BRPI0410510A - moléculas de ácido nucléico isolada, gene quimérico, yarrowia sp. transformada, métodos de produção de ácidos y-linolênico, estearidÈnico, eicosatetraenóico, eicosapentaenóico, di-homo-y-linoléico, docosapentaenóico, método de otimização de um gene, métodos de otimização da expressão de um gene e óleo microbiano - Google Patents
moléculas de ácido nucléico isolada, gene quimérico, yarrowia sp. transformada, métodos de produção de ácidos y-linolênico, estearidÈnico, eicosatetraenóico, eicosapentaenóico, di-homo-y-linoléico, docosapentaenóico, método de otimização de um gene, métodos de otimização da expressão de um gene e óleo microbianoInfo
- Publication number
- BRPI0410510A BRPI0410510A BRPI0410510-9A BRPI0410510A BRPI0410510A BR PI0410510 A BRPI0410510 A BR PI0410510A BR PI0410510 A BRPI0410510 A BR PI0410510A BR PI0410510 A BRPI0410510 A BR PI0410510A
- Authority
- BR
- Brazil
- Prior art keywords
- gene
- acid
- linolenic
- methods
- dihomo
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
"MOLéCULAS DE áCIDO NUCLéICO ISOLADA, GENE QUIMéRICO, YARROWIA SP. TRANSFORMADA, MéTODOS DE PRODUçãO DE áCIDOS <sym>-LINOLêNICO, ESTEARIDÈNICO, EICOSATETRAENóICO, EICOSAPENTAENóICO, DI-HOMO-<sym>-LINOLéICO, DOCOSAPENTAENóICO, MéTODO DE OTIMIZAçãO DE UM GENE, MéTODOS DE OTIMIZAçãO DA EXPRESSãO DE UM GENE E óLEO MICROBIANO". A presente invenção refere-se a elongases e dessaturases de ácidos graxos capazes de catalisar a conversão de ácido linoléico (LA) em ácido <sym>-linolênico (GLA); ácido <244>-linoléico (ALA) em ácido estearidónico (STA); GLA em ácido di-homo-<sym>-linoléico (DGLA); STA em ácido eicosatetraenóico (ETA): DGLA em ETA; ácido eicosapentaenóico (EPA) em ácido docosapentaenóico (DPA); e ácido araquidónico (ARA) em EPA. São descritas seqüências de ácidos nucléicos que codificam elongases e dessaturases otimizadas por códons, seqüências de ácidos nucléicos que se hibridizam a elas, construções de DNA que compreendem a elongase ou dessaturase otimizada por códon e microorganismos hospedeiros recombinates que expressam níveis maiores de dessaturase ou elongase.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46871803P | 2003-05-07 | 2003-05-07 | |
US46867703P | 2003-05-07 | 2003-05-07 | |
PCT/US2004/014442 WO2004101753A2 (en) | 2003-05-07 | 2004-05-07 | Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0410510A true BRPI0410510A (pt) | 2006-06-20 |
Family
ID=33457099
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0410510-9A BRPI0410510A (pt) | 2003-05-07 | 2004-05-07 | moléculas de ácido nucléico isolada, gene quimérico, yarrowia sp. transformada, métodos de produção de ácidos y-linolênico, estearidÈnico, eicosatetraenóico, eicosapentaenóico, di-homo-y-linoléico, docosapentaenóico, método de otimização de um gene, métodos de otimização da expressão de um gene e óleo microbiano |
Country Status (8)
Country | Link |
---|---|
US (4) | US7125672B2 (pt) |
EP (1) | EP1620542A4 (pt) |
JP (1) | JP2007504838A (pt) |
KR (1) | KR20060018833A (pt) |
BR (1) | BRPI0410510A (pt) |
CA (1) | CA2522692A1 (pt) |
NO (1) | NO20055785L (pt) |
WO (1) | WO2004101753A2 (pt) |
Families Citing this family (74)
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EP1756280B2 (en) | 2004-04-22 | 2024-01-17 | Commonwealth Scientific and Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
CN102559364B (zh) | 2004-04-22 | 2016-08-17 | 联邦科学技术研究组织 | 用重组细胞合成长链多不饱和脂肪酸 |
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-
2004
- 2004-05-06 US US10/840,478 patent/US7125672B2/en not_active Expired - Fee Related
- 2004-05-07 EP EP04751708A patent/EP1620542A4/en not_active Withdrawn
- 2004-05-07 BR BRPI0410510-9A patent/BRPI0410510A/pt not_active Application Discontinuation
- 2004-05-07 WO PCT/US2004/014442 patent/WO2004101753A2/en not_active Application Discontinuation
- 2004-05-07 KR KR1020057021009A patent/KR20060018833A/ko not_active Application Discontinuation
- 2004-05-07 CA CA002522692A patent/CA2522692A1/en not_active Abandoned
- 2004-05-07 JP JP2006532884A patent/JP2007504838A/ja active Pending
-
2005
- 2005-12-06 NO NO20055785A patent/NO20055785L/no not_active Application Discontinuation
-
2006
- 2006-08-04 US US11/499,549 patent/US7335476B2/en not_active Expired - Fee Related
- 2006-08-04 US US11/499,266 patent/US7511128B2/en not_active Expired - Fee Related
-
2008
- 2008-01-23 US US12/018,222 patent/US7838651B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
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US20040253621A1 (en) | 2004-12-16 |
US7511128B2 (en) | 2009-03-31 |
US20060270010A1 (en) | 2006-11-30 |
NO20055785L (no) | 2006-02-07 |
EP1620542A4 (en) | 2007-02-14 |
US20080154027A1 (en) | 2008-06-26 |
KR20060018833A (ko) | 2006-03-02 |
NO20055785D0 (no) | 2005-12-06 |
WO2004101753A2 (en) | 2004-11-25 |
CA2522692A1 (en) | 2004-11-25 |
US7335476B2 (en) | 2008-02-26 |
US20070004016A1 (en) | 2007-01-04 |
EP1620542A2 (en) | 2006-02-01 |
US7838651B2 (en) | 2010-11-23 |
WO2004101753A3 (en) | 2006-02-02 |
JP2007504838A (ja) | 2007-03-08 |
US7125672B2 (en) | 2006-10-24 |
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