JP2006512906A5 - - Google Patents
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- JP2006512906A5 JP2006512906A5 JP2004540017A JP2004540017A JP2006512906A5 JP 2006512906 A5 JP2006512906 A5 JP 2006512906A5 JP 2004540017 A JP2004540017 A JP 2004540017A JP 2004540017 A JP2004540017 A JP 2004540017A JP 2006512906 A5 JP2006512906 A5 JP 2006512906A5
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- Prior art keywords
- composition
- sirna
- shrna
- seq
- transcript
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108020004459 Small interfering RNA Proteins 0.000 claims description 144
- 210000004027 cell Anatomy 0.000 claims description 61
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- 108091027967 Small hairpin RNA Proteins 0.000 claims description 53
- 239000004055 small Interfering RNA Substances 0.000 claims description 51
- 241000712461 unidentified influenza virus Species 0.000 claims description 51
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- -1 cationic lipid Chemical class 0.000 claims description 6
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 5
- 206010022000 influenza Diseases 0.000 claims description 5
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- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims 2
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- WHTVZRBIWZFKQO-AWEZNQCLSA-N (S)-chloroquine Chemical compound ClC1=CC=C2C(N[C@@H](C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-AWEZNQCLSA-N 0.000 claims 1
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 1
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 claims 1
- 125000004080 3-carboxypropanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C(O[H])=O 0.000 claims 1
- 101710159080 Aconitate hydratase A Proteins 0.000 claims 1
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- WHTVZRBIWZFKQO-UHFFFAOYSA-N chloroquine Natural products ClC1=CC=C2C(NC(C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-UHFFFAOYSA-N 0.000 claims 1
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- 239000007922 nasal spray Substances 0.000 claims 1
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- 239000002777 nucleoside Substances 0.000 claims 1
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- 108010011110 polyarginine Proteins 0.000 claims 1
- 229920000656 polylysine Polymers 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
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- 108010048367 enhanced green fluorescent protein Proteins 0.000 description 2
- ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 description 2
- 229960005542 ethidium bromide Drugs 0.000 description 2
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41445702P | 2002-09-28 | 2002-09-28 | |
| US44637703P | 2003-02-10 | 2003-02-10 | |
| PCT/US2003/030502 WO2004028471A2 (en) | 2002-09-28 | 2003-09-29 | Influenza therapeutic |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006512906A JP2006512906A (ja) | 2006-04-20 |
| JP2006512906A5 true JP2006512906A5 (enExample) | 2009-07-30 |
Family
ID=32045286
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004540017A Pending JP2006512906A (ja) | 2002-09-28 | 2003-09-29 | インフルエンザ治療剤 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20050008617A1 (enExample) |
| EP (1) | EP1658304A4 (enExample) |
| JP (1) | JP2006512906A (enExample) |
| KR (1) | KR20050084607A (enExample) |
| AU (3) | AU2003279004B2 (enExample) |
| CA (1) | CA2500468A1 (enExample) |
| MX (1) | MXPA05003287A (enExample) |
| NO (1) | NO20052058L (enExample) |
| WO (2) | WO2004028471A2 (enExample) |
Families Citing this family (130)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080281041A1 (en) | 1999-06-07 | 2008-11-13 | Rozema David B | Reversibly Masked Polymers |
| US8541548B2 (en) * | 1999-06-07 | 2013-09-24 | Arrowhead Madison Inc. | Compounds and methods for reversible modification of biologically active molecules |
| US8008355B2 (en) * | 2002-03-11 | 2011-08-30 | Roche Madison Inc. | Endosomolytic poly(vinyl ether) polymers |
| US8138383B2 (en) * | 2002-03-11 | 2012-03-20 | Arrowhead Madison Inc. | Membrane active heteropolymers |
| DE10214983A1 (de) * | 2002-04-04 | 2004-04-08 | TransMIT Gesellschaft für Technologietransfer mbH | Vernebelbare Liposomen und ihre Verwendung zur pulmonalen Applikation von Wirkstoffen |
| AU2003268531A1 (en) | 2002-09-06 | 2004-03-29 | University Of South Florida | Materials and methods for treatment of allergic diseases |
| US8071560B2 (en) * | 2004-02-17 | 2011-12-06 | University Of South Florida | Materials and methods for reducing inflammation by inhibition of the atrial natriuretic peptide receptor |
| US20080214437A1 (en) * | 2002-09-06 | 2008-09-04 | Mohapatra Shyam S | Methods and compositions for reducing activity of the atrial natriuretic peptide receptor and for treatment of diseases |
| US20060160759A1 (en) * | 2002-09-28 | 2006-07-20 | Jianzhu Chen | Influenza therapeutic |
| US20050256071A1 (en) * | 2003-07-15 | 2005-11-17 | California Institute Of Technology | Inhibitor nucleic acids |
| JP2006528492A (ja) * | 2003-07-15 | 2006-12-21 | カリフォルニア インスティテュート オブ テクノロジー | 改良されたインヒビター核酸 |
| US8145436B2 (en) | 2003-07-15 | 2012-03-27 | The Trustees Of The University Of Pennsylvania | Method and systems for identifying micro-RNA targets and synthesizing novel micro-RNAs and uses of the same |
| WO2005026322A2 (en) * | 2003-09-11 | 2005-03-24 | Clontech Laboratories, Inc. | siRNA ENCODING CONSTRUCTS AND METHODS FOR USING THE SAME |
| AU2005227870A1 (en) * | 2004-02-17 | 2005-10-13 | University Of South Florida | Materials and methods for treatment of inflammatory and cell proliferation disorders |
| CA2558682A1 (en) * | 2004-02-20 | 2005-09-01 | Genesis Research And Development Corporation Limited | Targeted delivery of rna interference molecules for the treatment of ige-mediated disorders |
| WO2005110438A2 (en) * | 2004-04-15 | 2005-11-24 | Massachusetts Institute Of Technology | Methods and products related to the intracellular delivery of polysaccharides |
| US20050265927A1 (en) * | 2004-05-17 | 2005-12-01 | Yale University | Intranasal delivery of nucleic acid molecules |
| WO2006085987A2 (en) | 2004-07-09 | 2006-08-17 | University Of Iowa Research Foundation | Rna interference in respiratory epitheial cells |
| US20080222743A1 (en) * | 2004-08-25 | 2008-09-11 | Avigenics, Inc. | RNA interference and disease resistance in avians |
| US20090313712A1 (en) * | 2004-08-25 | 2009-12-17 | Leandro Christmann | RNA interference and disease resistance in avians |
| EP2325314B1 (en) * | 2004-09-24 | 2014-08-20 | Alnylam Pharmaceuticals, Inc. | Targeting opposite strand replication intermediates of single-stranded viruses by RNAI |
| US20060089324A1 (en) * | 2004-10-22 | 2006-04-27 | Sailen Barik | RNAi modulation of RSV, PIV and other respiratory viruses and uses thereof |
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| CN101103111A (zh) * | 2004-11-05 | 2008-01-09 | 因特拉迪格姆公司 | 用于治疗呼吸道病毒感染的组合物及其用途 |
| US8138327B2 (en) * | 2004-11-23 | 2012-03-20 | City Of Hope | Inducible systems and methods for controlling siRNA expression |
| NZ556097A (en) * | 2005-01-07 | 2009-12-24 | Alnylam Pharmaceuticals Inc | Rnai modulation of RSV and therapeutic uses thereof |
| US8076471B2 (en) * | 2005-02-03 | 2011-12-13 | Benitec, Inc. | RNAi expression constructs |
| US20070248535A1 (en) * | 2005-02-07 | 2007-10-25 | The Trustees Of Columbia University In The City Of New York | Methods to treat or prevent hormone-resistant prostate cancer using siRNA specific for protocadherin-PC, or other inhibitors of protocadherin-PC expression or activity |
| US8008468B2 (en) * | 2005-02-16 | 2011-08-30 | Benitec, Inc. | RNAi expression constructs with liver-specific enhancer/promoter |
| WO2006110688A2 (en) * | 2005-04-08 | 2006-10-19 | Nastech Pharmaceutical Company Inc. | Rnai therapeutic for respiratory virus infection |
| US20070213293A1 (en) * | 2005-04-08 | 2007-09-13 | Nastech Pharmaceutical Company Inc. | Rnai therapeutic for respiratory virus infection |
| CN101277704A (zh) * | 2005-04-12 | 2008-10-01 | 因特拉迪格姆公司 | 用于治疗癌症及其它新血管生成疾病的RNAi治疗剂的组合物和方法 |
| JP2008536874A (ja) | 2005-04-15 | 2008-09-11 | ボード オブ リージェンツ ザ ユニバーシティー オブ テキサス システム | 中性脂質組成物によるｓｉＲＮＡの送達 |
| NZ583564A (en) * | 2005-04-21 | 2011-09-30 | Univ Florida | Materials and Methods For Respiratory Disease Control in Canines |
| CA2606002A1 (en) * | 2005-04-28 | 2006-11-02 | Benitec Limited | Multiple-rnai expression cassettes for simultaneous delivery of rnai agents related to heterozygotic expression patterns |
| US7199109B2 (en) * | 2005-06-03 | 2007-04-03 | Cal Poly Pomona Foundation | Potent inhibition of influenza virus by specifically designed short interfering RNA |
| US20070031512A1 (en) * | 2005-08-03 | 2007-02-08 | Amcol International Corporation | Virus-interacting layered phyllosilicates and methods of inactivating viruses |
| US20100272769A1 (en) * | 2005-08-03 | 2010-10-28 | Amcol International | Virus-, Bacteria-, and Fungi-Interacting Layered Phyllosilicates and Methods of Use |
| US20080184618A1 (en) * | 2005-08-03 | 2008-08-07 | Amcol International | Virus-Interacting Layered Phyllosilicates and Methods of Use |
| US20070099858A1 (en) * | 2005-10-03 | 2007-05-03 | Sirna Therapeutics, Inc. | RNA interference mediated of inhibition of influenza virus gene expression using short interfering nucleic acid (siNA) |
| US20100129460A1 (en) * | 2005-10-14 | 2010-05-27 | Nastech Pharmaceutical Company Inc. | Compounds and methods for peptide ribonucleic acid condensate particles for rna therapeutics |
| US20070197460A1 (en) * | 2005-11-01 | 2007-08-23 | Alnylam Pharmaceuticals, Inc. | Rnai inhibition of influenza virus replication |
| WO2007056153A2 (en) * | 2005-11-04 | 2007-05-18 | Nastech Pharmaceutical Company Inc. | Peptide-dicer substrate rna conjugates as delivery vehicles for sirna |
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| CN100365122C (zh) * | 2005-12-30 | 2008-01-30 | 中国疾病预防控制中心病毒病预防控制所 | 针对乙型流感病毒多聚酶基因的siRNA序列及其应用 |
| CN100365123C (zh) * | 2005-12-30 | 2008-01-30 | 中国疾病预防控制中心病毒病预防控制所 | 针对乙型流感病毒膜蛋白基因的siRNA序列及其应用 |
| CN100365121C (zh) * | 2005-12-30 | 2008-01-30 | 中国疾病预防控制中心病毒病预防控制所 | 针对乙型流感病毒核壳蛋白基因的siRNA序列及其应用 |
| FI20060246A0 (fi) | 2006-03-16 | 2006-03-16 | Jukka Westermarck | Uusi kasvua stimuloiva proteiini ja sen käyttö |
| GB0605337D0 (en) | 2006-03-17 | 2006-04-26 | Genomica Sau | Treatment of CNS conditions |
| DE602007013559D1 (de) * | 2006-07-07 | 2011-05-12 | Univ Aarhus | Nanoteilchen zur abgabe von nukleinsäure |
| GB0613753D0 (en) * | 2006-07-11 | 2006-08-23 | Norwegian Radium Hospital Res | Method |
| US9127293B2 (en) * | 2006-07-26 | 2015-09-08 | The University Of Chicago | Receptor-mediated delivery: compositions and methods |
| WO2008022046A2 (en) * | 2006-08-18 | 2008-02-21 | Nastech Pharmaceutical Company Inc. | Dicer substrate rna peptide conjugates and methods for rna therapeutics |
| US8017109B2 (en) * | 2006-08-18 | 2011-09-13 | Roche Madison Inc. | Endosomolytic poly(acrylate) polymers |
| JP5274461B2 (ja) * | 2006-08-18 | 2013-08-28 | アローヘッド リサーチ コーポレイション | ポリヌクレオチドのインビボ送達のためのポリ結合体 |
| FI20060751A0 (fi) | 2006-08-23 | 2006-08-23 | Valtion Teknillinen | Menetelmä prostatasyövän hoitoon ja mainitusta menetelmästä hyödyntävien potilaiden seulonta |
| CA2661292A1 (en) * | 2006-08-24 | 2008-02-28 | British Columbia Cancer Agency Branch | Compositions and methods for treating myelosuppression |
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- 2003-09-29 EP EP03770515A patent/EP1658304A4/en not_active Withdrawn
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- 2003-09-29 US US10/674,087 patent/US20050008617A1/en not_active Abandoned
- 2003-09-29 WO PCT/US2003/030508 patent/WO2004029213A2/en not_active Ceased
- 2003-09-29 AU AU2003279004A patent/AU2003279004B2/en not_active Withdrawn - After Issue
- 2003-09-29 AU AU2003279010A patent/AU2003279010A1/en not_active Abandoned
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