JP2007505916A5 - - Google Patents
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- Publication number
- JP2007505916A5 JP2007505916A5 JP2006527026A JP2006527026A JP2007505916A5 JP 2007505916 A5 JP2007505916 A5 JP 2007505916A5 JP 2006527026 A JP2006527026 A JP 2006527026A JP 2006527026 A JP2006527026 A JP 2006527026A JP 2007505916 A5 JP2007505916 A5 JP 2007505916A5
- Authority
- JP
- Japan
- Prior art keywords
- alkoxy
- alkyl
- halo
- cycloalkyl
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003545 alkoxy group Chemical group 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 125000001475 halogen functional group Chemical group 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- -1 R 3 and R 4 are H Chemical group 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000006545 (C1-C9) alkyl group Chemical group 0.000 claims 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003302 alkenyloxy group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000005133 alkynyloxy group Chemical group 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 1
- 125000005844 heterocyclyloxy group Chemical group 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50414603P | 2003-09-19 | 2003-09-19 | |
| US60/504,146 | 2003-09-19 | ||
| PCT/US2004/030375 WO2005042478A2 (en) | 2003-09-19 | 2004-09-16 | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007505916A JP2007505916A (ja) | 2007-03-15 |
| JP2007505916A5 true JP2007505916A5 (enExample) | 2007-11-08 |
| JP4928941B2 JP4928941B2 (ja) | 2012-05-09 |
Family
ID=34549183
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006527026A Expired - Lifetime JP4928941B2 (ja) | 2003-09-19 | 2004-09-16 | ４−（（フェノキシアルキル）チオ）−フェノキシ酢酸および類似化合物 |
Country Status (29)
| Country | Link |
|---|---|
| US (9) | US7301050B2 (enExample) |
| EP (2) | EP2100877B1 (enExample) |
| JP (1) | JP4928941B2 (enExample) |
| KR (1) | KR101111475B1 (enExample) |
| CN (1) | CN1882533B (enExample) |
| AR (1) | AR045773A1 (enExample) |
| AT (1) | ATE542793T1 (enExample) |
| AU (1) | AU2004285849B2 (enExample) |
| BR (1) | BRPI0414268B8 (enExample) |
| CA (1) | CA2539446C (enExample) |
| CO (1) | CO5680476A2 (enExample) |
| CR (1) | CR8301A (enExample) |
| CY (1) | CY1110555T1 (enExample) |
| DE (1) | DE602004022179D1 (enExample) |
| DK (1) | DK1667964T3 (enExample) |
| EA (1) | EA012241B1 (enExample) |
| EC (1) | ECSP066434A (enExample) |
| ES (2) | ES2328581T3 (enExample) |
| IL (1) | IL174398A (enExample) |
| NO (2) | NO338511B1 (enExample) |
| NZ (1) | NZ545943A (enExample) |
| PL (1) | PL1667964T3 (enExample) |
| PT (1) | PT1667964E (enExample) |
| SG (1) | SG145752A1 (enExample) |
| SI (1) | SI1667964T1 (enExample) |
| TW (1) | TWI336238B (enExample) |
| UA (1) | UA87467C2 (enExample) |
| WO (1) | WO2005042478A2 (enExample) |
| ZA (1) | ZA200603085B (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2243766E (pt) * | 2003-09-19 | 2015-10-20 | Janssen Pharmaceutica Nv | Ácidos 4-((fenoxialquil)tio)-fenoxiacéticos e análogos |
| SG145752A1 (en) | 2003-09-19 | 2008-09-29 | Janssen Pharmaceutica Nv | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| MY145712A (en) * | 2004-09-15 | 2012-03-30 | Janssen Pharmaceutica Nv | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| MY147518A (en) * | 2004-09-15 | 2012-12-31 | Janssen Pharmaceutica Nv | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| JO3006B1 (ar) * | 2005-09-14 | 2016-09-05 | Janssen Pharmaceutica Nv | املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك |
| PE20080188A1 (es) * | 2006-04-18 | 2008-03-10 | Janssen Pharmaceutica Nv | Derivados del acido benzoazepin-oxi-acetico como agonistas de ppar-delta usados para aumentar hdl-c, reducir ldl-c y reducir colesterol |
| BRPI0920170A2 (pt) | 2008-10-17 | 2016-06-21 | Metabolex Inc | métodos para diminuir a quantidade de partículas ldl pequenas e densas e de níveis de triglicerídeos e ldl no sangue em um humano, e para identificar um indivíduo candidato para tratamento com um composto ou um sal, prodroga ou isômero do mesmo, composto ou um sal, prodroga ou isômero do mesmo, e método. |
| KR20150036407A (ko) * | 2012-07-06 | 2015-04-07 | 메르크 파텐트 게엠베하 | 바이메소제닉 화합물 및 메소제닉 매질 |
| AU2014353246A1 (en) | 2013-11-20 | 2016-06-16 | Cymabay Therapeutics, Inc. | Treatment of homozygous familial hypercholesterolemia |
| US10272058B2 (en) | 2014-03-20 | 2019-04-30 | Cymabay Therapeutics, Inc. | Treatment of intrahepatic cholestatic diseases |
| LT3119384T (lt) | 2014-03-20 | 2018-11-26 | Cymabay Therapeutics, Inc. | Intrahepatinių cholestazinių ligų gydymas |
| CN106163508A (zh) | 2014-04-11 | 2016-11-23 | 西玛贝医药公司 | Nafld和nash的治疗 |
| HK1231380A1 (zh) | 2014-06-26 | 2017-12-22 | Cymabay Therapeutics, Inc. | 严重高甘油三酯血症的治疗 |
| US10512622B2 (en) | 2017-07-14 | 2019-12-24 | Cymabay Therapeutics, Inc. | Treatment of intrahepatic cholestatic diseases |
| WO2019053582A1 (en) | 2017-09-13 | 2019-03-21 | Novartis Ag | COMBINATIONS HAVING FXR AGONISTS |
| UA125600C2 (uk) | 2017-09-26 | 2022-04-27 | Сімабей Терапьютікс, Інк. | Лікування холестатичного свербежу |
| US10702488B2 (en) * | 2017-12-19 | 2020-07-07 | Theriac Biomedical Inc. | PPAR-γ activators, HDAC inhibitors and their therapeutical usages |
| US11497723B1 (en) * | 2017-12-19 | 2022-11-15 | Tony Antakly | PPAR-gamma activators, HDAC inhibitors and their therapeutical usages |
| MX2021005725A (es) | 2018-11-16 | 2021-07-21 | Cymabay Therapeutics Inc | Tratamiento de la obesidad y sus complicaciones. |
| EA202191379A1 (ru) | 2018-11-16 | 2021-08-06 | Саймабэй Терапьютикс, Инк. | Комбинированное лечение nafld и nash |
| US20210145774A1 (en) | 2019-11-14 | 2021-05-20 | Cymabay Therapeutics, Inc. | Treatment of alcoholic liver disease |
| US20210145775A1 (en) | 2019-11-14 | 2021-05-20 | Cymabay Therapeutics, Inc. | Treatment of intestinal barrier dysfunction and associated diseases |
| CN119735532A (zh) * | 2019-11-21 | 2025-04-01 | 杭州百诚医药科技股份有限公司 | α-氟代查耳酮类衍生物及其应用 |
| US20220241228A1 (en) | 2021-02-01 | 2022-08-04 | Cymabay Therapeutics, Inc. | Treatment of cholangiopathies |
| CN120500333A (zh) | 2023-01-29 | 2025-08-15 | 西玛贝医药公司 | 尿毒症瘙痒的治疗 |
| EP4654958A1 (en) | 2023-01-29 | 2025-12-03 | CymaBay Therapeutics, Inc. | Treatment of chronic pruritic dermatoses |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3517051A (en) * | 1964-03-20 | 1970-06-23 | Merck & Co Inc | Phenoxy substituted phenylacetic acids |
| DE2460689C3 (de) * | 1974-12-20 | 1980-06-26 | Klinge Pharma Gmbh & Co, 8000 Muenchen | 13-disubstituierte Propanol-(2)-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US4109013A (en) * | 1974-12-20 | 1978-08-22 | Klinge Pharma Gmbh & Co. | Substituted propanol-(2) derivatives of hydroxamic acids and the use thereof as hypolipemic drugs |
| US4125732A (en) | 1977-05-06 | 1978-11-14 | American Cyanamid Company | 2-Aryloxy-2-(phenoxyalkoxy)phenyl acetic acid and esters |
| DE3026924A1 (de) | 1980-07-16 | 1982-02-18 | Klinge Pharma GmbH & Co, 8000 München | 1,3-diphenoxypropan-2-ol-derivate sowie verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
| DE3028776A1 (de) | 1980-07-29 | 1982-02-25 | Klinge Pharma GmbH & Co, 8000 München | Neue 1,3-diphenoxypropan-2-on-derivate sowie verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
| EP0056172B1 (en) * | 1981-01-09 | 1985-04-03 | FISONS plc | Phenoxy- and thiophenoxy compounds, methods for their preparation and pharmaceutical formulations containing them |
| JPS58177934A (ja) | 1982-04-13 | 1983-10-18 | Takeda Chem Ind Ltd | ベンゾキノン誘導体 |
| DE3366107D1 (en) * | 1982-09-30 | 1986-10-16 | Merck Frosst Canada Inc | Leukotriene antagonists, their production, and compositions containing them |
| US4820867A (en) * | 1983-04-21 | 1989-04-11 | Merck Frosst Canada, Inc. | Phenoxypropoxy halophenylacetic acids as leukotriene antagonists |
| US4513006A (en) | 1983-09-26 | 1985-04-23 | Mcneil Lab., Inc. | Anticonvulsant sulfamate derivatives |
| JPS61268651A (ja) * | 1985-05-23 | 1986-11-28 | Takeda Chem Ind Ltd | フエニル酢酸誘導体およびその製造法 |
| EP0204349A3 (de) | 1985-06-01 | 1990-01-03 | Dr. Karl Thomae GmbH | Neue heteroaromatische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| JPH0714910B2 (ja) | 1988-12-13 | 1995-02-22 | 塩野義製薬株式会社 | 安定な結晶性の塩およびそれを含有するトロンボキサン受容体拮抗剤 |
| US5487008A (en) | 1990-04-20 | 1996-01-23 | The Regents Of The University Of Michigan | Method and system for detecting the misfire of a reciprocating internal combustion engine in frequency domain |
| US5360909A (en) | 1992-03-23 | 1994-11-01 | Terumo Kabushiki Kaisha | Phenoxyacetic acid compounds and medical preparations containing them |
| US5726165A (en) * | 1994-07-29 | 1998-03-10 | Smithkline Beecham P.L.C. | Derivatives of 4-(2-aminoethyl)phenoxymethyl-phosphonic and -phosphinic acid and pharmaceutical and veterinary uses therefor |
| CA2244831A1 (en) * | 1996-02-02 | 1997-08-07 | John T. Olson | Method of treating diabetes and related disease states |
| WO1997028115A1 (en) | 1996-02-02 | 1997-08-07 | Merck & Co., Inc. | Antidiabetic agents |
| JP3268242B2 (ja) | 1996-11-14 | 2002-03-25 | 三共株式会社 | 縮合複素環化合物を含有する医薬 |
| US6300364B1 (en) | 1997-07-24 | 2001-10-09 | Yamanouchi Pharmaceutical Co., Ltd. | Medicinal compositions with cholesterol-lowering effect |
| SK9212000A3 (en) * | 1997-12-19 | 2001-02-12 | Merck & Co Inc | Arylthiazolidinedione derivatives, pharmaceutical compositions comprising the same and use thereof |
| BR0009864A (pt) | 1999-04-20 | 2002-01-08 | Novo Nordisk As | Composto, composição farmacêutica, métodos para o tratamento de doenças, para o tratamento e/ou prevenção de condições mediadas pelos receptores nucleares e para o tratamento e/ou prevenção de diabete e/ou obesidade, e, uso de um composto |
| CA2376919C (en) * | 1999-06-18 | 2008-11-04 | Merck & Co., Inc. | Arylthiazolidinedione and aryloxazolidinedione derivatives |
| GB9914977D0 (en) | 1999-06-25 | 1999-08-25 | Glaxo Group Ltd | Chemical compounds |
| GB0003310D0 (en) * | 2000-02-15 | 2000-04-05 | Univ Sheffield | Bone formation |
| GB0031107D0 (en) | 2000-12-20 | 2001-01-31 | Glaxo Group Ltd | Chemical compounds |
| IL158873A0 (en) | 2001-06-07 | 2004-05-12 | Lilly Co Eli | Modulators of peroxisome proliferator activated receptors |
| RU2004105956A (ru) * | 2001-07-30 | 2005-03-27 | Ново Нордиск А/С (DK) | Новые производные винилкарбоновых кислот и их применение в качестве антидиабетических средств и т.п. |
| BRPI0211844B8 (pt) | 2001-08-10 | 2021-05-25 | Nippon Chemiphar Co | composto de ácido fenóxi-acético ou um de seus sais farmaceuticamente aceitáveis, e, composição farmacêutica |
| ES2326411T3 (es) | 2001-10-12 | 2009-10-09 | Nippon Chemiphar Co., Ltd. | Activador del receptor delta activado por proliferadores de peroxisomas. |
| ITRM20020014A1 (it) | 2002-01-15 | 2003-07-15 | Sigma Tau Ind Farmaceuti | Derivati di acidi a-feniltiocarbossilici e a-fenilossicarbossilici utili per il trattamento di patologie che rispondono all'attivazione del |
| EP1480957A1 (en) * | 2002-03-01 | 2004-12-01 | Smithkline Beecham Corporation | Hppars activators |
| US6875780B2 (en) | 2002-04-05 | 2005-04-05 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods for their preparation |
| GB0214149D0 (en) | 2002-06-19 | 2002-07-31 | Glaxo Group Ltd | Chemical compounds |
| AU2003260282A1 (en) | 2002-09-05 | 2004-03-29 | Novo Nordisk A/S | Novel vinyl carboxylic acid derivatives and their therapeutical use |
| JP4584714B2 (ja) | 2002-10-28 | 2010-11-24 | ハイ・ポイント・ファーマスーティカルズ、エルエルシー | 新規化合物、その調製および使用 |
| WO2004037776A2 (en) | 2002-10-28 | 2004-05-06 | Novo Nordisk A/S | Novel compounds and their use as prar-modulators |
| WO2004074439A2 (en) | 2003-02-14 | 2004-09-02 | Biogen Idec Ma Inc. | An expression cassette and vector for transient or stable expression of exogenous molecules |
| WO2005019151A1 (en) | 2003-08-20 | 2005-03-03 | Eli Lilly And Company | Ppar modulators |
| PT2243766E (pt) * | 2003-09-19 | 2015-10-20 | Janssen Pharmaceutica Nv | Ácidos 4-((fenoxialquil)tio)-fenoxiacéticos e análogos |
| SG145752A1 (en) * | 2003-09-19 | 2008-09-29 | Janssen Pharmaceutica Nv | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| JP2007527416A (ja) | 2003-10-31 | 2007-09-27 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ペルオキシソーム増殖因子活性化受容体（ｐｐａｒ）二重作動薬として有用なフェノキシ酢酸誘導体 |
| DE602005020127D1 (de) | 2004-04-21 | 2010-05-06 | Schering Corp | Pyrazoloä4,3-eü-1,2,4-triazoloä1,5-cüpyrimidine als antagonisten des adenosin-a2a-rezeptors |
| CA2571722C (en) | 2004-07-01 | 2012-12-11 | F. Hoffmann-La Roche Ag | Phenyl derivatives comprising an acetylene group |
| MY147518A (en) * | 2004-09-15 | 2012-12-31 | Janssen Pharmaceutica Nv | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| PE20060664A1 (es) | 2004-09-15 | 2006-08-04 | Novartis Ag | Amidas biciclicas como inhibidores de cinasa |
| MY145712A (en) | 2004-09-15 | 2012-03-30 | Janssen Pharmaceutica Nv | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| JO3006B1 (ar) * | 2005-09-14 | 2016-09-05 | Janssen Pharmaceutica Nv | املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك |
| GB0618963D0 (en) | 2006-09-26 | 2006-11-08 | Ucl Business Plc | Formulations and composites with reactive fillers |
-
2004
- 2004-09-16 SG SG200806114-5A patent/SG145752A1/en unknown
- 2004-09-16 BR BRPI0414268A patent/BRPI0414268B8/pt active IP Right Grant
- 2004-09-16 ES ES04816875T patent/ES2328581T3/es not_active Expired - Lifetime
- 2004-09-16 PT PT04816875T patent/PT1667964E/pt unknown
- 2004-09-16 PL PL04816875T patent/PL1667964T3/pl unknown
- 2004-09-16 JP JP2006527026A patent/JP4928941B2/ja not_active Expired - Lifetime
- 2004-09-16 KR KR1020067007358A patent/KR101111475B1/ko not_active Expired - Lifetime
- 2004-09-16 CN CN2004800335902A patent/CN1882533B/zh not_active Expired - Lifetime
- 2004-09-16 CA CA2539446A patent/CA2539446C/en not_active Expired - Lifetime
- 2004-09-16 AT AT09075188T patent/ATE542793T1/de active
- 2004-09-16 WO PCT/US2004/030375 patent/WO2005042478A2/en not_active Ceased
- 2004-09-16 AU AU2004285849A patent/AU2004285849B2/en not_active Expired
- 2004-09-16 EP EP09075188A patent/EP2100877B1/en not_active Expired - Lifetime
- 2004-09-16 DE DE602004022179T patent/DE602004022179D1/de not_active Expired - Lifetime
- 2004-09-16 NZ NZ545943A patent/NZ545943A/en not_active IP Right Cessation
- 2004-09-16 UA UAA200603107A patent/UA87467C2/ru unknown
- 2004-09-16 SI SI200431248T patent/SI1667964T1/sl unknown
- 2004-09-16 DK DK04816875T patent/DK1667964T3/da active
- 2004-09-16 US US10/942,478 patent/US7301050B2/en not_active Expired - Lifetime
- 2004-09-16 ES ES09075188T patent/ES2378435T3/es not_active Expired - Lifetime
- 2004-09-16 EA EA200600440A patent/EA012241B1/ru unknown
- 2004-09-16 EP EP04816875A patent/EP1667964B1/en not_active Expired - Lifetime
- 2004-09-17 TW TW093128361A patent/TWI336238B/zh not_active IP Right Cessation
- 2004-09-20 AR ARP040103376A patent/AR045773A1/es active IP Right Grant
-
2006
- 2006-03-17 CR CR8301A patent/CR8301A/es not_active Application Discontinuation
- 2006-03-17 EC EC2006006434A patent/ECSP066434A/es unknown
- 2006-03-19 IL IL174398A patent/IL174398A/en active IP Right Grant
- 2006-03-30 CO CO06031466A patent/CO5680476A2/es active IP Right Grant
- 2006-04-18 ZA ZA200603085A patent/ZA200603085B/en unknown
- 2006-04-19 NO NO20061728A patent/NO338511B1/no unknown
-
2007
- 2007-10-15 US US11/872,417 patent/US7635718B2/en not_active Expired - Lifetime
-
2009
- 2009-10-20 CY CY20091101087T patent/CY1110555T1/el unknown
- 2009-11-23 US US12/623,824 patent/US8106095B2/en not_active Expired - Lifetime
-
2011
- 2011-12-21 US US13/332,453 patent/US8518997B2/en not_active Expired - Fee Related
-
2013
- 2013-08-14 US US13/966,493 patent/US20130331453A1/en not_active Abandoned
-
2015
- 2015-04-15 NO NO20150447A patent/NO341448B1/no unknown
-
2016
- 2016-03-18 US US15/074,125 patent/US9724322B2/en not_active Expired - Fee Related
-
2017
- 2017-07-10 US US15/644,993 patent/US20170304254A1/en not_active Abandoned
-
2019
- 2019-03-05 US US16/292,406 patent/US20190192475A1/en not_active Abandoned
-
2023
- 2023-03-13 US US18/120,484 patent/US20230210808A1/en active Pending