JP2002531548A5 - - Google Patents
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- Publication number
- JP2002531548A5 JP2002531548A5 JP2000586691A JP2000586691A JP2002531548A5 JP 2002531548 A5 JP2002531548 A5 JP 2002531548A5 JP 2000586691 A JP2000586691 A JP 2000586691A JP 2000586691 A JP2000586691 A JP 2000586691A JP 2002531548 A5 JP2002531548 A5 JP 2002531548A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- methyl
- methylsulfinyl
- carbamoyl
- methoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 trifluoromethylthio, trifluoromethylsulfinyl Chemical group 0.000 description 28
- 150000001875 compounds Chemical class 0.000 description 11
- 125000005115 alkyl carbamoyl group Chemical group 0.000 description 8
- 125000001424 substituent group Chemical group 0.000 description 8
- 125000000217 alkyl group Chemical group 0.000 description 7
- 229910052739 hydrogen Inorganic materials 0.000 description 6
- 239000001257 hydrogen Substances 0.000 description 6
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 5
- 125000005236 alkanoylamino group Chemical group 0.000 description 4
- 125000001589 carboacyl group Chemical group 0.000 description 4
- 125000005843 halogen group Chemical group 0.000 description 4
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 description 4
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 description 3
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 description 3
- 125000003545 alkoxy group Chemical group 0.000 description 3
- 125000005281 alkyl ureido group Chemical group 0.000 description 3
- 125000003178 carboxy group Chemical class [H]OC(*)=O 0.000 description 3
- 150000002431 hydrogen Chemical group 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- 125000006216 methylsulfinyl group Chemical group [H]C([H])([H])S(*)=O 0.000 description 3
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 3
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 description 2
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 description 2
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 description 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 2
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 description 2
- SNCZNSNPXMPCGN-UHFFFAOYSA-N butanediamide Chemical compound NC(=O)CCC(N)=O SNCZNSNPXMPCGN-UHFFFAOYSA-N 0.000 description 2
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 description 2
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 2
- 125000001153 fluoro group Chemical group F* 0.000 description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 2
- OBHBPXMWSDXYBR-UDKJZQBVSA-N 3-cyano-n-[(2s)-2-(3,4-dichlorophenyl)-4-[4-[2-[(s)-methylsulfinyl]phenyl]piperidin-1-yl]butyl]-2-ethyl-n-methyl-5,6,7,8-tetrahydronaphthalene-1-carboxamide Chemical compound C([C@H](CN(C)C(=O)C1=C2CCCCC2=CC(=C1CC)C#N)C=1C=C(Cl)C(Cl)=CC=1)CN(CC1)CCC1C1=CC=CC=C1[S@](C)=O OBHBPXMWSDXYBR-UDKJZQBVSA-N 0.000 description 1
- VMGLUFOETPZIEO-HCRJBYBTSA-N 3-cyano-n-[(2s)-2-(3,4-dichlorophenyl)-4-[4-[2-[(s)-methylsulfinyl]phenyl]piperidin-1-yl]butyl]-2-methoxy-n-methylsulfonyl-5,6,7,8-tetrahydronaphthalene-1-carboxamide Chemical compound C([C@H](CN(C(=O)C1=C2CCCCC2=CC(=C1OC)C#N)S(C)(=O)=O)C=1C=C(Cl)C(Cl)=CC=1)CN(CC1)CCC1C1=CC=CC=C1[S@](C)=O VMGLUFOETPZIEO-HCRJBYBTSA-N 0.000 description 1
- FHTGIBZAEUFTMT-CGQQATSGSA-N 3-cyano-n-[(2s)-2-(3,4-dichlorophenyl)-4-[4-[2-[(s)-methylsulfinyl]phenyl]piperidin-1-yl]butyl]-n,2-dimethyl-5,6,7,8-tetrahydronaphthalene-1-carboxamide Chemical compound C([C@H](CN(C)C(=O)C=1C=2CCCCC=2C=C(C=1C)C#N)C=1C=C(Cl)C(Cl)=CC=1)CN(CC1)CCC1C1=CC=CC=C1[S@](C)=O FHTGIBZAEUFTMT-CGQQATSGSA-N 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 description 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 description 1
- 0 Cc1ccc(*)cc1S(C)=O Chemical compound Cc1ccc(*)cc1S(C)=O 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 206010046543 Urinary incontinence Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 description 1
- 125000004423 acyloxy group Chemical group 0.000 description 1
- 125000004422 alkyl sulphonamide group Chemical group 0.000 description 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Chemical group C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 125000001246 bromo group Chemical group Br* 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- HNQIVZYLYMDVSB-UHFFFAOYSA-N methanesulfonimidic acid Chemical compound CS(N)(=O)=O HNQIVZYLYMDVSB-UHFFFAOYSA-N 0.000 description 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 1
- UCHNYFBTBPTIAE-CGQQATSGSA-N n-[(2s)-2-(3,4-dichlorophenyl)-4-[4-[2-[(s)-methylsulfinyl]phenyl]piperidin-1-yl]butyl]-2-methoxy-n,3-dimethyl-5,6,7,8-tetrahydronaphthalene-1-carboxamide Chemical compound C([C@H](CN(C)C(=O)C1=C2CCCCC2=CC(C)=C1OC)C=1C=C(Cl)C(Cl)=CC=1)CN(CC1)CCC1C1=CC=CC=C1[S@](C)=O UCHNYFBTBPTIAE-CGQQATSGSA-N 0.000 description 1
- KJGYWDDQBYCWPI-CGQQATSGSA-N n-[(2s)-2-(3,4-dichlorophenyl)-4-[4-[2-[(s)-methylsulfinyl]phenyl]piperidin-1-yl]butyl]-3-methoxy-n,2-dimethyl-5,6,7,8-tetrahydronaphthalene-1-carboxamide Chemical compound C([C@H](CN(C)C(=O)C=1C=2CCCCC=2C=C(C=1C)OC)C=1C=C(Cl)C(Cl)=CC=1)CN(CC1)CCC1C1=CC=CC=C1[S@](C)=O KJGYWDDQBYCWPI-CGQQATSGSA-N 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 125000005034 trifluormethylthio group Chemical group FC(S*)(F)F 0.000 description 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9826941.8 | 1998-12-09 | ||
| GBGB9826941.8A GB9826941D0 (en) | 1998-12-09 | 1998-12-09 | Compounds |
| PCT/GB1999/004118 WO2000034243A1 (en) | 1998-12-09 | 1999-12-06 | N-(2-phenyl-4-piperidinybutyl)-5,6,7,8-tetrahydro-1-naphthalenecarboxamides and their use as neurokinin 1 (nk1) and/or neurokinin 2 (nk2) receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002531548A JP2002531548A (ja) | 2002-09-24 |
| JP2002531548A5 true JP2002531548A5 (enExample) | 2007-01-25 |
Family
ID=10843818
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000586691A Pending JP2002531548A (ja) | 1998-12-09 | 1999-12-06 | Ｎ−（２−フェニルー４−ピペリジニルブチル）−５，６，７，８−テトラヒドロー１−ナフタレンカルボキサミド、およびニューロキニン１（ｎｋ１）および／またはニューロキニン２（ｎｋ２）リセプター拮抗薬としてのそれらの使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6403601B1 (enExample) |
| EP (1) | EP1137637A1 (enExample) |
| JP (1) | JP2002531548A (enExample) |
| AU (1) | AU1667500A (enExample) |
| GB (1) | GB9826941D0 (enExample) |
| WO (1) | WO2000034243A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6898636B1 (en) * | 1999-02-04 | 2005-05-24 | Intralinks, Inc. | Methods and systems for interchanging documents between a sender computer, a server and a receiver computer |
| GB9911017D0 (en) * | 1999-05-13 | 1999-07-14 | Zeneca Ltd | Pharmaceutical compositions |
| ATE400563T1 (de) * | 2000-04-06 | 2008-07-15 | Astrazeneca Ab | Neue neurokinin-antagonisten zum gebrauch als arzneimittel |
| JP2003530381A (ja) * | 2000-04-06 | 2003-10-14 | アストラゼネカ・アクチエボラーグ | 化合物 |
| US6903092B2 (en) | 2000-04-06 | 2005-06-07 | Peter Bernstein | Naphthamide neurokinin antagonists for use as medicaments |
| US6846814B2 (en) | 2000-04-06 | 2005-01-25 | Astra Zeneca Ab | Neurokinin antagonists for use as medicaments |
| GB0015246D0 (en) * | 2000-06-22 | 2000-08-16 | Astrazeneca Ab | Method for the treatment of urinary incontinence |
| SE0103795D0 (sv) | 2001-11-02 | 2001-11-02 | Astrazeneca Ab | Compounds and method for the treatment of överactive bladder |
| SE0103668D0 (sv) * | 2001-11-02 | 2001-11-02 | Astrazeneca Ab | Method for the treatment of overactive blader |
| TW200508221A (en) | 2003-06-13 | 2005-03-01 | Astrazeneca Ab | New azetidine compounds |
| US20040265238A1 (en) | 2003-06-27 | 2004-12-30 | Imtiaz Chaudry | Inhalable formulations for treating pulmonary hypertension and methods of using same |
| GB0418045D0 (en) | 2004-08-12 | 2004-09-15 | Glaxo Group Ltd | Compounds |
| SE0403005D0 (sv) * | 2004-12-09 | 2004-12-09 | Astrazeneca Ab | New use |
| AR056087A1 (es) * | 2005-09-29 | 2007-09-19 | Astrazeneca Ab | Derivados de azetidina como antagonistas de receptores de neuroquina nk |
| AR057828A1 (es) * | 2005-09-29 | 2007-12-19 | Astrazeneca Ab | Compuestos derivados de azetidina, su preparacion y composicion farmaceuutica |
| US8106208B2 (en) | 2006-05-18 | 2012-01-31 | Albireo Ab | Benzamide compounds that act as NK receptor antagonists |
| CN101641099A (zh) | 2007-01-24 | 2010-02-03 | 葛兰素集团有限公司 | 包含3,5-二氨基-6-(2,3-二氯苯基)-1,2,4-三嗪或r(-)-2,4-二氨基-5-(2,3-二氯苯基)-6-氟甲基嘧啶和nk1的药物组合物 |
| CN120476107A (zh) | 2022-12-15 | 2025-08-12 | 先正达农作物保护股份公司 | 可用作杀有害生物剂的新型的二环-甲酰胺化合物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL99320A (en) * | 1990-09-05 | 1995-07-31 | Sanofi Sa | Arylalkylamines, their preparation and pharmaceutical compositions containing them |
| GB9310066D0 (en) * | 1993-05-17 | 1993-06-30 | Zeneca Ltd | Alkyl substituted heterocycles |
| GB9310713D0 (en) | 1993-05-24 | 1993-07-07 | Zeneca Ltd | Aryl substituted heterocycles |
| GB9617730D0 (en) * | 1996-08-23 | 1996-10-02 | Pfizer Ltd | Quarternary ammonium compounds |
| US5789422A (en) * | 1996-10-28 | 1998-08-04 | Schering Corporation | Substituted arylalkylamines as neurokinin antagonists |
-
1998
- 1998-12-09 GB GBGB9826941.8A patent/GB9826941D0/en not_active Ceased
-
1999
- 1999-12-06 AU AU16675/00A patent/AU1667500A/en not_active Abandoned
- 1999-12-06 EP EP99959534A patent/EP1137637A1/en not_active Withdrawn
- 1999-12-06 US US09/857,833 patent/US6403601B1/en not_active Expired - Fee Related
- 1999-12-06 JP JP2000586691A patent/JP2002531548A/ja active Pending
- 1999-12-06 WO PCT/GB1999/004118 patent/WO2000034243A1/en not_active Ceased
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