JP2012521195A5 - - Google Patents
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- JP2012521195A5 JP2012521195A5 JP2012501000A JP2012501000A JP2012521195A5 JP 2012521195 A5 JP2012521195 A5 JP 2012521195A5 JP 2012501000 A JP2012501000 A JP 2012501000A JP 2012501000 A JP2012501000 A JP 2012501000A JP 2012521195 A5 JP2012521195 A5 JP 2012521195A5
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- Prior art keywords
- nucleic acid
- polypeptide
- activity
- acid molecule
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920001184 polypeptide Polymers 0.000 claims description 235
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 235
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 235
- 102000039446 nucleic acids Human genes 0.000 claims description 223
- 108020004707 nucleic acids Proteins 0.000 claims description 223
- 150000007523 nucleic acids Chemical class 0.000 claims description 223
- 230000000694 effects Effects 0.000 claims description 217
- 102000040430 polynucleotide Human genes 0.000 claims description 146
- 108091033319 polynucleotide Proteins 0.000 claims description 146
- 239000002157 polynucleotide Substances 0.000 claims description 146
- 210000004027 cell Anatomy 0.000 claims description 89
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 claims description 59
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims description 40
- 101710198510 Enoyl-[acyl-carrier-protein] reductase [NADH] Proteins 0.000 claims description 28
- 150000002632 lipids Chemical class 0.000 claims description 25
- 230000000813 microbial effect Effects 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 23
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims description 22
- 229940090949 docosahexaenoic acid Drugs 0.000 claims description 20
- 238000004519 manufacturing process Methods 0.000 claims description 17
- 108090000623 proteins and genes Proteins 0.000 claims description 17
- 210000004102 animal cell Anatomy 0.000 claims description 13
- 230000000295 complement effect Effects 0.000 claims description 6
- 241000894006 Bacteria Species 0.000 claims description 3
- 241000233866 Fungi Species 0.000 claims description 3
- 241000233671 Schizochytrium Species 0.000 claims description 3
- 230000004927 fusion Effects 0.000 claims description 3
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 claims description 3
- DVSZKTAMJJTWFG-SKCDLICFSA-N (2e,4e,6e,8e,10e,12e)-docosa-2,4,6,8,10,12-hexaenoic acid Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C=C\C=C\C(O)=O DVSZKTAMJJTWFG-SKCDLICFSA-N 0.000 claims description 2
- GZJLLYHBALOKEX-UHFFFAOYSA-N 6-Ketone, O18-Me-Ussuriedine Natural products CC=CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O GZJLLYHBALOKEX-UHFFFAOYSA-N 0.000 claims description 2
- 241001467333 Thraustochytriaceae Species 0.000 claims description 2
- 241000233675 Thraustochytrium Species 0.000 claims description 2
- KAUVQQXNCKESLC-UHFFFAOYSA-N docosahexaenoic acid (DHA) Natural products COC(=O)C(C)NOCC1=CC=CC=C1 KAUVQQXNCKESLC-UHFFFAOYSA-N 0.000 claims description 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 14
- 238000002955 isolation Methods 0.000 claims 1
- 150000001413 amino acids Chemical group 0.000 description 100
- 108010019608 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase Proteins 0.000 description 27
- 102100037149 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial Human genes 0.000 description 27
- 101710146995 Acyl carrier protein Proteins 0.000 description 20
- 101001110310 Lentilactobacillus kefiri NADP-dependent (R)-specific alcohol dehydrogenase Proteins 0.000 description 15
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 description 9
- 235000020673 eicosapentaenoic acid Nutrition 0.000 description 9
- 229960005135 eicosapentaenoic acid Drugs 0.000 description 9
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 description 9
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 6
- 241000256111 Aedes <genus> Species 0.000 description 2
- 108090000992 Transferases Proteins 0.000 description 2
- 102000004357 Transferases Human genes 0.000 description 2
- 125000002252 acyl group Chemical group 0.000 description 2
- 108700037654 Acyl carrier protein (ACP) Proteins 0.000 description 1
- 102000048456 Acyl carrier protein (ACP) Human genes 0.000 description 1
- LTYOQGRJFJAKNA-KKIMTKSISA-N Malonyl CoA Natural products S(C(=O)CC(=O)O)CCNC(=O)CCNC(=O)[C@@H](O)C(CO[P@](=O)(O[P@](=O)(OC[C@H]1[C@@H](OP(=O)(O)O)[C@@H](O)[C@@H](n2c3ncnc(N)c3nc2)O1)O)O)(C)C LTYOQGRJFJAKNA-KKIMTKSISA-N 0.000 description 1
- LTYOQGRJFJAKNA-DVVLENMVSA-N malonyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 LTYOQGRJFJAKNA-DVVLENMVSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16174209P | 2009-03-19 | 2009-03-19 | |
| US61/161,742 | 2009-03-19 | ||
| US29646010P | 2010-01-19 | 2010-01-19 | |
| US61/296,460 | 2010-01-19 | ||
| PCT/US2010/028009 WO2010108114A2 (en) | 2009-03-19 | 2010-03-19 | Polyunsaturated fatty acid synthase nucleic acid molecules and polypeptides, compositions, and methods of making and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015156630A Division JP6432867B2 (ja) | 2009-03-19 | 2015-08-07 | 多価不飽和脂肪酸シンターゼの核酸分子およびポリペプチド、組成物、ならびにそれらの作製方法および使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012521195A JP2012521195A (ja) | 2012-09-13 |
| JP2012521195A5 true JP2012521195A5 (https=) | 2013-05-09 |
Family
ID=42740260
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012501000A Withdrawn JP2012521195A (ja) | 2009-03-19 | 2010-03-19 | 多価不飽和脂肪酸シンターゼの核酸分子およびポリペプチド、組成物、ならびにそれらの作製方法および使用 |
| JP2015156630A Active JP6432867B2 (ja) | 2009-03-19 | 2015-08-07 | 多価不飽和脂肪酸シンターゼの核酸分子およびポリペプチド、組成物、ならびにそれらの作製方法および使用 |
| JP2017179405A Expired - Fee Related JP6659044B2 (ja) | 2009-03-19 | 2017-09-19 | 多価不飽和脂肪酸シンターゼの核酸分子およびポリペプチド、組成物、ならびにそれらの作製方法および使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015156630A Active JP6432867B2 (ja) | 2009-03-19 | 2015-08-07 | 多価不飽和脂肪酸シンターゼの核酸分子およびポリペプチド、組成物、ならびにそれらの作製方法および使用 |
| JP2017179405A Expired - Fee Related JP6659044B2 (ja) | 2009-03-19 | 2017-09-19 | 多価不飽和脂肪酸シンターゼの核酸分子およびポリペプチド、組成物、ならびにそれらの作製方法および使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US8940884B2 (https=) |
| EP (2) | EP2408797B1 (https=) |
| JP (3) | JP2012521195A (https=) |
| CN (1) | CN102741267B (https=) |
| AR (1) | AR075897A1 (https=) |
| AU (1) | AU2010226440B2 (https=) |
| BR (1) | BRPI1006435B1 (https=) |
| CA (2) | CA3012998C (https=) |
| ES (2) | ES2717102T3 (https=) |
| TW (1) | TWI600762B (https=) |
| WO (1) | WO2010108114A2 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8003772B2 (en) | 1999-01-14 | 2011-08-23 | Martek Biosciences Corporation | Chimeric PUFA polyketide synthase systems and uses thereof |
| EP2960325B1 (en) | 2000-01-28 | 2017-09-27 | DSM IP Assets B.V. | Enhanced production of lipids containing polyenoic fatty acids by high density cultures of eukaryotic microbes in fermentors |
| US20070243304A1 (en) * | 2004-05-24 | 2007-10-18 | Mahabaleshwar Hedge | Omega-3 Fatty Acid Compositions With Honey |
| ES2717102T3 (es) | 2009-03-19 | 2019-06-19 | Dsm Ip Assets Bv | Moléculas de ácido nucleico de ácido graso poliinsaturado sintasas, y polipéptidos, composiciones y métodos de preparación y usos de los mismos |
| US8207363B2 (en) | 2009-03-19 | 2012-06-26 | Martek Biosciences Corporation | Thraustochytrids, fatty acid compositions, and methods of making and uses thereof |
| WO2011090493A1 (en) | 2010-01-19 | 2011-07-28 | Martek Biosciences Corporation | Eicosapentaenoic acid-producing microorganisms, fatty acid compositions, and methods of making and uses thereof |
| TW201144442A (en) * | 2010-05-17 | 2011-12-16 | Dow Agrosciences Llc | Production of DHA and other LC-PUFAs in plants |
| WO2012120375A1 (en) | 2011-03-07 | 2012-09-13 | Ocean Nutrition Canada Limited | Engineering thraustochytrid microorganisms |
| AU2015252107B2 (en) * | 2011-03-07 | 2018-01-18 | Dsm Nutritional Products Ag | Engineering thraustochytrid microorganisms |
| US20140323569A1 (en) * | 2011-07-21 | 2014-10-30 | Krishna Raman | Microbial oils enriched in polyunsaturated fatty acids |
| HK1198515A1 (en) * | 2011-07-21 | 2015-05-15 | Dsm Ip Assets B.V. | Fatty acid compositions |
| TW201525136A (zh) * | 2013-11-26 | 2015-07-01 | Dow Agrosciences Llc | 利用破囊壺菌ＰＵＦＡ合成酶於油籽作物中生成ω－３長鏈多不飽和脂肪酸 |
| ES2721269T3 (es) | 2014-01-28 | 2019-07-30 | Dsm Ip Assets Bv | Factores para la producción y acumulación de ácidos grasos poliinsaturados (PUFA) obtenidos con PUFA sintasas |
| AU2016228545A1 (en) * | 2015-03-12 | 2017-09-21 | Synthetic Genomics. Inc. | Microorganisms for fatty acid production using elongase and desaturase enzymes |
| PL3302032T3 (pl) | 2015-06-06 | 2022-06-20 | Dsm Ip Assets B.V. | Wytwarzanie wielonienasyconych kwasów tłuszczowych (PUFA) z zastosowaniem nowej, modularnej syntazy kwasu dokozaheksaenowego (DHA) |
| CN109477079A (zh) * | 2016-05-12 | 2019-03-15 | 帝斯曼知识产权资产管理有限公司 | 增加微藻中ω-3多不饱和脂肪酸产量的方法 |
| BR112019000430A2 (pt) | 2016-07-13 | 2019-07-09 | Dsm Ip Assets Bv | sistema crispr-cas para uma célula hospedeira de algas |
| WO2018205165A1 (zh) * | 2017-05-10 | 2018-11-15 | 南京工业大学 | 一株裂殖壶菌菌株、其构建方法及应用 |
| EP3628679B1 (en) * | 2017-05-31 | 2024-07-17 | Xiamen Huison Biotech Co., Ltd. | Bacterium producing dha and epa, 6 gene fragments of genome of bacterium and use thereof |
| CN107384806A (zh) * | 2017-08-28 | 2017-11-24 | 厦门大学 | 一种基于同源重组的裂殖壶菌基因表达系统的构建及应用 |
| US11613728B2 (en) | 2018-08-10 | 2023-03-28 | Kyowa Hakko Bio Co., Ltd. | Microorganism producing eicosapentaenoic acid and method for producing eicosapentaenoic acid |
| WO2023144707A1 (en) | 2022-01-25 | 2023-08-03 | Dsm Ip Assets B.V. | Media refinement and nutrient feeding approaches to increase polyunsaturated fatty acid production |
| WO2025238190A1 (en) | 2024-05-15 | 2025-11-20 | Dsm Ip Assets B.V. | Spray-dried powders having high pufa content |
Family Cites Families (101)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4762785A (en) | 1982-08-12 | 1988-08-09 | Calgene, Inc. | Novel method and compositions for introducting alien DNA in vivo |
| EP0320500B1 (en) | 1983-01-13 | 2004-11-17 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Non-oncogenic ti plasmid vector system and recombinant DNA molecules for the introduction of expressible genes into plant cell genomes |
| US6051757A (en) | 1983-01-14 | 2000-04-18 | Washington University | Regeneration of plants containing genetically engineered T-DNA |
| EP0131624B1 (en) | 1983-01-17 | 1992-09-16 | Monsanto Company | Plasmids for transforming plant cells |
| NL8300699A (nl) | 1983-02-24 | 1984-09-17 | Univ Leiden | Werkwijze voor het inbouwen van vreemd dna in het genoom van tweezaadlobbige planten; werkwijze voor het produceren van agrobacterium tumefaciens bacterien; stabiele cointegraat plasmiden; planten en plantecellen met gewijzigde genetische eigenschappen; werkwijze voor het bereiden van chemische en/of farmaceutische produkten. |
| NL8300698A (nl) | 1983-02-24 | 1984-09-17 | Univ Leiden | Werkwijze voor het inbouwen van vreemd dna in het genoom van tweezaadlobbige planten; agrobacterium tumefaciens bacterien en werkwijze voor het produceren daarvan; planten en plantecellen met gewijzigde genetische eigenschappen; werkwijze voor het bereiden van chemische en/of farmaceutische produkten. |
| GB8317248D0 (en) | 1983-06-24 | 1983-07-27 | Wyeth John & Brother Ltd | Fat compositions |
| NL8401048A (nl) | 1984-04-03 | 1985-11-01 | Rijksuniversiteit Leiden En Pr | Werkwijze voor het inbouwen van vreemd dna in het genoom van eenzaadlobbige planten. |
| US5231019A (en) | 1984-05-11 | 1993-07-27 | Ciba-Geigy Corporation | Transformation of hereditary material of plants |
| NL8401780A (nl) | 1984-06-04 | 1986-01-02 | Rijksuniversiteit Leiden En Pr | Werkwijze voor het inbouwen van vreemd dna in het genoom van planten. |
| US5149645A (en) | 1984-06-04 | 1992-09-22 | Rijksuniversiteit Leiden | Process for introducing foreign DNA into the genome of plants |
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US5569597A (en) | 1985-05-13 | 1996-10-29 | Ciba Geigy Corp. | Methods of inserting viral DNA into plant material |
| AU7360087A (en) | 1986-04-30 | 1987-11-24 | Boyce Thompson Institute For Plant Research Inc. | Electric field mediated dna transformation of plant cells and organelles |
| US5188958A (en) | 1986-05-29 | 1993-02-23 | Calgene, Inc. | Transformation and foreign gene expression in brassica species |
| US5177010A (en) | 1986-06-30 | 1993-01-05 | University Of Toledo | Process for transforming corn and the products thereof |
| EP0267159A3 (de) | 1986-11-07 | 1990-05-02 | Ciba-Geigy Ag | Verfahren zur genetischen Modifikation monokotyler Pflanzen |
| SE455438B (sv) | 1986-11-24 | 1988-07-11 | Aga Ab | Sett att senka en brennares flamtemperatur samt brennare med munstycken for oxygen resp brensle |
| US5004863B2 (en) | 1986-12-03 | 2000-10-17 | Agracetus | Genetic engineering of cotton plants and lines |
| US5015580A (en) | 1987-07-29 | 1991-05-14 | Agracetus | Particle-mediated transformation of soybean plants and lines |
| US5246841A (en) * | 1986-12-26 | 1993-09-21 | Sagami Chemical Research Center | Microbial process for production of eicosapentaenoic acid |
| ES2074999T3 (es) | 1987-05-20 | 1995-10-01 | Ciba Geigy Ag | Plantas de zea mays y plantas de zea mays transgenicas regeneradas de protoplastos o celulas derivadas de protoplastos. |
| US5316931A (en) | 1988-02-26 | 1994-05-31 | Biosource Genetics Corp. | Plant viral vectors having heterologous subgenomic promoters for systemic expression of foreign genes |
| US5130242A (en) * | 1988-09-07 | 1992-07-14 | Phycotech, Inc. | Process for the heterotrophic production of microbial products with high concentrations of omega-3 highly unsaturated fatty acids |
| US5340742A (en) * | 1988-09-07 | 1994-08-23 | Omegatech Inc. | Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids |
| US5693507A (en) | 1988-09-26 | 1997-12-02 | Auburn University | Genetic engineering of plant chloroplasts |
| US5302523A (en) | 1989-06-21 | 1994-04-12 | Zeneca Limited | Transformation of plant cells |
| US5322783A (en) | 1989-10-17 | 1994-06-21 | Pioneer Hi-Bred International, Inc. | Soybean transformation by microparticle bombardment |
| US5451513A (en) | 1990-05-01 | 1995-09-19 | The State University of New Jersey Rutgers | Method for stably transforming plastids of multicellular plants |
| ES2260886T3 (es) | 1990-11-23 | 2006-11-01 | Bayer Bioscience N.V. | Procedimiento para transformar plantas monocotiledoneas. |
| US5601860A (en) | 1990-11-30 | 1997-02-11 | American Home Products Corporation | Corandomized fat compositions for infant formulas |
| US5141141A (en) | 1990-12-21 | 1992-08-25 | Nanette Leone | Bag for use on the body |
| US5384253A (en) | 1990-12-28 | 1995-01-24 | Dekalb Genetics Corporation | Genetic transformation of maize cells by electroporation of cells pretreated with pectin degrading enzymes |
| US5639790A (en) * | 1991-05-21 | 1997-06-17 | Calgene, Inc. | Plant medium-chain thioesterases |
| CA2124673C (en) | 1991-12-04 | 2008-08-05 | John Browse | Fatty acid desaturase genes from plants |
| JPH07505531A (ja) | 1992-04-15 | 1995-06-22 | プラント・ジェネティック・システムズ・エヌ・ブイ | 単子葉植物細胞の形質転換法 |
| US5683898A (en) * | 1992-05-15 | 1997-11-04 | Sagami Chemical Research Center | Gene coding for eicosapentaenoic acid synthesizing enzymes and process for production of eicosapentaenoic acid |
| AU673359B2 (en) | 1992-05-15 | 1996-11-07 | Sagami Chemical Research Center | Gene which codes for eicosapentaenoic acid synthetase group and process for producing eicosapentaenoic acid |
| US5798259A (en) * | 1992-05-15 | 1998-08-25 | Sagami Chemical Research Center | Gene coding for eicosapentaenoic acid synthesizing enzymes and process for production of eicosapentaenoic acid |
| ATE398679T1 (de) | 1992-07-07 | 2008-07-15 | Japan Tobacco Inc | Verfahren zur transformation einer monokotyledon pflanze |
| US6372965B1 (en) | 1992-11-17 | 2002-04-16 | E.I. Du Pont De Nemours And Company | Genes for microsomal delta-12 fatty acid desaturases and hydroxylases from plants |
| US5469976A (en) | 1993-04-30 | 1995-11-28 | Burchell; James R. | Shelf allocation and management system |
| DE69404385T2 (de) | 1993-06-04 | 1998-02-19 | Cavis Srl | Trägheitsschalter zur Ausschaltung der Batterie eines Kraftfahrzeuges |
| DE4323727A1 (de) * | 1993-07-15 | 1995-03-09 | Boehringer Mannheim Gmbh | Verfahren zur Identifizierung von menschlichen und tierischen Zellen mit der Fähigkeit zu unbegrenzter Proliferation oder zur Tumorbildung |
| US5672491A (en) * | 1993-09-20 | 1997-09-30 | The Leland Stanford Junior University | Recombinant production of novel polyketides |
| EP0831149A4 (en) | 1995-01-13 | 2000-12-06 | Sagami Chem Res | GENES CODING FOR THE GROUP OF ENZYMES FOR BIOSYNTHESIS OF EICOSAPENTIC ACID AND METHOD FOR PRODUCING EICOSAPENTIC ACID |
| US5659026A (en) | 1995-03-24 | 1997-08-19 | Pioneer Hi-Bred International | ALS3 promoter |
| AU5346296A (en) | 1995-04-17 | 1996-11-07 | Japan As Represented By Director-General Of Agency Of Industrial Science And Technology | Novel microorganisms capable of producing highly unsaturated fatty acids and process for producing highly unsaturated fa tty acids by using the microorganisms |
| EP0861021B1 (en) | 1995-10-13 | 2009-09-23 | Dow Agrosciences LLC | Modified bacillus thuringiensis gene for lepidopteran control in plants |
| AR006830A1 (es) | 1996-04-26 | 1999-09-29 | Du Pont | Aceite de soja con alta estabilidad oxidativa |
| AU727694B2 (en) | 1996-07-10 | 2000-12-21 | Sagami Chemical Research Center | Process for producing icosapentaenoic acid by genetic recombination |
| US6033883A (en) * | 1996-12-18 | 2000-03-07 | Kosan Biosciences, Inc. | Production of polyketides in bacteria and yeast |
| WO1998044917A1 (en) | 1997-03-27 | 1998-10-15 | Bristol-Myers Squibb Company | Use of docosahexanoic acid and arachidonic acid enhancing the growth of preterm infants |
| SA98190002B1 (ar) | 1997-03-28 | 2006-06-20 | ذي يونيفيرسيتي اوف تننيسي ريسيرش كوربوريشن | استخدام أحماض دهنية تحتوي على عدة روابط غير مشبعة polyunsaturated fatty acids لتقليل حدوث الالتهاب المعوي القولوني الناخر incidence of necrotizing enterocolitis |
| NZ337459A (en) | 1997-04-11 | 2000-07-28 | Abbott Lab | Nucleic acid construct in plants and dietary supplement |
| US6432684B1 (en) | 1997-04-11 | 2002-08-13 | Abbott Laboratories | Human desaturase gene and uses thereof |
| US6051754A (en) | 1997-04-11 | 2000-04-18 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants |
| BR9809946A (pt) | 1997-06-04 | 2000-08-01 | Calgene Llc | Produção de ácidos graxos poliinsaturados por expressão de genes de sìntese semelhantes a policetìdeo em plantas |
| US6566583B1 (en) * | 1997-06-04 | 2003-05-20 | Daniel Facciotti | Schizochytrium PKS genes |
| US6013665A (en) | 1997-12-16 | 2000-01-11 | Abbott Laboratories | Method for enhancing the absorption and transport of lipid soluble compounds using structured glycerides |
| US6677145B2 (en) * | 1998-09-02 | 2004-01-13 | Abbott Laboratories | Elongase genes and uses thereof |
| US7271315B2 (en) * | 1999-01-14 | 2007-09-18 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
| US7211418B2 (en) * | 1999-01-14 | 2007-05-01 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
| US20070244192A1 (en) * | 1999-01-14 | 2007-10-18 | Martek Biosciences Corporation | Plant seed oils containing polyunsaturated fatty acids |
| US7217856B2 (en) * | 1999-01-14 | 2007-05-15 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
| US7247461B2 (en) * | 1999-01-14 | 2007-07-24 | Martek Biosciences Corporation | Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof |
| US8003772B2 (en) | 1999-01-14 | 2011-08-23 | Martek Biosciences Corporation | Chimeric PUFA polyketide synthase systems and uses thereof |
| WO2001094565A2 (en) * | 2000-06-08 | 2001-12-13 | Miami University | FATTY ACID ELONGASE 3-KETOACYL CoA SYNTHASE POLYPEPTIDES |
| US20040010817A1 (en) * | 2000-07-21 | 2004-01-15 | Washington State University Research Foundation | Plant acyl-CoA synthetases |
| CN101845446B (zh) * | 2000-09-28 | 2016-01-20 | 生物源食物及科学公司 | 脂肪酸去饱和酶家族成员fad4、fad5、fad5-2和fad6及它们的应用 |
| TWI324181B (en) * | 2001-04-16 | 2010-05-01 | Martek Biosciences Corp | Product and process for transformation of thraustochytriales microorganisms |
| TWI426126B (zh) * | 2001-04-16 | 2014-02-11 | Dsm Ip Assets Bv | 多不飽和脂肪酸（ｐｕｆａ）聚乙醯合成酶系統及其用途（二） |
| EP1390507A2 (en) | 2001-05-21 | 2004-02-25 | Ecopia Biosciences Inc. | Genes and proteins involved in the biosynthesis of enediyne ring structures |
| US20040005672A1 (en) * | 2002-02-22 | 2004-01-08 | Santi Daniel V. | Heterologous production of polyketides |
| GB2385852A (en) * | 2002-02-27 | 2003-09-03 | Rothamsted Ex Station | Delta 6-desaturases from Primulaceae |
| AU2003224236A1 (en) * | 2002-03-16 | 2003-09-29 | The University Of York | Transgenic plants expressing enzymes involved in fatty acid biosynthesis |
| US20040172682A1 (en) | 2003-02-12 | 2004-09-02 | Kinney Anthony J. | Production of very long chain polyunsaturated fatty acids in oilseed plants |
| KR101234199B1 (ko) | 2003-03-26 | 2013-02-20 | 마텍 바이오싸이언스스 코포레이션 | Ｐｕｆａ 폴리케타이드 신타제 시스템 및 이의 용도 |
| EP1613746B1 (de) | 2003-03-31 | 2013-03-06 | University Of Bristol | Neue pflanzliche acyltransferasen spezifisch für langkettige, mehrfach ungesättigte fettsäuren |
| US7125672B2 (en) * | 2003-05-07 | 2006-10-24 | E. I. Du Pont De Nemours And Company | Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts |
| US7208590B2 (en) * | 2003-07-15 | 2007-04-24 | Abbott Laboratories | Genes involved in polyketide synthase pathways and uses thereof |
| AU2005214874B2 (en) | 2004-02-13 | 2010-02-18 | Martek Biosciences Corporation | Schizochytrium fatty acid synthase (FAS) and products and methods related thereto |
| DE102004017370A1 (de) * | 2004-04-08 | 2005-10-27 | Nutrinova Nutrition Specialties & Food Ingredients Gmbh | PUFA-PKS Gene aus Ulkenia |
| DE102004017369A1 (de) * | 2004-04-08 | 2005-11-03 | Nutrinova Nutrition Specialties & Food Ingredients Gmbh | Screeningverfahren zur Identifizierung von PUFA-PKS in Proben |
| US20050255440A1 (en) * | 2004-05-12 | 2005-11-17 | Downing Linda P | System and method of integrating levels of educational programs |
| DE102004060340A1 (de) | 2004-07-16 | 2006-02-09 | Basf Plant Science Gmbh | Verfahren zur Erhöhung des Gehalts an mehrfach ungesättigten langkettigen Fettsäuren in transgenen Organismen |
| EP2348117A1 (en) | 2004-09-20 | 2011-07-27 | BASF Plant Science GmbH | Arabidopsis genes encoding proteins involved in sugar and lipid metabolism and methods of use |
| US7456340B2 (en) | 2005-04-04 | 2008-11-25 | Dow Agrosciences Llc | Canola cultivar NQC02CNX21 |
| US7348473B2 (en) | 2004-09-30 | 2008-03-25 | Dow Agrosciences Llc | Canola cultivar NQC02CNX25 |
| US7355100B2 (en) | 2004-09-30 | 2008-04-08 | Dow Agrosciences Llc | Canola cultivar NQC02CNX12 |
| GB0421937D0 (en) | 2004-10-02 | 2004-11-03 | Univ York | Acyl CoA synthetases |
| AU2006246723A1 (en) | 2005-05-17 | 2006-11-23 | Photon Therapy Systems (Proprietary) Limited | A photon therapy device |
| WO2006135866A2 (en) * | 2005-06-10 | 2006-12-21 | Martek Biosciences Corporation | Pufa polyketide synthase systems and uses thereof |
| WO2007017952A1 (ja) | 2005-08-11 | 2007-02-15 | Fujitsu Limited | 光学素子および光情報記録再生装置 |
| EP1994424B1 (en) | 2006-03-15 | 2012-01-11 | QUALCOMM Incorporated | Global navigation satellite system |
| AU2013251201A1 (en) | 2006-03-15 | 2013-11-21 | Dsm Ip Assets B.V. | Polyunsaturated fatty acid production in heterologous organisms using pufa polyketide synthase systems |
| KR101524398B1 (ko) | 2006-03-15 | 2015-06-04 | 디에스엠 아이피 어셋츠 비.브이. | Ｐｕｆａ 폴리케티드 신타제 시스템을 이용한 이종 생물체내 다불포화 지방산의 제조 |
| ES2717102T3 (es) | 2009-03-19 | 2019-06-19 | Dsm Ip Assets Bv | Moléculas de ácido nucleico de ácido graso poliinsaturado sintasas, y polipéptidos, composiciones y métodos de preparación y usos de los mismos |
| WO2011090493A1 (en) * | 2010-01-19 | 2011-07-28 | Martek Biosciences Corporation | Eicosapentaenoic acid-producing microorganisms, fatty acid compositions, and methods of making and uses thereof |
| TW201525136A (zh) * | 2013-11-26 | 2015-07-01 | Dow Agrosciences Llc | 利用破囊壺菌ＰＵＦＡ合成酶於油籽作物中生成ω－３長鏈多不飽和脂肪酸 |
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