JP2008508303A - ピロロ−ピリジンキナーゼモジュレーター - Google Patents

ピロロ−ピリジンキナーゼモジュレーター Download PDF

Info

Publication number
JP2008508303A
JP2008508303A JP2007523808A JP2007523808A JP2008508303A JP 2008508303 A JP2008508303 A JP 2008508303A JP 2007523808 A JP2007523808 A JP 2007523808A JP 2007523808 A JP2007523808 A JP 2007523808A JP 2008508303 A JP2008508303 A JP 2008508303A
Authority
JP
Japan
Prior art keywords
substituted
unsubstituted
heteroaryl
alkyl
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2007523808A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008508303A5 (enExample
Inventor
ウィリアム・ディ・アーノルド
ピエール・ブーノー
アンドレアス・ゴスベルク
チェ・リ
イアン・マクドナルド
ルオ・ダブリュー・スティーンスマ
マーク・イー・ウィルソン
Original Assignee
エスジーエックス ファーマシューティカルズ、インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by エスジーエックス ファーマシューティカルズ、インコーポレイテッド filed Critical エスジーエックス ファーマシューティカルズ、インコーポレイテッド
Publication of JP2008508303A publication Critical patent/JP2008508303A/ja
Publication of JP2008508303A5 publication Critical patent/JP2008508303A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
JP2007523808A 2004-07-27 2005-07-27 ピロロ−ピリジンキナーゼモジュレーター Pending JP2008508303A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US59188804P 2004-07-27 2004-07-27
US59188704P 2004-07-27 2004-07-27
US68351005P 2005-05-19 2005-05-19
PCT/US2005/026792 WO2006015123A1 (en) 2004-07-27 2005-07-27 Pyrrolo-pyridine kinase modulators

Publications (2)

Publication Number Publication Date
JP2008508303A true JP2008508303A (ja) 2008-03-21
JP2008508303A5 JP2008508303A5 (enExample) 2008-09-11

Family

ID=35262080

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007523808A Pending JP2008508303A (ja) 2004-07-27 2005-07-27 ピロロ−ピリジンキナーゼモジュレーター

Country Status (15)

Country Link
US (3) US7361763B2 (enExample)
EP (2) EP2264033A1 (enExample)
JP (1) JP2008508303A (enExample)
KR (1) KR20070053237A (enExample)
AU (1) AU2005269386A1 (enExample)
BR (1) BRPI0513916A (enExample)
CA (1) CA2573362A1 (enExample)
EC (1) ECSP077280A (enExample)
IL (1) IL180790A0 (enExample)
MA (1) MA28810B1 (enExample)
MX (1) MX2007001127A (enExample)
NO (1) NO20070907L (enExample)
NZ (1) NZ553267A (enExample)
TN (1) TNSN07027A1 (enExample)
WO (1) WO2006015123A1 (enExample)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008523085A (ja) * 2004-12-08 2008-07-03 スミスクライン・ビーチャム・コーポレイション 1h−ピロロ[2,3−b]ピリジン
JP2008546797A (ja) * 2005-06-22 2008-12-25 プレキシコン,インコーポレーテッド キナーゼ調節のための化合物および方法,およびその適応症
JP2012509903A (ja) * 2008-11-25 2012-04-26 ユニバーシティー オブ ロチェスター Mlk阻害剤および使用方法
JP2013525490A (ja) * 2010-05-06 2013-06-20 メルク・シャープ・エンド・ドーム・コーポレイション Faahのモジュレータとして有用なアザインドール誘導体
JP2013537521A (ja) * 2010-07-21 2013-10-03 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト プロパン−1−スルホン酸{3−[5−(4−クロロ−フェニル)−1H−ピロロ[2,3−b]ピリジン−3−カルボニル]−2,4−ジフルオロ−フェニル}−アミドの新規製造方法
JP2014534246A (ja) * 2011-11-22 2014-12-18 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung 3−シアノアリール−1H−ピラゾロ[2.3−b]ピリジン誘導体
JP2016516823A (ja) * 2013-04-18 2016-06-09 アーリーン ファーマシューティカルズ エルエルシー 3,5−(非)置換−1H−ピロロ[2,3−b]ピリジン、1H−ピラゾロ[3,4−b]ピリジン、及び5H−ピロロ[2,3−b]ピラジン、ITK及びJAK3キナーゼの阻害剤
JP2018502853A (ja) * 2015-01-23 2018-02-01 コンフルエンス・ライフ・サイエンシズ,インコーポレーテッド 炎症およびがんを処置するための複素環式itk阻害剤
JP2018537533A (ja) * 2015-12-07 2018-12-20 プレキシコン インコーポレーテッドPlexxikon Inc. キナーゼ調節のための化合物及び方法ならびにそのための指示
JP2019048835A (ja) * 2009-01-15 2019-03-28 インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation Jak阻害剤および関連中間化合物の製造方法
JP2021518856A (ja) * 2018-03-01 2021-08-05 ザ トラスティーズ オブ コロンビア ユニバーシティー イン ザ シティー オブ ニューヨーク 有毒な小胞体ストレスを抑制するための化合物、組成物、および方法
KR20230006891A (ko) * 2020-05-01 2023-01-11 길리애드 사이언시즈, 인코포레이티드 Cd73를 억제하는 2,4-다이옥소피리미딘 화합물
JP2023545219A (ja) * 2020-10-05 2023-10-26 エンライブン インコーポレイテッド Bcr-ablチロシンキナーゼの阻害のための7-アザインドール化合物
JP2024519138A (ja) * 2021-05-21 2024-05-08 センター ナショナル デ ラ レシェルシェ サイエンティフィーク 抗ウイルス剤としての新規アザインドール誘導体

Families Citing this family (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7632955B2 (en) * 2001-12-13 2009-12-15 National Health Research Institutes Indole compounds
US7528165B2 (en) 2001-12-13 2009-05-05 National Health Research Institutes Indole compounds
PL1696920T3 (pl) 2003-12-19 2015-03-31 Plexxikon Inc Związki i sposoby opracowywania modulatorów Ret
US7507826B2 (en) * 2004-03-30 2009-03-24 Vertex Pharmaceuticals Incorporated Azaindoles useful as inhibitors of JAK and other protein kinases
US7498342B2 (en) * 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
EP2264033A1 (en) 2004-07-27 2010-12-22 SGX Pharmaceuticals, Inc. 3,5-DIPHENYL-SUBSTITUTED PYRROLO[2,3b]PYRIDINES USEFUL AS KINASE INHIBITORS
US7626021B2 (en) * 2004-07-27 2009-12-01 Sgx Pharmaceuticals, Inc. Fused ring heterocycle kinase modulators
US7709645B2 (en) * 2004-07-27 2010-05-04 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
US7361764B2 (en) 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
BRPI0513899A (pt) 2004-07-27 2008-05-20 Sgx Pharmaceuticals Inc moduladores de cinase heterocìclica de anel fundido
US7456289B2 (en) 2004-12-31 2008-11-25 National Health Research Institutes Anti-tumor compounds
US20080306054A1 (en) 2005-04-13 2008-12-11 Astex Therapeutics Limited Pharmaceutical Compounds
CA2608733A1 (en) * 2005-05-17 2007-02-01 Plexxikon, Inc. Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
WO2008079521A2 (en) * 2006-11-01 2008-07-03 Vertex Pharmaceuticals Incorporated Tricyclic heteroaryl compounds useful as inhibitors of janus kinase
TW201412738A (zh) 2006-01-17 2014-04-01 Vertex Pharma 適合作為傑納斯激酶(janus kinase)抑制劑之氮雜吲哚
US7754725B2 (en) 2006-03-01 2010-07-13 Astex Therapeutics Ltd. Dihydroxyphenyl isoindolymethanones
DE102006012617A1 (de) * 2006-03-20 2007-09-27 Merck Patent Gmbh 4-(Pyrrolopyridinyl)-pyrimidinyl-2-amin-derivate
AU2007254179B2 (en) * 2006-05-18 2013-03-21 Pharmacyclics Llc Intracellular kinase inhibitors
US20070286864A1 (en) * 2006-06-09 2007-12-13 Buck Elizabeth A Combined treatment with an EGFR kinase inhibitor and an agent that sensitizes tumor cells to the effects of EGFR kinase inhibitors
PE20080403A1 (es) 2006-07-14 2008-04-25 Amgen Inc Derivados heterociclicos fusionados y metodos de uso
US8198448B2 (en) 2006-07-14 2012-06-12 Amgen Inc. Fused heterocyclic derivatives and methods of use
US8217177B2 (en) 2006-07-14 2012-07-10 Amgen Inc. Fused heterocyclic derivatives and methods of use
US20080242694A1 (en) * 2006-09-18 2008-10-02 D Sidocky Neil R Amino-substituted heterocycles, compositions thereof, and methods of treatment therewith
SG158147A1 (en) 2006-10-09 2010-01-29 Takeda Pharmaceutical Kinase inhibitors
JO3598B1 (ar) * 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
JP5518478B2 (ja) 2006-10-12 2014-06-11 アステックス、セラピューティックス、リミテッド 医薬化合物
WO2008044041A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
JP5721949B2 (ja) 2006-10-12 2015-05-20 アステックス、セラピューティックス、リミテッドAstex Therapeutics Limited 複合薬剤
WO2008044045A1 (en) * 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
GB0620259D0 (en) 2006-10-12 2006-11-22 Astex Therapeutics Ltd Pharmaceutical compounds
US8148361B2 (en) 2006-11-10 2012-04-03 Bristol-Myers Squibb Company Kinase inhibitors
ES2560435T3 (es) 2006-11-22 2016-02-19 Incyte Holdings Corporation Imidazotriazinas e imidazopirimidinas como inhibidores de la quinasa
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
WO2008080015A2 (en) 2006-12-21 2008-07-03 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
PE20081581A1 (es) * 2006-12-21 2008-11-12 Plexxikon Inc COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA
NZ577798A (en) 2006-12-21 2012-04-27 Vertex Pharma 5-cyano-4- (pyrrolo [2, 3b] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors
WO2008079909A1 (en) 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
AU2008210455A1 (en) * 2007-01-31 2008-08-07 Vertex Pharmaceuticals Incorporated 2-aminopyridine derivatives useful as kinase inhibitors
GB0702259D0 (en) * 2007-02-06 2007-03-14 Eisai London Res Lab Ltd 7-azaindole derivatives
GB0702265D0 (en) * 2007-02-06 2007-03-14 Eisai London Res Lab Ltd 7-Azaindole derivatives
CN101679436A (zh) * 2007-04-10 2010-03-24 Sgx药品公司 稠环杂环激酶调节剂
US8263585B2 (en) * 2007-05-04 2012-09-11 Novartis Ag Organic compounds
KR101156845B1 (ko) * 2007-05-21 2012-06-18 에스지엑스 파마슈티컬스, 인코포레이티드 헤테로시클릭 키나제 조절제
DE102007028515A1 (de) * 2007-06-21 2008-12-24 Merck Patent Gmbh 6-(Pyrrolopyridinyl)-pyrimidinyl-2-amin-derivate
BRPI0813990A2 (pt) * 2007-07-06 2011-09-13 Paratek Pharmaceuticals, Inc. métodos para sintetizar compostos de minociclina substituìda
US20100190777A1 (en) 2007-07-17 2010-07-29 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
AU2008278966B2 (en) * 2007-07-26 2012-02-23 Novartis Ag Pyrimidine derivatives useful for the treatment of inflammatory or allergic conditions
US8183245B2 (en) * 2007-10-25 2012-05-22 Merck Sharp & Dohme Corp. Pyrazine substituted pyrrolopyridines as inhibitors of JAK and PDK1
US8598165B2 (en) 2007-11-26 2013-12-03 University Of Kansas Morpholines as selective inhibitors of cytochrome P450 2A13
US8268834B2 (en) * 2008-03-19 2012-09-18 Novartis Ag Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme
GB0806527D0 (en) 2008-04-11 2008-05-14 Astex Therapeutics Ltd Pharmaceutical compounds
MX393622B (es) 2008-05-21 2025-03-24 Incyte Corp Sales de 2-fluoro-n-metil-4-[7-(quinolin-6-il-metil)-imidazo[1,2-b][1,2,4]triazin-2-il]benzamida y procesos relacionados con la preparacion de las mismas.
CN102131809A (zh) 2008-07-23 2011-07-20 沃泰克斯药物股份有限公司 三环吡唑并吡啶激酶抑制剂
AU2009274011B2 (en) 2008-07-23 2014-12-18 Vertex Pharmaceuticals Incorporated Pyrazolopyridine kinase inhibitors
US8569337B2 (en) 2008-07-23 2013-10-29 Vertex Pharmaceuticals Incorporated Tri-cyclic pyrazolopyridine kinase inhibitors
CA2731095A1 (en) * 2008-08-05 2010-02-11 Abbott Laboratories Compounds useful as inhibitors of protein kinases
NZ590688A (en) 2008-08-05 2012-09-28 Daiichi Sankyo Co Ltd imidazo[4,5-b]pyridin-2-one derivatives
JP2011530527A (ja) * 2008-08-06 2011-12-22 バーテックス ファーマシューティカルズ インコーポレイテッド アミノピリジンキナーゼ阻害剤
FR2941948B1 (fr) 2009-02-12 2013-04-05 Nova Decision Derives d'azaindoles en tant qu'inhibiteur des proteines kinases abl et src
HUE027598T2 (en) * 2009-04-03 2016-10-28 Hoffmann La Roche Propane-1-sulfonic acid {3- [5- (4-chlorophenyl) -1H-pyrrolo [2,3-B] pyridine-3-carbonyl] -2,4-difluorophenyl} amide compositions and their uses
MX2011011653A (es) 2009-05-06 2012-01-20 Vertex Pharma Pirazolopiridinas.
DK2442809T3 (en) 2009-06-17 2016-12-19 Vertex Pharma Inhibitors of the replication of influenza virus
US8703808B2 (en) 2009-06-23 2014-04-22 Centre National De La Recherche Scientifique Use of derivatives of indoles for the treatment of cancer
EP2266562A1 (en) * 2009-06-23 2010-12-29 Centre National de la Recherche Scientifique Use of derivatives of indoles for the treatment of cancer
US8329724B2 (en) * 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
GB0918924D0 (en) * 2009-10-28 2009-12-16 Vantia Ltd Azaindole derivatives
ES2633317T3 (es) 2009-11-06 2017-09-20 Plexxikon, Inc. Compuestos y métodos para la modulación de quinasas, e indicaciones para ello
RS61281B1 (sr) 2009-12-31 2021-02-26 Hutchison Medipharma Ltd Sintetički intermedijer koristan u pripremi triazolopiridinskih c-met inhibitora
JP2013518114A (ja) 2010-01-27 2013-05-20 バーテックス ファーマシューティカルズ インコーポレイテッド ピラゾロピリミジンキナーゼ阻害剤
CN102858769A (zh) 2010-01-27 2013-01-02 沃泰克斯药物股份有限公司 吡唑并吡啶激酶抑制剂
AU2011209649A1 (en) 2010-01-27 2012-08-09 Vertex Pharmaceuticals Incorporated Pyrazolopyrazine kinase inhibitors
EP2531511A1 (en) * 2010-02-03 2012-12-12 Infinity Pharmaceuticals, Inc. Fatty acid amide hydrolase inhibitors
CA2795422A1 (en) * 2010-04-19 2011-10-27 Abbvie Inc. Pyrrolopyridine inhibitors of kinases
CA2800176C (en) 2010-05-24 2018-08-28 University Of Rochester Bicyclic heteroaryl kinase inhibitors and methods of use
AU2011343642A1 (en) 2010-12-16 2013-05-02 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
MA34948B1 (fr) 2011-02-07 2014-03-01 Plexxikon Inc Composes et procedes de modulation de kinase, et leurs indications
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
US8791112B2 (en) 2011-03-30 2014-07-29 Arrien Pharmaceuticals Llc Substituted 5-(pyrazin-2-yl)-1H-pyrazolo [3, 4-B] pyridine and pyrazolo [3, 4-B] pyridine derivatives as protein kinase inhibitors
EP2709622A4 (en) 2011-05-17 2015-03-04 Plexxikon Inc CINEMA MODULATION AND INDICATIONS THEREFOR
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
EP2763535B1 (en) 2011-10-03 2017-06-07 Merck Sharp & Dohme Corp. Azaindoles as janus kinase inhibitors
US9358235B2 (en) 2012-03-19 2016-06-07 Plexxikon Inc. Kinase modulation, and indications therefor
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
CN104884059B (zh) 2012-11-30 2018-08-10 罗切斯特大学 用于hiv/aids治疗的混合谱系激酶抑制剂
US9260426B2 (en) 2012-12-14 2016-02-16 Arrien Pharmaceuticals Llc Substituted 1H-pyrrolo [2, 3-b] pyridine and 1H-pyrazolo [3, 4-b] pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors
US20140303121A1 (en) 2013-03-15 2014-10-09 Plexxikon Inc. Heterocyclic compounds and uses thereof
HRP20181392T1 (hr) * 2013-03-15 2018-10-19 Plexxikon Inc. Heterociklični spojevi i njihova uporaba
CN104119331B (zh) * 2013-04-26 2018-02-06 广东东阳光药业有限公司 烯基化合物及其使用方法和用途
GB2515785A (en) * 2013-07-03 2015-01-07 Redx Pharma Ltd Compounds
RS57541B1 (sr) 2013-11-13 2018-10-31 Vertex Pharma Postupci za pripremu inhibitora replikacije virusa gripa
EP3068776B1 (en) 2013-11-13 2019-05-29 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
KR101660863B1 (ko) * 2015-04-03 2016-09-28 주식회사 녹십자 IKKε 및 TBK1 억제제로서의 7-아자인돌 또는 4,7-다이아자인돌 유도체 및 이를 포함하는 약학적 조성물
US10160755B2 (en) * 2015-04-08 2018-12-25 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
MA42422A (fr) 2015-05-13 2018-05-23 Vertex Pharma Inhibiteurs de la réplication des virus de la grippe
JP6704416B2 (ja) 2015-05-13 2020-06-03 バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated インフルエンザウイルスの複製の阻害剤を調製する方法
WO2017094026A1 (en) * 2015-11-30 2017-06-08 Council Of Scientific & Industrial Research 3-pyrimidinyl pyrrolo [2,3-b] pyridine as new anticancer agents and the process for the preparation thereof
US11331313B2 (en) 2017-05-22 2022-05-17 Whitehead Institute For Biomedical Research KCC2 expression enhancing compounds and uses thereof
WO2018226846A1 (en) 2017-06-07 2018-12-13 Plexxikon Inc. Compounds and methods for kinase modulation
CN107550905B (zh) * 2017-09-11 2020-07-17 浙江永宁药业股份有限公司 多取代吡咯并吡啶类化合物的药物用途及其制备方法
WO2019057660A1 (en) * 2017-09-25 2019-03-28 Basf Se INDOLE AND AZAINDOLE COMPOUNDS HAVING 6-CHANNEL SUBSTITUTED ARYL AND HETEROARYL CYCLES AS AGROCHEMICAL FUNGICIDES
US10717735B2 (en) 2017-10-13 2020-07-21 Plexxikon Inc. Solid forms of a compound for modulating kinases
CN113166139A (zh) * 2018-11-22 2021-07-23 百济神州有限公司 作为HPK1抑制剂的吡咯并[2,3-b]吡啶及其用途
WO2020210366A1 (en) * 2019-04-09 2020-10-15 Plexxikon Inc. Condensed azines for ep300 or cbp modulation and indications therefor
TWI848141B (zh) 2019-07-04 2024-07-11 英屬開曼群島商百濟神州有限公司 及其用途
CN112239473B (zh) 2019-07-17 2023-12-08 百济神州(北京)生物科技有限公司 作为hpk1抑制剂的三环化合物的制备方法
WO2023245327A1 (en) * 2022-06-20 2023-12-28 Biofront Ltd Multiple kinase degraders, compositions comprising the degrader, and methods of using the same
WO2023245329A1 (en) * 2022-06-20 2023-12-28 Biofront Ltd Multi-kinase inhibitors, compositions thereof, and methods of using the same

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002535331A (ja) * 1999-01-20 2002-10-22 メルク エンド カムパニー インコーポレーテッド 新規血管形成阻害薬
WO2003028724A1 (en) * 2001-10-04 2003-04-10 Smithkline Beecham Corporation Chk1 kinase inhibitors
WO2003082868A1 (en) * 2002-03-28 2003-10-09 Eisai Co., Ltd. 7-azaindoles as inhibitors of c-jun n-terminal kinases for the treatment of neurodegenerative disorders
JP2004501152A (ja) * 2000-06-19 2004-01-15 フアルマシア・イタリア・エツセ・ピー・アー アザインドール誘導体、その調製のためのプロセス、および抗腫瘍剤としてのその使用
JP2006521336A (ja) * 2003-03-06 2006-09-21 エーザイ株式会社 Jun阻害剤
JP2007521334A (ja) * 2003-12-19 2007-08-02 プレキシコン,インコーポレーテッド Ret調節剤の開発のための化合物および方法
JP2007531760A (ja) * 2004-03-30 2007-11-08 バーテックス ファーマシューティカルズ インコーポレイテッド Jakおよび他のプロテインキナーゼの阻害剤として有用なアザインドール
JP2007534653A (ja) * 2003-12-24 2007-11-29 ファイザー・イタリア・エス.アール.エル. キナーゼ阻害剤としての活性をもつピロロ[2,3−b]ピリジン誘導体、それらの調製方法、およびそれらを含む医薬組成物

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5604091A (en) 1984-03-01 1997-02-18 Microgenics Corporation Methods for protein binding enzyme complementation
US5019586A (en) 1987-04-14 1991-05-28 Glaxo Group Limited Ketone derivatives
MX19185A (es) 1989-01-20 1993-12-01 Pfizer Procedimiento para preparar 3-(1,2,5,6-tretrahidropiridil)-pirrolopiridinas.
FR2687402B1 (fr) 1992-02-14 1995-06-30 Lipha Nouveaux azaindoles, procedes de preparation et medicaments les contenant.
JP2886748B2 (ja) * 1992-09-17 1999-04-26 富士写真フイルム株式会社 写真用処理組成物及び処理方法
GB9416162D0 (en) 1994-08-10 1994-09-28 Merck Sharp & Dohme Therapeutic agents
GB2298199A (en) 1995-02-21 1996-08-28 Merck Sharp & Dohme Synthesis of azaindoles
AU5645196A (en) 1995-04-11 1996-10-30 Lonza A.G. Process for preparing azaindoles with an activated copper ch romite catalyst by catalytic dehydrocyclisation of alkylpyri dylamines (pyridopyridines)
WO2000024694A1 (en) 1998-10-28 2000-05-04 Eli Lilly And Company Photochemical process for making 1-deoxy-2-keto derivatives
US6492406B1 (en) 1999-05-21 2002-12-10 Astrazeneca Ab Pharmaceutically active compounds
GB9918035D0 (en) 1999-07-30 1999-09-29 Novartis Ag Organic compounds
DE19948417A1 (de) 1999-10-07 2001-04-19 Morphochem Ag Imidazol-Derivate und ihre Verwendung als Arzneimittel
DE10053122A1 (de) 1999-11-20 2001-05-23 Wella Ag Verfahren zur Herstellung von Indolen sowie die Verwendung dieser Indole in Färbemitteln
DE19955915C2 (de) 1999-11-20 2001-09-13 Wella Ag Tryptophanderivate und Tryptophanase enthaltende Haarfärbemittel sowie Verfahren zur enzymatischen Haarfärbung
US6476034B2 (en) 2000-02-22 2002-11-05 Bristol-Myers Squibb Company Antiviral azaindole derivatives
WO2002024694A1 (en) 2000-09-22 2002-03-28 Smithkline Beecham, P.L.C. Pyrazolopyridines and pyrazolopyridazines as antidiabetics
BR0116323A (pt) 2000-12-22 2003-10-14 Wyeth Corp Compostos de heterociclilindazol e -azaindazol como ligandos de 5-hidroxitriptamina-6
GB0115109D0 (en) * 2001-06-21 2001-08-15 Aventis Pharma Ltd Chemical compounds
FR2826653B1 (fr) 2001-06-29 2005-10-14 Servier Lab Nouveaux derives de pyrido-pyrido-pyrrolo[3,2-g]pyrrolo [3,4-e]-indole et pyrido-pyrrolo[2,3-a]pyrrolo[3,4-c] carbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US7101884B2 (en) 2001-09-14 2006-09-05 Merck & Co., Inc. Tyrosine kinase inhibitors
GB0128287D0 (en) 2001-11-26 2002-01-16 Smithkline Beecham Plc Novel method and compounds
AU2003245700A1 (en) 2002-02-12 2003-09-04 Glaxo Group Limited Pyrazolopyridine derivatives
US20030236277A1 (en) 2002-02-14 2003-12-25 Kadow John F. Indole, azaindole and related heterocyclic pyrrolidine derivatives
KR20050013534A (ko) 2002-03-28 2005-02-04 에자이 가부시키가이샤 c─Jun N─말단 키나아제 억제용 아자인돌
US20030229453A1 (en) 2002-04-09 2003-12-11 Antonysamy Stephen Suresh Crystals and structures of PAK4KD kinase PAK4KD
MXPA05001688A (es) 2002-08-12 2005-04-19 Sugen Inc 3-pirrolil-piridopirazoles y 3-pirrolil-indazoles como inhibidores de cinasa novedosos.
CA2503905A1 (en) 2002-09-16 2004-03-25 Plexxikon, Inc. Crystal structure of pim-1 kinase
NZ539390A (en) 2002-10-09 2007-05-31 Scios Inc Azaindole derivatives as inhibitors of p38 kinase
GB0305142D0 (en) 2003-03-06 2003-04-09 Eisai London Res Lab Ltd Synthesis
WO2004101565A2 (en) * 2003-05-16 2004-11-25 Eisai Co., Ltd. Jnk inhibitors
TWI339206B (en) 2003-09-04 2011-03-21 Vertex Pharma Compositions useful as inhibitors of protein kinases
FR2865313B1 (fr) 2004-01-15 2006-06-09 Diamecans Dispositif de manoeuvre bistable d'arbre mobile non traversant et coupe-circuit de batterie comprenant un tel dispositif
GB0405055D0 (en) 2004-03-05 2004-04-07 Eisai London Res Lab Ltd JNK inhibitors
US7361764B2 (en) 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
BRPI0513899A (pt) 2004-07-27 2008-05-20 Sgx Pharmaceuticals Inc moduladores de cinase heterocìclica de anel fundido
EP2264033A1 (en) 2004-07-27 2010-12-22 SGX Pharmaceuticals, Inc. 3,5-DIPHENYL-SUBSTITUTED PYRROLO[2,3b]PYRIDINES USEFUL AS KINASE INHIBITORS
BRPI0610828A2 (pt) 2005-05-16 2010-07-27 Irm Llc compostos e composições como inibidores de proteìna quinase

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002535331A (ja) * 1999-01-20 2002-10-22 メルク エンド カムパニー インコーポレーテッド 新規血管形成阻害薬
JP2004501152A (ja) * 2000-06-19 2004-01-15 フアルマシア・イタリア・エツセ・ピー・アー アザインドール誘導体、その調製のためのプロセス、および抗腫瘍剤としてのその使用
WO2003028724A1 (en) * 2001-10-04 2003-04-10 Smithkline Beecham Corporation Chk1 kinase inhibitors
WO2003082868A1 (en) * 2002-03-28 2003-10-09 Eisai Co., Ltd. 7-azaindoles as inhibitors of c-jun n-terminal kinases for the treatment of neurodegenerative disorders
JP2006521336A (ja) * 2003-03-06 2006-09-21 エーザイ株式会社 Jun阻害剤
JP2007521334A (ja) * 2003-12-19 2007-08-02 プレキシコン,インコーポレーテッド Ret調節剤の開発のための化合物および方法
JP2007534653A (ja) * 2003-12-24 2007-11-29 ファイザー・イタリア・エス.アール.エル. キナーゼ阻害剤としての活性をもつピロロ[2,3−b]ピリジン誘導体、それらの調製方法、およびそれらを含む医薬組成物
JP2007531760A (ja) * 2004-03-30 2007-11-08 バーテックス ファーマシューティカルズ インコーポレイテッド Jakおよび他のプロテインキナーゼの阻害剤として有用なアザインドール

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008523085A (ja) * 2004-12-08 2008-07-03 スミスクライン・ビーチャム・コーポレイション 1h−ピロロ[2,3−b]ピリジン
JP2008546797A (ja) * 2005-06-22 2008-12-25 プレキシコン,インコーポレーテッド キナーゼ調節のための化合物および方法,およびその適応症
JP2012509903A (ja) * 2008-11-25 2012-04-26 ユニバーシティー オブ ロチェスター Mlk阻害剤および使用方法
JP2015052009A (ja) * 2008-11-25 2015-03-19 ユニバーシティー オブ ロチェスター Mlk阻害剤および使用方法
JP2019048835A (ja) * 2009-01-15 2019-03-28 インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation Jak阻害剤および関連中間化合物の製造方法
JP2013525490A (ja) * 2010-05-06 2013-06-20 メルク・シャープ・エンド・ドーム・コーポレイション Faahのモジュレータとして有用なアザインドール誘導体
KR101501856B1 (ko) * 2010-07-21 2015-03-11 에프. 호프만-라 로슈 아게 프로판-1-설폰산{3-[5-(4-클로로-페닐)-1H-피롤로[2,3-b]피리딘-3-카본일]-2,4-다이플루오로-페닐}-아마이드의 신규 제조 방법
US9150594B2 (en) 2010-07-21 2015-10-06 Hoffmann-La Roche Inc. Processes for the manufacture of propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide
US9556172B2 (en) 2010-07-21 2017-01-31 Hoffman La-Roche Inc. Processes for the manufacture of propane-1-sulfonic acid (3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl)-amide
JP2013537521A (ja) * 2010-07-21 2013-10-03 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト プロパン−1−スルホン酸{3−[5−(4−クロロ−フェニル)−1H−ピロロ[2,3−b]ピリジン−3−カルボニル]−2,4−ジフルオロ−フェニル}−アミドの新規製造方法
JP2014534246A (ja) * 2011-11-22 2014-12-18 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung 3−シアノアリール−1H−ピラゾロ[2.3−b]ピリジン誘導体
JP2016516823A (ja) * 2013-04-18 2016-06-09 アーリーン ファーマシューティカルズ エルエルシー 3,5−(非)置換−1H−ピロロ[2,3−b]ピリジン、1H−ピラゾロ[3,4−b]ピリジン、及び5H−ピロロ[2,3−b]ピラジン、ITK及びJAK3キナーゼの阻害剤
US9834551B2 (en) 2013-04-18 2017-12-05 Arrien Pharmaceuticals Llc Substituted pyrrolo[2,3-b]pyrazines and substituted pyrazolo[3,4-b]pyridines as ITK and JAK kinase inhibitors
JP2018502853A (ja) * 2015-01-23 2018-02-01 コンフルエンス・ライフ・サイエンシズ,インコーポレーテッド 炎症およびがんを処置するための複素環式itk阻害剤
JP2018537533A (ja) * 2015-12-07 2018-12-20 プレキシコン インコーポレーテッドPlexxikon Inc. キナーゼ調節のための化合物及び方法ならびにそのための指示
JP2021518856A (ja) * 2018-03-01 2021-08-05 ザ トラスティーズ オブ コロンビア ユニバーシティー イン ザ シティー オブ ニューヨーク 有毒な小胞体ストレスを抑制するための化合物、組成物、および方法
JP7487170B2 (ja) 2018-03-01 2024-05-20 ザ トラスティーズ オブ コロンビア ユニバーシティー イン ザ シティー オブ ニューヨーク 毒性小胞体ストレスを抑制するための化合物、組成物および方法
JP2025148579A (ja) * 2018-03-01 2025-10-07 ザ トラスティーズ オブ コロンビア ユニバーシティー イン ザ シティー オブ ニューヨーク 毒性小胞体ストレスを抑制するための化合物、組成物および方法
KR20230006891A (ko) * 2020-05-01 2023-01-11 길리애드 사이언시즈, 인코포레이티드 Cd73를 억제하는 2,4-다이옥소피리미딘 화합물
JP2023524074A (ja) * 2020-05-01 2023-06-08 ギリアード サイエンシーズ, インコーポレイテッド Cd73阻害性2,4-ジオキソピリミジン化合物
JP7564888B2 (ja) 2020-05-01 2024-10-09 ギリアード サイエンシーズ, インコーポレイテッド Cd73阻害性2,4-ジオキソピリミジン化合物
KR102915068B1 (ko) 2020-05-01 2026-01-20 길리애드 사이언시즈, 인코포레이티드 Cd73를 억제하는 2,4-다이옥소피리미딘 화합물
JP2023545219A (ja) * 2020-10-05 2023-10-26 エンライブン インコーポレイテッド Bcr-ablチロシンキナーゼの阻害のための7-アザインドール化合物
JP7826325B2 (ja) 2020-10-05 2026-03-09 エンライブン インコーポレイテッド Bcr-ablチロシンキナーゼの阻害のための7-アザインドール化合物
JP2024519138A (ja) * 2021-05-21 2024-05-08 センター ナショナル デ ラ レシェルシェ サイエンティフィーク 抗ウイルス剤としての新規アザインドール誘導体

Also Published As

Publication number Publication date
EP1781654A1 (en) 2007-05-09
KR20070053237A (ko) 2007-05-23
US7361763B2 (en) 2008-04-22
TNSN07027A1 (en) 2008-06-02
AU2005269386A1 (en) 2006-02-09
NO20070907L (no) 2007-04-16
US7906648B2 (en) 2011-03-15
BRPI0513916A (pt) 2008-05-20
WO2006015123A1 (en) 2006-02-09
CA2573362A1 (en) 2006-02-09
EP2264033A1 (en) 2010-12-22
US20090306056A1 (en) 2009-12-10
ECSP077280A (es) 2007-03-29
MA28810B1 (fr) 2007-08-01
NZ553267A (en) 2010-09-30
US20060030583A1 (en) 2006-02-09
US7582637B2 (en) 2009-09-01
IL180790A0 (en) 2007-06-03
MX2007001127A (es) 2007-07-11
US20080221119A1 (en) 2008-09-11

Similar Documents

Publication Publication Date Title
US7582637B2 (en) Pyrrolo-pyridine kinase modulators
US7601839B2 (en) Pyrrolo-pyridine kinase modulators
US7709645B2 (en) Pyrrolo-pyridine kinase modulators
US7452993B2 (en) Fused ring heterocycle kinase modulators
US7626021B2 (en) Fused ring heterocycle kinase modulators
ZA200700315B (en) Pyrrolo-pyridine kinase modulators
KR20100066419A (ko) 융합 고리 헤테로사이클 키나제 조절제
ZA200700314B (en) Fused ring heterocycle kinase modulators
HK1147755A (en) Fused ring heterocycle kinase modulators
HK1142066A (en) Fused ring heterocycle kinase modulators

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080724

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20080724

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20110608

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110614

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110909

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20111220

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20120619