BRPI0417801A - incorporação seletiva de 5-hidroxitriptofano em proteìnas de células mamìferas - Google Patents
incorporação seletiva de 5-hidroxitriptofano em proteìnas de células mamìferasInfo
- Publication number
- BRPI0417801A BRPI0417801A BRPI0417801-7A BRPI0417801A BRPI0417801A BR PI0417801 A BRPI0417801 A BR PI0417801A BR PI0417801 A BRPI0417801 A BR PI0417801A BR PI0417801 A BRPI0417801 A BR PI0417801A
- Authority
- BR
- Brazil
- Prior art keywords
- hydroxytryptophan
- cell proteins
- mammalian cell
- selective incorporation
- incorporating
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"INCORPORAçãO SELETIVA DE 5-HIDROXITRIPTOFANO EM PROTEìNAS DE CéLULAS MAMìFERAS". Esta invenção provê métodos e composições para incorporação de um aminoácido não natural em um peptídeo utilizando RNAt sistetase aminoacil ortogonal / per RNAt. Em particular, um par ortogonal é provido para incorporar 5-hidróxi-L-triptofano em uma posição por uma mutação opalaa.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53131203P | 2003-12-18 | 2003-12-18 | |
US54876104P | 2004-02-26 | 2004-02-26 | |
PCT/US2004/042535 WO2006001832A2 (en) | 2003-12-18 | 2004-12-16 | Selective incorporation of 5-hyroxytryptophan into proteins in mammalian cells |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0417801A true BRPI0417801A (pt) | 2007-04-10 |
Family
ID=35782203
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0417801-7A BRPI0417801A (pt) | 2003-12-18 | 2004-12-16 | incorporação seletiva de 5-hidroxitriptofano em proteìnas de células mamìferas |
Country Status (10)
Country | Link |
---|---|
US (4) | US7709604B2 (pt) |
EP (1) | EP1725251A4 (pt) |
JP (1) | JP4752002B2 (pt) |
CN (1) | CN1897969B (pt) |
AU (2) | AU2004321117B2 (pt) |
BR (1) | BRPI0417801A (pt) |
CA (1) | CA2549830A1 (pt) |
IL (1) | IL176010A (pt) |
MX (1) | MXPA06006868A (pt) |
WO (1) | WO2006001832A2 (pt) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2128246T3 (da) * | 2001-04-19 | 2014-05-12 | Univ California | Fremgangsmåder og sammensætninger til fremstilling af ortogonale tRNA-aminoacyl-tRNA-syntetasepar. |
US20050123970A1 (en) * | 2001-04-25 | 2005-06-09 | Can Ozbal | High throughput autosampler |
US8414774B2 (en) * | 2001-04-25 | 2013-04-09 | Agilent Technologies, Inc. | Systems and methods for high-throughput screening of fluidic samples |
ATE445709T1 (de) * | 2002-10-16 | 2009-10-15 | Scripps Research Inst | Glycoproteinsynthese |
KR101171397B1 (ko) | 2003-04-17 | 2012-08-07 | 더 스크립스 리서치 인스티튜트 | 진핵 유전자 코드의 확장 |
US7993872B2 (en) | 2003-06-18 | 2011-08-09 | The Scripps Research Institute | Unnatural reactive amino acid genetic code additions |
WO2005019415A2 (en) * | 2003-07-07 | 2005-03-03 | The Scripps Research Institute | Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof |
EP1774018A2 (en) * | 2004-05-25 | 2007-04-18 | The Scripps Research Institute | Site specific incorporation of heavy atom-containing unnatural amino acids into proteins for crystal structure determination |
US20060110784A1 (en) * | 2004-09-22 | 2006-05-25 | The Scripps Research Institute | Site-specific labeling of proteins for NMR studies |
CA2583735A1 (en) | 2004-10-27 | 2006-10-19 | The Scripps Research Institute | Orthogonal translation components for the in vivo incorporation of unnatural amino acids |
RU2459866C2 (ru) * | 2005-10-12 | 2012-08-27 | Зе Скрипс Ресеч Инститьют | Селективная посттрансляционная модификация экспонируемых фагами полипептидов |
EP2339014B1 (en) | 2005-11-16 | 2015-05-27 | Ambrx, Inc. | Methods and compositions comprising non-natural amino acids |
CN101400796B (zh) * | 2006-03-09 | 2013-03-27 | 斯克利普斯研究院 | 在真细菌宿主细胞内表达正交翻译组分的系统 |
RU2464315C2 (ru) | 2006-03-16 | 2012-10-20 | Зе Скрипс Ресеч Инститьют | Генетически запрограммированная экспрессия белков, содержащих не встречающуюся в природе аминокислоту фенилселеноцистеин |
JP2009538136A (ja) * | 2006-05-23 | 2009-11-05 | ザ スクリップス リサーチ インスティテュート | 遺伝的にコードされた蛍光クマリンアミノ酸 |
US8420792B2 (en) * | 2006-09-08 | 2013-04-16 | Ambrx, Inc. | Suppressor tRNA transcription in vertebrate cells |
CN101516901B (zh) * | 2006-09-21 | 2014-01-08 | 斯克利普斯研究院 | 选择性硫酸化的蛋白质在真细菌中的遗传编程表达 |
AU2007333010A1 (en) | 2006-10-18 | 2008-06-19 | The Scripps Research Institute | Genetic incorporation of unnatural amino acids into proteins in mammalian cells |
US8183037B2 (en) * | 2007-04-13 | 2012-05-22 | The Salk Institute For Biological Studies | Methods of genetically encoding unnatural amino acids in eukaryotic cells using orthogonal tRNA/synthetase pairs |
JP2009017840A (ja) * | 2007-07-13 | 2009-01-29 | Japan Agengy For Marine-Earth Science & Technology | 外来遺伝子を細胞に安定に保持する方法 |
JP2009017842A (ja) * | 2007-07-13 | 2009-01-29 | Japan Agengy For Marine-Earth Science & Technology | 生産性改善法 |
CA2703736A1 (en) * | 2007-10-25 | 2009-04-30 | The Scripps Research Institute | Genetic incorporation of 3-aminotyrosine into reductases |
WO2009059056A2 (en) * | 2007-11-02 | 2009-05-07 | The Scripps Research Institute | A genetically encoded boronate amino acid |
EP2217356B1 (en) * | 2007-11-02 | 2018-10-17 | Biocius Life Sciences, Inc. | Devices and methods for coupling mass spectrometry devices with chromatography systems |
US9249408B2 (en) * | 2007-11-02 | 2016-02-02 | The Scripps Research Institute | Directed evolution using proteins comprising unnatural amino acids |
CN105647824A (zh) * | 2007-12-11 | 2016-06-08 | 斯克利普斯研究院 | 甲基营养酵母菌巴斯德毕赤酵母中的体内非天然氨基酸表达 |
EP2246428A4 (en) * | 2008-02-07 | 2011-04-13 | Univ Tokyo | MODIFIED TRNA WITH NON-NATURAL NUCLEOTIDE AND USE THEREOF |
MX2010008633A (es) * | 2008-02-08 | 2010-09-30 | Scripps Research Inst | Ruptura de tolerancia inmunologica con un aminoacido no natural geneticamente codificado. |
US20110076718A1 (en) * | 2008-02-27 | 2011-03-31 | The Scripps Research Institute | In vivo incorporation of an unnatural amino acid comprising a 1,2-aminothiol group |
EP2370473B1 (en) | 2008-12-10 | 2016-05-11 | The Scripps Research Institute | Production of carrier-peptide conjugates using chemically reactive unnatural amino acids |
US20090197339A1 (en) * | 2008-12-10 | 2009-08-06 | The Scripps Research Institute | In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris |
ES2552773T3 (es) | 2009-02-27 | 2015-12-02 | Atyr Pharma, Inc. | Motivos estructurales de polipéptidos asociados con la actividad de señalización celular |
US20130078660A1 (en) * | 2010-03-23 | 2013-03-28 | Salk Institute For Biological Studies | Methods and compositions for detecting protein modifications |
CN103118692A (zh) | 2010-04-26 | 2013-05-22 | Atyr医药公司 | 与半胱氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
JP6294074B2 (ja) | 2010-04-27 | 2018-03-14 | エータイアー ファーマ, インコーポレイテッド | イソロイシルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
US8986681B2 (en) | 2010-04-27 | 2015-03-24 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of threonyl-tRNA synthetases |
US8993723B2 (en) | 2010-04-28 | 2015-03-31 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl-tRNA synthetases |
CN103118693B (zh) | 2010-04-29 | 2017-05-03 | Atyr 医药公司 | 与缬氨酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
US8986680B2 (en) | 2010-04-29 | 2015-03-24 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Asparaginyl tRNA synthetases |
WO2011150279A2 (en) | 2010-05-27 | 2011-12-01 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-trna synthetases |
EP2566496B1 (en) | 2010-05-03 | 2018-02-28 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-trna synthetases |
AU2011248227B2 (en) | 2010-05-03 | 2016-12-01 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-tRNA synthetases |
WO2011139988A2 (en) | 2010-05-03 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of seryl-trna synthetases |
US8961961B2 (en) | 2010-05-03 | 2015-02-24 | a Tyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of arginyl-tRNA synthetases |
US9062301B2 (en) | 2010-05-04 | 2015-06-23 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutamyl-prolyl-tRNA synthetases |
WO2011140267A2 (en) | 2010-05-04 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-trna synthetase complex |
CN103200953B (zh) | 2010-05-14 | 2017-02-15 | Atyr 医药公司 | 与苯丙氨酰‑β‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
AU2011256366C1 (en) | 2010-05-17 | 2017-06-15 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-tRNA synthetases |
EP2575857B1 (en) | 2010-06-01 | 2018-01-24 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of lysyl-trna synthetases |
WO2012021249A2 (en) | 2010-07-12 | 2012-02-16 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of histidyl-trna synthetases |
AU2011289831C1 (en) | 2010-07-12 | 2017-06-15 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases |
US8999321B2 (en) | 2010-07-12 | 2015-04-07 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases |
CA2804278C (en) | 2010-07-12 | 2021-07-13 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of aspartyl-trna synthetases |
WO2012027611A2 (en) | 2010-08-25 | 2012-03-01 | Atyr Pharma, Inc. | INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF TYROSYL-tRNA SYNTHETASES |
EP2624857B1 (en) | 2010-10-06 | 2017-08-02 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tryptophanyl trna synthetases |
WO2013022982A2 (en) | 2011-08-09 | 2013-02-14 | Atyr Pharma, Inc. | Pegylated tyrosyl-trna synthetase polypeptides |
WO2013086216A1 (en) | 2011-12-06 | 2013-06-13 | Atyr Pharma, Inc. | Improved aspartyl-trna synthetases |
US9822353B2 (en) | 2011-12-06 | 2017-11-21 | Atyr Pharma, Inc. | PEGylated aspartyl-tRNA synthetase polypeptides |
CA2858613A1 (en) | 2011-12-29 | 2013-08-08 | Atyr Pharma, Inc. | Aspartyl-trna synthetase-fc conjugates |
US20150148525A1 (en) | 2012-05-18 | 2015-05-28 | Medical Research Council | Methods of incorporating an amino acid comprising a bcn group into a polypeptide using an orthogonal codon encoding it and an orthorgonal pylrs synthase |
MX369671B (es) * | 2013-03-13 | 2019-11-15 | Genentech Inc | Formulaciones con oxidacion reducida. |
US20140314778A1 (en) | 2013-03-13 | 2014-10-23 | Genentech, Inc. | Formulations with reduced oxidation |
CN105378075B (zh) | 2013-03-15 | 2022-04-05 | Atyr 医药公司 | 组氨酰-trna合成酶-fc缀合物 |
GB2528227A (en) | 2014-03-14 | 2016-01-20 | Medical Res Council | Cyclopropene amino acids and methods |
JP2018509172A (ja) * | 2015-03-27 | 2018-04-05 | ザ ユニバーシティ オブ クィーンズランド | タンパク質への非天然アミノ酸組込みのためのプラットフォーム |
JP2020517638A (ja) | 2017-04-20 | 2020-06-18 | エータイアー ファーマ, インコーポレイテッド | 肺の炎症を治療するための組成物および方法 |
CN108530544B (zh) * | 2018-03-09 | 2021-10-22 | 广东药科大学 | 一种肝癌细胞靶向抗菌肽嵌合体m27-39-htpp及其应用 |
CN111747869B (zh) * | 2020-06-12 | 2021-10-22 | 北京大学深圳研究生院 | 一种遗传编码的甲醛反应性非天然氨基酸、制备方法及其应用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2128246T3 (da) * | 2001-04-19 | 2014-05-12 | Univ California | Fremgangsmåder og sammensætninger til fremstilling af ortogonale tRNA-aminoacyl-tRNA-syntetasepar. |
-
2004
- 2004-12-16 CA CA002549830A patent/CA2549830A1/en not_active Abandoned
- 2004-12-16 MX MXPA06006868A patent/MXPA06006868A/es active IP Right Grant
- 2004-12-16 BR BRPI0417801-7A patent/BRPI0417801A/pt not_active Application Discontinuation
- 2004-12-16 EP EP04822141A patent/EP1725251A4/en not_active Withdrawn
- 2004-12-16 US US11/016,348 patent/US7709604B2/en active Active
- 2004-12-16 AU AU2004321117A patent/AU2004321117B2/en not_active Ceased
- 2004-12-16 WO PCT/US2004/042535 patent/WO2006001832A2/en active Application Filing
- 2004-12-16 CN CN2004800381169A patent/CN1897969B/zh not_active Expired - Fee Related
- 2004-12-16 JP JP2006545499A patent/JP4752002B2/ja not_active Expired - Fee Related
- 2004-12-16 US US10/580,987 patent/US7741071B2/en active Active
-
2006
- 2006-05-30 IL IL176010A patent/IL176010A/en not_active IP Right Cessation
-
2010
- 2010-04-14 US US12/798,979 patent/US8242244B2/en active Active
- 2010-08-11 AU AU2010212273A patent/AU2010212273B2/en not_active Ceased
-
2012
- 2012-07-11 US US13/546,582 patent/US8658395B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US8658395B2 (en) | 2014-02-25 |
CN1897969A (zh) | 2007-01-17 |
US7741071B2 (en) | 2010-06-22 |
IL176010A (en) | 2012-03-29 |
JP2007514447A (ja) | 2007-06-07 |
IL176010A0 (en) | 2006-10-05 |
US20050136513A1 (en) | 2005-06-23 |
JP4752002B2 (ja) | 2011-08-17 |
US20070111193A1 (en) | 2007-05-17 |
EP1725251A4 (en) | 2009-07-01 |
MXPA06006868A (es) | 2007-03-21 |
EP1725251A2 (en) | 2006-11-29 |
AU2010212273A1 (en) | 2010-09-02 |
US7709604B2 (en) | 2010-05-04 |
CA2549830A1 (en) | 2006-01-05 |
AU2004321117A1 (en) | 2006-01-05 |
US20110124080A1 (en) | 2011-05-26 |
WO2006001832A3 (en) | 2006-03-30 |
CN1897969B (zh) | 2013-09-18 |
US8242244B2 (en) | 2012-08-14 |
WO2006001832A2 (en) | 2006-01-05 |
US20120282626A1 (en) | 2012-11-08 |
AU2004321117B2 (en) | 2010-09-02 |
AU2010212273B2 (en) | 2012-02-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0417801A (pt) | incorporação seletiva de 5-hidroxitriptofano em proteìnas de células mamìferas | |
DK1255826T3 (da) | Automatisering af proteindesign for proteinbiblioteker | |
CY1109267T1 (el) | Μεθοδοι για την καλλιεργεια κυκλοϊου | |
CY1106789T1 (el) | Γενικος φορεας για στοχευση μοριων σε κυτταρα που εκφραζουν gb3 υποδοχεα | |
ATE541934T1 (de) | Zusammensetzungen von aminoacyl-trna-synthetase und verwendungen davon | |
HN1999000075A (es) | Agonistas y antagonistas il-2 selectivos | |
AR057614A1 (es) | Composiciones y metodos para producir moleculas de union con antigeno hibridas y usos de las mismas | |
BRPI0507159A (pt) | polipeptìdeos em feixe de quatro hélices humanos modificados e seus usos | |
DK1533380T3 (da) | Rekombinant proteinproduktion i en human celle indeholdende mindst ét E1-protein af adenovirus | |
HN2002000319A (es) | Benzamida, heteroarilamida y amidas inversas | |
NO20043245L (no) | Bindingsproteiner som biosensorer | |
BRPI0519170A8 (pt) | formulações de hormônio de crescimento humano que compreendem um aminoácido não naturalmente codificado | |
HK1132760A1 (en) | Site specific incorporation of non-natural amino acids by vertebrate cells | |
CY1105772T1 (el) | Συνθεσεις και μεθοδοι για βελτιωμενη κυτταρικη καλλιεργεια | |
DK1578949T3 (da) | Stedspecifik optagelse af keto-aminnosyrer hos proteiner | |
BRPI0507856A (pt) | composição farmacêutica, e, processo para preparar o anticorpo abeta | |
DE602004025943D1 (de) | Mikrosomvakzin | |
EA200701528A1 (ru) | Новые нутрицевтические композиции | |
EA200701293A1 (ru) | Терапевтическая композиция фактора роста кератиноцитов | |
BRPI0514411B8 (pt) | formulação, e, método de produzir uma formulação | |
WO2008030613A3 (en) | Hybrid suppressor trna for vertebrate cells | |
CY1105135T1 (el) | Ιξωδοελαστικες οφθαλμικες συνθεσεις οι οποιες πepιλαμβανουν υαλουρονικο οξυ και θειϊκη χονδροϊτινη | |
BRPI0415277A (pt) | célula, vetor, método para produzir proteìna gama-carboxilada, proteìna gama-carboxilada isolada, uso da mesma, método para produzir uma composição farmacêutica, composição farmacêutica, método para produzir fator x de humano gama-carboxilado, uso de fator x isolado, método para produzir protrombina de humano gama-carboxilada, uso de protrombina isolada, e, método para promover coagulação aumentada ou diminuìda em um indivìduo | |
WO2003052084A3 (fr) | Construits cellulaires cultives in vitro, preparation et utilisations | |
EA200501230A1 (ru) | Жидкие составы фактор некроза опухоли - связывающих белков |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B11E | Dismissal acc. art. 34 of ipl - requirements for examination incomplete | ||
B11T | Dismissal of application maintained [chapter 11.20 patent gazette] |