JP2008500050A5 - - Google Patents

Info

Publication number

JP2008500050A5

JP2008500050A5 JP2007515256A JP2007515256A JP2008500050A5 JP 2008500050 A5 JP2008500050 A5 JP 2008500050A5 JP 2007515256 A JP2007515256 A JP 2007515256A JP 2007515256 A JP2007515256 A JP 2007515256A JP 2008500050 A5 JP2008500050 A5 JP 2008500050A5

Authority

JP

Japan

Prior art keywords

amino acid

orthogonal

trna

position corresponding

seq

Prior art date

2005-05-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 150000001413 amino acids Chemical group 0.000 claims 26
• 102000052866 Amino Acyl-tRNA Synthetases Human genes 0.000 claims 16
• 108700028939 Amino Acyl-tRNA Synthetases Proteins 0.000 claims 16
• 235000001014 amino acid Nutrition 0.000 claims 15
• 102000004169 proteins and genes Human genes 0.000 claims 11
• 108090000623 proteins and genes Proteins 0.000 claims 11
• 235000018102 proteins Nutrition 0.000 claims 9
• 230000014616 translation Effects 0.000 claims 8
• 239000004475 Arginine Substances 0.000 claims 6
• 108020004705 Codon Proteins 0.000 claims 6
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 6
• ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 6
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 6
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 6
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 6
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 6
• 235000013922 glutamic acid Nutrition 0.000 claims 6
• 239000004220 glutamic acid Substances 0.000 claims 6
• 108020004707 nucleic acids Proteins 0.000 claims 5
• 102000039446 nucleic acids Human genes 0.000 claims 5
• 150000007523 nucleic acids Chemical class 0.000 claims 5
• 108091033319 polynucleotide Proteins 0.000 claims 5
• 102000040430 polynucleotide Human genes 0.000 claims 5
• 239000002157 polynucleotide Substances 0.000 claims 5
• MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 3
• ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 3
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• 230000000295 complement effect Effects 0.000 claims 2
• 239000013078 crystal Substances 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 230000000689 aminoacylating effect Effects 0.000 claims 1
• 230000002547 anomalous effect Effects 0.000 claims 1
• 238000002447 crystallographic data Methods 0.000 claims 1
• 238000000338 in vitro Methods 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 229920001184 polypeptide Polymers 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1