JP2010503690A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010503690A5 JP2010503690A5 JP2009528344A JP2009528344A JP2010503690A5 JP 2010503690 A5 JP2010503690 A5 JP 2010503690A5 JP 2009528344 A JP2009528344 A JP 2009528344A JP 2009528344 A JP2009528344 A JP 2009528344A JP 2010503690 A5 JP2010503690 A5 JP 2010503690A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- phenyl
- cyclotetradec
- diaza
- pyrazolo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 3-ethoxyphenyl Chemical group 0.000 claims 24
- 150000001875 compounds Chemical class 0.000 claims 21
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 18
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 5
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 125000000547 substituted alkyl group Chemical group 0.000 claims 3
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000031888 Mycoses Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 238000010276 construction Methods 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 125000005549 heteroarylene group Chemical group 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84531406P | 2006-09-18 | 2006-09-18 | |
| US60/845,314 | 2006-09-18 | ||
| US11/856,476 US7517882B2 (en) | 2006-09-18 | 2007-09-17 | Protein kinase inhibitors |
| US11/856,476 | 2007-09-17 | ||
| PCT/US2007/020231 WO2008036277A1 (en) | 2006-09-18 | 2007-09-18 | Pyraz0l0(l,5-a) (1, 3, 5) triazine and pyrazolo (1, 5-a) pyrimidine derivatives useful as protein kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010503690A JP2010503690A (ja) | 2010-02-04 |
| JP2010503690A5 true JP2010503690A5 (enExample) | 2010-11-04 |
| JP5232786B2 JP5232786B2 (ja) | 2013-07-10 |
Family
ID=39052753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009528344A Expired - Fee Related JP5232786B2 (ja) | 2006-09-18 | 2007-09-18 | タンパク質キナーゼ阻害剤として有用なピラゾロ（１，５−ａ）（１，３，５）トリアジン及びピラゾロ（１，５−ａ）ピリミジン誘導体 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7517882B2 (enExample) |
| EP (1) | EP2064214B1 (enExample) |
| JP (1) | JP5232786B2 (enExample) |
| KR (1) | KR101418619B1 (enExample) |
| CN (1) | CN101522683B (enExample) |
| AU (1) | AU2007297675B2 (enExample) |
| BR (1) | BRPI0718459A2 (enExample) |
| CA (1) | CA2663791C (enExample) |
| ES (1) | ES2400450T3 (enExample) |
| TW (1) | TWI472530B (enExample) |
| WO (1) | WO2008036277A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7517882B2 (en) * | 2006-09-18 | 2009-04-14 | Polaris Group | Protein kinase inhibitors |
| WO2009126514A1 (en) * | 2008-04-07 | 2009-10-15 | Irm Llc | Compounds and compositions as kinase inhibitors |
| KR20140078710A (ko) * | 2011-09-30 | 2014-06-25 | 온코디자인 에스.에이. | 거대고리 flt3 키나제 억제제 |
| SG11201507493SA (en) * | 2013-03-15 | 2015-10-29 | Oncodesign Sa | Macrocyclic salt-inducible kinase inhibitors |
| CN103570728B (zh) * | 2013-11-12 | 2015-12-30 | 山东大学 | 一种取代吡唑并[1,5-a]嘧啶类衍生物及其制备方法与应用 |
| EP3268000B1 (en) * | 2015-03-09 | 2021-08-04 | Aurigene Discovery Technologies Limited | Pyrazolo[1,5-a][1,3,5]triazine and pyrazolo[1,5-a]pyrimidine derivatives as cdk inhibitors |
| SG11201900163PA (en) * | 2016-07-28 | 2019-02-27 | Tp Therapeutics Inc | Macrocycle kinase inhibitors |
| SI3870579T1 (sl) | 2018-10-22 | 2025-03-31 | Alumis Inc. | Inhibitorji tyk2 in njihova uporaba |
| CN113811534B (zh) * | 2019-03-11 | 2024-10-29 | 阿鲁米斯公司 | Tyk2抑制剂和其用途 |
| US11780842B2 (en) * | 2019-03-26 | 2023-10-10 | Ventyx Biosciences, Inc. | TYK2 pseudokinase ligands |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10255343B4 (de) * | 2002-11-27 | 2006-09-07 | Nad Ag | N,N-Verbrückte, Stickstoff-Substituierte Carbacyclische Indolocarbazole als Proteinkinase-Inhibitoren |
| BRPI0410563B8 (pt) | 2003-05-22 | 2021-05-25 | Nerviano Medical Sciences Srl | compostos de pirazol-quinazolina, seus processos de preparação e composições farmacêuticas |
| NZ551938A (en) * | 2004-06-02 | 2010-07-30 | Takeda Pharmaceutical | Fused heterocyclic compound |
| US7517882B2 (en) * | 2006-09-18 | 2009-04-14 | Polaris Group | Protein kinase inhibitors |
-
2007
- 2007-09-17 US US11/856,476 patent/US7517882B2/en not_active Expired - Fee Related
- 2007-09-18 BR BRPI0718459-0A patent/BRPI0718459A2/pt not_active Application Discontinuation
- 2007-09-18 JP JP2009528344A patent/JP5232786B2/ja not_active Expired - Fee Related
- 2007-09-18 CN CN2007800342168A patent/CN101522683B/zh active Active
- 2007-09-18 WO PCT/US2007/020231 patent/WO2008036277A1/en not_active Ceased
- 2007-09-18 CA CA2663791A patent/CA2663791C/en not_active Expired - Fee Related
- 2007-09-18 EP EP07838443A patent/EP2064214B1/en not_active Not-in-force
- 2007-09-18 ES ES07838443T patent/ES2400450T3/es active Active
- 2007-09-18 KR KR1020097005501A patent/KR101418619B1/ko not_active Expired - Fee Related
- 2007-09-18 AU AU2007297675A patent/AU2007297675B2/en not_active Ceased
- 2007-09-19 TW TW96134833A patent/TWI472530B/zh not_active IP Right Cessation
-
2009
- 2009-03-03 US US12/396,919 patent/US20090247501A1/en not_active Abandoned