CA2573362A1 - Pyrrolo-pyridine kinase modulators - Google Patents
Pyrrolo-pyridine kinase modulators Download PDFInfo
- Publication number
- CA2573362A1 CA2573362A1 CA002573362A CA2573362A CA2573362A1 CA 2573362 A1 CA2573362 A1 CA 2573362A1 CA 002573362 A CA002573362 A CA 002573362A CA 2573362 A CA2573362 A CA 2573362A CA 2573362 A1 CA2573362 A1 CA 2573362A1
- Authority
- CA
- Canada
- Prior art keywords
- substituted
- unsubstituted
- compound
- heteroaryl
- heterocycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108091000080 Phosphotransferase Proteins 0.000 title claims abstract description 116
- 102000020233 phosphotransferase Human genes 0.000 title claims abstract description 116
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- 238000000034 method Methods 0.000 claims abstract description 209
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- 201000010099 disease Diseases 0.000 claims abstract description 28
- 150000001875 compounds Chemical class 0.000 claims description 274
- 125000000217 alkyl group Chemical group 0.000 claims description 114
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 109
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- 229910052757 nitrogen Inorganic materials 0.000 claims description 65
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 60
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- 125000001424 substituent group Chemical group 0.000 claims description 48
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 40
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Classifications
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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Landscapes
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- Pain & Pain Management (AREA)
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- Cardiology (AREA)
- Transplantation (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59188804P | 2004-07-27 | 2004-07-27 | |
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-
2005
- 2005-07-27 EP EP10003581A patent/EP2264033A1/en not_active Withdrawn
- 2005-07-27 AU AU2005269386A patent/AU2005269386A1/en not_active Abandoned
- 2005-07-27 BR BRPI0513916-3A patent/BRPI0513916A/pt not_active IP Right Cessation
- 2005-07-27 CA CA002573362A patent/CA2573362A1/en not_active Abandoned
- 2005-07-27 MX MX2007001127A patent/MX2007001127A/es not_active Application Discontinuation
- 2005-07-27 KR KR1020077004799A patent/KR20070053237A/ko not_active Withdrawn
- 2005-07-27 NZ NZ553267A patent/NZ553267A/en unknown
- 2005-07-27 US US11/192,341 patent/US7361763B2/en not_active Expired - Fee Related
- 2005-07-27 JP JP2007523808A patent/JP2008508303A/ja active Pending
- 2005-07-27 WO PCT/US2005/026792 patent/WO2006015123A1/en not_active Ceased
- 2005-07-27 EP EP05776481A patent/EP1781654A1/en not_active Withdrawn
-
2007
- 2007-01-18 IL IL180790A patent/IL180790A0/en unknown
- 2007-01-26 TN TNP2007000027A patent/TNSN07027A1/en unknown
- 2007-02-16 NO NO20070907A patent/NO20070907L/no not_active Application Discontinuation
- 2007-02-21 MA MA29695A patent/MA28810B1/fr unknown
- 2007-02-27 EC EC2007007280A patent/ECSP077280A/es unknown
-
2008
- 2008-02-29 US US12/040,527 patent/US7582637B2/en not_active Expired - Fee Related
-
2009
- 2009-07-10 US US12/501,328 patent/US7906648B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008508303A (ja) | 2008-03-21 |
| EP1781654A1 (en) | 2007-05-09 |
| KR20070053237A (ko) | 2007-05-23 |
| US7361763B2 (en) | 2008-04-22 |
| TNSN07027A1 (en) | 2008-06-02 |
| AU2005269386A1 (en) | 2006-02-09 |
| NO20070907L (no) | 2007-04-16 |
| US7906648B2 (en) | 2011-03-15 |
| BRPI0513916A (pt) | 2008-05-20 |
| WO2006015123A1 (en) | 2006-02-09 |
| EP2264033A1 (en) | 2010-12-22 |
| US20090306056A1 (en) | 2009-12-10 |
| ECSP077280A (es) | 2007-03-29 |
| MA28810B1 (fr) | 2007-08-01 |
| NZ553267A (en) | 2010-09-30 |
| US20060030583A1 (en) | 2006-02-09 |
| US7582637B2 (en) | 2009-09-01 |
| IL180790A0 (en) | 2007-06-03 |
| MX2007001127A (es) | 2007-07-11 |
| US20080221119A1 (en) | 2008-09-11 |
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| FZDE | Discontinued |