IL193722A0 - Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine - Google Patents
Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteineInfo
- Publication number
- IL193722A0 IL193722A0 IL193722A IL19372208A IL193722A0 IL 193722 A0 IL193722 A0 IL 193722A0 IL 193722 A IL193722 A IL 193722A IL 19372208 A IL19372208 A IL 19372208A IL 193722 A0 IL193722 A0 IL 193722A0
- Authority
- IL
- Israel
- Prior art keywords
- amino acid
- unnatural amino
- proteins containing
- genetically programmed
- programmed expression
- Prior art date
Links
- FXTLFZWJXBBXGX-QMMMGPOBSA-N (2R)-2-anilino-3-selanylpropanoic acid Chemical compound OC(=O)[C@H](C[SeH])NC1=CC=CC=C1 FXTLFZWJXBBXGX-QMMMGPOBSA-N 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/104—Aminoacyltransferases (2.3.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78327206P | 2006-03-16 | 2006-03-16 | |
| US86145606P | 2006-11-28 | 2006-11-28 | |
| PCT/US2007/006382 WO2007109035A2 (en) | 2006-03-16 | 2007-03-13 | Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL193722A0 true IL193722A0 (en) | 2011-08-01 |
Family
ID=38522926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL193722A IL193722A0 (en) | 2006-03-16 | 2008-08-27 | Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US7790847B2 (enExample) |
| EP (1) | EP1994165B1 (enExample) |
| JP (1) | JP5249194B2 (enExample) |
| KR (1) | KR20080113226A (enExample) |
| CN (1) | CN101405401B (enExample) |
| AU (1) | AU2007227592B2 (enExample) |
| BR (1) | BRPI0709603A2 (enExample) |
| CA (1) | CA2638772A1 (enExample) |
| IL (1) | IL193722A0 (enExample) |
| MX (1) | MX2008011669A (enExample) |
| RU (1) | RU2464315C2 (enExample) |
| WO (1) | WO2007109035A2 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005502322A (ja) * | 2001-04-19 | 2005-01-27 | ザ スクリップス リサーチ インスティテュート | 非天然アミノ酸のインビボ組込み |
| EP1558747B1 (en) * | 2002-10-16 | 2009-10-14 | The Scripps Research Institute | Glycoprotein synthesis |
| CN103215227B (zh) | 2003-04-17 | 2015-09-16 | 斯克利普斯研究院 | 扩展真核生物遗传密码 |
| ES2301099T3 (es) * | 2003-07-07 | 2008-06-16 | The Scripps Research Institute | Composiciones de parejas ortogonales lisil-arnt y aminoacil-arnt sintetasa y usos de las mismas. |
| US8216804B2 (en) | 2004-10-27 | 2012-07-10 | The Scripps Research Institute | Orthogonal translation components for the in vivo incorporation of unnatural amino acids |
| CN101400796B (zh) | 2006-03-09 | 2013-03-27 | 斯克利普斯研究院 | 在真细菌宿主细胞内表达正交翻译组分的系统 |
| RU2464315C2 (ru) | 2006-03-16 | 2012-10-20 | Зе Скрипс Ресеч Инститьют | Генетически запрограммированная экспрессия белков, содержащих не встречающуюся в природе аминокислоту фенилселеноцистеин |
| US7807411B2 (en) * | 2006-05-23 | 2010-10-05 | The Scripps Research Institute | Genetically encoded fluorescent coumarin amino acids |
| EP2052083B1 (en) * | 2006-09-21 | 2014-01-08 | The Scripps Research Institute | Genetically programmed expression of selectively sulfated proteins in eubacteria |
| EP2069481A4 (en) | 2006-10-18 | 2010-01-06 | Scripps Research Inst | GENETIC ASSEMBLY OF UNNATURAL AMINO ACIDS IN PROTEINS IN MAMMALIAN CELLS |
| JP5643100B2 (ja) | 2007-10-25 | 2014-12-17 | ザ スクリプス リサーチ インスティテュート | レダクターゼへの３−アミノチロシンの遺伝的組込み |
| EP2217702A4 (en) | 2007-11-02 | 2012-05-16 | Scripps Research Inst | DIRECTED EVOLUTION USING PROTEINS WITH NON-NATURAL AMINO ACIDS |
| WO2009059056A2 (en) * | 2007-11-02 | 2009-05-07 | The Scripps Research Institute | A genetically encoded boronate amino acid |
| EP2889370A1 (en) | 2007-12-11 | 2015-07-01 | The Scripps Research Institute | In vivo unnatural amino acid expression in the methylotrophic yeast Pichia pastoris |
| US8592199B2 (en) | 2007-12-28 | 2013-11-26 | David H. Ardell | Genetic encryption |
| PL2238242T3 (pl) | 2008-01-03 | 2015-06-30 | Basf Enzymes Llc | Transferazy i oksydoreduktazy, kwasy nukleinowe kodujące je oraz sposoby ich wytwarzania i zastosowania |
| JP2011514322A (ja) * | 2008-02-08 | 2011-05-06 | ザ スクリプス リサーチ インスティチュート | 遺伝的にコードされる非天然アミノ酸による免疫寛容解除 |
| WO2010068278A2 (en) | 2008-12-10 | 2010-06-17 | The Scripps Research Institute | Production of carrier-peptide conjugates using chemically reactive unnatural amino acids |
| US20090197339A1 (en) * | 2008-12-10 | 2009-08-06 | The Scripps Research Institute | In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris |
| US8658394B2 (en) * | 2011-02-02 | 2014-02-25 | Waterstone Pharmaceuticals | Methods, cells and systems for incorporating non-canonical amino acids into proteins |
| CN103215235B (zh) * | 2012-01-18 | 2014-11-05 | 中国科学院生物物理研究所 | 3-咪唑基酪氨酸翻译系统及其应用 |
| CN103571804B (zh) * | 2012-08-10 | 2015-08-12 | 中国科学院生物物理研究所 | 3-吡唑基酪氨酸翻译系统及其应用 |
| CA2887355C (en) | 2012-10-12 | 2023-03-07 | Sutro Biopharma, Inc. | Proteolytic inactivation of select proteins in bacterial extracts for improved expression |
| CN103820410B (zh) * | 2012-11-16 | 2016-03-30 | 中国科学院生物物理研究所 | 3-甲硫酪氨酸翻译系统及其应用 |
| CN104004723B (zh) * | 2013-02-22 | 2016-08-17 | 中国科学院生物物理研究所 | 3,5-二氟代酪氨酸翻译系统及其应用 |
| CN106047846B (zh) * | 2013-03-22 | 2020-02-04 | 中国科学院生物物理研究所 | 8-羟基喹啉丙氨酸翻译系统及其应用 |
| ES2927607T3 (es) | 2013-09-13 | 2022-11-08 | Scripps Research Inst | Agentes terapéuticos modificados y composiciones de los mismos |
| EP3082797A4 (en) | 2013-12-18 | 2017-12-13 | The California Institute for Biomedical Research | Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof |
| PL3458074T3 (pl) * | 2016-05-16 | 2024-11-12 | Board Of Regents Of The University Of Texas System | KOMPOZYCJA DO DOSTARCZANIA tRNA W POSTACI NANOCZĄSTEK I SPOSOBY ICH STOSOWANIA |
| EP3565904A1 (en) | 2016-12-29 | 2019-11-13 | Illumina, Inc. | Analysis system for orthogonal access to and tagging of biomolecules in cellular compartments |
| CN114644581B (zh) * | 2021-01-04 | 2024-07-16 | 北京惠大生物科技有限公司 | 含芳基硫酚或芳基硒酚经修饰的氨基酸、重组蛋白及其生物合成方法及应用 |
| IL309067A (en) | 2021-06-09 | 2024-02-01 | Scripps Research Inst | Long-acting dual gip/glp-1 peptide conjugates and methods of use |
| CN118389493B (zh) * | 2024-05-10 | 2025-04-11 | 北京大学 | 一种定点修饰的工程化tRNA及其应用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994001131A1 (en) * | 1992-07-13 | 1994-01-20 | Eukarion, Inc. | Transvascular and intracellular delivery of lipidized proteins |
| JP2005502322A (ja) | 2001-04-19 | 2005-01-27 | ザ スクリップス リサーチ インスティテュート | 非天然アミノ酸のインビボ組込み |
| EP1558747B1 (en) | 2002-10-16 | 2009-10-14 | The Scripps Research Institute | Glycoprotein synthesis |
| JP4444113B2 (ja) * | 2002-10-16 | 2010-03-31 | ザ スクリップス リサーチ インスティテュート | ケトアミノ酸の部位特異的蛋白質組込み方法 |
| MXPA05006836A (es) | 2002-12-22 | 2005-08-16 | Scripps Research Inst | Colecciones ordenadas de proteinas. |
| CN103215227B (zh) | 2003-04-17 | 2015-09-16 | 斯克利普斯研究院 | 扩展真核生物遗传密码 |
| JP5275566B2 (ja) * | 2003-06-18 | 2013-08-28 | ザ スクリプス リサーチ インスティチュート | 反応性非天然アミノ酸遺伝コード付加 |
| WO2005007624A2 (en) | 2003-07-07 | 2005-01-27 | The Scripps Research Institute | Compositions of orthogonal glutamyl-trna and aminoacyl trna synthetase pairs and uses thereof |
| ES2301099T3 (es) | 2003-07-07 | 2008-06-16 | The Scripps Research Institute | Composiciones de parejas ortogonales lisil-arnt y aminoacil-arnt sintetasa y usos de las mismas. |
| EP1704242A4 (en) | 2003-07-07 | 2008-06-18 | Scripps Research Inst | COMPOSITIONS WITH PAIRS OF ORTHOGONAL LEUCYL-TRNA AND AMINOACYL-TRNA-SYNTHETASE AND USES THEREOF |
| WO2005038002A2 (en) | 2003-10-14 | 2005-04-28 | The Scripps Research Institute | Site-specific incorporation of redox active amino acids into proteins |
| CA2549830A1 (en) | 2003-12-18 | 2006-01-05 | The Scripps Research Institute | Selective incorporation of 5-hyroxytryptophan into proteins in mammalian cells |
| US20050287639A1 (en) | 2004-05-17 | 2005-12-29 | California Institute Of Technology | Methods of incorporating amino acid analogs into proteins |
| MXPA06013586A (es) | 2004-05-25 | 2007-11-09 | Scripss Res Inst | Incorporacion especifica del sitio de aminoacidos no naturales que contienen atomos pesados en proteinas para la determinacion de la estructura cristalina. |
| US20060134746A1 (en) | 2004-09-21 | 2006-06-22 | The Scripps Research Institute | Adding photoregulated amino acids to the genetic code |
| CN101151366B (zh) | 2004-09-21 | 2012-12-19 | 斯克利普斯研究院 | 将炔基氨基酸体内掺入真细菌的蛋白 |
| EP1794312A4 (en) | 2004-09-22 | 2009-08-12 | Scripps Research Inst | LOCAL LABELING OF PROTEINS FOR NMR STUDIES |
| EP1809758A4 (en) | 2004-10-20 | 2009-04-01 | Scripps Research Inst | LOCAL IN VIVO INSTALLATION OF N-ACETYLGALACTOSAMINE AMINO ACIDS IN EU BACTERIA |
| US8216804B2 (en) | 2004-10-27 | 2012-07-10 | The Scripps Research Institute | Orthogonal translation components for the in vivo incorporation of unnatural amino acids |
| AU2006304110B2 (en) | 2005-10-12 | 2012-02-02 | The Scripps Research Institute | Selective posttranslational modification of phage-displayed polypeptides |
| CN101400796B (zh) | 2006-03-09 | 2013-03-27 | 斯克利普斯研究院 | 在真细菌宿主细胞内表达正交翻译组分的系统 |
| RU2464315C2 (ru) | 2006-03-16 | 2012-10-20 | Зе Скрипс Ресеч Инститьют | Генетически запрограммированная экспрессия белков, содержащих не встречающуюся в природе аминокислоту фенилселеноцистеин |
-
2007
- 2007-03-13 RU RU2008135114/10A patent/RU2464315C2/ru not_active IP Right Cessation
- 2007-03-13 JP JP2009500449A patent/JP5249194B2/ja not_active Expired - Fee Related
- 2007-03-13 AU AU2007227592A patent/AU2007227592B2/en not_active Ceased
- 2007-03-13 CN CN2007800092529A patent/CN101405401B/zh not_active Expired - Fee Related
- 2007-03-13 KR KR1020087024575A patent/KR20080113226A/ko not_active Ceased
- 2007-03-13 BR BRPI0709603-8A patent/BRPI0709603A2/pt not_active Application Discontinuation
- 2007-03-13 MX MX2008011669A patent/MX2008011669A/es active IP Right Grant
- 2007-03-13 EP EP07753037.6A patent/EP1994165B1/en not_active Not-in-force
- 2007-03-13 US US11/724,039 patent/US7790847B2/en active Active
- 2007-03-13 CA CA002638772A patent/CA2638772A1/en not_active Abandoned
- 2007-03-13 WO PCT/US2007/006382 patent/WO2007109035A2/en not_active Ceased
- 2007-03-13 US US12/225,261 patent/US8217145B2/en active Active
-
2008
- 2008-08-27 IL IL193722A patent/IL193722A0/en unknown
-
2012
- 2012-06-08 US US13/492,240 patent/US8394605B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20070238152A1 (en) | 2007-10-11 |
| US20120282668A1 (en) | 2012-11-08 |
| CN101405401A (zh) | 2009-04-08 |
| AU2007227592A1 (en) | 2007-09-27 |
| US20090209000A1 (en) | 2009-08-20 |
| JP2009529877A (ja) | 2009-08-27 |
| BRPI0709603A2 (pt) | 2011-07-19 |
| RU2008135114A (ru) | 2010-04-27 |
| EP1994165B1 (en) | 2014-11-05 |
| KR20080113226A (ko) | 2008-12-29 |
| AU2007227592B2 (en) | 2011-11-24 |
| US8217145B2 (en) | 2012-07-10 |
| CN101405401B (zh) | 2013-03-27 |
| MX2008011669A (es) | 2008-09-22 |
| WO2007109035A3 (en) | 2008-10-16 |
| JP5249194B2 (ja) | 2013-07-31 |
| EP1994165A4 (en) | 2012-11-07 |
| CA2638772A1 (en) | 2007-09-27 |
| US7790847B2 (en) | 2010-09-07 |
| RU2464315C2 (ru) | 2012-10-20 |
| US8394605B2 (en) | 2013-03-12 |
| WO2007109035A2 (en) | 2007-09-27 |
| EP1994165A2 (en) | 2008-11-26 |
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