JP2007269812A5 - - Google Patents
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- Publication number
- JP2007269812A5 JP2007269812A5 JP2007154127A JP2007154127A JP2007269812A5 JP 2007269812 A5 JP2007269812 A5 JP 2007269812A5 JP 2007154127 A JP2007154127 A JP 2007154127A JP 2007154127 A JP2007154127 A JP 2007154127A JP 2007269812 A5 JP2007269812 A5 JP 2007269812A5
- Authority
- JP
- Japan
- Prior art keywords
- endotoxemia
- inhibitor
- compound
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000037487 Endotoxemia Diseases 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/461,675 US5750664A (en) | 1995-06-05 | 1995-06-05 | Substituted liposaccharides useful in the treatment and prevention of endotoxemia |
| US08/461,675 | 1995-06-05 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50186897A Division JP4009318B2 (ja) | 1995-06-05 | 1996-06-05 | エンドトキセミアの治療及び防止に有用な置換されたリポ糖類 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011018401A Division JP2011121970A (ja) | 1995-06-05 | 2011-01-31 | エンドトキセミアの治療及び防止に有用な置換されたリポ糖類 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007269812A JP2007269812A (ja) | 2007-10-18 |
| JP2007269812A5 true JP2007269812A5 (OSRAM) | 2008-01-24 |
| JP4712001B2 JP4712001B2 (ja) | 2011-06-29 |
Family
ID=23833509
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50186897A Expired - Lifetime JP4009318B2 (ja) | 1995-06-05 | 1996-06-05 | エンドトキセミアの治療及び防止に有用な置換されたリポ糖類 |
| JP2007154127A Expired - Lifetime JP4712001B2 (ja) | 1995-06-05 | 2007-06-11 | エンドトキセミアの治療及び防止に有用な置換されたリポ糖類 |
| JP2011018401A Pending JP2011121970A (ja) | 1995-06-05 | 2011-01-31 | エンドトキセミアの治療及び防止に有用な置換されたリポ糖類 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50186897A Expired - Lifetime JP4009318B2 (ja) | 1995-06-05 | 1996-06-05 | エンドトキセミアの治療及び防止に有用な置換されたリポ糖類 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011018401A Pending JP2011121970A (ja) | 1995-06-05 | 2011-01-31 | エンドトキセミアの治療及び防止に有用な置換されたリポ糖類 |
Country Status (21)
| Country | Link |
|---|---|
| US (8) | US5681824A (OSRAM) |
| EP (1) | EP0853627B1 (OSRAM) |
| JP (3) | JP4009318B2 (OSRAM) |
| KR (1) | KR100416335B1 (OSRAM) |
| CN (1) | CN1067082C (OSRAM) |
| AT (1) | ATE258185T1 (OSRAM) |
| AU (1) | AU707779C (OSRAM) |
| CA (1) | CA2223140C (OSRAM) |
| DE (1) | DE69631376T2 (OSRAM) |
| DK (1) | DK0853627T3 (OSRAM) |
| ES (1) | ES2214543T3 (OSRAM) |
| HU (1) | HU221342B1 (OSRAM) |
| IL (2) | IL122251A0 (OSRAM) |
| MX (1) | MX9709502A (OSRAM) |
| NO (1) | NO310239B1 (OSRAM) |
| NZ (1) | NZ312299A (OSRAM) |
| PT (1) | PT853627E (OSRAM) |
| RU (1) | RU2170738C2 (OSRAM) |
| TW (1) | TW366345B (OSRAM) |
| WO (1) | WO1996039411A1 (OSRAM) |
| ZA (1) | ZA964666B (OSRAM) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6417172B1 (en) * | 1995-06-05 | 2002-07-09 | Eisai Co., Ltd. | Prevention and treatment of pulmonary bacterial infection or symptomatic pulmonary exposure to endotoxin by inhalation of antiendotoxin drugs |
| US5681824A (en) * | 1995-06-05 | 1997-10-28 | Eisai Co., Ltd. | Substituted liposaccharides useful in the treatment and prevention of endotoxemia |
| WO1998001139A1 (fr) * | 1996-07-03 | 1998-01-15 | Eisai Co., Ltd. | Produits pour injection contenant des analogues de lipides a et procede de preparation correspondant |
| US6828155B1 (en) | 1998-09-01 | 2004-12-07 | Eisai Co., Ltd. | Method for evaluating lipid a analog-containing injections |
| EP1158990B1 (en) * | 1999-01-14 | 2007-10-17 | Eisai R&D Management Co., Ltd. | Use of e5564 for the treatment of sepsis by intravenous infusion |
| US20030130212A1 (en) * | 1999-01-14 | 2003-07-10 | Rossignol Daniel P. | Administration of an anti-endotoxin drug by intravenous infusion |
| US20040006242A1 (en) * | 1999-02-01 | 2004-01-08 | Hawkins Lynn D. | Immunomodulatory compounds and method of use thereof |
| US7915238B2 (en) * | 1999-02-01 | 2011-03-29 | Eisai R & D Management Co., Ltd. | Immunomodulatory compounds and methods of use thereof |
| US6835721B2 (en) | 1999-02-01 | 2004-12-28 | Eisai Co., Ltd. | Immunomodulatory compounds and methods of use thereof |
| TW527358B (en) | 1999-02-10 | 2003-04-11 | Sankyo Co | Ether type lipid A1 position carboxylic acid analogue |
| US20050101549A1 (en) * | 2000-01-14 | 2005-05-12 | Melvyn Lynn | Prevention and treatment of endotoxemia and related complications associated with surgery |
| JP2003524638A (ja) * | 2000-01-14 | 2003-08-19 | エーザイ株式会社 | 手術に伴う内毒素血症及び関連する合併症の予防及び治療 |
| US6906042B2 (en) | 2000-02-18 | 2005-06-14 | Eisai Co., Ltd. | Micelles |
| US6861512B2 (en) * | 2000-03-01 | 2005-03-01 | Eisai Co., Ltd. | Separation of olefinic isomers |
| AU2001275520A1 (en) * | 2000-06-09 | 2001-12-17 | Eisai Co. Ltd. | Administration of an anti-endotoxin drug by bolus or intermittent intravenous infusion |
| US20030105033A1 (en) * | 2000-06-09 | 2003-06-05 | Rossignol Daniel P. | Administration of an anti-endotoxin drug by bolus or intermittent intravenous infusion |
| WO2002088062A1 (en) * | 2001-04-23 | 2002-11-07 | Eisai Co., Ltd. | Process for preparation of alcohol derivatives |
| JPWO2002088072A1 (ja) * | 2001-04-23 | 2004-08-12 | エーザイ株式会社 | アルキレン化合物の製造方法 |
| US20040198652A1 (en) * | 2001-04-24 | 2004-10-07 | Carter J. Paul | Methods and compositions for preventing and treating septic shock and endotoxemia |
| US7759323B2 (en) * | 2001-05-22 | 2010-07-20 | Eisai R & D Management Co., Ltd. | Highly purified antiendotoxin compound |
| DE10125179A1 (de) * | 2001-05-23 | 2002-12-05 | Laves Ralph Georg | Verwendung von LPS zur Behandlung intestinaler Entzündungsprozesse |
| WO2003013440A2 (en) * | 2001-08-10 | 2003-02-20 | Eisai Co., Ltd. | Treatment and prevention of heat shock protein-associated diseases and conditions |
| US7727974B2 (en) * | 2001-08-10 | 2010-06-01 | Eisai R & D Management Co., Ltd. | Methods of reducing the severity of mucositis |
| WO2003050137A2 (en) * | 2001-12-11 | 2003-06-19 | David Schwartz | Toll-like receptor 4 mutations |
| AU2002950657A0 (en) * | 2002-08-08 | 2002-09-12 | Alchemia Limited | Derivatives of monosaccharides for drug discovery |
| AU2002951995A0 (en) * | 2002-10-11 | 2002-10-31 | Alchemia Limited | Classes of compounds that interact with gpcrs |
| WO2004058788A1 (ja) * | 2002-12-24 | 2004-07-15 | Sankyo Company, Limited | 右糖グルコースリピドa類縁体 |
| CN101080234A (zh) * | 2003-01-06 | 2007-11-28 | 科里克萨有限公司 | 一些氨烷基氨基葡糖苷磷酸酯化合物和它们的用途 |
| KR100856819B1 (ko) * | 2003-01-28 | 2008-09-05 | 아카데미슈 지켄후이스 라이덴 | Ll―37 유래의 펩티드성 독소 억제제 |
| JP4773336B2 (ja) * | 2003-02-20 | 2011-09-14 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Lpsアンタゴニストb1287およびその立体異性体の調製のための試薬および方法 |
| AU2004218358A1 (en) * | 2003-03-05 | 2004-09-16 | Eisai R&D Management Co., Ltd. | Compositions and methods for preventing and treating endotoxin-related diseases and conditions |
| WO2005027826A2 (en) * | 2003-07-14 | 2005-03-31 | Eisai, Co, Ltd. | Methods and treating severe acute respiratory syndrome |
| US20050208470A1 (en) | 2003-12-16 | 2005-09-22 | University Of Massachusetts | Toll-like receptor assays |
| BRPI0506671A (pt) * | 2004-01-08 | 2007-05-15 | Sankyo Co | análogo de levulose glicose-lipìdio |
| JP5185813B2 (ja) | 2005-04-26 | 2013-04-17 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 癌免疫治療のための組成物および方法 |
| US20070292418A1 (en) * | 2005-04-26 | 2007-12-20 | Eisai Co., Ltd. | Compositions and methods for immunotherapy |
| EP1895842A4 (en) * | 2005-06-17 | 2009-06-03 | Univ Rochester | METHODS AND COMPOSITIONS FOR ENHANCING IMMUNE MEMORY BY BLOCKING INTRAHEPATIC ERASURE OF ACTIVE T CELLS |
| JP5118968B2 (ja) * | 2005-08-31 | 2013-01-16 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | リピッドa類縁体の製造方法 |
| AU2006285926B2 (en) * | 2005-08-31 | 2012-05-24 | Eisai R & D Management Co., Ltd. | Process for production of lipid A analogue |
| US7943588B2 (en) | 2006-03-28 | 2011-05-17 | Trustees Of Dartmouth College | Method for preventing or treating neuropathic pain |
| WO2008059307A2 (en) * | 2006-11-16 | 2008-05-22 | Om Pharma | Functionalized beta 1,6 glucosamine disaccharides and process for their preparation |
| ES2392890T3 (es) * | 2006-11-22 | 2012-12-14 | Eisai R&D Management Co., Ltd. | Sal sódica de un compuesto disacarídico, procedimiento para la producción de la misma y uso de la misma |
| CA2669674C (en) | 2006-11-22 | 2016-05-17 | Eisai R&D Management Co., Ltd. | Sodium salt of disaccharide compound, method for producing the same, and use of the same |
| JP5358450B2 (ja) | 2006-11-23 | 2013-12-04 | カディラ ファーマシューティカルズ リミテッド | ポリ−tlrアンタゴニスト |
| WO2011035026A1 (en) * | 2009-09-16 | 2011-03-24 | Heidi Ehrentraut | Methods for treating myocardial disorders |
| WO2011038537A1 (zh) * | 2009-09-29 | 2011-04-07 | 上海南方基因科技有限公司 | 败血症以及败血症休克的预测、预防和治疗方法及试剂盒 |
| GB201013785D0 (en) | 2010-08-17 | 2010-09-29 | Ucl Business Plc | Treatment |
| JP2012246470A (ja) | 2011-05-31 | 2012-12-13 | Sharp Corp | 半導体ナノ粒子の製造方法、半導体ナノ粒子、ならびにこれを用いた蛍光体 |
| WO2013093631A2 (en) * | 2011-12-22 | 2013-06-27 | Nanoco Technologies, Inc. | Surface modified nanoparticles |
| KR20140139063A (ko) | 2012-03-28 | 2014-12-04 | 유니버시티 오브 매릴랜드, 발티모어 | 오르토믹소바이러스 감염 치료를 위한 에리토란 또는 그의 제약학상 허용가능한 염의 투여 |
| WO2014113048A1 (en) * | 2013-01-18 | 2014-07-24 | Loma Linda University | Compositions and methods for diagnosing and treating sepsis |
| EP3019200B1 (en) | 2013-07-11 | 2022-03-23 | Alnylam Pharmaceuticals, Inc. | Oligonucleotide-ligand conjugates and process for their preparation |
| US9584991B1 (en) * | 2014-06-19 | 2017-02-28 | Isaac S. Daniel | Method of communicating and accessing social networks using interactive coded messages |
| CN108884121B (zh) * | 2016-03-30 | 2022-05-31 | 阿尤维斯研究有限公司 | 新组合物和治疗方法 |
| US10570074B2 (en) | 2016-09-14 | 2020-02-25 | Genomatica, Inc. | 1,3-fatty diol compounds and derivatives thereof |
| EP3512508B1 (en) * | 2016-09-16 | 2022-03-16 | Eisai R&D Management Co., Ltd. | Method of use of eritoran as a tlr4 antagonist for treatment of ebola and marburg disease |
| CN112930184B (zh) * | 2018-12-17 | 2024-07-12 | 卫材R&D管理有限公司 | 包含脂质体的配制品 |
| WO2021207218A1 (en) | 2020-04-06 | 2021-10-14 | Eisai R&D Management Co., Ltd. | Treatment of nidovirales infection with eritoran |
| CN113527396B (zh) * | 2020-04-17 | 2024-02-02 | 上海医药工业研究院 | 一种疫苗佐剂mpla的中间体、合成及应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4495346A (en) * | 1981-03-30 | 1985-01-22 | Wisconsin Alumni Research Foundation | Method of preparing a disaccharide |
| US4987237A (en) * | 1983-08-26 | 1991-01-22 | Ribi Immunochem Research, Inc. | Derivatives of monophosphoryl lipid A |
| JPS6153295A (ja) * | 1984-08-24 | 1986-03-17 | Dai Ichi Seiyaku Co Ltd | ジサツカライド誘導体 |
| US5066794A (en) * | 1984-08-24 | 1991-11-19 | Daiichi Pharmaceutical Co., Ltd. | Process for preparing a disaccharide derivative |
| NL8601551A (nl) * | 1985-06-28 | 1987-01-16 | Sandoz Ag | Nieuwe saccharides, hun bereiding en farmaceutische samenstellingen, die hen bevatten. |
| US4912094B1 (en) * | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| US5158939A (en) * | 1989-07-21 | 1992-10-27 | Wisconsin Alumni Research Foundation | Method of stimulating the immune systems of animals and compositions useful therefor |
| JP2839916B2 (ja) * | 1989-10-20 | 1998-12-24 | 三共株式会社 | リピドa3位エーテル類縁体 |
| DD295854A5 (de) | 1989-12-11 | 1991-11-14 | ��@���������@�������k�� | Lipid-a-austauschstoffe mit immunoaktivierender und antitumorwirkung |
| JP2847319B2 (ja) | 1990-05-18 | 1999-01-20 | イビデン株式会社 | 電子部品搭載用多層ボンディング基板 |
| JP3040847B2 (ja) | 1990-06-22 | 2000-05-15 | 三共株式会社 | リピドx類縁体 |
| AU660325B2 (en) * | 1991-10-11 | 1995-06-22 | Eisai Co. Ltd. | Anti-endotoxin compounds and related molecules and methods |
| US5530113A (en) * | 1991-10-11 | 1996-06-25 | Eisai Co., Ltd. | Anti-endotoxin compounds |
| JP3135990B2 (ja) | 1992-07-31 | 2001-02-19 | 沖電気工業株式会社 | パリティ付加回路 |
| US5413785A (en) * | 1993-01-27 | 1995-05-09 | New England Deaconess Hospital Corp. | Methodology employing lactobacillus GG for reduction of plasma endotoxin levels circulating in-vivo |
| PL181241B1 (pl) * | 1993-11-17 | 2001-06-29 | Deutsche Om Arzneimittel Gmbh | Disacharydy beta(1 6)glukozoaminowe, sposób wytwarzania disacharydu beta(1 6) glukozoaminowego, zawierająca je kompozycja farmaceutyczna i środek immunomodulujący i/lub przeciwnowotworowy oraz szczepionka |
| US6417172B1 (en) | 1995-06-05 | 2002-07-09 | Eisai Co., Ltd. | Prevention and treatment of pulmonary bacterial infection or symptomatic pulmonary exposure to endotoxin by inhalation of antiendotoxin drugs |
| US5681824A (en) * | 1995-06-05 | 1997-10-28 | Eisai Co., Ltd. | Substituted liposaccharides useful in the treatment and prevention of endotoxemia |
| JP4235193B2 (ja) | 2005-06-07 | 2009-03-11 | 日本電信電話株式会社 | イベント履歴蓄積装置、イベント情報検証装置、イベント履歴蓄積方法、イベント情報検証方法およびイベント情報処理システム |
-
1995
- 1995-06-05 US US08/461,677 patent/US5681824A/en not_active Expired - Lifetime
- 1995-06-05 US US08/461,675 patent/US5750664A/en not_active Expired - Lifetime
-
1996
- 1996-06-05 NZ NZ312299A patent/NZ312299A/xx not_active IP Right Cessation
- 1996-06-05 PT PT96923234T patent/PT853627E/pt unknown
- 1996-06-05 KR KR1019970708583A patent/KR100416335B1/ko not_active Expired - Lifetime
- 1996-06-05 TW TW085106735A patent/TW366345B/zh not_active IP Right Cessation
- 1996-06-05 CA CA002223140A patent/CA2223140C/en not_active Expired - Lifetime
- 1996-06-05 JP JP50186897A patent/JP4009318B2/ja not_active Expired - Lifetime
- 1996-06-05 HU HU9802662A patent/HU221342B1/hu unknown
- 1996-06-05 ES ES96923234T patent/ES2214543T3/es not_active Expired - Lifetime
- 1996-06-05 WO PCT/US1996/009578 patent/WO1996039411A1/en not_active Ceased
- 1996-06-05 CN CN96195890A patent/CN1067082C/zh not_active Expired - Lifetime
- 1996-06-05 RU RU98100107/04A patent/RU2170738C2/ru active
- 1996-06-05 IL IL12225196A patent/IL122251A0/xx not_active IP Right Cessation
- 1996-06-05 US US08/658,656 patent/US5935938A/en not_active Expired - Lifetime
- 1996-06-05 ZA ZA964666A patent/ZA964666B/xx unknown
- 1996-06-05 DE DE69631376T patent/DE69631376T2/de not_active Expired - Lifetime
- 1996-06-05 AU AU63802/96A patent/AU707779C/en not_active Expired
- 1996-06-05 EP EP96923234A patent/EP0853627B1/en not_active Expired - Lifetime
- 1996-06-05 DK DK96923234T patent/DK0853627T3/da active
- 1996-06-05 AT AT96923234T patent/ATE258185T1/de active
-
1997
- 1997-12-04 NO NO19975644A patent/NO310239B1/no not_active IP Right Cessation
- 1997-12-04 MX MX9709502A patent/MX9709502A/es unknown
-
1999
- 1999-04-16 US US09/293,856 patent/US6184366B1/en not_active Expired - Lifetime
-
2001
- 2001-01-30 US US09/774,541 patent/US20020028927A1/en not_active Abandoned
-
2002
- 2002-05-13 US US10/144,670 patent/US20030144503A1/en not_active Abandoned
- 2002-06-02 IL IL149971A patent/IL149971A/en not_active IP Right Cessation
-
2007
- 2007-06-11 JP JP2007154127A patent/JP4712001B2/ja not_active Expired - Lifetime
- 2007-07-30 US US11/830,412 patent/US7737129B2/en not_active Expired - Fee Related
-
2010
- 2010-05-17 US US12/781,166 patent/US7994154B2/en not_active Expired - Fee Related
-
2011
- 2011-01-31 JP JP2011018401A patent/JP2011121970A/ja active Pending
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