JP2008000001A - 免疫刺激オリゴヌクレオチドおよびその医薬用途 - Google Patents

免疫刺激オリゴヌクレオチドおよびその医薬用途 Download PDF

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Publication number
JP2008000001A
JP2008000001A JP2004287102A JP2004287102A JP2008000001A JP 2008000001 A JP2008000001 A JP 2008000001A JP 2004287102 A JP2004287102 A JP 2004287102A JP 2004287102 A JP2004287102 A JP 2004287102A JP 2008000001 A JP2008000001 A JP 2008000001A
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JP
Japan
Prior art keywords
oligonucleotide
seq
immunostimulatory
activity
nucleotide sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2004287102A
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English (en)
Japanese (ja)
Inventor
Hideki Narimi
英樹 成見
Akihito Kaneda
明仁 金田
Kazumasa Fukao
和正 深尾
Shizuo Akira
静男 審良
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Osaka University NUC
Toray Industries Inc
Original Assignee
Osaka University NUC
Toray Industries Inc
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Filing date
Publication date
Application filed by Osaka University NUC, Toray Industries Inc filed Critical Osaka University NUC
Priority to JP2004287102A priority Critical patent/JP2008000001A/ja
Priority to PCT/JP2005/018148 priority patent/WO2006035939A1/fr
Publication of JP2008000001A publication Critical patent/JP2008000001A/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2004287102A 2004-09-30 2004-09-30 免疫刺激オリゴヌクレオチドおよびその医薬用途 Pending JP2008000001A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2004287102A JP2008000001A (ja) 2004-09-30 2004-09-30 免疫刺激オリゴヌクレオチドおよびその医薬用途
PCT/JP2005/018148 WO2006035939A1 (fr) 2004-09-30 2005-09-30 Oligonucléotide immunostimulant et utilisation de celui-ci dans la pharmacie

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2004287102A JP2008000001A (ja) 2004-09-30 2004-09-30 免疫刺激オリゴヌクレオチドおよびその医薬用途

Publications (1)

Publication Number Publication Date
JP2008000001A true JP2008000001A (ja) 2008-01-10

Family

ID=36119081

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004287102A Pending JP2008000001A (ja) 2004-09-30 2004-09-30 免疫刺激オリゴヌクレオチドおよびその医薬用途

Country Status (2)

Country Link
JP (1) JP2008000001A (fr)
WO (1) WO2006035939A1 (fr)

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100790479B1 (ko) * 2001-12-04 2008-01-02 엘지.필립스 엘시디 주식회사 에어 나이프 건조장치
KR100789216B1 (ko) * 2006-09-08 2008-01-02 디엠이엔씨(주) 네일건을 사용하여 시공되는 배수판결합구조 및 이를이용한 배수판시공방법
KR100794896B1 (ko) * 2006-01-23 2008-01-14 미츠이 긴조쿠 고교 가부시키가이샤 차량 시트 잠금장치
KR100797786B1 (ko) * 2006-11-20 2008-01-24 (주)맵클래스 광고판
KR100797453B1 (ko) * 2007-11-15 2008-01-24 이텍산업 주식회사 노면 청소차용 롤러브러시 자동 틸팅장치
KR100800489B1 (ko) * 2006-12-21 2008-02-04 삼성전자주식회사 반도체 집적 회로의 기준 전압 제공 장치
KR100802223B1 (ko) * 2001-12-21 2008-02-11 주식회사 하이닉스반도체 반도체 장치의 챠지 펌프회로
KR100802274B1 (ko) * 2007-02-27 2008-02-11 지멘스 오토모티브 주식회사 자동차의 에러 관리 방법
KR100801714B1 (ko) * 2006-09-25 2008-02-11 조용성 히트파이프를 이용한 터널 외부 노면의 결빙 방지 시스템
KR100801677B1 (ko) * 2008-01-08 2008-02-11 주식회사 프리웍스 통신 중계기의 냉각 장치
KR100803994B1 (ko) * 1997-12-05 2008-02-18 토탈 페트로케미칼스 리서치 펠루이 올레핀의 제조
KR100805349B1 (ko) * 2006-11-14 2008-02-20 김부성 접이식 뒷굽을 가지는 여성용 구두
KR100808771B1 (ko) * 2006-12-18 2008-02-29 덴소풍성전자(주) 입체감을 구현하는 계기의 문자판
KR100808840B1 (ko) * 2007-04-30 2008-03-03 주식회사 화승알앤에이 자동차의 윈도우 레귤레이터
KR100815905B1 (ko) * 2001-12-29 2008-03-21 엘지.필립스 엘시디 주식회사 식각용 버블판 및 그를 이용한 식각장치
KR100816119B1 (ko) * 2006-12-28 2008-03-21 주식회사 하이닉스반도체 멀티 다이 패키지 장치
KR100817126B1 (ko) * 2001-12-21 2008-03-27 엘지.필립스 엘시디 주식회사 자성레지스트 인쇄장치 및 이를 이용한 패턴형성방법
KR100816987B1 (ko) * 2006-10-24 2008-03-27 주식회사 포스코 실수율 저감 방지기능을 구비한 합금철 분배장치
KR100824762B1 (ko) * 2005-10-11 2008-04-24 키몬다 아게 용량성 커플링 어시스트 전압 스위칭
KR100832338B1 (ko) * 2002-07-16 2008-05-26 엘지전자 주식회사 개인정보관리기능이 구비된 이동통신단말기 및 그 제어방법
KR100837199B1 (ko) * 2000-11-21 2008-06-13 유니챰 가부시키가이샤 시트 포장체
KR100842718B1 (ko) * 2006-10-30 2008-07-01 한국단자공업 주식회사 단자 하우징
KR100855561B1 (ko) * 2004-04-16 2008-09-01 코딩 테크놀러지스 에이비 로우-비트 레이트 애플리케이션용 파라메트릭 표현을생성하는 방법
KR100860755B1 (ko) * 2000-05-15 2008-09-29 제너럴 일렉트릭 캄파니 백색 조명 시스템
KR100861237B1 (ko) * 2006-10-26 2008-10-02 한태환 시험용 시간 관리 시계
CN100434245C (zh) * 2004-12-23 2008-11-19 黄山市阊林木业有限责任公司 一种细木工板加工工艺
KR100872318B1 (ko) * 2006-12-07 2008-12-08 최승진 방수콘센트
US8592566B2 (en) 2006-05-31 2013-11-26 Toray Industries, Inc. Immunostimulatory oligonucleotides and use thereof in pharmaceuticals

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009069448A1 (fr) * 2007-11-28 2009-06-04 Toray Industries, Inc. Adjuvant pour vaccin contre encéphalite b japonaise et vaccin contre l'encéphalite b japonaise
WO2009069447A1 (fr) * 2007-11-28 2009-06-04 Toray Industries, Inc. Adjuvant pour vaccin contre la grippe et vaccin contre la grippe
JP5359883B2 (ja) * 2007-11-28 2013-12-04 東レ株式会社 肝炎の治療剤又は予防剤
CN114807152A (zh) 2016-06-08 2022-07-29 哈佛学院院长及董事 工程化病毒载体减少了炎症和免疫反应的诱导
JP7048102B2 (ja) 2019-05-23 2022-04-05 国立研究開発法人医薬基盤・健康・栄養研究所 免疫賦活活性を有する核酸多糖複合体の抗腫瘍薬としての応用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04352724A (ja) * 1990-07-27 1992-12-07 Mitsui Toatsu Chem Inc 免疫調節型治療剤
EP0772619B2 (fr) * 1994-07-15 2010-12-08 The University of Iowa Research Foundation Oligonucleotides immunomodulateurs
US6207646B1 (en) * 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
CA2291483C (fr) * 1997-06-06 2012-09-18 Dynavax Technologies Corporation Oligonucleotides immunostimulateurs, compositions correspondantes et leurs procedes d'utilisation
DK1009413T3 (da) * 1997-09-05 2007-06-11 Univ California Anvendelse af immunstimulerende oligonukleotider til forebyggelse eller behandling af astma
EP1220684B2 (fr) * 1999-09-27 2010-07-14 Coley Pharmaceutical Group, Inc. Methodes concernant l'interferon induit par des acides nucleiques immunostimulateurs
EP1992635B1 (fr) * 2002-12-23 2012-02-08 Dynavax Technologies Corporation Oligonucléotides à séquence immunostimulatrice et ses procédés d'utilisation

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100803994B1 (ko) * 1997-12-05 2008-02-18 토탈 페트로케미칼스 리서치 펠루이 올레핀의 제조
KR100860755B1 (ko) * 2000-05-15 2008-09-29 제너럴 일렉트릭 캄파니 백색 조명 시스템
KR100837199B1 (ko) * 2000-11-21 2008-06-13 유니챰 가부시키가이샤 시트 포장체
KR100790479B1 (ko) * 2001-12-04 2008-01-02 엘지.필립스 엘시디 주식회사 에어 나이프 건조장치
KR100817126B1 (ko) * 2001-12-21 2008-03-27 엘지.필립스 엘시디 주식회사 자성레지스트 인쇄장치 및 이를 이용한 패턴형성방법
KR100802223B1 (ko) * 2001-12-21 2008-02-11 주식회사 하이닉스반도체 반도체 장치의 챠지 펌프회로
KR100815905B1 (ko) * 2001-12-29 2008-03-21 엘지.필립스 엘시디 주식회사 식각용 버블판 및 그를 이용한 식각장치
KR100832338B1 (ko) * 2002-07-16 2008-05-26 엘지전자 주식회사 개인정보관리기능이 구비된 이동통신단말기 및 그 제어방법
KR100855561B1 (ko) * 2004-04-16 2008-09-01 코딩 테크놀러지스 에이비 로우-비트 레이트 애플리케이션용 파라메트릭 표현을생성하는 방법
CN100434245C (zh) * 2004-12-23 2008-11-19 黄山市阊林木业有限责任公司 一种细木工板加工工艺
KR100824762B1 (ko) * 2005-10-11 2008-04-24 키몬다 아게 용량성 커플링 어시스트 전압 스위칭
KR100794896B1 (ko) * 2006-01-23 2008-01-14 미츠이 긴조쿠 고교 가부시키가이샤 차량 시트 잠금장치
US8592566B2 (en) 2006-05-31 2013-11-26 Toray Industries, Inc. Immunostimulatory oligonucleotides and use thereof in pharmaceuticals
KR100789216B1 (ko) * 2006-09-08 2008-01-02 디엠이엔씨(주) 네일건을 사용하여 시공되는 배수판결합구조 및 이를이용한 배수판시공방법
KR100801714B1 (ko) * 2006-09-25 2008-02-11 조용성 히트파이프를 이용한 터널 외부 노면의 결빙 방지 시스템
KR100816987B1 (ko) * 2006-10-24 2008-03-27 주식회사 포스코 실수율 저감 방지기능을 구비한 합금철 분배장치
KR100861237B1 (ko) * 2006-10-26 2008-10-02 한태환 시험용 시간 관리 시계
KR100842718B1 (ko) * 2006-10-30 2008-07-01 한국단자공업 주식회사 단자 하우징
KR100805349B1 (ko) * 2006-11-14 2008-02-20 김부성 접이식 뒷굽을 가지는 여성용 구두
KR100797786B1 (ko) * 2006-11-20 2008-01-24 (주)맵클래스 광고판
KR100872318B1 (ko) * 2006-12-07 2008-12-08 최승진 방수콘센트
KR100808771B1 (ko) * 2006-12-18 2008-02-29 덴소풍성전자(주) 입체감을 구현하는 계기의 문자판
KR100800489B1 (ko) * 2006-12-21 2008-02-04 삼성전자주식회사 반도체 집적 회로의 기준 전압 제공 장치
KR100816119B1 (ko) * 2006-12-28 2008-03-21 주식회사 하이닉스반도체 멀티 다이 패키지 장치
KR100802274B1 (ko) * 2007-02-27 2008-02-11 지멘스 오토모티브 주식회사 자동차의 에러 관리 방법
KR100808840B1 (ko) * 2007-04-30 2008-03-03 주식회사 화승알앤에이 자동차의 윈도우 레귤레이터
KR100797453B1 (ko) * 2007-11-15 2008-01-24 이텍산업 주식회사 노면 청소차용 롤러브러시 자동 틸팅장치
KR100801677B1 (ko) * 2008-01-08 2008-02-11 주식회사 프리웍스 통신 중계기의 냉각 장치

Also Published As

Publication number Publication date
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