JP2010527244A5 - - Google Patents
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- Publication number
- JP2010527244A5 JP2010527244A5 JP2010508603A JP2010508603A JP2010527244A5 JP 2010527244 A5 JP2010527244 A5 JP 2010527244A5 JP 2010508603 A JP2010508603 A JP 2010508603A JP 2010508603 A JP2010508603 A JP 2010508603A JP 2010527244 A5 JP2010527244 A5 JP 2010527244A5
- Authority
- JP
- Japan
- Prior art keywords
- pks system
- pufa pks
- seq
- chimeric
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 claims description 167
- 150000007523 nucleic acids Chemical group 0.000 claims description 55
- 241000233671 Schizochytrium Species 0.000 claims description 38
- 108020004707 nucleic acids Proteins 0.000 claims description 29
- 102000039446 nucleic acids Human genes 0.000 claims description 29
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 26
- 241000233675 Thraustochytrium Species 0.000 claims description 24
- 108700010070 Codon Usage Proteins 0.000 claims description 20
- 244000005700 microbiome Species 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 19
- 102000004169 proteins and genes Human genes 0.000 claims description 16
- 108090000623 proteins and genes Proteins 0.000 claims description 16
- 108700016155 Acyl transferases Proteins 0.000 claims description 6
- 102000057234 Acyl transferases Human genes 0.000 claims description 6
- 101710130262 Probable Vpr-like protein Proteins 0.000 claims description 6
- 108010019608 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase Proteins 0.000 claims description 4
- 102000000157 3-oxoacyl-(acyl-carrier-protein) reductase Human genes 0.000 claims description 4
- 108010055468 3-oxoacyl-(acyl-carrier-protein) reductase Proteins 0.000 claims description 4
- 102100037149 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial Human genes 0.000 claims description 4
- 101710198510 Enoyl-[acyl-carrier-protein] reductase [NADH] Proteins 0.000 claims description 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 4
- 150000001413 amino acids Chemical group 0.000 claims description 4
- 235000020665 omega-6 fatty acid Nutrition 0.000 claims description 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- 241000894006 Bacteria Species 0.000 claims description 2
- LTYOQGRJFJAKNA-KKIMTKSISA-N Malonyl CoA Natural products S(C(=O)CC(=O)O)CCNC(=O)CCNC(=O)[C@@H](O)C(CO[P@](=O)(O[P@](=O)(OC[C@H]1[C@@H](OP(=O)(O)O)[C@@H](O)[C@@H](n2c3ncnc(N)c3nc2)O1)O)O)(C)C LTYOQGRJFJAKNA-KKIMTKSISA-N 0.000 claims description 2
- 102000002508 Peptide Elongation Factors Human genes 0.000 claims description 2
- 108010068204 Peptide Elongation Factors Proteins 0.000 claims description 2
- 241001467333 Thraustochytriaceae Species 0.000 claims description 2
- 102000037865 fusion proteins Human genes 0.000 claims description 2
- 108020001507 fusion proteins Proteins 0.000 claims description 2
- LTYOQGRJFJAKNA-DVVLENMVSA-N malonyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 LTYOQGRJFJAKNA-DVVLENMVSA-N 0.000 claims description 2
- 230000000813 microbial effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/749,686 US8003772B2 (en) | 1999-01-14 | 2007-05-16 | Chimeric PUFA polyketide synthase systems and uses thereof |
| US11/749,686 | 2007-05-16 | ||
| PCT/US2008/063835 WO2008144473A2 (en) | 2007-05-16 | 2008-05-16 | Chimeric pufa polyketide synthase systems and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010527244A JP2010527244A (ja) | 2010-08-12 |
| JP2010527244A5 true JP2010527244A5 (https=) | 2011-06-30 |
| JP5551584B2 JP5551584B2 (ja) | 2014-07-16 |
Family
ID=40122412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010508603A Expired - Fee Related JP5551584B2 (ja) | 2007-05-16 | 2008-05-16 | キメラｐｕｆａポリケチドシンターゼシステムおよびその使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US8003772B2 (https=) |
| EP (1) | EP2160470B1 (https=) |
| JP (1) | JP5551584B2 (https=) |
| KR (1) | KR101539470B1 (https=) |
| CN (1) | CN101849014B (https=) |
| AU (1) | AU2008254837B2 (https=) |
| BR (1) | BRPI0810302A2 (https=) |
| CA (1) | CA2687523C (https=) |
| ES (1) | ES2467918T3 (https=) |
| IL (1) | IL202131A (https=) |
| MX (1) | MX2009012395A (https=) |
| WO (1) | WO2008144473A2 (https=) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6566583B1 (en) * | 1997-06-04 | 2003-05-20 | Daniel Facciotti | Schizochytrium PKS genes |
| US7247461B2 (en) * | 1999-01-14 | 2007-07-24 | Martek Biosciences Corporation | Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof |
| US8003772B2 (en) * | 1999-01-14 | 2011-08-23 | Martek Biosciences Corporation | Chimeric PUFA polyketide synthase systems and uses thereof |
| US7211418B2 (en) * | 1999-01-14 | 2007-05-01 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
| US7217856B2 (en) * | 1999-01-14 | 2007-05-15 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
| US20070244192A1 (en) * | 1999-01-14 | 2007-10-18 | Martek Biosciences Corporation | Plant seed oils containing polyunsaturated fatty acids |
| TWI377253B (en) | 2001-04-16 | 2012-11-21 | Martek Biosciences Corp | Product and process for transformation of thraustochytriales microorganisms |
| CN103451246B (zh) | 2004-04-22 | 2018-02-16 | 联邦科学技术研究组织 | 用重组细胞合成长链多不饱和脂肪酸 |
| EP2357244A3 (en) | 2004-04-22 | 2011-11-23 | Commonwealth Scientific and Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells. |
| WO2007106905A2 (en) * | 2006-03-15 | 2007-09-20 | Martek Biosciences Corporation | Polyunsaturated fatty acid production in heterologous organisms using pufa polyketide synthase systems |
| RU2009111266A (ru) | 2006-08-29 | 2010-10-10 | Коммонвелт Сайентифик энд Индастриал Рисерч Организейшн (AU) | Синтез жирных кислот |
| BRPI0910482A2 (pt) | 2008-04-29 | 2019-09-24 | Abbott Lab | imunoglobinas de domínio variável duplo e usos das mesmas |
| PE20100092A1 (es) | 2008-06-03 | 2010-03-12 | Abbott Lab | Inmunoglobulina con dominio variable dual y usos de la misma |
| BRPI0921467B1 (pt) | 2008-11-18 | 2021-12-14 | Commonwealth Scientific And Industrial Research Organisation | Processo para a produção de óleo compreendendo ácido eicosapentaenóico (epa), ácido docosapentaenóico (dpa) e ácido docosahexaenóico (dha) |
| ES2752196T3 (es) * | 2009-03-16 | 2020-04-03 | Dsm Ip Assets Bv | Producción de proteínas en microorganismos del filo Labyrinthulomycota |
| US8207363B2 (en) | 2009-03-19 | 2012-06-26 | Martek Biosciences Corporation | Thraustochytrids, fatty acid compositions, and methods of making and uses thereof |
| US8940884B2 (en) | 2009-03-19 | 2015-01-27 | Dsm Ip Assets B.V. | Polyunsaturated fatty acid synthase nucleic acid molecules and polypeptides, compositions, and methods of making and uses thereof |
| WO2011037207A1 (ja) * | 2009-09-24 | 2011-03-31 | 国立大学法人九州大学 | ストラメノパイルの形質転換方法 |
| EP2519636B8 (en) * | 2009-12-28 | 2017-08-09 | DSM IP Assets B.V. | Production of hemagglutinin-neuraminidase protein in microalgae |
| IN2012DN06277A (https=) | 2009-12-28 | 2015-09-25 | Dsm Ip Assets Bv | |
| ES2651313T3 (es) * | 2009-12-28 | 2018-01-25 | Dsm Ip Assets B.V. | Traustoquítridos recombinantes que crecen en xilosa, y composiciones, métodos de preparación y usos de los mismos |
| CN103260643A (zh) | 2009-12-28 | 2013-08-21 | 梅里亚有限公司 | 重组ndv抗原及其用途 |
| CN103068965A (zh) | 2009-12-28 | 2013-04-24 | Dsmip资产公司 | 在蔗糖上生长的重组破囊壶菌和其组合物、制备方法及用途 |
| US9924733B2 (en) * | 2010-01-19 | 2018-03-27 | Dsm Ip Assets B.V. | Eicosapentaenoic acid-producing microorganisms, fatty acid compositions, and methods of making and uses thereof |
| ES2617743T3 (es) | 2010-03-12 | 2017-06-19 | Merial, Inc. | Vacunas recombinantes del virus de la lengua azul y sus utilizaciones |
| US11236351B2 (en) * | 2010-05-17 | 2022-02-01 | Dow Agrosciences Llc | Production of DHA and other LC PUFAs in plants |
| TW201144442A (en) * | 2010-05-17 | 2011-12-16 | Dow Agrosciences Llc | Production of DHA and other LC-PUFAs in plants |
| UY33492A (es) | 2010-07-09 | 2012-01-31 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| US8735546B2 (en) | 2010-08-03 | 2014-05-27 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
| US9062315B2 (en) * | 2010-10-01 | 2015-06-23 | Kyushu University, National University Corporation | Method for transformation of stramenopile |
| PT2683824T (pt) * | 2011-03-07 | 2018-06-07 | Dsm Nutritional Products Ag | Modificação de microorganismos thraustochytrid |
| AU2012285806B2 (en) | 2011-07-21 | 2017-09-14 | Dsm Ip Assets B.V. | Fatty acid compositions |
| TW201307553A (zh) | 2011-07-26 | 2013-02-16 | Dow Agrosciences Llc | 在植物中生產二十二碳六烯酸（ｄｈａ）及其他長鏈多元不飽和脂肪酸（ｌｃ－ｐｕｆａ）之技術 |
| WO2013185184A2 (en) | 2012-06-15 | 2013-12-19 | Commonwealth Scientific And Industrial Research Organisation | Production of long chain polyunsaturated fatty acids in plant cells |
| TW201525136A (zh) | 2013-11-26 | 2015-07-01 | Dow Agrosciences Llc | 利用破囊壺菌ＰＵＦＡ合成酶於油籽作物中生成ω－３長鏈多不飽和脂肪酸 |
| EP3082405A4 (en) | 2013-12-18 | 2017-12-13 | Commonwealth Scientific and Industrial Research Organisation | Lipid comprising long chain polyunsaturated fatty acids |
| SG11201610596PA (en) | 2014-06-27 | 2017-01-27 | Commw Scient Ind Res Org | Lipid comprising docosapentaenoic acid |
| CA2977271A1 (en) | 2015-03-02 | 2016-09-09 | Synthetic Genomics, Inc. | Regulatory elements from labyrinthulomycetes microorganisms |
| AU2016228545A1 (en) * | 2015-03-12 | 2017-09-21 | Synthetic Genomics. Inc. | Microorganisms for fatty acid production using elongase and desaturase enzymes |
| EP3795586A3 (en) | 2016-03-16 | 2021-06-23 | Conagen Inc. | Production of proteins in labyrinthulomycetes |
| PL3455351T3 (pl) | 2016-05-12 | 2022-11-21 | Dsm Ip Assets B.V. | Sposób zwiększania wytwarzania wielonienasyconych kwasów tłuszczowych omega-3 w mikroalgach |
| KR102319845B1 (ko) | 2016-07-13 | 2021-11-01 | 디에스엠 아이피 어셋츠 비.브이. | 조류 숙주 세포에 대한 crispr-cas 시스템 |
| US10633454B2 (en) | 2016-11-01 | 2020-04-28 | Conagen Inc. | Expression of modified glycoproteins and glycopeptides |
| CN106947706B (zh) * | 2017-05-10 | 2020-07-07 | 南京工业大学 | 一株裂殖壶菌菌株、其构建方法及应用 |
| US12241101B2 (en) | 2018-08-10 | 2025-03-04 | Kyowa Hakko Bio Co., Ltd. | Microorganism producing polyunsaturated fatty acid and method for producing polyunsaturated fatty acid |
| BR112021002300A2 (pt) | 2018-08-10 | 2021-05-04 | Kyowa Hakko Bio Co., Ltd | microrganismo que produz ácido eicosapentaenoico e método para a produção de ácido eicosapentaenoico |
| US20250129395A1 (en) | 2022-01-25 | 2025-04-24 | Dsm Ip Assets B.V. | Media refinement and nutrient feeding approaches to increase polyunsaturated fatty acid production |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5246841A (en) * | 1986-12-26 | 1993-09-21 | Sagami Chemical Research Center | Microbial process for production of eicosapentaenoic acid |
| US5130242A (en) * | 1988-09-07 | 1992-07-14 | Phycotech, Inc. | Process for the heterotrophic production of microbial products with high concentrations of omega-3 highly unsaturated fatty acids |
| US5340742A (en) * | 1988-09-07 | 1994-08-23 | Omegatech Inc. | Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids |
| US5639790A (en) * | 1991-05-21 | 1997-06-17 | Calgene, Inc. | Plant medium-chain thioesterases |
| US5683898A (en) * | 1992-05-15 | 1997-11-04 | Sagami Chemical Research Center | Gene coding for eicosapentaenoic acid synthesizing enzymes and process for production of eicosapentaenoic acid |
| US5798259A (en) * | 1992-05-15 | 1998-08-25 | Sagami Chemical Research Center | Gene coding for eicosapentaenoic acid synthesizing enzymes and process for production of eicosapentaenoic acid |
| EP0594868A4 (en) | 1992-05-15 | 1997-01-02 | Sagami Chem Res | Gene which codes for eicosapentaenoic acid synthetase group and process for producing eicosapentaenoic acid |
| US5310242A (en) * | 1992-09-28 | 1994-05-10 | Golder Kimberly A | Portable infant seat |
| DE4323727A1 (de) * | 1993-07-15 | 1995-03-09 | Boehringer Mannheim Gmbh | Verfahren zur Identifizierung von menschlichen und tierischen Zellen mit der Fähigkeit zu unbegrenzter Proliferation oder zur Tumorbildung |
| US5672491A (en) * | 1993-09-20 | 1997-09-30 | The Leland Stanford Junior University | Recombinant production of novel polyketides |
| EP0831149A4 (en) | 1995-01-13 | 2000-12-06 | Sagami Chem Res | GENES CODING FOR THE GROUP OF ENZYMES FOR BIOSYNTHESIS OF EICOSAPENTIC ACID AND METHOD FOR PRODUCING EICOSAPENTIC ACID |
| US6582941B1 (en) | 1995-04-17 | 2003-06-24 | Japan As Represented By Director-General Of Agency Of Industrial Science And Technology | Microorganisms capable of producing highly unsaturated fatty acids and process for producing highly unsaturated fatty acids by using the microorganisms |
| US6033883A (en) * | 1996-12-18 | 2000-03-07 | Kosan Biosciences, Inc. | Production of polyketides in bacteria and yeast |
| AU745551B2 (en) | 1997-03-27 | 2002-03-21 | Bristol-Myers Squibb Company | Use of docosahexanoic acid and arachidonic acid enhancing the growth of preterm infants |
| BR9808506A (pt) | 1997-04-11 | 2000-05-23 | Calgene Llc | Métodos e composições para sìntese de ácidos graxos poliinsaturados de cadeia longa em plantas |
| US6566583B1 (en) | 1997-06-04 | 2003-05-20 | Daniel Facciotti | Schizochytrium PKS genes |
| CA2283422A1 (en) * | 1997-06-04 | 1998-12-10 | Calgene, Llc | Production of polyunsaturated fatty acids by expression of polyketide-like synthesis genes in plants |
| US6677145B2 (en) * | 1998-09-02 | 2004-01-13 | Abbott Laboratories | Elongase genes and uses thereof |
| US7211418B2 (en) * | 1999-01-14 | 2007-05-01 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
| US8003772B2 (en) * | 1999-01-14 | 2011-08-23 | Martek Biosciences Corporation | Chimeric PUFA polyketide synthase systems and uses thereof |
| US7247461B2 (en) * | 1999-01-14 | 2007-07-24 | Martek Biosciences Corporation | Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof |
| US7217856B2 (en) * | 1999-01-14 | 2007-05-15 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
| US20070244192A1 (en) * | 1999-01-14 | 2007-10-18 | Martek Biosciences Corporation | Plant seed oils containing polyunsaturated fatty acids |
| US7271315B2 (en) * | 1999-01-14 | 2007-09-18 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
| AU2001268296B2 (en) * | 2000-06-08 | 2006-05-25 | Miami University | Fatty acid elongase 3-ketoacyl coa synthase polypeptides |
| US20040010817A1 (en) * | 2000-07-21 | 2004-01-15 | Washington State University Research Foundation | Plant acyl-CoA synthetases |
| EP1911837B1 (en) * | 2000-09-28 | 2011-05-25 | Bioriginal Food & Science Corp. | FAD5-2 fatty acid desaturase family member and uses thereof |
| TWI377253B (en) * | 2001-04-16 | 2012-11-21 | Martek Biosciences Corp | Product and process for transformation of thraustochytriales microorganisms |
| TWI337619B (en) | 2001-04-16 | 2011-02-21 | Martek Biosciences Corp | Pufa polyketide synthase systems and uses thereof |
| US20040005672A1 (en) * | 2002-02-22 | 2004-01-08 | Santi Daniel V. | Heterologous production of polyketides |
| GB2385852A (en) * | 2002-02-27 | 2003-09-03 | Rothamsted Ex Station | Delta 6-desaturases from Primulaceae |
| EP1487985B1 (en) * | 2002-03-16 | 2011-01-12 | The University Of York | Transgenic plants expressing enzymes involved in fatty acid biosynthesis |
| US20040172682A1 (en) | 2003-02-12 | 2004-09-02 | Kinney Anthony J. | Production of very long chain polyunsaturated fatty acids in oilseed plants |
| CN101389213B (zh) | 2003-03-26 | 2014-05-28 | Dsmip资产公司 | Pufa聚酮化合物合酶系统及其用途 |
| EP1613746B1 (de) | 2003-03-31 | 2013-03-06 | University Of Bristol | Neue pflanzliche acyltransferasen spezifisch für langkettige, mehrfach ungesättigte fettsäuren |
| US7125672B2 (en) * | 2003-05-07 | 2006-10-24 | E. I. Du Pont De Nemours And Company | Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts |
| US7208590B2 (en) * | 2003-07-15 | 2007-04-24 | Abbott Laboratories | Genes involved in polyketide synthase pathways and uses thereof |
| DE102004017370A1 (de) | 2004-04-08 | 2005-10-27 | Nutrinova Nutrition Specialties & Food Ingredients Gmbh | PUFA-PKS Gene aus Ulkenia |
| DE102004060340A1 (de) | 2004-07-16 | 2006-02-09 | Basf Plant Science Gmbh | Verfahren zur Erhöhung des Gehalts an mehrfach ungesättigten langkettigen Fettsäuren in transgenen Organismen |
| AR050881A1 (es) | 2004-09-20 | 2006-11-29 | Basf Plant Science Gmbh | Genes de arabidopsis que codifican proteinas que participan en el metabolismo de azucares y lipidos y metodos de uso |
| WO2006135866A2 (en) * | 2005-06-10 | 2006-12-21 | Martek Biosciences Corporation | Pufa polyketide synthase systems and uses thereof |
| WO2007106905A2 (en) * | 2006-03-15 | 2007-09-20 | Martek Biosciences Corporation | Polyunsaturated fatty acid production in heterologous organisms using pufa polyketide synthase systems |
| US8940884B2 (en) | 2009-03-19 | 2015-01-27 | Dsm Ip Assets B.V. | Polyunsaturated fatty acid synthase nucleic acid molecules and polypeptides, compositions, and methods of making and uses thereof |
-
2007
- 2007-05-16 US US11/749,686 patent/US8003772B2/en not_active Expired - Fee Related
-
2008
- 2008-05-16 CN CN200880024785.9A patent/CN101849014B/zh not_active Expired - Fee Related
- 2008-05-16 MX MX2009012395A patent/MX2009012395A/es active IP Right Grant
- 2008-05-16 BR BRPI0810302-0A patent/BRPI0810302A2/pt not_active IP Right Cessation
- 2008-05-16 CA CA2687523A patent/CA2687523C/en active Active
- 2008-05-16 AU AU2008254837A patent/AU2008254837B2/en not_active Ceased
- 2008-05-16 EP EP08755645.2A patent/EP2160470B1/en active Active
- 2008-05-16 ES ES08755645.2T patent/ES2467918T3/es active Active
- 2008-05-16 JP JP2010508603A patent/JP5551584B2/ja not_active Expired - Fee Related
- 2008-05-16 KR KR1020097026099A patent/KR101539470B1/ko not_active Expired - Fee Related
- 2008-05-16 WO PCT/US2008/063835 patent/WO2008144473A2/en not_active Ceased
-
2009
- 2009-11-15 IL IL202131A patent/IL202131A/en active IP Right Grant
-
2011
- 2011-06-27 US US13/170,011 patent/US8309796B2/en not_active Expired - Fee Related
-
2012
- 2012-10-02 US US13/633,770 patent/US8859855B2/en not_active Expired - Fee Related
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