JP2007505916A5 - - Google Patents
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- Publication number
- JP2007505916A5 JP2007505916A5 JP2006527026A JP2006527026A JP2007505916A5 JP 2007505916 A5 JP2007505916 A5 JP 2007505916A5 JP 2006527026 A JP2006527026 A JP 2006527026A JP 2006527026 A JP2006527026 A JP 2006527026A JP 2007505916 A5 JP2007505916 A5 JP 2007505916A5
- Authority
- JP
- Japan
- Prior art keywords
- alkoxy
- alkyl
- halo
- cycloalkyl
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50414603P | 2003-09-19 | 2003-09-19 | |
| US60/504,146 | 2003-09-19 | ||
| PCT/US2004/030375 WO2005042478A2 (en) | 2003-09-19 | 2004-09-16 | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007505916A JP2007505916A (ja) | 2007-03-15 |
| JP2007505916A5 true JP2007505916A5 (enExample) | 2007-11-08 |
| JP4928941B2 JP4928941B2 (ja) | 2012-05-09 |
Family
ID=34549183
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006527026A Expired - Lifetime JP4928941B2 (ja) | 2003-09-19 | 2004-09-16 | ４−（（フェノキシアルキル）チオ）−フェノキシ酢酸および類似化合物 |
Country Status (29)
| Country | Link |
|---|---|
| US (9) | US7301050B2 (enExample) |
| EP (2) | EP2100877B1 (enExample) |
| JP (1) | JP4928941B2 (enExample) |
| KR (1) | KR101111475B1 (enExample) |
| CN (1) | CN1882533B (enExample) |
| AR (1) | AR045773A1 (enExample) |
| AT (1) | ATE542793T1 (enExample) |
| AU (1) | AU2004285849B2 (enExample) |
| BR (1) | BRPI0414268B8 (enExample) |
| CA (1) | CA2539446C (enExample) |
| CO (1) | CO5680476A2 (enExample) |
| CR (1) | CR8301A (enExample) |
| CY (1) | CY1110555T1 (enExample) |
| DE (1) | DE602004022179D1 (enExample) |
| DK (1) | DK1667964T3 (enExample) |
| EA (1) | EA012241B1 (enExample) |
| EC (1) | ECSP066434A (enExample) |
| ES (2) | ES2378435T3 (enExample) |
| IL (1) | IL174398A (enExample) |
| NO (2) | NO338511B1 (enExample) |
| NZ (1) | NZ545943A (enExample) |
| PL (1) | PL1667964T3 (enExample) |
| PT (1) | PT1667964E (enExample) |
| SG (1) | SG145752A1 (enExample) |
| SI (1) | SI1667964T1 (enExample) |
| TW (1) | TWI336238B (enExample) |
| UA (1) | UA87467C2 (enExample) |
| WO (1) | WO2005042478A2 (enExample) |
| ZA (1) | ZA200603085B (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA87467C2 (xx) * | 2003-09-19 | 2009-07-27 | Янссен Фармацевтика Н.В | 4-((феноксіалкіл)тіо)феноксіоцтова кислота та її аналоги$4-((феноксиалкил)тио)феноксиуксусная кислота и ее аналоги |
| CA2539403C (en) * | 2003-09-19 | 2013-11-19 | Janssen Pharmaceutica N.V. | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| MY145712A (en) * | 2004-09-15 | 2012-03-30 | Janssen Pharmaceutica Nv | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| MY147518A (en) * | 2004-09-15 | 2012-12-31 | Janssen Pharmaceutica Nv | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| JO3006B1 (ar) * | 2005-09-14 | 2016-09-05 | Janssen Pharmaceutica Nv | املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك |
| PE20080188A1 (es) * | 2006-04-18 | 2008-03-10 | Janssen Pharmaceutica Nv | Derivados del acido benzoazepin-oxi-acetico como agonistas de ppar-delta usados para aumentar hdl-c, reducir ldl-c y reducir colesterol |
| JP5694941B2 (ja) | 2008-10-17 | 2015-04-01 | シーマベイ セラピューティクス，インコーポレイティド | 小型高密度ｌｄｌ粒子を減少させる方法 |
| KR20150036407A (ko) * | 2012-07-06 | 2015-04-07 | 메르크 파텐트 게엠베하 | 바이메소제닉 화합물 및 메소제닉 매질 |
| HK1224186A1 (zh) | 2013-11-20 | 2017-08-18 | Cymabay Therapeutics, Inc. | 纯阖家族型高胆固醇血症的治疗 |
| ES2701094T3 (es) | 2014-03-20 | 2019-02-20 | Cymabay Therapeutics Inc | Tratamiento de enfermedades colestáticas intrahepáticas |
| US10272058B2 (en) | 2014-03-20 | 2019-04-30 | Cymabay Therapeutics, Inc. | Treatment of intrahepatic cholestatic diseases |
| CA2944139C (en) | 2014-04-11 | 2020-11-03 | Cymabay Therapeutics, Inc. | Treatment of nafld and nash |
| CN106470675A (zh) | 2014-06-26 | 2017-03-01 | 西玛贝医药公司 | 严重高甘油三酯血症的治疗 |
| US10512622B2 (en) | 2017-07-14 | 2019-12-24 | Cymabay Therapeutics, Inc. | Treatment of intrahepatic cholestatic diseases |
| JP2020533339A (ja) | 2017-09-13 | 2020-11-19 | ノバルティス アーゲー | Ｆｘｒアゴニストを含む組合せ |
| JP7023371B2 (ja) | 2017-09-26 | 2022-02-21 | サイマベイ・セラピューティクス・インコーポレイテッド | 胆汁うっ滞性そう痒の処置 |
| US11497723B1 (en) * | 2017-12-19 | 2022-11-15 | Tony Antakly | PPAR-gamma activators, HDAC inhibitors and their therapeutical usages |
| US10702488B2 (en) * | 2017-12-19 | 2020-07-07 | Theriac Biomedical Inc. | PPAR-γ activators, HDAC inhibitors and their therapeutical usages |
| MX2021005724A (es) | 2018-11-16 | 2021-07-21 | Cymabay Therapeutics Inc | Tratamiento combinado contra nafld y nash. |
| WO2020102351A1 (en) | 2018-11-16 | 2020-05-22 | Cymabay Therapeutics, Inc. | Treatment of obesity and its complications |
| US20210145774A1 (en) | 2019-11-14 | 2021-05-20 | Cymabay Therapeutics, Inc. | Treatment of alcoholic liver disease |
| WO2021097034A1 (en) | 2019-11-14 | 2021-05-20 | Cymabay Therapeutics, Inc. | Seladelpar for use in the treatment of intestinal barrier dysfunction and associated diseases |
| CN119735532A (zh) * | 2019-11-21 | 2025-04-01 | 杭州百诚医药科技股份有限公司 | α-氟代查耳酮类衍生物及其应用 |
| RS65546B1 (sr) | 2021-02-01 | 2024-06-28 | Cymabay Therapeutics Inc | Tretman holangiopatija sa seladelparom |
| US20240252499A1 (en) | 2023-01-29 | 2024-08-01 | Cymabay Therapeutics, Inc. | Treatment of uremic pruritus |
| KR20250139304A (ko) | 2023-01-29 | 2025-09-23 | 사이머베이 쎄라퓨틱스, 인코퍼레이티드 | 만성 소양증 피부병의 치료 |
| US20260055055A1 (en) * | 2024-07-31 | 2026-02-26 | Cymabay Therapeutics, Inc. | Process for making seladelpar |
| WO2026030533A1 (en) | 2024-07-31 | 2026-02-05 | Cymabay Therapeutics, Inc. | Seladelpar for use in treating liver disease |
| US20260207538A1 (en) | 2024-12-20 | 2026-07-23 | Gilead Sciences, Inc. | Combinations for liver disease |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3517051A (en) * | 1964-03-20 | 1970-06-23 | Merck & Co Inc | Phenoxy substituted phenylacetic acids |
| DE2460689C3 (de) * | 1974-12-20 | 1980-06-26 | Klinge Pharma Gmbh & Co, 8000 Muenchen | 13-disubstituierte Propanol-(2)-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US4109013A (en) * | 1974-12-20 | 1978-08-22 | Klinge Pharma Gmbh & Co. | Substituted propanol-(2) derivatives of hydroxamic acids and the use thereof as hypolipemic drugs |
| US4125732A (en) | 1977-05-06 | 1978-11-14 | American Cyanamid Company | 2-Aryloxy-2-(phenoxyalkoxy)phenyl acetic acid and esters |
| DE3026924A1 (de) | 1980-07-16 | 1982-02-18 | Klinge Pharma GmbH & Co, 8000 München | 1,3-diphenoxypropan-2-ol-derivate sowie verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
| DE3028776A1 (de) | 1980-07-29 | 1982-02-25 | Klinge Pharma GmbH & Co, 8000 München | Neue 1,3-diphenoxypropan-2-on-derivate sowie verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
| EP0056172B1 (en) * | 1981-01-09 | 1985-04-03 | FISONS plc | Phenoxy- and thiophenoxy compounds, methods for their preparation and pharmaceutical formulations containing them |
| JPS58177934A (ja) | 1982-04-13 | 1983-10-18 | Takeda Chem Ind Ltd | ベンゾキノン誘導体 |
| ATE22072T1 (de) * | 1982-09-30 | 1986-09-15 | Merck Frosst Canada Inc | Leukotrienantagonisten, deren herstellung und diese enthaltende zusammensetzungen. |
| US4820867A (en) * | 1983-04-21 | 1989-04-11 | Merck Frosst Canada, Inc. | Phenoxypropoxy halophenylacetic acids as leukotriene antagonists |
| US4513006A (en) | 1983-09-26 | 1985-04-23 | Mcneil Lab., Inc. | Anticonvulsant sulfamate derivatives |
| JPS61268651A (ja) * | 1985-05-23 | 1986-11-28 | Takeda Chem Ind Ltd | フエニル酢酸誘導体およびその製造法 |
| EP0204349A3 (de) | 1985-06-01 | 1990-01-03 | Dr. Karl Thomae GmbH | Neue heteroaromatische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| JPH0714910B2 (ja) | 1988-12-13 | 1995-02-22 | 塩野義製薬株式会社 | 安定な結晶性の塩およびそれを含有するトロンボキサン受容体拮抗剤 |
| US5487008A (en) | 1990-04-20 | 1996-01-23 | The Regents Of The University Of Michigan | Method and system for detecting the misfire of a reciprocating internal combustion engine in frequency domain |
| CA2092152A1 (en) | 1992-03-23 | 1993-09-24 | Azuma Igarashi | Phenoxyacetic acid compounds and medical preparations containing them |
| US5726165A (en) * | 1994-07-29 | 1998-03-10 | Smithkline Beecham P.L.C. | Derivatives of 4-(2-aminoethyl)phenoxymethyl-phosphonic and -phosphinic acid and pharmaceutical and veterinary uses therefor |
| JP2002503202A (ja) | 1996-02-02 | 2002-01-29 | メルク エンド カンパニー インコーポレーテッド | 抗糖尿病薬 |
| CA2244831A1 (en) * | 1996-02-02 | 1997-08-07 | John T. Olson | Method of treating diabetes and related disease states |
| JP3268242B2 (ja) | 1996-11-14 | 2002-03-25 | 三共株式会社 | 縮合複素環化合物を含有する医薬 |
| AU8355998A (en) | 1997-07-24 | 1999-02-16 | Yamanouchi Pharmaceutical Co., Ltd. | Medicinal compositions with cholesterol-lowering effect |
| ID24878A (id) * | 1997-12-19 | 2000-08-31 | Merck & Co Inc | Turunan ariltiazolidinedion |
| HUP0200807A3 (en) | 1999-04-20 | 2003-03-28 | Novo Nordisk As | Substituted propionic acid derivatives, process for their preparation, pharmaceutical compositions containing them and their use |
| EP1194146B1 (en) * | 1999-06-18 | 2006-07-19 | Merck & Co., Inc. | Arylthiazolidinedione and aryloxazolidinedione derivatives |
| GB9914977D0 (en) | 1999-06-25 | 1999-08-25 | Glaxo Group Ltd | Chemical compounds |
| GB0003310D0 (en) * | 2000-02-15 | 2000-04-05 | Univ Sheffield | Bone formation |
| GB0031107D0 (en) | 2000-12-20 | 2001-01-31 | Glaxo Group Ltd | Chemical compounds |
| CN1543451A (zh) | 2001-06-07 | 2004-11-03 | 过氧化物酶体增生剂激活的受体的调节剂 | |
| EP1414778A1 (en) * | 2001-07-30 | 2004-05-06 | Novo Nordisk A/S | Novel vinyl carboxylic acid derivatives and their use as antidiabetics etc. |
| WO2003016291A1 (en) | 2001-08-10 | 2003-02-27 | Nippon Chemiphar Co., Ltd. | ACTIVATOR FOR PEROXISOME PROLIFERATOR-RESPONSIVE RECEPTOR δ |
| MXPA04003398A (es) | 2001-10-12 | 2004-11-22 | Nippon Chemiphar Co | Activador para el receptor o activado con el proliferador de peroxisoma. |
| ITRM20020014A1 (it) | 2002-01-15 | 2003-07-15 | Sigma Tau Ind Farmaceuti | Derivati di acidi a-feniltiocarbossilici e a-fenilossicarbossilici utili per il trattamento di patologie che rispondono all'attivazione del |
| JP4383177B2 (ja) * | 2002-03-01 | 2009-12-16 | スミスクライン ビーチャム コーポレーション | ｈＰＰＡＲ活性化剤 |
| US6875780B2 (en) | 2002-04-05 | 2005-04-05 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods for their preparation |
| GB0214149D0 (en) | 2002-06-19 | 2002-07-31 | Glaxo Group Ltd | Chemical compounds |
| CA2499380A1 (en) | 2002-09-05 | 2004-03-18 | Novo Nordisk A/S | Novel vinyl carboxylic acid derivatives and their therapeutical use |
| KR20050061562A (ko) | 2002-10-28 | 2005-06-22 | 노보 노르디스크 에이/에스 | 신규 화합물, 그들의 제제 및 사용 |
| DE60332860D1 (de) | 2002-10-28 | 2010-07-15 | High Point Pharmaceuticals Llc | Neue verbindungen, die sich f r die behandlung von durch ppar vermittelten krankheiten eignen |
| PL378110A1 (pl) | 2003-02-14 | 2006-03-06 | Biogen Idec Ma Inc. | Kaseta ekspresyjna i wektor do przejściowej albo stabilnej ekspresji egzogennych cząsteczek |
| JP2007502815A (ja) * | 2003-08-20 | 2007-02-15 | イーライ リリー アンド カンパニー | Ｐｐａｒ調節因子 |
| UA87467C2 (xx) * | 2003-09-19 | 2009-07-27 | Янссен Фармацевтика Н.В | 4-((феноксіалкіл)тіо)феноксіоцтова кислота та її аналоги$4-((феноксиалкил)тио)феноксиуксусная кислота и ее аналоги |
| CA2539403C (en) * | 2003-09-19 | 2013-11-19 | Janssen Pharmaceutica N.V. | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| ATE362367T1 (de) | 2003-10-31 | 2007-06-15 | Janssen Pharmaceutica Nv | Phenoxyessigsäure-derivate als peroxisom- proliferator-aktivierte rezeptor (ppar) dual- agonisten |
| ATE461932T1 (de) | 2004-04-21 | 2010-04-15 | Schering Corp | Pyrazoloä4,3-eü-1,2,4-triazoloä1,5-cüpyrimidine als antagonisten des adenosin-a2a-rezeptors |
| CN1997619B (zh) | 2004-07-01 | 2010-08-25 | 霍夫曼-拉罗奇有限公司 | 包含乙炔基的苯基衍生物 |
| MY145712A (en) * | 2004-09-15 | 2012-03-30 | Janssen Pharmaceutica Nv | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| PE20060664A1 (es) | 2004-09-15 | 2006-08-04 | Novartis Ag | Amidas biciclicas como inhibidores de cinasa |
| MY147518A (en) * | 2004-09-15 | 2012-12-31 | Janssen Pharmaceutica Nv | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| JO3006B1 (ar) * | 2005-09-14 | 2016-09-05 | Janssen Pharmaceutica Nv | املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك |
| GB0618963D0 (en) | 2006-09-26 | 2006-11-08 | Ucl Business Plc | Formulations and composites with reactive fillers |
-
2004
- 2004-09-16 UA UAA200603107A patent/UA87467C2/ru unknown
- 2004-09-16 US US10/942,478 patent/US7301050B2/en not_active Expired - Lifetime
- 2004-09-16 BR BRPI0414268A patent/BRPI0414268B8/pt active IP Right Grant
- 2004-09-16 ES ES09075188T patent/ES2378435T3/es not_active Expired - Lifetime
- 2004-09-16 EP EP09075188A patent/EP2100877B1/en not_active Expired - Lifetime
- 2004-09-16 AU AU2004285849A patent/AU2004285849B2/en not_active Expired
- 2004-09-16 KR KR1020067007358A patent/KR101111475B1/ko not_active Expired - Lifetime
- 2004-09-16 AT AT09075188T patent/ATE542793T1/de active
- 2004-09-16 SI SI200431248T patent/SI1667964T1/sl unknown
- 2004-09-16 DK DK04816875T patent/DK1667964T3/da active
- 2004-09-16 EA EA200600440A patent/EA012241B1/ru unknown
- 2004-09-16 PT PT04816875T patent/PT1667964E/pt unknown
- 2004-09-16 PL PL04816875T patent/PL1667964T3/pl unknown
- 2004-09-16 DE DE602004022179T patent/DE602004022179D1/de not_active Expired - Lifetime
- 2004-09-16 CN CN2004800335902A patent/CN1882533B/zh not_active Expired - Lifetime
- 2004-09-16 WO PCT/US2004/030375 patent/WO2005042478A2/en not_active Ceased
- 2004-09-16 ES ES04816875T patent/ES2328581T3/es not_active Expired - Lifetime
- 2004-09-16 JP JP2006527026A patent/JP4928941B2/ja not_active Expired - Lifetime
- 2004-09-16 NZ NZ545943A patent/NZ545943A/en not_active IP Right Cessation
- 2004-09-16 SG SG200806114-5A patent/SG145752A1/en unknown
- 2004-09-16 CA CA2539446A patent/CA2539446C/en not_active Expired - Lifetime
- 2004-09-16 EP EP04816875A patent/EP1667964B1/en not_active Expired - Lifetime
- 2004-09-17 TW TW093128361A patent/TWI336238B/zh not_active IP Right Cessation
- 2004-09-20 AR ARP040103376A patent/AR045773A1/es active IP Right Grant
-
2006
- 2006-03-17 EC EC2006006434A patent/ECSP066434A/es unknown
- 2006-03-17 CR CR8301A patent/CR8301A/es not_active Application Discontinuation
- 2006-03-19 IL IL174398A patent/IL174398A/en active IP Right Grant
- 2006-03-30 CO CO06031466A patent/CO5680476A2/es active IP Right Grant
- 2006-04-18 ZA ZA200603085A patent/ZA200603085B/en unknown
- 2006-04-19 NO NO20061728A patent/NO338511B1/no unknown
-
2007
- 2007-10-15 US US11/872,417 patent/US7635718B2/en not_active Expired - Lifetime
-
2009
- 2009-10-20 CY CY20091101087T patent/CY1110555T1/el unknown
- 2009-11-23 US US12/623,824 patent/US8106095B2/en not_active Expired - Lifetime
-
2011
- 2011-12-21 US US13/332,453 patent/US8518997B2/en not_active Expired - Fee Related
-
2013
- 2013-08-14 US US13/966,493 patent/US20130331453A1/en not_active Abandoned
-
2015
- 2015-04-15 NO NO20150447A patent/NO341448B1/no unknown
-
2016
- 2016-03-18 US US15/074,125 patent/US9724322B2/en not_active Expired - Fee Related
-
2017
- 2017-07-10 US US15/644,993 patent/US20170304254A1/en not_active Abandoned
-
2019
- 2019-03-05 US US16/292,406 patent/US20190192475A1/en not_active Abandoned
-
2023
- 2023-03-13 US US18/120,484 patent/US20230210808A1/en not_active Abandoned