JP2012521195A5 - - Google Patents
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- JP2012521195A5 JP2012521195A5 JP2012501000A JP2012501000A JP2012521195A5 JP 2012521195 A5 JP2012521195 A5 JP 2012521195A5 JP 2012501000 A JP2012501000 A JP 2012501000A JP 2012501000 A JP2012501000 A JP 2012501000A JP 2012521195 A5 JP2012521195 A5 JP 2012521195A5
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- Prior art keywords
- nucleic acid
- polypeptide
- activity
- acid molecule
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920001184 polypeptide Polymers 0.000 claims description 235
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 235
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 235
- 102000039446 nucleic acids Human genes 0.000 claims description 223
- 108020004707 nucleic acids Proteins 0.000 claims description 223
- 150000007523 nucleic acids Chemical class 0.000 claims description 223
- 230000000694 effects Effects 0.000 claims description 217
- 102000040430 polynucleotide Human genes 0.000 claims description 146
- 108091033319 polynucleotide Proteins 0.000 claims description 146
- 239000002157 polynucleotide Substances 0.000 claims description 146
- 210000004027 cell Anatomy 0.000 claims description 89
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 claims description 59
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims description 40
- 101710198510 Enoyl-[acyl-carrier-protein] reductase [NADH] Proteins 0.000 claims description 28
- 150000002632 lipids Chemical class 0.000 claims description 25
- 230000000813 microbial effect Effects 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 23
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims description 22
- 229940090949 docosahexaenoic acid Drugs 0.000 claims description 20
- 238000004519 manufacturing process Methods 0.000 claims description 17
- 108090000623 proteins and genes Proteins 0.000 claims description 17
- 210000004102 animal cell Anatomy 0.000 claims description 13
- 230000000295 complement effect Effects 0.000 claims description 6
- 241000894006 Bacteria Species 0.000 claims description 3
- 241000233866 Fungi Species 0.000 claims description 3
- 241000233671 Schizochytrium Species 0.000 claims description 3
- 230000004927 fusion Effects 0.000 claims description 3
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 claims description 3
- DVSZKTAMJJTWFG-SKCDLICFSA-N (2e,4e,6e,8e,10e,12e)-docosa-2,4,6,8,10,12-hexaenoic acid Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C=C\C=C\C(O)=O DVSZKTAMJJTWFG-SKCDLICFSA-N 0.000 claims description 2
- GZJLLYHBALOKEX-UHFFFAOYSA-N 6-Ketone, O18-Me-Ussuriedine Natural products CC=CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O GZJLLYHBALOKEX-UHFFFAOYSA-N 0.000 claims description 2
- 241001467333 Thraustochytriaceae Species 0.000 claims description 2
- 241000233675 Thraustochytrium Species 0.000 claims description 2
- KAUVQQXNCKESLC-UHFFFAOYSA-N docosahexaenoic acid (DHA) Natural products COC(=O)C(C)NOCC1=CC=CC=C1 KAUVQQXNCKESLC-UHFFFAOYSA-N 0.000 claims description 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 14
- 238000002955 isolation Methods 0.000 claims 1
- 150000001413 amino acids Chemical group 0.000 description 100
- 108010019608 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase Proteins 0.000 description 27
- 102100037149 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial Human genes 0.000 description 27
- 101710146995 Acyl carrier protein Proteins 0.000 description 20
- 101001110310 Lentilactobacillus kefiri NADP-dependent (R)-specific alcohol dehydrogenase Proteins 0.000 description 15
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 description 9
- 235000020673 eicosapentaenoic acid Nutrition 0.000 description 9
- 229960005135 eicosapentaenoic acid Drugs 0.000 description 9
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 description 9
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 6
- 241000256111 Aedes <genus> Species 0.000 description 2
- 108090000992 Transferases Proteins 0.000 description 2
- 102000004357 Transferases Human genes 0.000 description 2
- 125000002252 acyl group Chemical group 0.000 description 2
- 108700037654 Acyl carrier protein (ACP) Proteins 0.000 description 1
- 102000048456 Acyl carrier protein (ACP) Human genes 0.000 description 1
- LTYOQGRJFJAKNA-KKIMTKSISA-N Malonyl CoA Natural products S(C(=O)CC(=O)O)CCNC(=O)CCNC(=O)[C@@H](O)C(CO[P@](=O)(O[P@](=O)(OC[C@H]1[C@@H](OP(=O)(O)O)[C@@H](O)[C@@H](n2c3ncnc(N)c3nc2)O1)O)O)(C)C LTYOQGRJFJAKNA-KKIMTKSISA-N 0.000 description 1
- LTYOQGRJFJAKNA-DVVLENMVSA-N malonyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 LTYOQGRJFJAKNA-DVVLENMVSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16174209P | 2009-03-19 | 2009-03-19 | |
| US61/161,742 | 2009-03-19 | ||
| US29646010P | 2010-01-19 | 2010-01-19 | |
| US61/296,460 | 2010-01-19 | ||
| PCT/US2010/028009 WO2010108114A2 (en) | 2009-03-19 | 2010-03-19 | Polyunsaturated fatty acid synthase nucleic acid molecules and polypeptides, compositions, and methods of making and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015156630A Division JP6432867B2 (ja) | 2009-03-19 | 2015-08-07 | 多価不飽和脂肪酸シンターゼの核酸分子およびポリペプチド、組成物、ならびにそれらの作製方法および使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012521195A JP2012521195A (ja) | 2012-09-13 |
| JP2012521195A5 true JP2012521195A5 (https=) | 2013-05-09 |
Family
ID=42740260
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012501000A Withdrawn JP2012521195A (ja) | 2009-03-19 | 2010-03-19 | 多価不飽和脂肪酸シンターゼの核酸分子およびポリペプチド、組成物、ならびにそれらの作製方法および使用 |
| JP2015156630A Active JP6432867B2 (ja) | 2009-03-19 | 2015-08-07 | 多価不飽和脂肪酸シンターゼの核酸分子およびポリペプチド、組成物、ならびにそれらの作製方法および使用 |
| JP2017179405A Expired - Fee Related JP6659044B2 (ja) | 2009-03-19 | 2017-09-19 | 多価不飽和脂肪酸シンターゼの核酸分子およびポリペプチド、組成物、ならびにそれらの作製方法および使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015156630A Active JP6432867B2 (ja) | 2009-03-19 | 2015-08-07 | 多価不飽和脂肪酸シンターゼの核酸分子およびポリペプチド、組成物、ならびにそれらの作製方法および使用 |
| JP2017179405A Expired - Fee Related JP6659044B2 (ja) | 2009-03-19 | 2017-09-19 | 多価不飽和脂肪酸シンターゼの核酸分子およびポリペプチド、組成物、ならびにそれらの作製方法および使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US8940884B2 (https=) |
| EP (2) | EP3192871B1 (https=) |
| JP (3) | JP2012521195A (https=) |
| CN (1) | CN102741267B (https=) |
| AR (1) | AR075897A1 (https=) |
| AU (1) | AU2010226440B2 (https=) |
| BR (1) | BRPI1006435B1 (https=) |
| CA (2) | CA2755639C (https=) |
| ES (2) | ES2717102T3 (https=) |
| TW (1) | TWI600762B (https=) |
| WO (1) | WO2010108114A2 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8003772B2 (en) | 1999-01-14 | 2011-08-23 | Martek Biosciences Corporation | Chimeric PUFA polyketide synthase systems and uses thereof |
| KR20070073986A (ko) | 2000-01-28 | 2007-07-10 | 마텍 바이오싸이언스스 코포레이션 | 발효기 내에서 진핵 미생물의 고밀도 배양에 의한고도불포화 지방산을 함유하는 지질의 증진된 생산 방법 |
| WO2005120174A2 (en) * | 2004-05-24 | 2005-12-22 | Interactive Research Institute For Health Affairs | Omega-3 fatty acid compositions with honey |
| US8207363B2 (en) | 2009-03-19 | 2012-06-26 | Martek Biosciences Corporation | Thraustochytrids, fatty acid compositions, and methods of making and uses thereof |
| US8940884B2 (en) | 2009-03-19 | 2015-01-27 | Dsm Ip Assets B.V. | Polyunsaturated fatty acid synthase nucleic acid molecules and polypeptides, compositions, and methods of making and uses thereof |
| US9924733B2 (en) | 2010-01-19 | 2018-03-27 | Dsm Ip Assets B.V. | Eicosapentaenoic acid-producing microorganisms, fatty acid compositions, and methods of making and uses thereof |
| TW201144442A (en) * | 2010-05-17 | 2011-12-16 | Dow Agrosciences Llc | Production of DHA and other LC-PUFAs in plants |
| PT2683824T (pt) | 2011-03-07 | 2018-06-07 | Dsm Nutritional Products Ag | Modificação de microorganismos thraustochytrid |
| AU2015252107B2 (en) * | 2011-03-07 | 2018-01-18 | Dsm Nutritional Products Ag | Engineering thraustochytrid microorganisms |
| AU2012285806B2 (en) | 2011-07-21 | 2017-09-14 | Dsm Ip Assets B.V. | Fatty acid compositions |
| US20140323569A1 (en) * | 2011-07-21 | 2014-10-30 | Krishna Raman | Microbial oils enriched in polyunsaturated fatty acids |
| TW201525136A (zh) | 2013-11-26 | 2015-07-01 | Dow Agrosciences Llc | 利用破囊壺菌ＰＵＦＡ合成酶於油籽作物中生成ω－３長鏈多不飽和脂肪酸 |
| ES2721269T3 (es) | 2014-01-28 | 2019-07-30 | Dsm Ip Assets Bv | Factores para la producción y acumulación de ácidos grasos poliinsaturados (PUFA) obtenidos con PUFA sintasas |
| AU2016228545A1 (en) * | 2015-03-12 | 2017-09-21 | Synthetic Genomics. Inc. | Microorganisms for fatty acid production using elongase and desaturase enzymes |
| CN107846857B (zh) | 2015-06-06 | 2021-07-02 | 帝斯曼知识产权资产管理有限公司 | 使用新模块二十二碳六烯酸(dha)合酶生成多不饱和脂肪酸(pufas) |
| PL3455351T3 (pl) * | 2016-05-12 | 2022-11-21 | Dsm Ip Assets B.V. | Sposób zwiększania wytwarzania wielonienasyconych kwasów tłuszczowych omega-3 w mikroalgach |
| KR102319845B1 (ko) | 2016-07-13 | 2021-11-01 | 디에스엠 아이피 어셋츠 비.브이. | 조류 숙주 세포에 대한 crispr-cas 시스템 |
| US11248244B2 (en) | 2017-05-10 | 2022-02-15 | Nanjing University Of Technology | Schizochytrium limacinum strain, building method therefor and application thereof |
| WO2018219171A1 (zh) * | 2017-05-31 | 2018-12-06 | 厦门汇盛生物有限公司 | 一株生产dha和epa的细菌、该细菌基因组中的6个基因片段及它们的应用 |
| CN107384806A (zh) * | 2017-08-28 | 2017-11-24 | 厦门大学 | 一种基于同源重组的裂殖壶菌基因表达系统的构建及应用 |
| BR112021002300A2 (pt) | 2018-08-10 | 2021-05-04 | Kyowa Hakko Bio Co., Ltd | microrganismo que produz ácido eicosapentaenoico e método para a produção de ácido eicosapentaenoico |
| US20250129395A1 (en) | 2022-01-25 | 2025-04-24 | Dsm Ip Assets B.V. | Media refinement and nutrient feeding approaches to increase polyunsaturated fatty acid production |
| WO2025238190A1 (en) | 2024-05-15 | 2025-11-20 | Dsm Ip Assets B.V. | Spray-dried powders having high pufa content |
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