JP2006509715A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2006509715A5 JP2006509715A5 JP2003569634A JP2003569634A JP2006509715A5 JP 2006509715 A5 JP2006509715 A5 JP 2006509715A5 JP 2003569634 A JP2003569634 A JP 2003569634A JP 2003569634 A JP2003569634 A JP 2003569634A JP 2006509715 A5 JP2006509715 A5 JP 2006509715A5
- Authority
- JP
- Japan
- Prior art keywords
- pyridin
- urea
- thiazol
- piperidin
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 C 1 -C 6 -alkyl Chemical group 0.000 claims 98
- 125000000623 heterocyclic group Chemical group 0.000 claims 16
- 239000004202 carbamide Substances 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 14
- 125000002757 morpholinyl group Chemical group 0.000 claims 12
- 125000003386 piperidinyl group Chemical group 0.000 claims 11
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 11
- 229910052757 nitrogen Inorganic materials 0.000 claims 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 9
- 125000004193 piperazinyl group Chemical group 0.000 claims 9
- 125000005843 halogen group Chemical group 0.000 claims 7
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 7
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 7
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 6
- 125000006264 diethylaminomethyl group Chemical group [H]C([H])([H])C([H])([H])N(C([H])([H])*)C([H])([H])C([H])([H])[H] 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 5
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims 4
- 125000004397 aminosulfonyl group Chemical class NS(=O)(=O)* 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 4
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 4
- 125000003282 alkyl amino group Chemical group 0.000 claims 3
- 125000006222 dimethylaminomethyl group Chemical group [H]C([H])([H])N(C([H])([H])[H])C([H])([H])* 0.000 claims 3
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 3
- IEJANKDXAXHCGG-UHFFFAOYSA-N (2-phenyl-1,3-thiazol-4-yl)urea Chemical compound NC(=O)NC1=CSC(C=2C=CC=CC=2)=N1 IEJANKDXAXHCGG-UHFFFAOYSA-N 0.000 claims 2
- SLTYXVYQMFLHPK-UHFFFAOYSA-N 1-(2-bromo-1,3-thiazol-4-yl)-3-[6-(2-piperidin-4-ylethoxy)pyridin-2-yl]urea Chemical compound S1C(Br)=NC(NC(=O)NC=2N=C(OCCC3CCNCC3)C=CC=2)=C1 SLTYXVYQMFLHPK-UHFFFAOYSA-N 0.000 claims 2
- HWZCMNUJXAECNS-UHFFFAOYSA-N 1-(2-bromo-1,3-thiazol-4-yl)-3-[6-(3-hydroxypropylamino)pyridin-2-yl]urea Chemical compound OCCCNC1=CC=CC(NC(=O)NC=2N=C(Br)SC=2)=N1 HWZCMNUJXAECNS-UHFFFAOYSA-N 0.000 claims 2
- DSMUBPNMLFTCDI-UHFFFAOYSA-N 1-(2-bromo-1,3-thiazol-4-yl)-3-[6-[(1-methylpyrrolidin-2-yl)methoxy]pyridin-2-yl]urea Chemical compound CN1CCCC1COC1=CC=CC(NC(=O)NC=2N=C(Br)SC=2)=N1 DSMUBPNMLFTCDI-UHFFFAOYSA-N 0.000 claims 2
- JWKLQSUSVODONX-UHFFFAOYSA-N 1-(2-bromo-1,3-thiazol-4-yl)-3-[6-[(3-methylpiperidin-1-yl)methyl]pyridin-2-yl]urea Chemical compound C1C(C)CCCN1CC1=CC=CC(NC(=O)NC=2N=C(Br)SC=2)=N1 JWKLQSUSVODONX-UHFFFAOYSA-N 0.000 claims 2
- KXLVMMWTXTUXTK-UHFFFAOYSA-N 1-(2-chloro-1,3-thiazol-4-yl)-3-[6-(2-piperidin-4-ylethoxy)pyridin-2-yl]urea Chemical compound S1C(Cl)=NC(NC(=O)NC=2N=C(OCCC3CCNCC3)C=CC=2)=C1 KXLVMMWTXTUXTK-UHFFFAOYSA-N 0.000 claims 2
- LPOXYHGDUYOQNZ-UHFFFAOYSA-N 1-(2-chloro-1,3-thiazol-4-yl)-3-[6-(piperidin-1-ylmethyl)pyridin-2-yl]urea Chemical compound S1C(Cl)=NC(NC(=O)NC=2N=C(CN3CCCCC3)C=CC=2)=C1 LPOXYHGDUYOQNZ-UHFFFAOYSA-N 0.000 claims 2
- FFXYWEJGHJTSOI-UHFFFAOYSA-N 1-(2-chloro-1,3-thiazol-4-yl)-3-[6-(piperidin-4-ylmethoxy)pyridin-2-yl]urea Chemical compound S1C(Cl)=NC(NC(=O)NC=2N=C(OCC3CCNCC3)C=CC=2)=C1 FFXYWEJGHJTSOI-UHFFFAOYSA-N 0.000 claims 2
- KIZXTRYBMBRXFW-UHFFFAOYSA-N 1-(2-chloro-1,3-thiazol-4-yl)-3-[6-[(1-methylpyrrolidin-2-yl)methoxy]pyridin-2-yl]urea Chemical compound CN1CCCC1COC1=CC=CC(NC(=O)NC=2N=C(Cl)SC=2)=N1 KIZXTRYBMBRXFW-UHFFFAOYSA-N 0.000 claims 2
- DOPRSVFHJQVOTC-UHFFFAOYSA-N 1-(2-chloro-1,3-thiazol-4-yl)-3-[6-[(3-methylpiperidin-1-yl)methyl]pyridin-2-yl]urea Chemical compound C1C(C)CCCN1CC1=CC=CC(NC(=O)NC=2N=C(Cl)SC=2)=N1 DOPRSVFHJQVOTC-UHFFFAOYSA-N 0.000 claims 2
- QQPSZKJHHPRADH-UHFFFAOYSA-N 1-(2-phenyl-1,3-thiazol-4-yl)-3-[6-(2-piperidin-4-ylethoxy)pyridin-2-yl]urea Chemical compound C=1C=CC(OCCC2CCNCC2)=NC=1NC(=O)NC(N=1)=CSC=1C1=CC=CC=C1 QQPSZKJHHPRADH-UHFFFAOYSA-N 0.000 claims 2
- HPUUYQVAMNKGNY-UHFFFAOYSA-N 1-(2-phenyl-1,3-thiazol-4-yl)-3-[6-(piperidin-4-ylmethoxy)pyridin-2-yl]urea Chemical compound C=1C=CC(OCC2CCNCC2)=NC=1NC(=O)NC(N=1)=CSC=1C1=CC=CC=C1 HPUUYQVAMNKGNY-UHFFFAOYSA-N 0.000 claims 2
- KJNURJSIHRMSAP-UHFFFAOYSA-N 1-(2-phenyl-1,3-thiazol-4-yl)-3-[6-(pyrrolidin-1-ylmethyl)pyridin-2-yl]urea Chemical compound C=1C=CC(CN2CCCC2)=NC=1NC(=O)NC(N=1)=CSC=1C1=CC=CC=C1 KJNURJSIHRMSAP-UHFFFAOYSA-N 0.000 claims 2
- ALAVWAINFQQTTB-UHFFFAOYSA-N 1-(2-phenyl-1,3-thiazol-4-yl)-3-[6-[(propan-2-ylamino)methyl]pyridin-2-yl]urea Chemical compound CC(C)NCC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CC=CC=2)=N1 ALAVWAINFQQTTB-UHFFFAOYSA-N 0.000 claims 2
- GWHBHIFNZJPJPU-UHFFFAOYSA-N 1-(2-pyridin-4-yl-1,3-thiazol-4-yl)-3-[6-(1,2,3,6-tetrahydropyridin-4-yl)pyridin-2-yl]urea Chemical compound C=1C=CC(C=2CCNCC=2)=NC=1NC(=O)NC(N=1)=CSC=1C1=CC=NC=C1 GWHBHIFNZJPJPU-UHFFFAOYSA-N 0.000 claims 2
- KJAMWKJQNWQDRV-UHFFFAOYSA-N 1-(2-pyridin-4-yl-1,3-thiazol-4-yl)-3-[6-(pyrrolidin-2-ylmethoxy)pyridin-2-yl]urea Chemical compound C=1C=CC(OCC2NCCC2)=NC=1NC(=O)NC(N=1)=CSC=1C1=CC=NC=C1 KJAMWKJQNWQDRV-UHFFFAOYSA-N 0.000 claims 2
- QFFRNDMIERRDMZ-UHFFFAOYSA-N 1-(2-pyridin-4-yl-1,3-thiazol-4-yl)-3-[6-(pyrrolidin-3-ylmethoxy)pyridin-2-yl]urea Chemical compound C=1C=CC(OCC2CNCC2)=NC=1NC(=O)NC(N=1)=CSC=1C1=CC=NC=C1 QFFRNDMIERRDMZ-UHFFFAOYSA-N 0.000 claims 2
- CUJKKZCQZNVMMK-UHFFFAOYSA-N 1-[2-(1h-indazol-5-yl)-1,3-thiazol-4-yl]-3-[6-(piperidin-1-ylmethyl)pyridin-2-yl]urea Chemical compound C=1SC(C=2C=C3C=NNC3=CC=2)=NC=1NC(=O)NC(N=1)=CC=CC=1CN1CCCCC1 CUJKKZCQZNVMMK-UHFFFAOYSA-N 0.000 claims 2
- RLRPCJOWGTXWIZ-UHFFFAOYSA-N 1-[2-(2-chloropyridin-4-yl)-1,3-thiazol-4-yl]-3-[6-(piperidin-1-ylmethyl)pyridin-2-yl]urea Chemical compound C1=NC(Cl)=CC(C=2SC=C(NC(=O)NC=3N=C(CN4CCCCC4)C=CC=3)N=2)=C1 RLRPCJOWGTXWIZ-UHFFFAOYSA-N 0.000 claims 2
- GRBSNCWHCWHCJE-UHFFFAOYSA-N 1-[2-(2-methoxypyridin-4-yl)-1,3-thiazol-4-yl]-3-[6-(piperidin-1-ylmethyl)pyridin-2-yl]urea Chemical compound C1=NC(OC)=CC(C=2SC=C(NC(=O)NC=3N=C(CN4CCCCC4)C=CC=3)N=2)=C1 GRBSNCWHCWHCJE-UHFFFAOYSA-N 0.000 claims 2
- VGNQPRZWLLRSEI-UHFFFAOYSA-N 1-[2-(2-methoxypyridin-4-yl)-1,3-thiazol-4-yl]-3-[6-[(1-methylpyrrolidin-2-yl)methoxy]pyridin-2-yl]urea Chemical compound C1=NC(OC)=CC(C=2SC=C(NC(=O)NC=3N=C(OCC4N(CCC4)C)C=CC=3)N=2)=C1 VGNQPRZWLLRSEI-UHFFFAOYSA-N 0.000 claims 2
- DBMVSKQVJPGMQP-UHFFFAOYSA-N 1-[4-(diethylaminomethyl)pyridin-2-yl]-3-(2-pyridin-4-yl-1,3-thiazol-4-yl)urea Chemical compound CCN(CC)CC1=CC=NC(NC(=O)NC=2N=C(SC=2)C=2C=CN=CC=2)=C1 DBMVSKQVJPGMQP-UHFFFAOYSA-N 0.000 claims 2
- PEJSESOMOHCUQP-UHFFFAOYSA-N 1-[4-(piperidine-1-carbonyl)pyridin-2-yl]-3-(2-pyridin-4-yl-1,3-thiazol-4-yl)urea Chemical compound C=1C(C(=O)N2CCCCC2)=CC=NC=1NC(=O)NC(N=1)=CSC=1C1=CC=NC=C1 PEJSESOMOHCUQP-UHFFFAOYSA-N 0.000 claims 2
- TWRFTDFREDHKHH-UHFFFAOYSA-N 1-[6-(1-methylpiperidin-4-yl)oxypyridin-2-yl]-3-(2-phenyl-1,3-thiazol-4-yl)urea Chemical compound C1CN(C)CCC1OC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CC=CC=2)=N1 TWRFTDFREDHKHH-UHFFFAOYSA-N 0.000 claims 2
- BPDZREVVZIEUCZ-UHFFFAOYSA-N 1-[6-(1-methylpiperidin-4-yl)oxypyridin-2-yl]-3-(2-pyridin-4-yl-1,3-thiazol-4-yl)urea Chemical compound C1CN(C)CCC1OC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CN=CC=2)=N1 BPDZREVVZIEUCZ-UHFFFAOYSA-N 0.000 claims 2
- NNXOJRIQZFGDGC-UHFFFAOYSA-N 1-[6-(1-piperidin-1-ylethyl)pyridin-2-yl]-3-(2-pyridin-4-yl-1,3-thiazol-4-yl)urea Chemical compound C=1C=CC(NC(=O)NC=2N=C(SC=2)C=2C=CN=CC=2)=NC=1C(C)N1CCCCC1 NNXOJRIQZFGDGC-UHFFFAOYSA-N 0.000 claims 2
- GTJRLXQLWKRRSK-UHFFFAOYSA-N 1-[6-(2-piperidin-4-ylethoxy)pyridin-2-yl]-3-(2-thiophen-2-yl-1,3-thiazol-4-yl)urea Chemical compound C=1C=CC(OCCC2CCNCC2)=NC=1NC(=O)NC(N=1)=CSC=1C1=CC=CS1 GTJRLXQLWKRRSK-UHFFFAOYSA-N 0.000 claims 2
- WYZQMGVLWMBISV-UHFFFAOYSA-N 1-[6-(3-hydroxypropylamino)pyridin-2-yl]-3-(2-pyridin-4-yl-1,3-thiazol-4-yl)urea Chemical compound OCCCNC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CN=CC=2)=N1 WYZQMGVLWMBISV-UHFFFAOYSA-N 0.000 claims 2
- DBONYUFYBZLPJE-UHFFFAOYSA-N 1-[6-(4-ethylpiperazin-1-yl)pyridin-2-yl]-3-(2-phenyl-1,3-thiazol-4-yl)urea Chemical compound C1CN(CC)CCN1C1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CC=CC=2)=N1 DBONYUFYBZLPJE-UHFFFAOYSA-N 0.000 claims 2
- BIYDCUBOPOIKRD-UHFFFAOYSA-N 1-[6-(azetidin-3-ylmethoxy)pyridin-2-yl]-3-(2-bromo-1,3-thiazol-4-yl)urea Chemical compound S1C(Br)=NC(NC(=O)NC=2N=C(OCC3CNC3)C=CC=2)=C1 BIYDCUBOPOIKRD-UHFFFAOYSA-N 0.000 claims 2
- FSESKXXUUGQRSX-UHFFFAOYSA-N 1-[6-(azetidin-3-ylmethoxy)pyridin-2-yl]-3-(2-chloro-1,3-thiazol-4-yl)urea Chemical compound S1C(Cl)=NC(NC(=O)NC=2N=C(OCC3CNC3)C=CC=2)=C1 FSESKXXUUGQRSX-UHFFFAOYSA-N 0.000 claims 2
- DQJUWPHMOYYKEF-UHFFFAOYSA-N 1-[6-(azetidin-3-ylmethoxy)pyridin-2-yl]-3-(2-phenyl-1,3-thiazol-4-yl)urea Chemical compound C=1C=CC(OCC2CNC2)=NC=1NC(=O)NC(N=1)=CSC=1C1=CC=CC=C1 DQJUWPHMOYYKEF-UHFFFAOYSA-N 0.000 claims 2
- AZZNKOCSCQDFQX-UHFFFAOYSA-N 1-[6-(diethylaminomethyl)pyridin-2-yl]-3-(2-phenyl-1,3-thiazol-4-yl)urea Chemical compound CCN(CC)CC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CC=CC=2)=N1 AZZNKOCSCQDFQX-UHFFFAOYSA-N 0.000 claims 2
- FBENHJKGNFJIJY-UHFFFAOYSA-N 1-[6-(diethylcarbamothioyl)pyridin-2-yl]-3-(2-pyridin-4-yl-1,3-thiazol-4-yl)urea Chemical compound CCN(CC)C(=S)C1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CN=CC=2)=N1 FBENHJKGNFJIJY-UHFFFAOYSA-N 0.000 claims 2
- BVLQUUAQCAVKNY-UHFFFAOYSA-N 1-[6-(oxolan-3-ylmethoxy)pyridin-2-yl]-3-(2-pyridin-4-yl-1,3-thiazol-4-yl)urea Chemical compound C=1C=CC(OCC2COCC2)=NC=1NC(=O)NC(N=1)=CSC=1C1=CC=NC=C1 BVLQUUAQCAVKNY-UHFFFAOYSA-N 0.000 claims 2
- FTRAJCMIWNGRHU-UHFFFAOYSA-N 1-[6-(oxolan-3-yloxy)pyridin-2-yl]-3-(2-pyridin-4-yl-1,3-thiazol-4-yl)urea Chemical compound C=1C=CC(OC2COCC2)=NC=1NC(=O)NC(N=1)=CSC=1C1=CC=NC=C1 FTRAJCMIWNGRHU-UHFFFAOYSA-N 0.000 claims 2
- HWDNFJNJZDAYBC-UHFFFAOYSA-N 1-[6-(piperidin-2-ylmethylamino)pyridin-2-yl]-3-(2-pyridin-4-yl-1,3-thiazol-4-yl)urea Chemical compound C=1C=CC(NCC2NCCCC2)=NC=1NC(=O)NC(N=1)=CSC=1C1=CC=NC=C1 HWDNFJNJZDAYBC-UHFFFAOYSA-N 0.000 claims 2
- FMWGSWOSIWGDLY-UHFFFAOYSA-N 1-[6-(piperidin-4-ylmethoxy)pyridin-2-yl]-3-(2-pyridin-4-yl-1,3-thiazol-4-yl)urea Chemical compound C=1C=CC(OCC2CCNCC2)=NC=1NC(=O)NC(N=1)=CSC=1C1=CC=NC=C1 FMWGSWOSIWGDLY-UHFFFAOYSA-N 0.000 claims 2
- GYVYPFIYLAVURX-UHFFFAOYSA-N 1-[6-[(1-methylazetidin-3-yl)methoxy]pyridin-2-yl]-3-(2-phenyl-1,3-thiazol-4-yl)urea Chemical compound C1N(C)CC1COC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CC=CC=2)=N1 GYVYPFIYLAVURX-UHFFFAOYSA-N 0.000 claims 2
- QWKUDEFKJWXTNX-UHFFFAOYSA-N 1-[6-[(1-methylazetidin-3-yl)methoxy]pyridin-2-yl]-3-(2-pyridin-4-yl-1,3-thiazol-4-yl)urea Chemical compound C1N(C)CC1COC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CN=CC=2)=N1 QWKUDEFKJWXTNX-UHFFFAOYSA-N 0.000 claims 2
- OIIDTSSKXKAXCW-UHFFFAOYSA-N 1-[6-[(1-methylpiperidin-4-yl)methoxy]pyridin-2-yl]-3-(2-phenyl-1,3-thiazol-4-yl)urea Chemical compound C1CN(C)CCC1COC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CC=CC=2)=N1 OIIDTSSKXKAXCW-UHFFFAOYSA-N 0.000 claims 2
- RACVMKFOBUIPAT-UHFFFAOYSA-N 1-[6-[(1-methylpiperidin-4-yl)methoxy]pyridin-2-yl]-3-(2-pyridin-4-yl-1,3-thiazol-4-yl)urea Chemical compound C1CN(C)CCC1COC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CN=CC=2)=N1 RACVMKFOBUIPAT-UHFFFAOYSA-N 0.000 claims 2
- XJYDJVBUWZFERN-UHFFFAOYSA-N 1-[6-[(1-methylpyrrolidin-2-yl)methoxy]pyridin-2-yl]-3-(2-pyridin-4-yl-1,3-thiazol-4-yl)urea Chemical compound CN1CCCC1COC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CN=CC=2)=N1 XJYDJVBUWZFERN-UHFFFAOYSA-N 0.000 claims 2
- JHJZVKHAOGFOOI-UHFFFAOYSA-N 1-[6-[(1-methylpyrrolidin-2-yl)methoxy]pyridin-2-yl]-3-[2-(thiophen-2-ylsulfonylmethyl)-1,3-thiazol-4-yl]urea Chemical compound CN1CCCC1COC1=CC=CC(NC(=O)NC=2N=C(CS(=O)(=O)C=3SC=CC=3)SC=2)=N1 JHJZVKHAOGFOOI-UHFFFAOYSA-N 0.000 claims 2
- CTJAVOPVEAPWCL-UHFFFAOYSA-N 1-[6-[(2,6-dimethylpiperidin-1-yl)methyl]pyridin-2-yl]-3-(2-pyridin-4-yl-1,3-thiazol-4-yl)urea Chemical compound CC1CCCC(C)N1CC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CN=CC=2)=N1 CTJAVOPVEAPWCL-UHFFFAOYSA-N 0.000 claims 2
- KVSKMFBILRBMKJ-UHFFFAOYSA-N 1-[6-[(3-methylpiperidin-1-yl)methyl]pyridin-2-yl]-3-(2-phenyl-1,3-thiazol-4-yl)urea Chemical compound C1C(C)CCCN1CC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CC=CC=2)=N1 KVSKMFBILRBMKJ-UHFFFAOYSA-N 0.000 claims 2
- XEHKSCOHBUEMMC-UHFFFAOYSA-N 1-[6-[(propan-2-ylamino)methyl]pyridin-2-yl]-3-(2-pyridin-4-yl-1,3-thiazol-4-yl)urea Chemical compound CC(C)NCC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CN=CC=2)=N1 XEHKSCOHBUEMMC-UHFFFAOYSA-N 0.000 claims 2
- JUILEWQVNWYLJL-UHFFFAOYSA-N 1-[6-[2-(dimethylamino)ethoxy]pyridin-2-yl]-3-[2-(2-methoxypyridin-4-yl)-1,3-thiazol-4-yl]urea Chemical compound C1=NC(OC)=CC(C=2SC=C(NC(=O)NC=3N=C(OCCN(C)C)C=CC=3)N=2)=C1 JUILEWQVNWYLJL-UHFFFAOYSA-N 0.000 claims 2
- XIUKUYBQSUQPBK-INIZCTEOSA-N 1-[6-[[(2s)-1-methylpyrrolidin-2-yl]methoxy]pyridin-2-yl]-3-(2-phenyl-1,3-thiazol-4-yl)urea Chemical compound CN1CCC[C@H]1COC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CC=CC=2)=N1 XIUKUYBQSUQPBK-INIZCTEOSA-N 0.000 claims 2
- OMXRPPSIMAHWBU-OAHLLOKOSA-N 1-[6-[[(3r)-3-methylpiperidin-1-yl]methyl]pyridin-2-yl]-3-(2-pyridin-4-yl-1,3-thiazol-4-yl)urea Chemical compound C1[C@H](C)CCCN1CC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CN=CC=2)=N1 OMXRPPSIMAHWBU-OAHLLOKOSA-N 0.000 claims 2
- OMXRPPSIMAHWBU-HNNXBMFYSA-N 1-[6-[[(3s)-3-methylpiperidin-1-yl]methyl]pyridin-2-yl]-3-(2-pyridin-4-yl-1,3-thiazol-4-yl)urea Chemical compound C1[C@@H](C)CCCN1CC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CN=CC=2)=N1 OMXRPPSIMAHWBU-HNNXBMFYSA-N 0.000 claims 2
- 125000003830 C1- C4 alkylcarbonylamino group Chemical group 0.000 claims 2
- 101001059454 Homo sapiens Serine/threonine-protein kinase MARK2 Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000012902 Nervous system disease Diseases 0.000 claims 2
- 102100028904 Serine/threonine-protein kinase MARK2 Human genes 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 230000004663 cell proliferation Effects 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 2
- 125000001041 indolyl group Chemical group 0.000 claims 2
- AOOWXVLNSQUELZ-UHFFFAOYSA-N n,n-diethyl-6-[(2-phenyl-1,3-thiazol-4-yl)carbamoylamino]pyridine-2-carboxamide Chemical compound CCN(CC)C(=O)C1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CC=CC=2)=N1 AOOWXVLNSQUELZ-UHFFFAOYSA-N 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000006296 sulfonyl amino group Chemical group [H]N(*)S(*)(=O)=O 0.000 claims 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 239000011593 sulfur Substances 0.000 claims 2
- MVXHZHFSJDOJPI-UHFFFAOYSA-N tert-butyl 2-[[6-[(2-pyridin-4-yl-1,3-thiazol-4-yl)carbamoylamino]pyridin-2-yl]oxymethyl]pyrrolidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCCC1COC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CN=CC=2)=N1 MVXHZHFSJDOJPI-UHFFFAOYSA-N 0.000 claims 2
- YASDBTBEDJEUQP-UHFFFAOYSA-N tert-butyl 2-[[[6-[(2-pyridin-4-yl-1,3-thiazol-4-yl)carbamoylamino]pyridin-2-yl]amino]methyl]piperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCCCC1CNC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CN=CC=2)=N1 YASDBTBEDJEUQP-UHFFFAOYSA-N 0.000 claims 2
- MIYPESNNYZVKQU-UHFFFAOYSA-N tert-butyl 3-[[6-[(2-pyridin-4-yl-1,3-thiazol-4-yl)carbamoylamino]pyridin-2-yl]oxymethyl]pyrrolidine-1-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCC1COC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CN=CC=2)=N1 MIYPESNNYZVKQU-UHFFFAOYSA-N 0.000 claims 2
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 125000006569 (C5-C6) heterocyclic group Chemical group 0.000 claims 1
- PYNKENWDVGFMQY-UHFFFAOYSA-N 1-(2-bromo-1,3-thiazol-4-yl)-3-[4-(piperidine-1-carbonyl)pyridin-2-yl]urea Chemical compound S1C(Br)=NC(NC(=O)NC=2N=CC=C(C=2)C(=O)N2CCCCC2)=C1 PYNKENWDVGFMQY-UHFFFAOYSA-N 0.000 claims 1
- DHTXAVKDVZVRPT-UHFFFAOYSA-N 1-(2-bromo-1,3-thiazol-4-yl)-3-[6-(piperidin-4-ylmethoxy)pyridin-2-yl]urea Chemical compound S1C(Br)=NC(NC(=O)NC=2N=C(OCC3CCNCC3)C=CC=2)=C1 DHTXAVKDVZVRPT-UHFFFAOYSA-N 0.000 claims 1
- ZFFOIDHFLFKHBI-UHFFFAOYSA-N 1-(2-bromo-1,3-thiazol-4-yl)-3-[6-[(propan-2-ylamino)methyl]pyridin-2-yl]urea Chemical compound CC(C)NCC1=CC=CC(NC(=O)NC=2N=C(Br)SC=2)=N1 ZFFOIDHFLFKHBI-UHFFFAOYSA-N 0.000 claims 1
- YZFRQCLJMBSIJK-UHFFFAOYSA-N 1-(2-chloro-1,3-thiazol-4-yl)-3-[4-(piperidine-1-carbonyl)pyridin-2-yl]urea Chemical compound S1C(Cl)=NC(NC(=O)NC=2N=CC=C(C=2)C(=O)N2CCCCC2)=C1 YZFRQCLJMBSIJK-UHFFFAOYSA-N 0.000 claims 1
- OOZDAVBSDIZTBO-UHFFFAOYSA-N 1-(2-cyclopropyl-1,3-thiazol-4-yl)-3-[6-(2-piperidin-4-ylethoxy)pyridin-2-yl]urea Chemical compound C=1C=CC(OCCC2CCNCC2)=NC=1NC(=O)NC(N=1)=CSC=1C1CC1 OOZDAVBSDIZTBO-UHFFFAOYSA-N 0.000 claims 1
- DWGQFABAMZZBFN-UHFFFAOYSA-N 1-(2-phenyl-1,3-thiazol-4-yl)-3-[4-(piperidine-1-carbonyl)pyridin-2-yl]urea Chemical compound C=1C(C(=O)N2CCCCC2)=CC=NC=1NC(=O)NC(N=1)=CSC=1C1=CC=CC=C1 DWGQFABAMZZBFN-UHFFFAOYSA-N 0.000 claims 1
- OTPDGNKMGMOSAV-UHFFFAOYSA-N 1-[6-[(1-methylpyrrolidin-2-yl)methoxy]pyridin-2-yl]-3-[2-(3-sulfamoylphenyl)-1,3-thiazol-4-yl]urea Chemical compound CN1CCCC1COC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=C(C=CC=2)S(N)(=O)=O)=N1 OTPDGNKMGMOSAV-UHFFFAOYSA-N 0.000 claims 1
- 125000004484 1-methylpiperidin-4-yl group Chemical group CN1CCC(CC1)* 0.000 claims 1
- ZINRZVULMXTYGZ-UHFFFAOYSA-N 2-[(2-bromo-1,3-thiazol-4-yl)carbamoylamino]-n,n-diethylpyridine-4-carboxamide Chemical compound CCN(CC)C(=O)C1=CC=NC(NC(=O)NC=2N=C(Br)SC=2)=C1 ZINRZVULMXTYGZ-UHFFFAOYSA-N 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 claims 1
- 125000004657 aryl sulfonyl amino group Chemical group 0.000 claims 1
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 claims 1
- 125000002393 azetidinyl group Chemical group 0.000 claims 1
- 125000001246 bromo group Chemical group Br* 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000005357 cycloalkylalkynyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 125000005143 heteroarylsulfonyl group Chemical group 0.000 claims 1
- 125000004531 indol-5-yl group Chemical group [H]N1C([H])=C([H])C2=C([H])C(*)=C([H])C([H])=C12 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- 125000005415 substituted alkoxy group Chemical group 0.000 claims 1
- QAFCNJYRJPTTPS-UHFFFAOYSA-N tert-butyl 4-[6-[(2-pyridin-4-yl-1,3-thiazol-4-yl)carbamoylamino]pyridin-2-yl]-3,6-dihydro-2h-pyridine-1-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCC(C=2N=C(NC(=O)NC=3N=C(SC=3)C=3C=CN=CC=3)C=CC=2)=C1 QAFCNJYRJPTTPS-UHFFFAOYSA-N 0.000 claims 1
- PYIQZGPIWGGADX-UHFFFAOYSA-N tert-butyl n-[[6-[(2-phenyl-1,3-thiazol-4-yl)carbamoylamino]pyridin-2-yl]methyl]-n-propan-2-ylcarbamate Chemical compound CC(C)(C)OC(=O)N(C(C)C)CC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CC=CC=2)=N1 PYIQZGPIWGGADX-UHFFFAOYSA-N 0.000 claims 1
- QAYURVVBRZRNMC-UHFFFAOYSA-N tert-butyl n-propan-2-yl-n-[[6-[(2-pyridin-4-yl-1,3-thiazol-4-yl)carbamoylamino]pyridin-2-yl]methyl]carbamate Chemical compound CC(C)(C)OC(=O)N(C(C)C)CC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CN=CC=2)=N1 QAYURVVBRZRNMC-UHFFFAOYSA-N 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/077,124 US6645990B2 (en) | 2000-08-15 | 2002-02-15 | Thiazolyl urea compounds and methods of uses |
| PCT/US2003/004537 WO2003070727A1 (en) | 2002-02-15 | 2003-02-13 | Thiazolyl urea compounds for the treatment of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006509715A JP2006509715A (ja) | 2006-03-23 |
| JP2006509715A5 true JP2006509715A5 (OSRAM) | 2006-05-11 |
Family
ID=27752688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003569634A Pending JP2006509715A (ja) | 2002-02-15 | 2003-02-13 | 癌の治療用チアゾイル尿素化合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US6645990B2 (OSRAM) |
| EP (1) | EP1483263A1 (OSRAM) |
| JP (1) | JP2006509715A (OSRAM) |
| AU (1) | AU2003215231A1 (OSRAM) |
| CA (1) | CA2476411A1 (OSRAM) |
| MX (1) | MXPA04007970A (OSRAM) |
| PL (1) | PL372211A1 (OSRAM) |
| WO (1) | WO2003070727A1 (OSRAM) |
Families Citing this family (134)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030171411A1 (en) * | 2001-12-21 | 2003-09-11 | Kodra Janos Tibor | Amide derivatives as therapeutic agents |
| US20040014744A1 (en) * | 2002-04-05 | 2004-01-22 | Fortuna Haviv | Substituted pyridines having antiangiogenic activity |
| US20030236287A1 (en) * | 2002-05-03 | 2003-12-25 | Piotrowski David W. | Positive allosteric modulators of the nicotinic acetylcholine receptor |
| RU2340605C2 (ru) * | 2002-06-27 | 2008-12-10 | Ново Нордиск А/С | Арилкарбонильные производные в качестве терапевтических средств |
| EP1531815B1 (en) * | 2002-06-27 | 2014-09-24 | Novo Nordisk A/S | Glucokinase activators |
| US7071636B2 (en) * | 2002-11-26 | 2006-07-04 | Stmicroelectronics S.A. | Scanning circuit of electron tube displays |
| US7144911B2 (en) * | 2002-12-31 | 2006-12-05 | Deciphera Pharmaceuticals Llc | Anti-inflammatory medicaments |
| US7202257B2 (en) * | 2003-12-24 | 2007-04-10 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
| WO2004064730A2 (en) * | 2003-01-14 | 2004-08-05 | Cytokinetics, Inc. | Compounds, compositions and methods |
| CN100491361C (zh) * | 2003-01-27 | 2009-05-27 | 安斯泰来制药有限公司 | 噻唑衍生物及其作为vap-1抑制剂的用途 |
| CA2520763A1 (en) | 2003-04-03 | 2004-10-21 | The Regents Of The University Of California | Improved inhibitors for the soluble epoxide hydrolase |
| EP1684762A4 (en) * | 2003-11-13 | 2009-06-17 | Ambit Biosciences Corp | UREA DERIVATIVES AS MODULATORS OF KINASE |
| EP1544189B1 (en) * | 2003-12-15 | 2013-09-25 | Mitsubishi Gas Chemical Company, Inc. | Method for producing halogen-substituted aromatic aldehydes |
| US7250258B2 (en) * | 2003-12-15 | 2007-07-31 | Pgxhealth Llc | CDK5 genetic markers associated with galantamine response |
| DK1723128T3 (da) * | 2004-01-06 | 2013-02-18 | Novo Nordisk As | Heteroarylurinstoffer og deres anvendelse som glucokinaseaktivatorer |
| CA2559665A1 (en) | 2004-03-16 | 2005-09-29 | The Regents Of The University Of California | Reducing nephropathy with inhibitors of soluble epoxide hydrolase and epoxyeicosanoids |
| CN1972914A (zh) * | 2004-03-31 | 2007-05-30 | 詹森药业有限公司 | 作为组胺h3受体配合体的非咪唑杂环化合物 |
| AU2005264988B2 (en) | 2004-06-17 | 2011-09-22 | Cytokinetics, Inc. | Substituted urea derivatives for treating cardiac diseases |
| US7176222B2 (en) | 2004-07-27 | 2007-02-13 | Cytokinetics, Inc. | Syntheses of ureas |
| EP1789390B1 (en) | 2004-09-02 | 2011-11-09 | Genentech, Inc. | Pyridyl inhibitors of hedgehog signalling |
| FR2876584B1 (fr) * | 2004-10-15 | 2007-04-13 | Centre Nat Rech Scient Cnrse | Utilisation de la kenpaullone pour la fabrication de medicaments pour le traitement de la mucoviscidose et de maladies liees a un defaut d'adressage des proteines dans les cellules |
| US7662910B2 (en) | 2004-10-20 | 2010-02-16 | The Regents Of The University Of California | Inhibitors for the soluble epoxide hydrolase |
| US20090156565A1 (en) * | 2004-12-03 | 2009-06-18 | The Children's Hospital Of Philadelphia | Composition and use thereof in enhancing a therapeutic effect of an antiepileptic drug |
| US20090312349A1 (en) * | 2004-12-23 | 2009-12-17 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
| AU2005321946B2 (en) | 2004-12-23 | 2012-08-16 | Deciphera Pharmaceuticals, Llc | Enzyme modulators and treatments |
| JP2008526721A (ja) | 2004-12-30 | 2008-07-24 | アステックス、セラピューティックス、リミテッド | Ｃｄｋ、ｇｓｋ及びオーロラキナーゼの活性を調節するチアゾールおよびイソチアゾール誘導体 |
| JP2008526988A (ja) * | 2005-01-14 | 2008-07-24 | シージーアイ ファーマシューティカルズ，インコーポレーテッド | キナーゼ活性モジュレーターとしての１，３−ジアリール置換尿素 |
| PL1858877T3 (pl) * | 2005-01-14 | 2014-08-29 | Gilead Connecticut Inc | 1,3 podstawione diarylem moczniki jako modulatory aktywności kinazy |
| US7786153B2 (en) | 2005-03-02 | 2010-08-31 | Abbott Laboratories Inc. | Compounds that are useful for improving pharmacokinetics |
| US7777040B2 (en) * | 2005-05-03 | 2010-08-17 | Cgi Pharmaceuticals, Inc. | Certain substituted ureas, as modulators of kinase activity |
| ATE547396T1 (de) * | 2005-07-08 | 2012-03-15 | Novo Nordisk As | Dicycloalkylcarbamoyl-harnstoffe als glucokinase- aktivatoren |
| RU2443691C2 (ru) * | 2005-07-14 | 2012-02-27 | Транстех Фарма, Инк. | Мочевинные активаторы глюкокиназы |
| US7538223B2 (en) * | 2005-08-04 | 2009-05-26 | Cytokinetics, Inc. | Compounds, compositions and methods |
| EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
| EP2275095A3 (en) | 2005-08-26 | 2011-08-17 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| WO2007041341A2 (en) * | 2005-09-29 | 2007-04-12 | The Trustees Of Columbia University In The City Of New York | Identification of anti-cancer compounds and compounds for treating huntington's disease and methods of treatment thereof |
| CA2625153A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| EP1959947A2 (en) * | 2005-12-15 | 2008-08-27 | Cytokinetics, Inc. | Certain chemical entities, compositions and methods |
| US7825120B2 (en) * | 2005-12-15 | 2010-11-02 | Cytokinetics, Inc. | Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas |
| EP1959960B1 (en) * | 2005-12-15 | 2013-04-10 | Cytokinetics, Inc. | Certain chemical entities, compositions and methods |
| US20070208000A1 (en) * | 2005-12-15 | 2007-09-06 | Morgan Bradley P | Certain chemical entities, compositions and methods |
| EP1959962A2 (en) | 2005-12-16 | 2008-08-27 | Cytokinetics, Inc. | Certain chemical entities, compositions, and methods |
| US7989455B2 (en) * | 2005-12-19 | 2011-08-02 | Cytokinetics, Inc. | Compounds, compositions and methods |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| AR059826A1 (es) * | 2006-03-13 | 2008-04-30 | Univ California | Inhibidores de urea conformacionalmente restringidos de epoxido hidrolasa soluble |
| JP2009536669A (ja) | 2006-05-09 | 2009-10-15 | ブレインセルス，インコーポレイティド | アンジオテンシン調節による神経新生 |
| BRPI0711385A2 (pt) * | 2006-05-09 | 2011-11-08 | Novartis Ag | combinação compreendendo um quelante de ferro e um agente anti-neoplástico e seu uso |
| US7678808B2 (en) | 2006-05-09 | 2010-03-16 | Braincells, Inc. | 5 HT receptor mediated neurogenesis |
| EA015555B1 (ru) | 2006-05-30 | 2011-08-30 | Янссен Фармацевтика Н.В. | Замещенные пиридиламидные соединения в качестве модуляторов гистаминового h-рецептора |
| EP2038269A1 (en) * | 2006-06-29 | 2009-03-25 | Janssen Pharmaceutica N.V. | Substituted benzamide modulators of the histamine h3 receptor |
| WO2008027932A2 (en) * | 2006-08-31 | 2008-03-06 | Abbott Laboratories | Cytochrome p450 oxidase inhibitors and uses thereof |
| AU2007292848A1 (en) * | 2006-09-08 | 2008-03-13 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
| US8188113B2 (en) | 2006-09-14 | 2012-05-29 | Deciphera Pharmaceuticals, Inc. | Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| US7790756B2 (en) | 2006-10-11 | 2010-09-07 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases |
| JP2010515701A (ja) * | 2007-01-09 | 2010-05-13 | ノボ・ノルデイスク・エー／エス | ウレアグルコキナーゼアクチベーター |
| EP2099777B1 (en) * | 2007-01-11 | 2015-08-12 | Novo Nordisk A/S | Urea glucokinase activators |
| CN101772498A (zh) * | 2007-04-10 | 2010-07-07 | H.隆德贝克有限公司 | 作为p2x7拮抗剂的杂芳基酰胺类似物 |
| BRPI0807717A2 (pt) * | 2007-04-20 | 2014-05-20 | Deciphera Pharmaceuticals Llc | Inibidores de quinase úteis para o tratamento de doenças mieloproliferativas e outras doenças proliferativas. |
| US20110189167A1 (en) * | 2007-04-20 | 2011-08-04 | Flynn Daniel L | Methods and Compositions for the Treatment of Myeloproliferative Diseases and other Proliferative Diseases |
| US8883776B2 (en) | 2007-11-20 | 2014-11-11 | Janssen Pharmaceutica N.V. | Cycloalkyloxy- and heterocycloalkyloxypyridine compounds as modulators of the histamine H3 receptor |
| JPWO2009096198A1 (ja) * | 2008-02-01 | 2011-05-26 | 一般社団法人ファルマＩｐ | 新規ビアリール誘導体 |
| US20090209488A1 (en) * | 2008-02-19 | 2009-08-20 | Roger Wayne Brown | Compositions for the treatment of exercise induced asthma |
| WO2009148623A2 (en) | 2008-06-05 | 2009-12-10 | Stc.Unm | Methods and related compositions for the treatment of cancer |
| US20100015072A1 (en) * | 2008-06-30 | 2010-01-21 | Christopher Polla | Topical Compositions Comprising Isonicotinamide |
| KR20110099687A (ko) * | 2008-10-29 | 2011-09-08 | 데시페라 파마슈티칼스, 엘엘씨. | 항-암과 항-증식성 활성을 나타내는 시클로프로판 아미드와 유사체 |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| UA107791C2 (en) | 2009-05-05 | 2015-02-25 | Dow Agrosciences Llc | Pesticidal compositions |
| TW201124391A (en) * | 2009-10-20 | 2011-07-16 | Lundbeck & Co As H | 2-substituted-ethynylthiazole derivatives and uses of same |
| EP2528604B1 (en) | 2010-01-29 | 2017-11-22 | The Regents of the University of California | Acyl piperidine inhibitors of soluble epoxide hydrolase |
| CN105360132A (zh) | 2010-11-03 | 2016-03-02 | 陶氏益农公司 | 杀虫组合物和与其相关的方法 |
| EP2701699B1 (en) | 2011-04-28 | 2019-10-16 | The Broad Institute, Inc. | Inhibitors of histone deacetylase |
| US20140296064A1 (en) | 2011-07-15 | 2014-10-02 | Basf Se | Pesticidal methods using substituted 3-pyridyl thiazole compounds and derivatives for combating animal pests i |
| ES2899850T3 (es) | 2011-10-26 | 2022-03-15 | Corteva Agriscience Llc | Composiciones plaguicidas y procedimientos relacionados con las mismas |
| US9282739B2 (en) | 2012-04-27 | 2016-03-15 | Dow Agrosciences Llc | Pesticidal compositions and processes related thereto |
| MX2014013069A (es) | 2012-04-27 | 2015-07-06 | Dow Agrosciences Llc | Composiciones plaguicidas y procesos relacionados. |
| US9708288B2 (en) | 2012-04-27 | 2017-07-18 | Dow Agrosciences Llc | Pesticidal compositions and processes related thereto |
| US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| WO2014018979A1 (en) | 2012-07-27 | 2014-01-30 | The Broad Institute, Inc. | Inhibitors of histone deacetylase |
| US10092574B2 (en) | 2012-09-26 | 2018-10-09 | Valorisation-Recherche, Limited Partnership | Inhibitors of polynucleotide repeat-associated RNA foci and uses thereof |
| JP2015535525A (ja) * | 2012-11-12 | 2015-12-14 | ダウ アグロサイエンシィズ エルエルシー | 有害生物防除作用をもつピリミジン化合物 |
| CN102964295B (zh) * | 2012-12-17 | 2014-08-20 | 寿光富康制药有限公司 | 一种2-取代-4-（哌啶基甲基）吡啶的制备方法 |
| WO2014100438A1 (en) | 2012-12-20 | 2014-06-26 | The Broad Institute, Inc. | Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors |
| CN104250245A (zh) * | 2013-06-25 | 2014-12-31 | 苏州科捷生物医药有限公司 | 1-(5-(2-氨基苯并[d]恶唑-5-基)-1,3,4-噻二唑-2-基)-3-(2-氟-5-甲基苯基)脲的合成及其用途 |
| JP6487426B2 (ja) | 2013-10-17 | 2019-03-20 | ダウ アグロサイエンシィズ エルエルシー | 有害生物防除化合物の調製法 |
| EP3057431A4 (en) | 2013-10-17 | 2017-04-05 | Dow AgroSciences LLC | Processes for the preparation of pesticidal compounds |
| MX2016004942A (es) | 2013-10-17 | 2016-06-28 | Dow Agrosciences Llc | Procesos para la preparacion de compuestos plaguicidas. |
| CN105636440A (zh) | 2013-10-17 | 2016-06-01 | 美国陶氏益农公司 | 制备杀虫化合物的方法 |
| JP2016536295A (ja) | 2013-10-17 | 2016-11-24 | ダウ アグロサイエンシィズ エルエルシー | 有害生物防除性化合物の製造方法 |
| CN105636446B (zh) | 2013-10-17 | 2018-07-13 | 美国陶氏益农公司 | 制备杀虫化合物的方法 |
| CA2926095A1 (en) | 2013-10-17 | 2015-04-23 | Dow Agrosciences Llc | Processes for the preparation of pesticidal compounds |
| CA2926345A1 (en) | 2013-10-22 | 2015-04-30 | Dow Agrosciences Llc | Synergistic pesticidal compositions and related methods |
| CA2927195A1 (en) | 2013-10-22 | 2015-04-30 | Dow Agrosciences Llc | Synergistic pesticidal compositions and related methods |
| KR20160074633A (ko) | 2013-10-22 | 2016-06-28 | 다우 아그로사이언시즈 엘엘씨 | 상승작용적 살충 조성물 및 관련 방법 |
| CN105848481A (zh) | 2013-10-22 | 2016-08-10 | 美国陶氏益农公司 | 协同杀虫组合物和相关方法 |
| KR20160074635A (ko) | 2013-10-22 | 2016-06-28 | 다우 아그로사이언시즈 엘엘씨 | 상승작용적 살충 조성물 및 관련 방법 |
| KR102286233B1 (ko) | 2013-10-22 | 2021-08-06 | 코르테바 애그리사이언스 엘엘씨 | 살충 조성물 및 관련 방법 |
| CA2926101C (en) | 2013-10-22 | 2022-05-31 | Dow Agrosciences Llc | Pesticidal compositions and related methods |
| KR20160074582A (ko) | 2013-10-22 | 2016-06-28 | 다우 아그로사이언시즈 엘엘씨 | 상승작용적 살충 조성물 및 관련 방법 |
| EP3060047A4 (en) | 2013-10-22 | 2017-04-26 | Dow AgroSciences, LLC | Pesticidal compositions and related methods |
| AU2014340430B2 (en) | 2013-10-22 | 2017-05-25 | Dow Agrosciences Llc | Pesticidal compositions and related methods |
| EP3060046A4 (en) | 2013-10-22 | 2017-07-26 | Dow AgroSciences LLC | Pesticidal compositions and related methods |
| AR098096A1 (es) | 2013-10-22 | 2016-05-04 | Dow Agrosciences Llc | Composiciones plaguicidas sinérgicas y métodos relacionados |
| WO2015061147A1 (en) | 2013-10-22 | 2015-04-30 | Dow Agrosciences Llc | Synergistic pesticidal compositions and related methods |
| RU2016119571A (ru) | 2013-10-22 | 2017-11-28 | ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи | Синергетические пестицидные композиции и связанные с ними способы |
| EP3060051A4 (en) | 2013-10-22 | 2017-04-05 | Dow AgroSciences LLC | Synergistic pesticidal compositions and related methods |
| TW201519782A (zh) | 2013-10-22 | 2015-06-01 | Dow Agrosciences Llc | 殺蟲組成物及相關方法（五） |
| CN105658062A (zh) | 2013-10-22 | 2016-06-08 | 美国陶氏益农公司 | 协同杀虫组合物和相关方法 |
| DK3068766T3 (en) * | 2013-11-15 | 2018-04-23 | Bayer Cropscience Ag | CATALYTIC HYDROGENATION OF NITRILS |
| BR112017000418A2 (pt) | 2014-07-31 | 2017-11-07 | Dow Agrosciences Llc | processo para a preparação de 3-(3-cloro-1h-pirazol-1-il)piridina |
| CA2954345A1 (en) | 2014-07-31 | 2016-02-04 | Dow Agrosciences Llc | Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine |
| EP3186230A4 (en) | 2014-07-31 | 2018-01-10 | Dow AgroSciences, LLC | Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine |
| EP3183238A4 (en) | 2014-08-19 | 2018-01-10 | Dow AgroSciences LLC | Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine |
| BR112017004613A2 (pt) | 2014-09-12 | 2017-12-05 | Dow Agrosciences Llc | processo para a preparação de 3-(3-cloro-1h-pirazol-1-il)piridina |
| EP3353182A1 (en) | 2015-09-24 | 2018-08-01 | Pfizer Inc | Tetrahydropyrano[3,4-d][1,3]oxazin derivatives and their use as bace inhibitors |
| US20190060286A1 (en) | 2016-02-29 | 2019-02-28 | University Of Florida Research Foundation, Incorpo | Chemotherapeutic Methods |
| WO2017152117A1 (en) * | 2016-03-03 | 2017-09-08 | Cornell University | Small molecule ire1-alpha inhibitors |
| US10100033B2 (en) | 2016-12-29 | 2018-10-16 | Dow Agrosciences Llc | Processes for the preparation of pesticidal compounds |
| WO2018125817A1 (en) | 2016-12-29 | 2018-07-05 | Dow Agrosciences Llc | Processes for the preparation of pesticidal compounds |
| CA3125731A1 (en) | 2018-01-12 | 2019-07-18 | KDAc Therapeutics, Inc. | Combination of a selective histone deacetylase 3 (hdac3) inhibitor and an immunotherapy agent for the treatment of cancer |
| EP3746060A1 (en) | 2018-01-31 | 2020-12-09 | Deciphera Pharmaceuticals, LLC | Combination therapy for the treatment of mastocytosis |
| BR112020015581A2 (pt) | 2018-01-31 | 2021-02-02 | Deciphera Pharmaceuticals, Llc | terapia de combinação para o tratamento de tumores estromais gastrointestinais |
| WO2019241089A1 (en) | 2018-06-12 | 2019-12-19 | Vtv Therapeutics Llc | Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs |
| GB201813065D0 (en) * | 2018-08-10 | 2018-09-26 | Aritos Pharma Ltd | Novel compounds |
| KR20220045189A (ko) | 2019-08-12 | 2022-04-12 | 데시페라 파마슈티칼스, 엘엘씨. | 위장관 기질 종양을 치료하는 방법 |
| WO2021030405A1 (en) | 2019-08-12 | 2021-02-18 | Deciphera Pharmaceuticals, Llc | Ripretinib for treating gastrointestinal stromal tumors |
| CN118948773A (zh) | 2019-12-30 | 2024-11-15 | 德西费拉制药有限责任公司 | 1-(4溴-5-(1乙基-7-(甲氨基)-2侧氧基-1,2-二氢-1,6-萘啶-3基)-2氟苯基)-3-苯基脲的组合物 |
| SMT202300467T1 (it) | 2019-12-30 | 2024-01-10 | Deciphera Pharmaceuticals Llc | Formulazioni di inibitori di chinasi amorfi e loro procedimenti d’uso |
| WO2021167840A1 (en) | 2020-02-18 | 2021-08-26 | Vtv Therapeutics Llc | Sulfoxide and sulfone glucokinase activators and methods of use thereof |
| WO2021204626A1 (en) | 2020-04-06 | 2021-10-14 | Almirall, S.A. | Aryl and heteroaryl-carboxamide substituted heteroaryl compounds as tyk2 inhibitors |
| CA3181722A1 (en) | 2020-06-08 | 2021-12-16 | Jing TENG | Salts or co-crystals of {2-[3-cyclohexyl-3-(trans-4-propoxy-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid and uses thereof |
| AU2021391453A1 (en) * | 2020-12-04 | 2023-07-13 | Eubulus Biotherapeutics Inc. | Heteroaryl-acetylenes, pharmaceutical compositions thereof, and their therapeutic applications |
| US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA962269A (en) | 1971-05-05 | 1975-02-04 | Robert E. Grahame (Jr.) | Thiazoles, and their use as insecticides |
| FR2155856A1 (en) | 1971-10-11 | 1973-05-25 | Leurquin Lab | N-2 pyridylureas - with antiinflammatory and analgesic activity |
| HU168393B (OSRAM) | 1973-11-09 | 1976-04-28 | ||
| FR2617844B1 (fr) * | 1987-07-10 | 1990-06-15 | Rhone Poulenc Agrochimie | Compositions fongicides a base de derives nicotiniques. nouveaux derives nicotiniques et leur preparation |
| US5041426A (en) | 1987-12-21 | 1991-08-20 | Brigham Young University | Immune system enhancing 3-β-d-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and nucleotides |
| US5364871A (en) | 1989-09-15 | 1994-11-15 | Fujisawa Pharmaceutical Co., Ltd. | New thiazole derivatives, and pharmaceutical composition comprising the same |
| IL96891A0 (en) | 1990-01-17 | 1992-03-29 | Merck Sharp & Dohme | Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them |
| MY107955A (en) | 1990-07-27 | 1996-07-15 | Ici Plc | Fungicides. |
| US5208248A (en) | 1991-01-11 | 1993-05-04 | Merck Sharpe & Dohme, Ltd. | Indazole-substituted five-membered heteroaromatic compounds |
| DE4204452A1 (de) | 1991-02-19 | 1992-08-20 | Ciba Geigy Ag | Cyclohexylcarbonylharnstoffe |
| DE4204492A1 (de) | 1991-02-19 | 1992-08-20 | Ciba Geigy Ag | Cyclohexenylcarbonylharnstoffe |
| WO1993007751A1 (en) | 1991-10-18 | 1993-04-29 | Monsanto Company | Fungicides for the control of take-all disease of plants |
| GB9200210D0 (en) | 1992-01-07 | 1992-02-26 | British Bio Technology | Compounds |
| DE4222771A1 (de) | 1992-07-10 | 1994-01-13 | Bayer Ag | Heterocyclyltriazolinone |
| DE4224929A1 (de) | 1992-07-28 | 1994-02-03 | Bayer Ag | Heterocyclyltriazolinone |
| JPH06122677A (ja) * | 1992-08-28 | 1994-05-06 | Sankyo Co Ltd | 光学活性なカルボン酸アミド誘導体 |
| GB9324018D0 (en) * | 1993-11-23 | 1994-01-12 | Merck Sharp & Dohme | Therapeutic agents |
| GB2293380A (en) | 1994-09-22 | 1996-03-27 | Zeneca Ltd | Pesticidal heterocyclic and phenyl compounds |
| NZ301265A (en) | 1995-02-02 | 1998-12-23 | Smithkline Beecham Plc | Indole derivatives as 5ht receptor antagonists, preparation and pharmaceutical compositions thereof |
| HUP9801057A3 (en) | 1995-05-26 | 2000-06-28 | Bayer Ag | Pyridyl-thiazoles and their use to protect plants against infections by micro-organisms |
| GB9512961D0 (en) | 1995-06-26 | 1995-08-30 | Pfizer Ltd | Antifungal agents |
| NZ299242A (en) | 1995-09-11 | 1997-12-19 | Nihon Nohyaku Co Ltd | N-phenyl-n'-(phenyl substituted imidazol-5-yl, -oxazol-4-yl, and -thiazol-4-yl)urea derivatives |
| CZ183198A3 (cs) | 1995-12-14 | 1998-10-14 | Merck And Co., Inc. | Nepeptidové deriváty, antagonizující hormon, uvolňující gonadotropin a farmaceutický prostředek |
| EP0795328A1 (en) | 1996-03-15 | 1997-09-17 | Pfizer Inc. | Use of naphthalene derivatives in treating lung carcinoma |
| DE69826695T2 (de) | 1997-05-23 | 2006-02-02 | Bayer Pharmaceuticals Corp., West Haven | Arylharnstoffderivate zur behandlung von inflammatorischen oder immunomodulatorischen erkrankungen |
| DE19725450A1 (de) | 1997-06-16 | 1998-12-17 | Hoechst Schering Agrevo Gmbh | 4-Haloalkyl-3-heterocyclylpyridine und 4-Haloalkyl-5-heterocyclylpyrimidine, Verfahren zu ihrer Herstellung, sie enthaltende Mittel und ihre Verwendung als Schädlingsbekämpfungsmittel |
| US6093742A (en) | 1997-06-27 | 2000-07-25 | Vertex Pharmaceuticals, Inc. | Inhibitors of p38 |
| EP0911634A1 (en) | 1997-10-24 | 1999-04-28 | Het Nederlands Kanker Instituut | Pharmaceutical uses of CDK-2 regulators |
| WO1999021555A2 (en) | 1997-10-27 | 1999-05-06 | Takeda Chemical Industries, Ltd. | Adenosine a3 receptor antagonists |
| JP2001521934A (ja) | 1997-11-03 | 2001-11-13 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | 抗炎症薬としての芳香族ヘテロ環式化合物 |
| US6040321A (en) | 1997-11-12 | 2000-03-21 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
| CA2315715C (en) | 1997-12-22 | 2010-06-22 | Bayer Corporation | Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas |
| RU2265597C2 (ru) | 1997-12-22 | 2005-12-10 | Байер Копэрейшн | Арил- и гетероарилзамещенные гетероциклические производные мочевины, способ ингибирования киназы raf и фармацевтическая композиция |
| CN1213022C (zh) | 1997-12-22 | 2005-08-03 | 拜尔有限公司 | 用对称和不对称的取代二苯脲抑制raf激酶 |
| CA2315720A1 (en) | 1997-12-22 | 1999-07-01 | Bayer Corporation | Inhibition of p38 kinase activity using substituted heterocyclic ureas |
| DK1043995T3 (da) | 1997-12-22 | 2007-03-05 | Bayer Pharmaceuticals Corp | Inhibering af p38 kinaseaktivitet ved anvendelse af aryl- og heteroaryl-substituerede, heterocykliske urinstoffer |
| DK1047418T3 (da) | 1997-12-22 | 2005-11-21 | Bayer Pharmaceuticals Corp | Inhibering af raf-kinase ved hjælp af substituerede heterocykliske urinstoffer |
| WO1999046244A1 (en) | 1998-03-12 | 1999-09-16 | Novo Nordisk A/S | Modulators of protein tyrosine phosphatases (ptpases) |
| MY132496A (en) | 1998-05-11 | 2007-10-31 | Vertex Pharma | Inhibitors of p38 |
| EP1087951B9 (en) | 1998-06-18 | 2006-09-13 | Bristol-Myers Squibb Company | Carbon substituted aminothiazole inhibitors of cyclin dependent kinases |
| US6531477B1 (en) | 1998-10-13 | 2003-03-11 | Dupont Pharmaceuticals Company | 6-substituted pyrazolo [3,4-d] pyrimidin-4-ones useful as cyclin dependent kinase inhibitors |
| AU1131800A (en) | 1998-10-23 | 2000-05-15 | Dow Agrosciences Llc | 3-(substituted phenyl)-5-(substituted heterocyclyl)-1,2,4-triazole compounds |
| PT1123287E (pt) | 1998-10-23 | 2003-12-31 | Dow Agrosciences Llc | 1-(piridil substituido)-1,2,4-triazoles insecticidas |
| GB9823873D0 (en) | 1998-10-30 | 1998-12-30 | Pharmacia & Upjohn Spa | 2-ureido-thiazole derivatives,process for their preparation,and their use as antitumour agents |
| US6337338B1 (en) * | 1998-12-15 | 2002-01-08 | Telik, Inc. | Heteroaryl-aryl ureas as IGF-1 receptor antagonists |
| AU3891300A (en) * | 1999-03-19 | 2000-10-09 | Parker Hughes Institute | Thiourea and urea liquid-phase combinatorial libraries: synthesis and apoptosis induction |
| CA2389360C (en) | 1999-11-16 | 2008-06-03 | Steffen Breitfelder | Urea derivatives as anti-inflammatory agents |
| US20020173507A1 (en) * | 2000-08-15 | 2002-11-21 | Vincent Santora | Urea compounds and methods of uses |
-
2002
- 2002-02-15 US US10/077,124 patent/US6645990B2/en not_active Expired - Fee Related
-
2003
- 2003-02-13 AU AU2003215231A patent/AU2003215231A1/en not_active Abandoned
- 2003-02-13 WO PCT/US2003/004537 patent/WO2003070727A1/en not_active Ceased
- 2003-02-13 CA CA002476411A patent/CA2476411A1/en not_active Abandoned
- 2003-02-13 JP JP2003569634A patent/JP2006509715A/ja active Pending
- 2003-02-13 EP EP03711046A patent/EP1483263A1/en not_active Withdrawn
- 2003-02-13 PL PL03372211A patent/PL372211A1/xx not_active Application Discontinuation
- 2003-02-13 MX MXPA04007970A patent/MXPA04007970A/es unknown
- 2003-07-30 US US10/632,044 patent/US20040044044A1/en not_active Abandoned
- 2003-07-30 US US10/631,423 patent/US7196104B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2006509715A5 (OSRAM) | ||
| HRP20210094T1 (hr) | POSTUPAK PRIPRAVE DERIVATIVA OKSAZOLO[4,5-b]PIRIDINA I TIAZOLO[4,5-b]PIRIDINA KAO INHIBITORA IRAK4 NAMIJENJENIH LIJEČENJU RAKA | |
| JP6710754B2 (ja) | 新規なフェロポーチン阻害剤 | |
| US10189810B2 (en) | Pyrazolyl-substituted pyridone compounds as serine protease inhibitors | |
| US9199979B2 (en) | Thiazolylphenyl-benzenesulfonamido derivatives as kinase inhibitors | |
| JP5426543B2 (ja) | ピリダジノン誘導体 | |
| HRP20192323T1 (hr) | Novi derivati dihidrokinolin-2-ona | |
| JP2014501269A5 (OSRAM) | ||
| JPWO2021055744A5 (OSRAM) | ||
| CA2592986A1 (en) | Heteroaromatic quinoline compounds | |
| HRP20221454T1 (hr) | Piridinamin-piridonski i pirimidinamin-piridonski spojevi | |
| JP2018536687A5 (OSRAM) | ||
| RU2014139601A (ru) | Ингибиторы серин/треониновых киназ | |
| RU2012136643A (ru) | [5,6]- гетероциклическое соединение | |
| JP2010514788A5 (OSRAM) | ||
| JP2017524028A (ja) | 薬剤としてのｒｉｐ１キナーゼ阻害剤である複素環式アミド | |
| RU2018115722A (ru) | N-СУЛЬФОНИЛИРОВАННЫЕ ПИРАЗОЛО[3,4-b]ПИРИДИН-6-КАРБОКСАМИДЫ И СПОСОБ ИХ ПРИМЕНЕНИЯ | |
| CA2873097A1 (en) | Pyridazine and pyridine derivatives as nampt inhibitors | |
| US20110172248A1 (en) | Substituted heteroarylamide analogs as mglur5 negative allosteric modulators and methods of making and using the same | |
| JP2008536825A5 (OSRAM) | ||
| US10392404B2 (en) | Compounds and compositions as kinase inhibitors | |
| RU2413726C2 (ru) | Замещенные биарильные аналоги пиперазинилпиридина, их применение в терапии, фармацевтическая композиция, фармацевтический препарат, способы уменьшения проводимости кальция и ингибирования связывания капсаициновых рецепторов | |
| US12233065B2 (en) | Inhibitors of RNA helicase DHX9 and uses thereof | |
| KR20130105914A (ko) | Ｈ-ｐｇｄｓ 억제제로서 다중헤테로아릴 화합물 및 프로스타글란딘 ｄ2 매개된 질병의 치료를 위한 그의 용도 | |
| JPWO2020009156A5 (OSRAM) |