 2024-05-10 | 2025-04-11 | 北京大学 | 一种定点修饰的工程化tRNA及其应用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ255043A (en) * | 1992-07-13 | 1997-03-24 | Eukarion Inc | Lipidized proteins and compositions thereof and their use in targeting proteins to intracellular compartments and enhancing organ uptake of them |
| EP1490483B1 (en) | 2001-04-19 | 2015-06-03 | The Scripps Research Institute | In vivo incorporation of unnatural amino acids |
| DK1578949T3 (da) | 2002-10-16 | 2009-07-27 | Scripps Research Inst | Stedspecifik optagelse af keto-aminnosyrer hos proteiner |
| KR20050073559A (ko) | 2002-10-16 | 2005-07-14 | 더 스크립스 리서치 인스티튜트 | 당단백질 합성 |
| EP1583816A4 (en) | 2002-12-22 | 2007-06-13 | Scripps Research Inst | PROTEIN ARRAYS |
| CN103289960B (zh) * | 2003-04-17 | 2017-04-26 | 斯克利普斯研究院 | 扩展真核生物遗传密码 |
| WO2005003294A2 (en) * | 2003-06-18 | 2005-01-13 | The Scripps Research Institute | Unnatural reactive amino acid genetic code additions |
| WO2005007624A2 (en) | 2003-07-07 | 2005-01-27 | The Scripps Research Institute | Compositions of orthogonal glutamyl-trna and aminoacyl trna synthetase pairs and uses thereof |
| DE602004011789T2 (de) | 2003-07-07 | 2009-02-12 | The Scripps Research Institute, La Jolla | Zusammensetzungen der orthogonalen Lysyl-tRNA und Aminoacyl-tRNA Synthetase Paaren und ihre Verwendungen |
| WO2005007870A2 (en) | 2003-07-07 | 2005-01-27 | The Scripps Research Institute | COMPOSITIONS OF ORTHOGONAL LEUCYL-tRNA AND AMINOACYL-tRNA SYNTHETASE PAIRS AND USES THEREOF |
| WO2005038002A2 (en) * | 2003-10-14 | 2005-04-28 | The Scripps Research Institute | Site-specific incorporation of redox active amino acids into proteins |
| BRPI0417801A (pt) * | 2003-12-18 | 2007-04-10 | Scripps Research Inst | incorporação seletiva de 5-hidroxitriptofano em proteìnas de células mamìferas |
| US20050287639A1 (en) * | 2004-05-17 | 2005-12-29 | California Institute Of Technology | Methods of incorporating amino acid analogs into proteins |
| AU2005248392A1 (en) | 2004-05-25 | 2005-12-08 | Irm, Llc | Site specific incorporation of heavy atom-containing unnatural amino acids into proteins for crystal structure determination |
| EP1794323B1 (en) * | 2004-09-21 | 2014-08-06 | The Scripps Research Institute | In vivo incorporation of alkynyl amino acids into proteins in eubacteria |
| EP1797177A4 (en) | 2004-09-21 | 2008-07-09 | Scripps Research Inst | ADDITION OF PHOTOREGULATED AMINO ACIDS TO THE GENETIC CODE |
| JP2008513806A (ja) * | 2004-09-22 | 2008-05-01 | ザ スクリップス リサーチ インスティテュート | Ｎｍｒ試験のための蛋白質の部位特異的標識 |
| EP1809758A4 (en) * | 2004-10-20 | 2009-04-01 | Scripps Research Inst | LOCAL IN VIVO INSTALLATION OF N-ACETYLGALACTOSAMINE AMINO ACIDS IN EU BACTERIA |
| AU2005330514B2 (en) | 2004-10-27 | 2011-05-12 | The Scripps Research Institute | Orthogonal translation components for the in vivo incorporation of unnatural amino acids |
| CA2624290A1 (en) | 2005-10-12 | 2007-04-26 | Scripps Research Institute | Selective posttranslational modification of phage-displayed polypeptides |
| CA2638763A1 (en) | 2006-03-09 | 2007-09-13 | The Scripps Research Institute | System for the expression of orthogonal translation components in eubacterial host cells |
| JP5249194B2 (ja) | 2006-03-16 | 2013-07-31 | ザ スクリプス リサーチ インスティチュート | 非天然アミノ酸フェニルセレノシステインを含有するタンパク質の遺伝的にプログラムされた発現 |
-
2007
- 2007-03-13 JP JP2009500449A patent/JP5249194B2/ja not_active Expired - Fee Related
- 2007-03-13 US US11/724,039 patent/US7790847B2/en active Active
- 2007-03-13 KR KR1020087024575A patent/KR20080113226A/ko not_active Ceased
- 2007-03-13 MX MX2008011669A patent/MX2008011669A/es active IP Right Grant
- 2007-03-13 WO PCT/US2007/006382 patent/WO2007109035A2/en not_active Ceased
- 2007-03-13 US US12/225,261 patent/US8217145B2/en active Active
- 2007-03-13 CA CA002638772A patent/CA2638772A1/en not_active Abandoned
- 2007-03-13 RU RU2008135114/10A patent/RU2464315C2/ru not_active IP Right Cessation
- 2007-03-13 AU AU2007227592A patent/AU2007227592B2/en not_active Ceased
- 2007-03-13 EP EP07753037.6A patent/EP1994165B1/en not_active Not-in-force
- 2007-03-13 CN CN2007800092529A patent/CN101405401B/zh not_active Expired - Fee Related
- 2007-03-13 BR BRPI0709603-8A patent/BRPI0709603A2/pt not_active Application Discontinuation
-
2008
- 2008-08-27 IL IL193722A patent/IL193722A0/en unknown
-
2012
- 2012-06-08 US US13/492,240 patent/US8394605B2/en not_active Expired - Fee Related
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