JP2006501187A5 - - Google Patents

Download PDF

Info

Publication number
JP2006501187A5
JP2006501187A5 JP2004520018A JP2004520018A JP2006501187A5 JP 2006501187 A5 JP2006501187 A5 JP 2006501187A5 JP 2004520018 A JP2004520018 A JP 2004520018A JP 2004520018 A JP2004520018 A JP 2004520018A JP 2006501187 A5 JP2006501187 A5 JP 2006501187A5
Authority
JP
Japan
Prior art keywords
compound
inhibitors
agent
alkyl
structural formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2004520018A
Other languages
English (en)
Japanese (ja)
Other versions
JP4541883B2 (ja
JP2006501187A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2003/021331 external-priority patent/WO2004004655A2/en
Publication of JP2006501187A publication Critical patent/JP2006501187A/ja
Publication of JP2006501187A5 publication Critical patent/JP2006501187A5/ja
Application granted granted Critical
Publication of JP4541883B2 publication Critical patent/JP4541883B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2004520018A 2002-07-09 2003-07-08 抗糖尿病薬および抗肥満症薬として有用な置換へテロ環誘導体、並びに方法 Expired - Fee Related JP4541883B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39455302P 2002-07-09 2002-07-09
PCT/US2003/021331 WO2004004655A2 (en) 2002-07-09 2003-07-08 Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method

Publications (3)

Publication Number Publication Date
JP2006501187A JP2006501187A (ja) 2006-01-12
JP2006501187A5 true JP2006501187A5 (enExample) 2006-08-31
JP4541883B2 JP4541883B2 (ja) 2010-09-08

Family

ID=30115733

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004520018A Expired - Fee Related JP4541883B2 (ja) 2002-07-09 2003-07-08 抗糖尿病薬および抗肥満症薬として有用な置換へテロ環誘導体、並びに方法

Country Status (23)

Country Link
US (2) US6875782B2 (enExample)
EP (1) EP1531810B1 (enExample)
JP (1) JP4541883B2 (enExample)
KR (1) KR101120337B1 (enExample)
CN (1) CN1665500A (enExample)
AT (1) ATE543497T1 (enExample)
AU (1) AU2003248861B2 (enExample)
BR (1) BR0312503A (enExample)
CA (1) CA2490972C (enExample)
ES (1) ES2380319T3 (enExample)
GE (1) GEP20084475B (enExample)
HR (1) HRP20050001A2 (enExample)
IL (1) IL165809A (enExample)
IS (1) IS7629A (enExample)
MX (1) MXPA05000279A (enExample)
NO (1) NO329328B1 (enExample)
NZ (1) NZ537251A (enExample)
PL (1) PL375230A1 (enExample)
RS (1) RS20050002A (enExample)
RU (1) RU2325381C2 (enExample)
UA (1) UA79296C2 (enExample)
WO (1) WO2004004655A2 (enExample)
ZA (1) ZA200500029B (enExample)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2493253A1 (en) * 2002-08-01 2004-02-12 Neurosearch A/S Compounds useful for the treatment of diseases responsive to antiangiogenetic therapy
US20060183897A1 (en) * 2003-03-18 2006-08-17 Chakravarty Prasun K Biaryl substituted triazoles as sodium channel blockers
MY142651A (en) 2003-03-18 2010-12-15 Merck Sharp & Dohme Biaryl substituted triazoles as sodium channel blockers
US20040242566A1 (en) 2003-03-25 2004-12-02 Syrrx, Inc. Dipeptidyl peptidase inhibitors
JP2007511467A (ja) 2003-05-14 2007-05-10 タケダ サン ディエゴ インコーポレイテッド ジペプチジルペプチダーゼインヒビター
MXPA06001601A (es) 2003-08-13 2006-08-25 Takeda Pharmaceutical Derivados de 4-pirimidona y su uso como inhibidores de dipeptidilpeptidasa.
FR2861303A1 (fr) * 2003-10-24 2005-04-29 Sanofi Synthelabo Utilisation d'un derive de pyrazole pour la preparation de medicaments utiles dans la prevention et le traitement du syndrome metabolique
FR2861302A1 (fr) * 2003-10-24 2005-04-29 Sanofi Synthelabo Utilisation d'un derive du pyrazole, pour la preparation de medicaments utiles dans la prevention et le traitement du syndrome metabolique.
FR2861301B1 (fr) * 2003-10-24 2008-07-11 Sanofi Synthelabo Utilisation du derive du pyrazole pour la preparation de medicaments utiles dans la prevention et le traitement du syndrome metabolique.
FR2861300B1 (fr) * 2003-10-24 2008-07-11 Sanofi Synthelabo Utilisation d'un derive du pyrazole, pour la preparation de medicaments utiles dans la prevention et le traitement du syndrome metabolique
CA2546601A1 (en) * 2003-11-19 2005-06-09 Metabasis Therapeutics, Inc. Novel phosphorus-containing thyromimetics
JP5697296B2 (ja) 2004-03-05 2015-04-08 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 高脂血症および高コレステロール血症に関連する障害または疾患を、副作用を最小限にしつつ処置するための方法
US7323480B2 (en) * 2004-05-25 2008-01-29 Metabolex, Inc. Substituted triazoles as modulators of PPAR and methods of their preparation
JP2008500358A (ja) * 2004-05-25 2008-01-10 メタボレックス インコーポレーティッド Ｐｐａｒのモジュレーターとしての、二環式の置換されたトリアゾール、およびこれらの調製方法
US20060058224A1 (en) * 2004-09-15 2006-03-16 Yancopoulos George D Methods of treating obesity with combination therapeutics
WO2006039334A1 (en) * 2004-09-29 2006-04-13 Schering Corporation Combinations of substituted azetidonones and cb1 antagonists
WO2006105127A2 (en) * 2005-03-31 2006-10-05 Takeda San Diego, Inc. Hydroxysteroid dehydrogenase inhibitors
WO2006117743A1 (en) * 2005-05-03 2006-11-09 Ranbaxy Laboratories Limited Substituted aromatic compounds as antidiabetic agents
US20090232879A1 (en) 2005-05-26 2009-09-17 Metabasis Therapeutics, Inc. Thyromimetics for the Treatment of Fatty Liver Diseases
RU2007148927A (ru) * 2005-05-26 2009-07-10 Метабэйзис Терапьютикс, Инк. (Us) Новые тиреомиметики, содержащие фосфиновую кислоту
FR2889191A1 (fr) * 2005-07-28 2007-02-02 Cerep Sa Composes derives de 5-benzylidene imidazolidine 2,4-dione et leur utilisation en tant qu'antagonistes de mchr-1
SI1942898T2 (sl) 2005-09-14 2014-08-29 Takeda Pharmaceutical Company Limited Dipeptidil-peptidazni inhibitorji za zdravljenje diabetesa
EP1924567B1 (en) 2005-09-16 2012-08-22 Takeda Pharmaceutical Company Limited Process for the preparation of pyrimidinedione derivatives
US20080253985A1 (en) * 2005-10-18 2008-10-16 Wisler Gerald L Compositions for Lowering Serum Cholesterol and/or Triglycerides
MX2008015228A (es) * 2006-05-30 2008-12-12 Astrazeneca Ab Acido 5-fenilamino-1,3,4-oxadiazol-2-ilcarbonilamino-4-fenoxi-cicl ohexanocarboxilico sustituido como inhibidor de diacilglicerol aciltransferasa de acetil coenzima a.
EP2041099A1 (en) * 2006-05-30 2009-04-01 AstraZeneca AB 1, 3, 4 -oxadiazole derivatives as dgat1 inhibitors
US20080009534A1 (en) * 2006-07-07 2008-01-10 Bristol-Myers Squibb Company Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
US8324383B2 (en) 2006-09-13 2012-12-04 Takeda Pharmaceutical Company Limited Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
US8217025B2 (en) * 2006-11-17 2012-07-10 Harbor Therapeutics, Inc. Drug screening and treatment methods
TW200838536A (en) 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
AU2007338625A1 (en) * 2006-12-21 2008-07-03 Aegerion Pharmaceuticals, Inc. Methods for treating obesity with a combination comprising a MTP inhibitor and a cholesterol absorption inhibitor
US8093236B2 (en) 2007-03-13 2012-01-10 Takeda Pharmaceuticals Company Limited Weekly administration of dipeptidyl peptidase inhibitors
TW200906823A (en) 2007-07-16 2009-02-16 Lilly Co Eli Compounds and methods for modulating FXR
US8652527B1 (en) 2013-03-13 2014-02-18 Upsher-Smith Laboratories, Inc Extended-release topiramate capsules
US9101545B2 (en) 2013-03-15 2015-08-11 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules
CN103694195B (zh) * 2013-09-18 2016-04-06 华东师范大学 芳香杂环类小分子有机化合物及衍生物、制备方法及医药用途
EP3190103A1 (en) * 2016-01-08 2017-07-12 Rijksuniversiteit Groningen Inhibitors of the pd-1/pd-l1 protein/protein interaction
JP2020500199A (ja) 2016-11-21 2020-01-09 バイキング・セラピューティクス・インコーポレイテッド グリコーゲン蓄積症の治療方法
AU2018280118B2 (en) 2017-06-05 2021-07-15 Viking Therapeutics, Inc. Compositions for the treatment of fibrosis
KR101943382B1 (ko) 2017-09-19 2019-01-29 오토텔릭바이오 주식회사 Sglt-2 저해제 및 안지오텐신 수용체 차단제를 포함하는 의약 조성물
EA202091979A1 (ru) 2018-03-22 2021-06-22 Вайкинг Терапьютикс, Инк. Кристаллические формы и способы получения кристаллических форм соединения
GB201810486D0 (en) * 2018-06-26 2018-08-08 Imperial Innovations Ltd Natural killer cells
KR102131359B1 (ko) * 2018-09-07 2020-07-07 오토텔릭바이오 주식회사 안정성이 향상된 의약 조성물
US12102646B2 (en) 2018-12-05 2024-10-01 Viking Therapeutics, Inc. Compositions for the treatment of fibrosis and inflammation
AU2021316011A1 (en) 2020-07-29 2023-02-09 Amryt Pharmaceuticals Inc. Lomitapide for use in methods of treating hyperlipidemia and hypercholesterolemia in pediatric patients

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69427023T2 (de) 1993-12-28 2001-10-31 Meiji Seika K.K., Tokio/Tokyo Tricyclische benzazepin-und benzothiazepin derivate
ES2186720T3 (es) * 1994-05-27 2003-05-16 Merck & Co Inc Composiciones para inhibir la reabsorcion osea mediada por osteoclastos.
CN1066148C (zh) 1995-06-15 2001-05-23 明治制果株式会社 三环性苯并氮杂䓬化合物
GB9604242D0 (en) * 1996-02-28 1996-05-01 Glaxo Wellcome Inc Chemical compounds
JP3215048B2 (ja) * 1996-04-03 2001-10-02 日本たばこ産業株式会社 プロピオン酸誘導体及びその用途
JPH1067759A (ja) 1996-06-20 1998-03-10 Sankyo Co Ltd 除草性アゾール誘導体
JPH11263775A (ja) 1997-09-08 1999-09-28 Sankyo Co Ltd ヒドロキシアニリン誘導体
CN1155599C (zh) 1997-09-29 2004-06-30 明治制果株式会社 三环三唑并苯并氮杂�衍生物、用于制备该衍生物的方法和抗变态反应剂
DE69941777D1 (de) * 1998-03-10 2010-01-21 Ono Pharmaceutical Co Carbonsäurederivate und medikamente die diese als aktiven wirkstoff enthalten
FR2778314B1 (fr) 1998-05-07 2002-06-14 Rhone Poulenc Agrochimie Composition fongicide synergique comprenant un compose analogue de la strobilurine
GB9914977D0 (en) * 1999-06-25 1999-08-25 Glaxo Group Ltd Chemical compounds
DE60008763T2 (de) 1999-09-08 2005-02-10 Glaxo Group Ltd., Greenford Oxazol ppar antagonisten
TW200514783A (en) * 1999-09-22 2005-05-01 Bristol Myers Squibb Co Substituted acid derivatives useful as antiodiabetic and antiobesity agents and method
US6414002B1 (en) * 1999-09-22 2002-07-02 Bristol-Myers Squibb Company Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
IL149493A0 (en) 1999-11-10 2002-11-10 Takeda Chemical Industries Ltd 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity
GB0029974D0 (en) * 2000-12-08 2001-01-24 Glaxo Group Ltd Chemical compounds

Similar Documents

Publication Publication Date Title
JP2006501187A5 (enExample)
CA2490972A1 (en) Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method
JP2004536070A5 (enExample)
CA2366871A1 (en) Heterocyclic containing biphenyl ap2 inhibitors and method
JP4332315B2 (ja) 抗糖尿病剤および抗肥満剤として有用な置換酸誘導体および方法
DE02729306T1 (de) Substituierte azolsäurederivate, die sich als mittel gegen diabetes und obesitas eignen, und verfahren
JP4579681B2 (ja) 抗糖尿病薬および抗肥満薬として有用な置換ヘテロシクロ誘導体および方法
US6414002B1 (en) Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
JP2004500416A5 (enExample)
EA010026B1 (ru) 4-биарилил-1-фенилазетидин-2-оны
JP2003511458A5 (enExample)
RU2003101064A (ru) Ингибиторы hmg-coa редуктазы
RU2013107748A (ru) Производные с-арилглюкозидов, способ их получения и фармацевтическое применение
RU2002125491A (ru) Ингибиторы дипептидилпептидазы IV на основе конденсированных циклопропилпирролидинов и способ их применения
RU2002109477A (ru) С-арилглюкозидные ингибиторы SGTL2
JP2005502600A5 (enExample)
EP2136637B1 (en) Inhibitors of cholesterol ester transfer protein
RU2005114373A (ru) Хиральные производные оксазоларилпропионовой кислоты и их применение в качестве агонистов рецепторов, активированных пролифератором пароксисомы (ppar агонистов)
JP6302937B2 (ja) ２−（（１ｒ，４ｒ）−４−（４−（５−（ベンゾオキサゾール−２−イルアミノ）ピリジン−２−イル）フェニル）シクロヘキシル）酢酸のメグルミン塩形態、およびｄｇａｔ１阻害剤としてのそれらの使用
CN115244043B (zh) 作为trpv1拮抗剂的苯并咪唑酮基肉桂酰胺衍生物和含有其作为活性成分的用于治疗或预防疼痛的药物组合物
RU2012153702A (ru) Соединения, обладающие активирующим действием на подтипы рецепторов, активируемых пролифератором пероксисом (ppars), и способ получения и применения указанных соединений
RU2001129702A (ru) Содержащие гетероцикл бифенил ингибиторы aP2
US20090118320A1 (en) Derivatives of 5,9-methanocycloocta[b]pyridin-2-(1h)-one, their preparation and use as analgesics
FR2463766A1 (fr) Nouvelles 1(2h)-isoquinolones, utiles notamment comme analgesiques
CN117986158A (zh) 取代联苯类化合物、制备方法及应用