JP2007504839A5 - - Google Patents
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- Publication number
- JP2007504839A5 JP2007504839A5 JP2006532907A JP2006532907A JP2007504839A5 JP 2007504839 A5 JP2007504839 A5 JP 2007504839A5 JP 2006532907 A JP2006532907 A JP 2006532907A JP 2006532907 A JP2006532907 A JP 2006532907A JP 2007504839 A5 JP2007504839 A5 JP 2007504839A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- desaturase
- gene encoding
- yeast
- oleaginous yeast
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 52
- 108090000623 proteins and genes Proteins 0.000 claims description 43
- 238000000034 method Methods 0.000 claims description 39
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 22
- 229910052799 carbon Inorganic materials 0.000 claims description 22
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims description 21
- 229940012843 omega-3 fatty acid Drugs 0.000 claims description 21
- 235000020665 omega-6 fatty acid Nutrition 0.000 claims description 20
- 229940033080 omega-6 fatty acid Drugs 0.000 claims description 20
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims description 18
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims description 17
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims description 17
- 229960005135 eicosapentaenoic acid Drugs 0.000 claims description 17
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims description 17
- 241000235015 Yarrowia lipolytica Species 0.000 claims description 14
- 230000006696 biosynthetic metabolic pathway Effects 0.000 claims description 14
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 10
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 10
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 10
- 102000004190 Enzymes Human genes 0.000 claims description 10
- 108090000790 Enzymes Proteins 0.000 claims description 10
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 10
- 239000005642 Oleic acid Substances 0.000 claims description 10
- 241000223252 Rhodotorula Species 0.000 claims description 10
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 10
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 10
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims description 9
- 229940090949 docosahexaenoic acid Drugs 0.000 claims description 9
- 241000223230 Trichosporon Species 0.000 claims description 8
- 102100034542 Acyl-CoA (8-3)-desaturase Human genes 0.000 claims description 7
- 102100034544 Acyl-CoA 6-desaturase Human genes 0.000 claims description 7
- 108010073542 Delta-5 Fatty Acid Desaturase Proteins 0.000 claims description 7
- 108010037138 Linoleoyl-CoA Desaturase Proteins 0.000 claims description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 6
- 241000235013 Yarrowia Species 0.000 claims description 6
- -1 elongase Proteins 0.000 claims description 6
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims description 5
- 241001527609 Cryptococcus Species 0.000 claims description 5
- 101000912235 Rebecca salina Acyl-lipid (7-3)-desaturase Proteins 0.000 claims description 4
- 101000877236 Siganus canaliculatus Acyl-CoA Delta-4 desaturase Proteins 0.000 claims description 4
- 108010011713 delta-15 desaturase Proteins 0.000 claims description 4
- 108010087894 Fatty acid desaturases Proteins 0.000 claims description 2
- 241001149698 Lipomyces Species 0.000 claims description 2
- 102000016553 Stearoyl-CoA Desaturase Human genes 0.000 claims description 2
- 150000001412 amines Chemical class 0.000 claims description 2
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 claims description 2
- 150000004676 glycans Chemical class 0.000 claims description 2
- 230000000813 microbial effect Effects 0.000 claims description 2
- 150000002772 monosaccharides Chemical class 0.000 claims description 2
- 229920001542 oligosaccharide Polymers 0.000 claims description 2
- 150000002482 oligosaccharides Chemical class 0.000 claims description 2
- 229920001282 polysaccharide Polymers 0.000 claims description 2
- 239000005017 polysaccharide Substances 0.000 claims description 2
- 150000003626 triacylglycerols Chemical class 0.000 claims description 2
- 229920001184 polypeptide Polymers 0.000 description 28
- 108090000765 processed proteins & peptides Proteins 0.000 description 28
- 102000004196 processed proteins & peptides Human genes 0.000 description 28
- 239000000758 substrate Substances 0.000 description 15
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 10
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 9
- 229960004232 linoleic acid Drugs 0.000 description 9
- IQLUYYHUNSSHIY-HZUMYPAESA-N eicosatetraenoic acid Chemical compound CCCCCCCCCCC\C=C\C=C\C=C\C=C\C(O)=O IQLUYYHUNSSHIY-HZUMYPAESA-N 0.000 description 8
- 108020004707 nucleic acids Proteins 0.000 description 8
- 102000039446 nucleic acids Human genes 0.000 description 8
- 150000007523 nucleic acids Chemical class 0.000 description 8
- 229940098330 gamma linoleic acid Drugs 0.000 description 7
- 238000005406 washing Methods 0.000 description 6
- YUFFSWGQGVEMMI-JLNKQSITSA-N (7Z,10Z,13Z,16Z,19Z)-docosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCCCC(O)=O YUFFSWGQGVEMMI-JLNKQSITSA-N 0.000 description 5
- 235000021294 Docosapentaenoic acid Nutrition 0.000 description 5
- OPGOLNDOMSBSCW-CLNHMMGSSA-N Fursultiamine hydrochloride Chemical compound Cl.C1CCOC1CSSC(\CCO)=C(/C)N(C=O)CC1=CN=C(C)N=C1N OPGOLNDOMSBSCW-CLNHMMGSSA-N 0.000 description 5
- 235000021342 arachidonic acid Nutrition 0.000 description 5
- 229940114079 arachidonic acid Drugs 0.000 description 5
- VZCCETWTMQHEPK-UHFFFAOYSA-N gamma-Linolensaeure Natural products CCCCCC=CCC=CCC=CCCCCC(O)=O VZCCETWTMQHEPK-UHFFFAOYSA-N 0.000 description 5
- VZCCETWTMQHEPK-QNEBEIHSSA-N gamma-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCC(O)=O VZCCETWTMQHEPK-QNEBEIHSSA-N 0.000 description 5
- 235000020664 gamma-linolenic acid Nutrition 0.000 description 5
- 229960002733 gamolenic acid Drugs 0.000 description 5
- JIWBIWFOSCKQMA-UHFFFAOYSA-N stearidonic acid Natural products CCC=CCC=CCC=CCC=CCCCCC(O)=O JIWBIWFOSCKQMA-UHFFFAOYSA-N 0.000 description 5
- 125000003275 alpha amino acid group Chemical group 0.000 description 4
- 235000020778 linoleic acid Nutrition 0.000 description 4
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 4
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 3
- 238000009396 hybridization Methods 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46867703P | 2003-05-07 | 2003-05-07 | |
| PCT/US2004/014541 WO2004101757A2 (en) | 2003-05-07 | 2004-05-07 | Production of polyunsaturated fatty acids in oleaginous yeasts |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007504839A JP2007504839A (ja) | 2007-03-08 |
| JP2007504839A5 true JP2007504839A5 (https=) | 2007-06-28 |
Family
ID=33452224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006532907A Pending JP2007504839A (ja) | 2003-05-07 | 2004-05-07 | 油性酵母菌における多不飽和脂肪酸の生成 |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US7238482B2 (https=) |
| EP (4) | EP2402448B1 (https=) |
| JP (1) | JP2007504839A (https=) |
| KR (1) | KR20060018832A (https=) |
| CN (4) | CN1816630A (https=) |
| BR (1) | BRPI0410688A (https=) |
| CA (1) | CA2526935C (https=) |
| DK (3) | DK2402448T3 (https=) |
| NO (1) | NO20055784L (https=) |
| WO (1) | WO2004101757A2 (https=) |
Families Citing this family (114)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7459546B2 (en) * | 2003-06-25 | 2008-12-02 | E.I. Du Pont De Nemours And Company | Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase regulatory sequences for gene expression in oleaginous yeast |
| US20110059496A1 (en) * | 2003-06-25 | 2011-03-10 | E. I. Du Pont De Nemours And Company | Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase promoters for gene expression in oleaginous yeast |
| US7267976B2 (en) * | 2003-07-02 | 2007-09-11 | E.I. Du Pont De Nemours And Company | Acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous yeasts |
| CA2568689A1 (en) * | 2004-06-04 | 2005-12-15 | Fluxome Sciences A/S | Metabolically engineered cells for the production of polyunsaturated fatty acids |
| US7550651B2 (en) | 2004-06-25 | 2009-06-23 | E.I. Du Pont De Nemours And Company | Delta-8 desaturase and its use in making polyunsaturated fatty acids |
| US7465564B2 (en) * | 2004-08-10 | 2008-12-16 | E.I. Du Pont De Nemours And Company | Production of γ-linolenic acid in oleaginous yeast |
| US7264949B2 (en) | 2004-09-15 | 2007-09-04 | E.I. Du Pont De Nemours And Company | Glycerol-3-phosphate o-acyltransferase promoter for gene expression in oleaginous yeast |
| US7273746B2 (en) | 2004-11-04 | 2007-09-25 | E.I. Dupont De Nemours And Company | Diacylglycerol acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms |
| US20060094102A1 (en) | 2004-11-04 | 2006-05-04 | Zhixiong Xue | Ammonium transporter promoter for gene expression in oleaginous yeast |
| US7192762B2 (en) | 2004-11-04 | 2007-03-20 | E. I. Du Pont De Nemours And Company | Mortierella alpina glycerol-3-phosphate o-acyltransferase for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms |
| US8685679B2 (en) | 2004-11-04 | 2014-04-01 | E I Du Pont De Nemours And Company | Acyltransferase regulation to increase the percent of polyunsaturated fatty acids in total lipids and oils of oleaginous organisms |
| US7189559B2 (en) * | 2004-11-04 | 2007-03-13 | E. I. Du Pont De Nemours And Company | Mortierella alpina lysophosphatidic acid acyltransferase homolog for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms |
| US7550286B2 (en) | 2004-11-04 | 2009-06-23 | E. I. Du Pont De Nemours And Company | Docosahexaenoic acid producing strains of Yarrowia lipolytica |
| AU2005315358A1 (en) * | 2004-12-14 | 2006-06-22 | Avesthagen Limited | Recombinant production docosahexaenoic acid (DHA) in yeast |
| DE102004062141A1 (de) * | 2004-12-23 | 2006-07-06 | Nutrinova Nutrition Specialties & Food Ingredients Gmbh | Verfahren zur Herstellung eines Rohöls aus Gemischen von Mikroorganismen und Pflanzen, das so hergestellte Öl sowie die spezifischen Verwendungen des so hergestellten und gegebenenfalls zusätzlich raffinierten Öls |
| CN103589650A (zh) | 2005-03-18 | 2014-02-19 | 米克罗比亚公司 | 产油酵母和真菌中类胡萝卜素的产生 |
| US7470532B2 (en) * | 2005-10-19 | 2008-12-30 | E.I. Du Pont De Nemours And Company | Mortierella alpina C16/18 fatty acid elongase |
| DK1951866T3 (da) | 2005-11-23 | 2014-10-27 | Du Pont | Delta-9-elongaser og anvendelse heraf til fremstilling af flerumættede fedtsyrer |
| US7465793B2 (en) | 2006-04-20 | 2008-12-16 | E.I. Du Pont De Nemours And Company | Synthetic Δ17 desaturase derived from Phytophthora ramourum and its use in making polyunsaturated fatty acids |
| US7943823B2 (en) | 2006-04-28 | 2011-05-17 | E.I. Du Pont De Nemours And Company | Delta-8 desaturase and its use in making polyunsaturated fatty acids |
| US20070254299A1 (en) | 2006-05-01 | 2007-11-01 | Yadav Narendra S | Fungal delta 12 desaturase and delta 15 desaturase motifs |
| US7678560B2 (en) * | 2006-05-17 | 2010-03-16 | E.I. Du Pont De Nemours And Company | Δ 5 desaturase and its use in making polyunsaturated fatty acids |
| US7695950B2 (en) * | 2006-05-17 | 2010-04-13 | E. I. Du Pont De Nemours And Company | Δ5 desaturase and its use in making polyunsaturated fatty acids |
| WO2008042338A2 (en) | 2006-09-28 | 2008-04-10 | Microbia, Inc. | Production of carotenoids in oleaginous yeast and fungi |
| US20110016581A1 (en) | 2006-10-23 | 2011-01-20 | E.I. Du Pont De Nemours And Company | Delta-8 desaturases and their use in making polyunsaturated fatty acids |
| DK2087105T3 (da) | 2006-10-30 | 2015-05-26 | Du Pont | Delta 17-desaturase og anvendelse heraf ved fremstilling af flerumættede fedtsyrer |
| US7709239B2 (en) * | 2006-12-07 | 2010-05-04 | E.I. Du Pont De Nemours And Company | Mutant Δ8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids |
| US8846374B2 (en) | 2006-12-12 | 2014-09-30 | E I Du Pont De Nemours And Company | Carotenoid production in a recombinant oleaginous yeast |
| US8389808B2 (en) | 2007-02-12 | 2013-03-05 | E.I. Du Pont De Nemours And Company | Production of arachidonic acid in oilseed plants |
| ES2559312T3 (es) * | 2007-04-03 | 2016-02-11 | E. I. Du Pont De Nemours And Company | Multienzimas y su uso en la fabricación de ácidos grasos poliinsaturados |
| US7790156B2 (en) | 2007-04-10 | 2010-09-07 | E. I. Du Pont De Nemours And Company | Δ-8 desaturases and their use in making polyunsaturated fatty acids |
| US7794701B2 (en) | 2007-04-16 | 2010-09-14 | E.I. Du Pont De Nemours And Company | Δ-9 elongases and their use in making polyunsaturated fatty acids |
| US8957280B2 (en) | 2007-05-03 | 2015-02-17 | E. I. Du Pont De Nemours And Company | Delta-5 desaturases and their use in making polyunsaturated fatty acids |
| US20090004715A1 (en) * | 2007-06-01 | 2009-01-01 | Solazyme, Inc. | Glycerol Feedstock Utilization for Oil-Based Fuel Manufacturing |
| US8673623B2 (en) * | 2007-08-31 | 2014-03-18 | Board Of Regents, The University Of Texas System | Apparatus for performing magnetic electroporation |
| CN101874117A (zh) | 2007-09-12 | 2010-10-27 | 马太克生物科学公司 | 生物油及其制备与应用 |
| US20090117253A1 (en) * | 2007-10-03 | 2009-05-07 | E. I. Du Pont De Nemours And Company | Peroxisome biogenesis factor protein (pex) disruptions for altering polyunsaturated fatty acids and total lipid content in oleaginous eukaryotic organisms |
| WO2009126890A2 (en) * | 2008-04-10 | 2009-10-15 | Microbia, Inc. | Production of carotenoids in oleaginous yeast and fungi |
| US8168858B2 (en) | 2008-06-20 | 2012-05-01 | E. I. Du Pont De Nemours And Company | Delta-9 fatty acid elongase genes and their use in making polyunsaturated fatty acids |
| WO2010025374A2 (en) | 2008-08-29 | 2010-03-04 | E. I. Du Pont De Nemours And Company | Manipulation of snf1 protein kinase activity for altered oil content in oleaginous organisms |
| AU2009293160B2 (en) | 2008-09-19 | 2013-11-21 | E. I. Du Pont De Nemours And Company | Mutant delta5 desaturases and their use in making polyunsaturated fatty acids |
| NO2358882T3 (https=) | 2008-11-18 | 2017-12-23 | ||
| WO2010067352A1 (en) * | 2008-12-09 | 2010-06-17 | Ben Gurion University Of The Negev Research And Development Authority | Polyunsaturated fatty acid elongase |
| CN102257126B (zh) | 2008-12-18 | 2014-07-09 | 纳幕尔杜邦公司 | 减少发酵过程中的丙二酸副产物 |
| FR2940315B1 (fr) * | 2008-12-19 | 2012-12-14 | Airbus France | Nouveau procede de culture de levures du genre yarrowia |
| JP5709196B2 (ja) * | 2009-01-09 | 2015-04-30 | 国立大学法人山梨大学 | 油脂生産菌の培養方法 |
| DE102009007402A1 (de) | 2009-02-04 | 2010-08-05 | VLB Berlin e. V. Institut für Mikrobiologie | Biosynthese und Gewinnung von Substanzen aus Zellen |
| US8916154B2 (en) * | 2009-04-27 | 2014-12-23 | Abbott Laboratories | Antibodies against delta-5 desaturase and uses thereof |
| EP2442666B1 (en) | 2009-06-16 | 2015-04-08 | E. I. du Pont de Nemours and Company | High eicosapentaenoic acid oils from improved optimized strains of yarrowia lipolytica |
| DK2475679T3 (da) | 2009-06-16 | 2016-05-09 | Du Pont | Forbedrede, optimerede stammer af yarrowia lipolytica til fremstilling af højkoncentreret eicosapentaensyre |
| CN102459627B (zh) | 2009-06-16 | 2015-07-29 | 纳幕尔杜邦公司 | 通过酰基-辅酶A溶血磷脂酰基转移酶的表达对长链ω-3和ω-6多不饱和脂肪酸的生物合成的改善 |
| US8637298B2 (en) * | 2009-06-16 | 2014-01-28 | E I Du Pont De Nemours And Company | Optimized strains of yarrowia lipolytica for high eicosapentaenoic acid production |
| US20110065161A1 (en) * | 2009-09-14 | 2011-03-17 | Board Of Regents, The University Of Texas System | Bipolar solid state marx generator |
| CN104982920A (zh) * | 2009-11-03 | 2015-10-21 | 帝斯曼知识产权资产管理有限公司 | 包含细胞和具有至少20个碳原子的多不饱和脂肪酸(lc-pufa)的组合物 |
| DK2496092T3 (en) * | 2009-11-03 | 2018-07-16 | Dsm Ip Assets Bv | COMPOSITION WITH CELLS AND A POLYUM Saturated FAT ACID WITH AT LEAST 20 CARBON ATOMS (LC-PUFA) |
| US9029108B2 (en) | 2009-11-06 | 2015-05-12 | Diversified Technologies, Inc. | Pulsed electric field (PEF) method for continuous enhanced extraction of oil and lipids from small aquatic plants |
| EP2516638A1 (en) | 2009-12-24 | 2012-10-31 | E.I. Du Pont De Nemours And Company | Plant membrane bound o-acyl transferase (mboat) family protein sequences and their uses for altering fatty acid compositions |
| WO2011087981A2 (en) | 2010-01-15 | 2011-07-21 | E. I. Du Pont De Nemours And Company | Clinical benefits of eicosapentaenoic acid in humans |
| CN103189513A (zh) * | 2010-03-31 | 2013-07-03 | 纳幕尔杜邦公司 | 上调磷酸戊糖途径以提高转基因微生物中受关注的非天然产物的产量 |
| WO2011133610A1 (en) | 2010-04-22 | 2011-10-27 | E. I. Du Pont De Nemours And Company | Method for obtaining polyunsaturated fatty acid-containing compositions from microbial biomass |
| US8592188B2 (en) | 2010-05-28 | 2013-11-26 | Solazyme, Inc. | Tailored oils produced from recombinant heterotrophic microorganisms |
| EP2603094A1 (en) | 2010-08-11 | 2013-06-19 | E.I. Du Pont De Nemours And Company | A sustainable aquaculture feeding strategy |
| US20120040076A1 (en) | 2010-08-11 | 2012-02-16 | E. I. Du Pont De Nemours And Company | Aquaculture feed compositions |
| WO2012021686A1 (en) | 2010-08-11 | 2012-02-16 | E. I. Du Pont De Nemours And Company | Improved aquaculture meat products |
| CA2808002A1 (en) | 2010-08-26 | 2012-03-01 | E. I. Du Pont De Nemours And Company | Mutant hpgg motif and hdash motif delta-5 desaturases and their use in making polyunsaturated fatty acids |
| AU2011293167B2 (en) | 2010-08-26 | 2016-12-08 | E. I. Du Pont De Nemours And Company | Mutant delta-9 elongases and their use in making polyunsaturated fatty acids |
| EP2609203B1 (en) | 2010-08-26 | 2018-06-20 | E. I. du Pont de Nemours and Company | Recombinant microbial host cells for high eicosapentaenoic acid production |
| EP2635663B1 (en) | 2010-11-03 | 2019-05-08 | Corbion Biotech, Inc. | Microbial oils with lowered pour points, dielectric fluids produced therefrom, and related methods |
| JP2014505472A (ja) | 2010-12-30 | 2014-03-06 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 油性酵母中のｙａｐ１転写因子活性を増大させることにより増加した含油率 |
| JP2014503216A (ja) | 2010-12-30 | 2014-02-13 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | スクロース利用のための、ヤロウィア・リポリティカ（Ｙａｒｒｏｗｉａｌｉｐｏｌｙｔｉｃａ）におけるサッカロミセス・セレビシア（Ｓａｃｃｈａｒｏｍｙｃｅｓｃｅｒｅｖｉｓｉａｅ）ＳＵＣ２遺伝子の使用 |
| KR101964965B1 (ko) | 2011-02-02 | 2019-04-03 | 테라비아 홀딩스 인코포레이티드 | 재조합 유지성 미생물로부터 생산된 맞춤 오일 |
| US20130040340A1 (en) | 2011-02-07 | 2013-02-14 | E. I. Du Pont De Nemours And Company | Production of alcohol esters in situ using alcohols and fatty acids produced by microorganisms |
| US8999663B2 (en) | 2011-02-11 | 2015-04-07 | E L Du Pont De Nemours And Company | Method for obtaining a lipid-containing composition from microbial biomass |
| EP2691518A1 (en) | 2011-03-31 | 2014-02-05 | E.I. Du Pont De Nemours And Company | Yarrowia diacylglycerol acyltransferase promoter regions for gene expression in yeast |
| US20120247066A1 (en) | 2011-04-01 | 2012-10-04 | Ice House America, Llc | Ice bagging apparatus and methods |
| EP2694665A1 (en) | 2011-04-01 | 2014-02-12 | E. I. Du Pont de Nemours and Company | Yarrowia esterase/lipase promoter regions for gene expression in yeast |
| US8735094B2 (en) | 2011-04-05 | 2014-05-27 | E I Du Pont De Nemours And Company | Yarrowia n-alkane-hydroxylating cytochrome P450 promoter regions for gene expression in yeast |
| EP2702148A1 (en) | 2011-04-07 | 2014-03-05 | E.I. Du Pont De Nemours And Company | Yarrowia peroxisomal 2,4-dienoyl-coa reductase promoter regions for gene expression in yeast |
| CA2833400A1 (en) | 2011-05-26 | 2012-11-29 | E.I. Dupont De Nemours And Company | Expression of caleosin in recombinant oleaginous microorganisms to increase oil content therein |
| CN103717745B (zh) * | 2011-08-15 | 2016-04-27 | 丰田自动车株式会社 | 烷烃的制造方法及具有烷烃合成能力的重组微生物 |
| US20140322779A1 (en) * | 2011-11-11 | 2014-10-30 | Genomatica, Inc. | Eukaryotic organisms and methods for increasing the availability of cytosolic acetyl-coa, and for the producing 1,3-butanediol |
| US9347067B2 (en) | 2011-12-27 | 2016-05-24 | Commonwealth Scientific And Industrial Research Organisation | Production of dihydrosterculic acid and derivatives thereof |
| US8945908B2 (en) | 2012-04-18 | 2015-02-03 | Solazyme, Inc. | Tailored oils |
| PL2861059T3 (pl) | 2012-06-15 | 2017-10-31 | Commw Scient Ind Res Org | Wytwarzanie długołańcuchowych wielonienasyconych kwasów tłuszczowych w komórkach roślinnych |
| US9416382B2 (en) | 2012-06-19 | 2016-08-16 | E I Du Pont De Nemours And Company | Production of polyunsaturated fatty acids by coexpression of acyl-CoA:lysophosphatidylcholine acyltransferases and phospholipid:diacylglycerol acyltransferases |
| CN102787128A (zh) * | 2012-08-28 | 2012-11-21 | 江南大学 | 一种用于多不饱和脂肪酸生物合成的脱饱和酶Δ9 Des |
| CA2893409A1 (en) | 2012-12-21 | 2014-06-26 | E. I. Du Pont De Nemours And Company | Recombinant microbial cells that produce at least 28% eicosapentaenoic acid as dry cell weight |
| EP2935591B1 (en) | 2012-12-21 | 2017-07-05 | E. I. du Pont de Nemours and Company | Down-regulation of a polynucleotide encoding a sou2 sorbitol utilization protein to modify lipid production in microbial cells |
| MX372724B (es) | 2012-12-24 | 2020-06-19 | Qualitas Health Inc | Formulaciones de acido eicosapentaenoico (epa). |
| WO2015001505A2 (en) | 2013-07-05 | 2015-01-08 | Basf Plant Science Company Gmbh | Gene expression or activity enhancing elements |
| MX369685B (es) | 2013-10-04 | 2019-11-19 | Terravia Holdings Inc | Aceites adaptables. |
| DE102014220186B4 (de) | 2013-12-12 | 2017-06-22 | Technische Universität Dresden | Hefestämme und Verfahren zur Produktion von Omega-Hydroxyfettsäuren und Dicarbonsäuren |
| NZ721036A (en) | 2013-12-18 | 2023-07-28 | Grains Res & Dev Corp | Lipid comprising long chain polyunsaturated fatty acids |
| SG10201909391QA (en) * | 2014-06-27 | 2019-11-28 | Commw Scient Ind Res Org | Lipid comprising docosapentaenoic acid |
| PH12016502586B1 (en) | 2014-06-27 | 2023-07-19 | Commw Scient Ind Res Org | Lipid comprising docosapentaenoic acid |
| US9969990B2 (en) | 2014-07-10 | 2018-05-15 | Corbion Biotech, Inc. | Ketoacyl ACP synthase genes and uses thereof |
| JP6898915B2 (ja) | 2015-07-22 | 2021-07-07 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ | 生物を用いる長鎖ジカルボン酸の高レベルの生産 |
| CN105181832A (zh) * | 2015-08-31 | 2015-12-23 | 广州金域医学检验中心有限公司 | 一种快速检测全血红细胞二十烷二烯酸的方法 |
| WO2017055169A1 (en) | 2015-10-01 | 2017-04-06 | Dsm Ip Assets B.V. | Supplement material for use in pet food |
| AU2019207737B2 (en) | 2018-01-10 | 2023-07-13 | Brightseed, Inc. | Method for modulating metabolism |
| WO2020081637A1 (en) * | 2018-10-17 | 2020-04-23 | Archer Daniels Midland Company | Enzyme addition to fermentation broth for the reduction of oligosaccharides introduced through sterilized dextrose solution |
| CN110373436B (zh) * | 2018-12-11 | 2022-09-23 | 山东理工大学 | 一种产双高-γ-亚麻酸卷枝毛霉细胞工厂的构建方法及发酵技术 |
| CN110229832A (zh) * | 2019-06-16 | 2019-09-13 | 山东理工大学 | 一种提高耶式解脂酵母生物量和细胞壁产量的菌株和方法 |
| KR102892573B1 (ko) | 2019-07-29 | 2025-12-01 | 브라이트씨드, 인크. | 소화기 건강의 개선 방법 |
| US11572546B2 (en) | 2019-07-29 | 2023-02-07 | Ginkgo Bioworks, Inc. | Methods and compositions involving promoters derived from Yarrowia lipolytica |
| JP2023501483A (ja) | 2019-11-11 | 2023-01-18 | ブライトシード・インコーポレイテッド | 抽出物、消費可能な製品及び抽出物における生物活性代謝産物を濃縮するための方法 |
| WO2021130078A1 (en) | 2019-12-23 | 2021-07-01 | Dsm Ip Assets B.V. | Aquaculture feed |
| WO2022115503A1 (en) | 2020-11-25 | 2022-06-02 | Dupont Nutrition Biosciences Aps | Treatment and prevention of coronavirus infection |
| WO2022129592A1 (en) | 2020-12-17 | 2022-06-23 | Dsm Ip Assets B.V. | Aquaculture feed |
| WO2022178302A1 (en) * | 2021-02-18 | 2022-08-25 | Zero Acre Farms Inc. | Systems and methods of making oil from microorganisms |
| WO2023148154A1 (en) | 2022-02-01 | 2023-08-10 | Dsm Ip Assets B.V. | Aquaculture feed |
| CN119464235A (zh) * | 2023-08-11 | 2025-02-18 | 中国科学院青岛生物能源与过程研究所 | Δ12-脂肪酸去饱和酶及应用 |
| WO2025125658A1 (en) | 2023-12-14 | 2025-06-19 | Dsm Ip Assets B.V. | Aquaculture feed |
| DE102024127318A1 (de) | 2024-09-23 | 2026-03-26 | Rheinisch-Westfälische Technische Hochschule Aachen, abgekürzt RWTH Aachen, Körperschaft des öffentlichen Rechts | Plattform zur Herstellung mikrobieller Triglyzeridmischungen mit einstellbarer Zusammensetzung |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ190194A (en) | 1978-05-08 | 1982-02-23 | Cpc International Inc | Production of oil by fermenting yeast in fatty acids |
| US5071764A (en) | 1983-10-06 | 1991-12-10 | Pfizer Inc. | Process for integrative transformation of yarrowia lipolytica |
| US4880741A (en) | 1983-10-06 | 1989-11-14 | Pfizer Inc. | Process for transformation of Yarrowia lipolytica |
| GB8407195D0 (en) | 1984-03-20 | 1984-04-26 | Cadbury Schweppes Plc | Microbial desaturase enzyme inhibitors |
| US4792523A (en) | 1984-08-31 | 1988-12-20 | Cetus Corporation | 3'Expression enhancing fragments and method |
| DD227448A1 (de) | 1984-10-18 | 1985-09-18 | Akad Wissenschaften Ddr | Verfahren zur herstellung von zitronensaeure auf mikrobiellem wege |
| US4677072A (en) * | 1985-02-28 | 1987-06-30 | Westvaco Corporation | Rhodotorula having desaturase enzymes |
| GB8507058D0 (en) | 1985-03-19 | 1985-04-24 | Efamol Ltd | Pharmaceutical & dietary compositions |
| GB8524275D0 (en) | 1985-10-02 | 1985-11-06 | Efamol Ltd | Pharmaceutical & dietary compositions |
| GB8524276D0 (en) | 1985-10-02 | 1985-11-06 | Efamol Ltd | Pharmaceutical & dietary compositions |
| US5107065A (en) | 1986-03-28 | 1992-04-21 | Calgene, Inc. | Anti-sense regulation of gene expression in plant cells |
| JP2527340B2 (ja) | 1986-12-15 | 1996-08-21 | アプライド バイオシステムズ インコーポレイテッド | ロ―ダミン染料の５−及び６−スクシニミジルカルボキシレ―ト異性体 |
| DD259637A1 (de) | 1987-04-09 | 1988-08-31 | Adw Ddr | Verfahren zur herstellung von isozitratlyase in rekombinanten mikroorganismen |
| SU1454852A1 (ru) | 1987-05-19 | 1989-01-30 | Институт Микробиологии Им.Августа Кирхенштейна | Штамм дрожжей JaRRoWIa LIроLYтIса-продуцент липазы и питательна среда дл его культивировани |
| DD267999B5 (de) | 1988-01-06 | 2000-08-10 | Akad Wissenschaften Ddr | Verfahren zur herstellung von 2-oxoglutarsaeure durch hefen |
| US5116871A (en) | 1988-09-13 | 1992-05-26 | Efamol Holdings Plc | Fatty acid therapy and compositions for the treatment of myalgic encephalomyelitis |
| DD275480A1 (de) | 1988-09-15 | 1990-01-24 | Ve Forschungszentrum Biotechno | Verfahren zur herstellung von zitronensaeure durch aerobe submerse kultivierung von hefen |
| US5057419A (en) | 1988-09-22 | 1991-10-15 | Rutgers University | Genetically engineered plasmid and organisms for the production of specialized oils |
| DD279267A1 (de) | 1989-01-05 | 1990-05-30 | Akad Wissenschaften Ddr | Verfahren zur herstellung mikrobieller lipase |
| PL160027B1 (pl) | 1989-03-23 | 1993-01-29 | Akad Rolnicza | Sposób jednoczesnego otrzymywania kwasu cytrynowego i kwasu izocytrynowego PL |
| DD285370A5 (de) | 1989-06-29 | 1990-12-12 | Ingenieurtechnik Im Stammbetrieb Veb Kombinat Suesswaren,Dd | Verfahren zur immobilisierung von mikroorganismen bzw. coimmobilisierung von mikroorganismen und enzymen |
| DD285372A5 (de) | 1989-06-29 | 1990-12-12 | Ingenieurtechnik,Dd | Verfahren zur immobilisierung von mikroorganismen bzw. coimmobilisierung von mikroorganismen und enzymen |
| US5366860A (en) | 1989-09-29 | 1994-11-22 | Applied Biosystems, Inc. | Spectrally resolvable rhodamine dyes for nucleic acid sequence determination |
| US5407957A (en) | 1990-02-13 | 1995-04-18 | Martek Corporation | Production of docosahexaenoic acid by dinoflagellates |
| ATE241007T1 (de) | 1990-03-16 | 2003-06-15 | Calgene Llc | Dnas, die für pflanzliche desaturasen kodieren und deren anwendungen |
| US5244921A (en) * | 1990-03-21 | 1993-09-14 | Martek Corporation | Eicosapentaenoic acids and methods for their production |
| WO1991018985A1 (en) | 1990-05-25 | 1991-12-12 | E.I. Du Pont De Nemours And Company | Nucleotide sequence of soybean stearoyl-acp desaturase gene |
| US5658767A (en) | 1991-01-24 | 1997-08-19 | Martek Corporation | Arachidonic acid and methods for the production and use thereof |
| CA2124673C (en) | 1991-12-04 | 2008-08-05 | John Browse | Fatty acid desaturase genes from plants |
| EP0578388B1 (en) | 1992-06-25 | 1998-11-04 | INTERNATIONAL FLAVORS & FRAGRANCES INC. | Fermentation process for preparing 10-hydroxy-C18-carboxylic acid and gamma-dodecalactone derivatives |
| IT1256043B (it) | 1992-08-12 | 1995-11-21 | Ceppo mutante di yarrowia lipolytica e procedimento per la produzione di acido citrico | |
| DK0668919T3 (da) | 1992-11-17 | 2003-09-15 | Du Pont | Gener for mikorsomale delta-12-fedtsyredesaturaser og beslægtede enzymer fra planter |
| FR2734843A1 (fr) | 1995-06-02 | 1996-12-06 | Centre Nat Rech Scient | Nouveau procede de bioconversion microbienne. |
| EP0770683A1 (en) | 1995-10-04 | 1997-05-02 | Mitsubishi Chemical Corporation | Method for producing erythritol |
| JPH09252790A (ja) | 1996-03-21 | 1997-09-30 | Japan Energy Corp | 発酵法によるピルビン酸の製造方法 |
| US6166230A (en) * | 1996-05-15 | 2000-12-26 | Gist-Brocades B.V. | Sterol extraction with polar solvent to give low sterol, high triglyceride, microbial oil |
| WO1997044470A1 (en) | 1996-05-21 | 1997-11-27 | Novo Nordisk A/S | Novel yeast promoters suitable for expression cloning in yeast and heterologous expression of proteins in yeast |
| RU2090611C1 (ru) | 1996-09-27 | 1997-09-20 | Финогенова Татьяна Васильевна | Штамм дрожжей yarrowia lipolytica - продуцент лимонной кислоты, способ получения лимонной кислоты и способ выделения цитрата натрия |
| US5972664A (en) * | 1997-04-11 | 1999-10-26 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids |
| US6432684B1 (en) * | 1997-04-11 | 2002-08-13 | Abbott Laboratories | Human desaturase gene and uses thereof |
| US6075183A (en) | 1997-04-11 | 2000-06-13 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants |
| US5968809A (en) * | 1997-04-11 | 1999-10-19 | Abbot Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids |
| WO1999028508A1 (en) | 1997-12-04 | 1999-06-10 | Smithkline Beecham Corporation | Method of generating conditionally expressed mutant cells using expressible antisense sequences |
| US6403349B1 (en) * | 1998-09-02 | 2002-06-11 | Abbott Laboratories | Elongase gene and uses thereof |
| US6677145B2 (en) | 1998-09-02 | 2004-01-13 | Abbott Laboratories | Elongase genes and uses thereof |
| EP0997533A1 (de) | 1998-10-24 | 2000-05-03 | Haarmann & Reimer Gmbh | Verfahren zur Gewinnung von Gamma-Decalacton |
| AU2000244105A1 (en) | 2000-04-28 | 2001-11-12 | Laboratoires Mayoly Spindler | Cloning and expressing an acid-resistant extracellular lipase of yarrowia lipolytica |
| EP1283266A4 (en) | 2000-05-19 | 2005-01-05 | Kaneka Corp | TRANSFORMANT AND PROCESS FOR PRODUCING POLYESTER USING THE TRANSFORMANT |
| WO2002081668A2 (en) | 2001-01-25 | 2002-10-17 | Abbott Laboratories | Desaturase genes and uses thereof |
| JP2002296554A (ja) | 2001-03-30 | 2002-10-09 | Minebea Co Ltd | ファラデー回転子 |
| US7045683B2 (en) | 2001-05-04 | 2006-05-16 | Abbott Laboratories | Δ4-desaturase genes and uses thereof |
| US7211656B2 (en) | 2002-01-30 | 2007-05-01 | Abbott Laboratories | Desaturase genes, enzymes encoded thereby, and uses thereof |
| WO2003099216A2 (en) | 2002-05-22 | 2003-12-04 | Monsanto Technology Llc | Fatty acid desaturases from fungi |
| US7214491B2 (en) * | 2003-05-07 | 2007-05-08 | E. I. Du Pont De Nemours And Company | Δ-12 desaturase gene suitable for altering levels of polyunsaturated fatty acids in oleaginous yeasts |
| US7364883B2 (en) | 2004-05-07 | 2008-04-29 | Yeastern Biotech Co., Ltd. | Process for producing poly-unsaturated fatty acids by oleaginous yeasts |
-
2004
- 2004-05-06 US US10/840,579 patent/US7238482B2/en not_active Expired - Lifetime
- 2004-05-07 EP EP11155007.5A patent/EP2402448B1/en not_active Expired - Lifetime
- 2004-05-07 BR BRPI0410688 patent/BRPI0410688A/pt not_active Application Discontinuation
- 2004-05-07 EP EP20110155002 patent/EP2392665A3/en not_active Withdrawn
- 2004-05-07 WO PCT/US2004/014541 patent/WO2004101757A2/en not_active Ceased
- 2004-05-07 CN CNA200480019355XA patent/CN1816630A/zh active Pending
- 2004-05-07 CN CN200480019580A patent/CN100591773C/zh not_active Expired - Fee Related
- 2004-05-07 CN CN200910266075A patent/CN101824441A/zh active Pending
- 2004-05-07 CA CA 2526935 patent/CA2526935C/en not_active Expired - Lifetime
- 2004-05-07 DK DK11155007.5T patent/DK2402448T3/en active
- 2004-05-07 EP EP04751769.3A patent/EP1620543B1/en not_active Expired - Lifetime
- 2004-05-07 DK DK04751769.3T patent/DK1620543T3/en active
- 2004-05-07 JP JP2006532907A patent/JP2007504839A/ja active Pending
- 2004-05-07 EP EP11154995.2A patent/EP2392664B1/en not_active Expired - Lifetime
- 2004-05-07 CN CNA2004800193545A patent/CN1816559A/zh active Pending
- 2004-05-07 KR KR20057021008A patent/KR20060018832A/ko not_active Withdrawn
- 2004-05-07 DK DK11154995.2T patent/DK2392664T3/en active
-
2005
- 2005-12-06 NO NO20055784A patent/NO20055784L/no not_active Application Discontinuation
-
2007
- 2007-03-05 US US11/714,377 patent/US7553628B2/en not_active Expired - Lifetime
-
2009
- 2009-05-20 US US12/469,467 patent/US8399242B2/en not_active Expired - Fee Related
- 2009-05-20 US US12/469,494 patent/US20090233347A1/en not_active Abandoned
-
2012
- 2012-11-15 US US13/677,911 patent/US9133465B2/en not_active Expired - Fee Related
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