JP2007505916A5 - - Google Patents
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- Publication number
- JP2007505916A5 JP2007505916A5 JP2006527026A JP2006527026A JP2007505916A5 JP 2007505916 A5 JP2007505916 A5 JP 2007505916A5 JP 2006527026 A JP2006527026 A JP 2006527026A JP 2006527026 A JP2006527026 A JP 2006527026A JP 2007505916 A5 JP2007505916 A5 JP 2007505916A5
- Authority
- JP
- Japan
- Prior art keywords
- alkoxy
- alkyl
- halo
- cycloalkyl
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003545 alkoxy group Chemical group 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 125000001475 halogen functional group Chemical group 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- -1 R 3 and R 4 are H Chemical group 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000006545 (C1-C9) alkyl group Chemical group 0.000 claims 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003302 alkenyloxy group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000005133 alkynyloxy group Chemical group 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 1
- 125000005844 heterocyclyloxy group Chemical group 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
Claims (1)
- 式(I):
Xは共有結合、S、またはOから選択され、
YはSまたはOであり、
−−−−W−−−−は、=CH−、−CH=、−CH2−、−CH2−CH2−、=CH
−CH2−、−CH2−CH=、=CH−CH=、および−CH=CH−から選択される
基を表し、
ZはO、CH、およびCH2から選択され、ただしYがOの場合には、ZはOであり、
R1およびR2はH、C1-3アルキル、C1-3アルコキシ、ハロ、およびNRaRb
から独立して選択され、ここでRaおよびRbは独立してHまたはC1-3アルキルであ
り、
R3およびR4はH、ハロ、シアノ、ヒドロキシ、アセチル、C1-5アルキル、C1-
4アルコキシ、およびNRcRdから独立して選択され、ここでRcおよびRdは独立し
てHまたはC1-3アルキルであり、ただしR3およびR4は双方がHではなく、
R5はハロ、フェニル、フェノキシ、(フェニル)C1-5アルコキシ、(フェニル)C
1-5アルキル、C2-5ヘテロアリールオキシ、C2-5ヘテロアリールC1-5アル
コキシ、C2-5ヘテロシクリルオキシ、C1-9アルキル、C1-8アルコキシ、C2
-9アルケニル、C2-9アルケニルオキシ、C2-9アルキニル、C2-9アルキニル
オキシ、C3-7シクロアルキル、C3-7シクロアルコキシ、C3-7シクロアルキル
−C1-7アルキル、C3-7シクロアルキル−C1-7アルコキシ、C3-7シクロア
ルキルオキシ−C1-6アルキル、C1-6アルコキシ−C1-6アルキル、C1-5ア
ルコキシ−C1-5アルコキシ、またはC3-7シクロアルキルオキシ−C1-7アルコ
キシから選択され、
−−−−W−−−−が−CH=、−CH2−、−CH2−CH2−、−CH2−CH=、
および−CH=CH−から選択される基を表す場合にはR6はHであり、または−−−−
W−−−−が=CH−、=CH−CH2−、および=CH−CH=から選択される基を表
す場合に、R6は存在せず、そして
nは1または2である〕
の化合物またはその製薬学的に許容され得る塩。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50414603P | 2003-09-19 | 2003-09-19 | |
US60/504,146 | 2003-09-19 | ||
PCT/US2004/030375 WO2005042478A2 (en) | 2003-09-19 | 2004-09-16 | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2007505916A JP2007505916A (ja) | 2007-03-15 |
JP2007505916A5 true JP2007505916A5 (ja) | 2007-11-08 |
JP4928941B2 JP4928941B2 (ja) | 2012-05-09 |
Family
ID=34549183
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006527026A Active JP4928941B2 (ja) | 2003-09-19 | 2004-09-16 | 4−((フェノキシアルキル)チオ)−フェノキシ酢酸および類似化合物 |
Country Status (30)
Country | Link |
---|---|
US (9) | US7301050B2 (ja) |
EP (2) | EP1667964B1 (ja) |
JP (1) | JP4928941B2 (ja) |
KR (1) | KR101111475B1 (ja) |
CN (1) | CN1882533B (ja) |
AR (1) | AR045773A1 (ja) |
AT (1) | ATE542793T1 (ja) |
AU (1) | AU2004285849B2 (ja) |
BR (1) | BRPI0414268B8 (ja) |
CA (1) | CA2539446C (ja) |
CO (1) | CO5680476A2 (ja) |
CR (1) | CR8301A (ja) |
CY (1) | CY1110555T1 (ja) |
DE (1) | DE602004022179D1 (ja) |
DK (1) | DK1667964T3 (ja) |
EA (1) | EA012241B1 (ja) |
EC (1) | ECSP066434A (ja) |
ES (2) | ES2328581T3 (ja) |
HK (2) | HK1092784A1 (ja) |
IL (1) | IL174398A (ja) |
NO (2) | NO338511B1 (ja) |
NZ (1) | NZ545943A (ja) |
PL (1) | PL1667964T3 (ja) |
PT (1) | PT1667964E (ja) |
SG (1) | SG145752A1 (ja) |
SI (1) | SI1667964T1 (ja) |
TW (1) | TWI336238B (ja) |
UA (1) | UA87467C2 (ja) |
WO (1) | WO2005042478A2 (ja) |
ZA (1) | ZA200603085B (ja) |
Families Citing this family (24)
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DK1667964T3 (da) | 2003-09-19 | 2009-10-26 | Janssen Pharmaceutica Nv | 4-((Phenoxyalkyl)thio)-phenoxyeddikesyrer og analoger |
SG149041A1 (en) | 2003-09-19 | 2009-01-29 | Janssen Pharmaceutica Nv | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
MY147518A (en) * | 2004-09-15 | 2012-12-31 | Janssen Pharmaceutica Nv | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
MY145712A (en) * | 2004-09-15 | 2012-03-30 | Janssen Pharmaceutica Nv | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
JO3006B1 (ar) * | 2005-09-14 | 2016-09-05 | Janssen Pharmaceutica Nv | املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك |
PE20080188A1 (es) * | 2006-04-18 | 2008-03-10 | Janssen Pharmaceutica Nv | Derivados del acido benzoazepin-oxi-acetico como agonistas de ppar-delta usados para aumentar hdl-c, reducir ldl-c y reducir colesterol |
ES2712052T3 (es) * | 2008-10-17 | 2019-05-09 | Cymabay Therapeutics Inc | Métodos para reducir partículas de LDL pequeñas y densas |
WO2014005671A1 (en) * | 2012-07-06 | 2014-01-09 | Merck Patent Gmbh | Bimesogenic compounds and mesogenic media |
JP2017505285A (ja) | 2013-11-20 | 2017-02-16 | サイマベイ・セラピューティクス・インコーポレイテッドCymaBay Therapeutics,Inc. | ホモ接合性家族性高コレステロール血症の治療 |
AU2015231232B2 (en) | 2014-03-20 | 2018-08-02 | Cymabay Therapeutics, Inc. | Treatment of intrahepatic cholestatic diseases |
US10272058B2 (en) | 2014-03-20 | 2019-04-30 | Cymabay Therapeutics, Inc. | Treatment of intrahepatic cholestatic diseases |
WO2015157697A1 (en) | 2014-04-11 | 2015-10-15 | Cymabay Therapeutics, Inc. | Treatment of nafld and nash |
AU2015279905A1 (en) | 2014-06-26 | 2017-02-02 | Cymabay Therapeutics, Inc. | Treatment of severe hypertriglyceridemia |
US10512622B2 (en) | 2017-07-14 | 2019-12-24 | Cymabay Therapeutics, Inc. | Treatment of intrahepatic cholestatic diseases |
EP3681537A1 (en) | 2017-09-13 | 2020-07-22 | Novartis AG | Combinations comprising fxr agonists |
US20190105291A1 (en) | 2017-09-26 | 2019-04-11 | Cymabay Therapeutics, Inc. | Treatment of cholestatic pruritus |
US11497723B1 (en) * | 2017-12-19 | 2022-11-15 | Tony Antakly | PPAR-gamma activators, HDAC inhibitors and their therapeutical usages |
US10702488B2 (en) * | 2017-12-19 | 2020-07-07 | Theriac Biomedical Inc. | PPAR-γ activators, HDAC inhibitors and their therapeutical usages |
JP2022507644A (ja) | 2018-11-16 | 2022-01-18 | サイマベイ・セラピューティクス・インコーポレイテッド | Nafldおよびnashの併用治療 |
MX2021005725A (es) | 2018-11-16 | 2021-07-21 | Cymabay Therapeutics Inc | Tratamiento de la obesidad y sus complicaciones. |
US20210145774A1 (en) | 2019-11-14 | 2021-05-20 | Cymabay Therapeutics, Inc. | Treatment of alcoholic liver disease |
US20210145775A1 (en) | 2019-11-14 | 2021-05-20 | Cymabay Therapeutics, Inc. | Treatment of intestinal barrier dysfunction and associated diseases |
CN112824380A (zh) * | 2019-11-21 | 2021-05-21 | 杭州百诚医药科技股份有限公司 | α-氟代查耳酮类衍生物及其应用 |
KR20230107700A (ko) | 2021-02-01 | 2023-07-17 | 사이머베이 쎄라퓨틱스, 인코퍼레이티드 | 셀라델파르에 의한 담관병증의 치료 |
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2004
- 2004-09-16 DK DK04816875T patent/DK1667964T3/da active
- 2004-09-16 EA EA200600440A patent/EA012241B1/ru unknown
- 2004-09-16 PL PL04816875T patent/PL1667964T3/pl unknown
- 2004-09-16 KR KR1020067007358A patent/KR101111475B1/ko active IP Right Grant
- 2004-09-16 BR BRPI0414268A patent/BRPI0414268B8/pt active IP Right Grant
- 2004-09-16 EP EP04816875A patent/EP1667964B1/en active Active
- 2004-09-16 UA UAA200603107A patent/UA87467C2/ru unknown
- 2004-09-16 AU AU2004285849A patent/AU2004285849B2/en active Active
- 2004-09-16 NZ NZ545943A patent/NZ545943A/en unknown
- 2004-09-16 JP JP2006527026A patent/JP4928941B2/ja active Active
- 2004-09-16 DE DE602004022179T patent/DE602004022179D1/de active Active
- 2004-09-16 AT AT09075188T patent/ATE542793T1/de active
- 2004-09-16 CA CA2539446A patent/CA2539446C/en active Active
- 2004-09-16 EP EP09075188A patent/EP2100877B1/en active Active
- 2004-09-16 CN CN2004800335902A patent/CN1882533B/zh active Active
- 2004-09-16 WO PCT/US2004/030375 patent/WO2005042478A2/en active Application Filing
- 2004-09-16 SI SI200431248T patent/SI1667964T1/sl unknown
- 2004-09-16 SG SG200806114-5A patent/SG145752A1/en unknown
- 2004-09-16 ES ES04816875T patent/ES2328581T3/es active Active
- 2004-09-16 PT PT04816875T patent/PT1667964E/pt unknown
- 2004-09-16 US US10/942,478 patent/US7301050B2/en active Active
- 2004-09-16 ES ES09075188T patent/ES2378435T3/es active Active
- 2004-09-17 TW TW093128361A patent/TWI336238B/zh active
- 2004-09-20 AR ARP040103376A patent/AR045773A1/es active IP Right Grant
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2006
- 2006-03-17 CR CR8301A patent/CR8301A/es not_active Application Discontinuation
- 2006-03-17 EC EC2006006434A patent/ECSP066434A/es unknown
- 2006-03-19 IL IL174398A patent/IL174398A/en active IP Right Grant
- 2006-03-30 CO CO06031466A patent/CO5680476A2/es active IP Right Grant
- 2006-04-18 ZA ZA200603085A patent/ZA200603085B/en unknown
- 2006-04-19 NO NO20061728A patent/NO338511B1/no unknown
- 2006-12-11 HK HK06113590.1A patent/HK1092784A1/xx unknown
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2007
- 2007-10-15 US US11/872,417 patent/US7635718B2/en active Active
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2009
- 2009-10-20 CY CY20091101087T patent/CY1110555T1/el unknown
- 2009-11-23 US US12/623,824 patent/US8106095B2/en active Active
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2010
- 2010-03-15 HK HK10102665.8A patent/HK1137737A1/xx unknown
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2011
- 2011-12-21 US US13/332,453 patent/US8518997B2/en active Active
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2013
- 2013-08-14 US US13/966,493 patent/US20130331453A1/en not_active Abandoned
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2015
- 2015-04-15 NO NO20150447A patent/NO341448B1/no unknown
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2016
- 2016-03-18 US US15/074,125 patent/US9724322B2/en active Active
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2017
- 2017-07-10 US US15/644,993 patent/US20170304254A1/en not_active Abandoned
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2019
- 2019-03-05 US US16/292,406 patent/US20190192475A1/en not_active Abandoned
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2023
- 2023-03-13 US US18/120,484 patent/US20230210808A1/en active Pending