JP2006513724A - 癌の処置および検出において有用な１９１Ｐ４Ｄ１２（ｂ）と称される、核酸および対応タンパク質 - Google Patents

癌の処置および検出において有用な１９１Ｐ４Ｄ１２（ｂ）と称される、核酸および対応タンパク質 Download PDF

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JP2006513724A
JP2006513724A JP2005502039A JP2005502039A JP2006513724A JP 2006513724 A JP2006513724 A JP 2006513724A JP 2005502039 A JP2005502039 A JP 2005502039A JP 2005502039 A JP2005502039 A JP 2005502039A JP 2006513724 A JP2006513724 A JP 2006513724A
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protein
cancer
cell
antibody
peptide
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アーサー ビー． ライタノ，
ピア エム． チャリッタ−エイド，
アヤ ジャコボビッツ，
マリー ファリス，
ワンマオ ゲ，
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アジェンシス， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
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  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
JP2005502039A 2002-08-16 2003-04-23 癌の処置および検出において有用な１９１Ｐ４Ｄ１２（ｂ）と称される、核酸および対応タンパク質 Pending JP2006513724A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40430602P 2002-08-16 2002-08-16
US42329002P 2002-11-01 2002-11-01
PCT/US2003/013013 WO2004016799A2 (en) 2002-08-16 2003-04-23 NUCLEIC ACIDS AND CORRESPONDING PROTEINS ENTITLED 191P4D12(b) USEFUL IN TREATMENT AND DETECTION OF CANCER

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JP2009167283A Division JP2009278988A (ja) 2002-08-16 2009-07-15 癌の処置および検出において有用な１９１Ｐ４Ｄ１２（ｂ）と称される、核酸および対応タンパク質

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JP2006513724A true JP2006513724A (ja) 2006-04-27
JP2006513724A5 JP2006513724A5 (https=) 2006-06-15

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JP2005502039A Pending JP2006513724A (ja) 2002-08-16 2003-04-23 癌の処置および検出において有用な１９１Ｐ４Ｄ１２（ｂ）と称される、核酸および対応タンパク質
JP2005502040A Pending JP2006511232A (ja) 2002-08-16 2003-05-09 癌の処置および検出において有用な２８２ｐ１ｇ３と称される、核酸および対応タンパク質
JP2009002970A Expired - Fee Related JP4490502B2 (ja) 2002-08-16 2009-01-08 癌の処置および検出において有用な２８２ｐ１ｇ３と称される、核酸および対応タンパク質
JP2009135785A Pending JP2009278977A (ja) 2002-08-16 2009-06-05 癌の処置および検出において有用な２８２ｐ１ｇ３と称される、核酸および対応タンパク質
JP2009167283A Withdrawn JP2009278988A (ja) 2002-08-16 2009-07-15 癌の処置および検出において有用な１９１Ｐ４Ｄ１２（ｂ）と称される、核酸および対応タンパク質
JP2009286607A Pending JP2010142228A (ja) 2002-08-16 2009-12-17 癌の処置および検出において有用な２８２ｐ１ｇ３と称される、核酸および対応タンパク質

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JP2005502040A Pending JP2006511232A (ja) 2002-08-16 2003-05-09 癌の処置および検出において有用な２８２ｐ１ｇ３と称される、核酸および対応タンパク質
JP2009002970A Expired - Fee Related JP4490502B2 (ja) 2002-08-16 2009-01-08 癌の処置および検出において有用な２８２ｐ１ｇ３と称される、核酸および対応タンパク質
JP2009135785A Pending JP2009278977A (ja) 2002-08-16 2009-06-05 癌の処置および検出において有用な２８２ｐ１ｇ３と称される、核酸および対応タンパク質
JP2009167283A Withdrawn JP2009278988A (ja) 2002-08-16 2009-07-15 癌の処置および検出において有用な１９１Ｐ４Ｄ１２（ｂ）と称される、核酸および対応タンパク質
JP2009286607A Pending JP2010142228A (ja) 2002-08-16 2009-12-17 癌の処置および検出において有用な２８２ｐ１ｇ３と称される、核酸および対応タンパク質

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US (16) US20040081653A1 (https=)
EP (6) EP2332966A1 (https=)
JP (6) JP2006513724A (https=)
AU (6) AU2003243151A1 (https=)
CA (5) CA3066279A1 (https=)
CY (1) CY1113247T1 (https=)
DK (2) DK1576170T3 (https=)
ES (2) ES2392341T3 (https=)
IL (6) IL166531A (https=)
PT (2) PT1576170E (https=)
SI (2) SI1576170T1 (https=)
WO (5) WO2004016733A2 (https=)

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JP2013543498A (ja) * 2010-09-29 2013-12-05 アジェンシス，インコーポレイテッド １９１ｐ４ｄ１２タンパク質に結合する抗体薬物結合体（ａｄｃ）
US12257340B2 (en) 2018-12-03 2025-03-25 Agensys, Inc. Pharmaceutical compositions comprising anti-191P4D12 antibody drug conjugates and methods of use thereof

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USRE48389E1 (en) 2010-09-29 2021-01-12 Agensys, Inc. Antibody drug conjugates (ADC) that bind to 191P4D12 proteins
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JP2017110002A (ja) * 2010-09-29 2017-06-22 アジェンシス，インコーポレイテッド １９１ｐ４ｄ１２タンパク質に結合する抗体薬物結合体（ａｄｃ）
JP7370405B2 (ja) 2010-09-29 2023-10-27 アジェンシス，インコーポレイテッド １９１ｐ４ｄ１２タンパク質に結合する抗体薬物結合体（ａｄｃ）
JP2023179713A (ja) * 2010-09-29 2023-12-19 アジェンシス，インコーポレイテッド １９１ｐ４ｄ１２タンパク質に結合する抗体薬物結合体（ａｄｃ）
JP7688088B6 (ja) 2010-09-29 2025-06-23 アジェンシス，インコーポレイテッド １９１ｐ４ｄ１２タンパク質に結合する抗体薬物結合体（ａｄｃ）
JP2022075818A (ja) * 2010-09-29 2022-05-18 アジェンシス，インコーポレイテッド １９１ｐ４ｄ１２タンパク質に結合する抗体薬物結合体（ａｄｃ）
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