JP2007507578A5 - - Google Patents
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- Publication number
- JP2007507578A5 JP2007507578A5 JP2006530760A JP2006530760A JP2007507578A5 JP 2007507578 A5 JP2007507578 A5 JP 2007507578A5 JP 2006530760 A JP2006530760 A JP 2006530760A JP 2006530760 A JP2006530760 A JP 2006530760A JP 2007507578 A5 JP2007507578 A5 JP 2007507578A5
- Authority
- JP
- Japan
- Prior art keywords
- saccharide
- sialic acid
- acetylated
- acid residues
- serogroup
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001720 carbohydrates Chemical class 0.000 claims 37
- 125000005629 sialic acid group Chemical group 0.000 claims 20
- 239000000427 antigen Substances 0.000 claims 10
- 102000036639 antigens Human genes 0.000 claims 10
- 108091007433 antigens Proteins 0.000 claims 10
- 150000002402 hexoses Chemical class 0.000 claims 8
- 102000014914 Carrier Proteins Human genes 0.000 claims 5
- 108010078791 Carrier Proteins Proteins 0.000 claims 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 4
- 150000002016 disaccharides Chemical group 0.000 claims 4
- 229930182830 galactose Natural products 0.000 claims 4
- 239000008103 glucose Substances 0.000 claims 4
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 3
- 235000000346 sugar Nutrition 0.000 claims 3
- 150000008163 sugars Chemical class 0.000 claims 3
- 229960003983 diphtheria toxoid Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000002163 immunogen Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229960000814 tetanus toxoid Drugs 0.000 claims 2
- 241000588832 Bordetella pertussis Species 0.000 claims 1
- 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 claims 1
- 241000991587 Enterovirus C Species 0.000 claims 1
- 241000606768 Haemophilus influenzae Species 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010027249 Meningitis meningococcal Diseases 0.000 claims 1
- 201000010924 Meningococcal meningitis Diseases 0.000 claims 1
- 101710188053 Protein D Proteins 0.000 claims 1
- 101710132893 Resolvase Proteins 0.000 claims 1
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 1
- 238000006640 acetylation reaction Methods 0.000 claims 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims 1
- 230000005875 antibody response Effects 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229940045808 haemophilus influenzae type b Drugs 0.000 claims 1
- 208000005252 hepatitis A Diseases 0.000 claims 1
- 208000002672 hepatitis B Diseases 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 238000006116 polymerization reaction Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 claims 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0323103.2A GB0323103D0 (en) | 2003-10-02 | 2003-10-02 | De-acetylated saccharides |
| GB0323103.2 | 2003-10-02 | ||
| PCT/IB2004/003366 WO2005033148A1 (en) | 2003-10-02 | 2004-10-04 | Hypo- and hyper-acetylated meningococcal capsular saccharides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012028524A Division JP2012097284A (ja) | 2003-10-02 | 2012-02-13 | 低アセチル化または高アセチル化された髄膜炎菌の莢膜糖類 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007507578A JP2007507578A (ja) | 2007-03-29 |
| JP2007507578A5 true JP2007507578A5 (cg-RX-API-DMAC7.html) | 2007-11-22 |
| JP5590760B2 JP5590760B2 (ja) | 2014-09-17 |
Family
ID=29415385
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006530760A Expired - Lifetime JP5590760B2 (ja) | 2003-10-02 | 2004-10-04 | 低アセチル化または高アセチル化された髄膜炎菌の莢膜糖類 |
| JP2012028524A Withdrawn JP2012097284A (ja) | 2003-10-02 | 2012-02-13 | 低アセチル化または高アセチル化された髄膜炎菌の莢膜糖類 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012028524A Withdrawn JP2012097284A (ja) | 2003-10-02 | 2012-02-13 | 低アセチル化または高アセチル化された髄膜炎菌の莢膜糖類 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20100092509A1 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2267036A1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP5590760B2 (cg-RX-API-DMAC7.html) |
| CN (3) | CN102977219A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE545659T1 (cg-RX-API-DMAC7.html) |
| AU (2) | AU2004278170B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0415048A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2541020C (cg-RX-API-DMAC7.html) |
| CY (3) | CY1112763T1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2379792T3 (cg-RX-API-DMAC7.html) |
| GB (1) | GB0323103D0 (cg-RX-API-DMAC7.html) |
| MX (1) | MXPA06003729A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ546668A (cg-RX-API-DMAC7.html) |
| PT (1) | PT1678212E (cg-RX-API-DMAC7.html) |
| RU (1) | RU2362784C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2005033148A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (82)
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| ATE352631T1 (de) | 2000-02-28 | 2007-02-15 | Novartis Vaccines & Diagnostic | Heterologe expression von neisseria proteine |
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| DK2255826T3 (en) * | 2002-08-02 | 2016-06-20 | Glaxosmithkline Biologicals Sa | Neisserial vaccine compositions comprising a combination of antigens. |
| EP2353608B1 (en) | 2002-10-11 | 2019-12-18 | Novartis Vaccines and Diagnostics S.r.l. | Polypeptide-vaccines for broad protection against hypervirulent meningococcal lineages |
| PT1961426E (pt) | 2003-10-02 | 2011-06-28 | Novartis Vaccines & Diagnostic | Vacinas combinadas contra a meningite |
| GB0409745D0 (en) | 2004-04-30 | 2004-06-09 | Chiron Srl | Compositions including unconjugated carrier proteins |
| GB0411387D0 (en) | 2004-05-21 | 2004-06-23 | Chiron Srl | Analysis of saccharide length |
| GB0413868D0 (en) | 2004-06-21 | 2004-07-21 | Chiron Srl | Dimensional anlaysis of saccharide conjugates |
| GB0505518D0 (en) * | 2005-03-17 | 2005-04-27 | Chiron Srl | Combination vaccines with whole cell pertussis antigen |
| JP5135220B2 (ja) | 2005-09-01 | 2013-02-06 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス ゲーエムベーハー アンド カンパニー カーゲー | 血清群ｃ髄膜炎菌を含む複数ワクチン接種 |
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| EP2476433A1 (en) | 2006-03-30 | 2012-07-18 | GlaxoSmithKline Biologicals S.A. | Immunogenic composition |
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| AU2010227220B2 (en) | 2009-03-24 | 2014-11-13 | Glaxosmithkline Biologicals S.A. | Combinations of meningococcal factor H binding protein and pneumococcal saccharide conjugates |
| LT2411048T (lt) | 2009-03-24 | 2020-06-25 | Glaxosmithkline Biologicals Sa | Adjuvantinį meningokokinį faktorių h surišantis baltymas |
| PE20110023A1 (es) | 2009-06-22 | 2011-01-31 | Wyeth Llc | Composiciones inmunogenicas de antigenos de staphylococcus aureus |
| EP3461496B1 (en) | 2009-06-22 | 2023-08-23 | Wyeth LLC | Compositions and methods for preparing staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions |
| GB0913681D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
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| SI3246044T2 (sl) | 2010-08-23 | 2024-06-28 | Wyeth Llc | Stabilne formulacije antigenov neisseria meningitidis RLP2086 |
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-
2003
- 2003-10-02 GB GBGB0323103.2A patent/GB0323103D0/en not_active Ceased
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2004
- 2004-10-04 WO PCT/IB2004/003366 patent/WO2005033148A1/en not_active Ceased
- 2004-10-04 JP JP2006530760A patent/JP5590760B2/ja not_active Expired - Lifetime
- 2004-10-04 EP EP10180746A patent/EP2267036A1/en not_active Ceased
- 2004-10-04 MX MXPA06003729A patent/MXPA06003729A/es active IP Right Grant
- 2004-10-04 RU RU2006114695/04A patent/RU2362784C2/ru not_active IP Right Cessation
- 2004-10-04 ES ES04791697T patent/ES2379792T3/es not_active Expired - Lifetime
- 2004-10-04 CN CN2012104254031A patent/CN102977219A/zh active Pending
- 2004-10-04 CA CA2541020A patent/CA2541020C/en not_active Expired - Lifetime
- 2004-10-04 PT PT04791697T patent/PT1678212E/pt unknown
- 2004-10-04 CN CNA2004800345251A patent/CN1882612A/zh active Pending
- 2004-10-04 CN CN201110359118XA patent/CN102633893A/zh active Pending
- 2004-10-04 AU AU2004278170A patent/AU2004278170B2/en not_active Ceased
- 2004-10-04 AT AT04791697T patent/ATE545659T1/de active
- 2004-10-04 US US10/574,437 patent/US20100092509A1/en not_active Abandoned
- 2004-10-04 EP EP04791697A patent/EP1678212B1/en not_active Revoked
- 2004-10-04 BR BRPI0415048-1A patent/BRPI0415048A/pt not_active IP Right Cessation
- 2004-10-04 NZ NZ546668A patent/NZ546668A/en not_active IP Right Cessation
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2008
- 2008-06-19 AU AU2008202708A patent/AU2008202708B2/en not_active Ceased
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2012
- 2012-02-13 JP JP2012028524A patent/JP2012097284A/ja not_active Withdrawn
- 2012-05-08 CY CY20121100422T patent/CY1112763T1/el unknown
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- 2014-05-01 US US14/267,248 patent/US9827301B2/en not_active Expired - Fee Related
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