ES2186720T3 - Composiciones para inhibir la reabsorcion osea mediada por osteoclastos. - Google Patents
Composiciones para inhibir la reabsorcion osea mediada por osteoclastos.Info
- Publication number
- ES2186720T3 ES2186720T3 ES95920409T ES95920409T ES2186720T3 ES 2186720 T3 ES2186720 T3 ES 2186720T3 ES 95920409 T ES95920409 T ES 95920409T ES 95920409 T ES95920409 T ES 95920409T ES 2186720 T3 ES2186720 T3 ES 2186720T3
- Authority
- ES
- Spain
- Prior art keywords
- inhibit
- callast
- osab
- osea
- reabsorption
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000001404 mediated effect Effects 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 230000009103 reabsorption Effects 0.000 title 1
- 208000006386 Bone Resorption Diseases 0.000 abstract 1
- 230000024279 bone resorption Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 210000002997 osteoclast Anatomy 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
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- C—CHEMISTRY; METALLURGY
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- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
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- C—CHEMISTRY; METALLURGY
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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
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- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
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Abstract
COMPOSICIONES DE LA ESTRUCTURA GENERAL SIGUIENTE:X-Y-Z-ARIL-AB, POR EJEMPLO (I), QUE INHIBEN LA REABSORCION OSEA INFLUIDA POR OSTEOCLASTOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25021894A | 1994-05-27 | 1994-05-27 |
Publications (1)
Publication Number | Publication Date |
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ES2186720T3 true ES2186720T3 (es) | 2003-05-16 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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ES95920409T Expired - Lifetime ES2186720T3 (es) | 1994-05-27 | 1995-05-12 | Composiciones para inhibir la reabsorcion osea mediada por osteoclastos. |
Country Status (9)
Country | Link |
---|---|
US (2) | US5741796A (es) |
EP (1) | EP0760658B1 (es) |
JP (1) | JPH10501222A (es) |
AT (1) | ATE227567T1 (es) |
AU (1) | AU701776B2 (es) |
CA (1) | CA2190870A1 (es) |
DE (1) | DE69528829T2 (es) |
ES (1) | ES2186720T3 (es) |
WO (1) | WO1995032710A1 (es) |
Families Citing this family (124)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6100423A (en) * | 1995-08-30 | 2000-08-08 | G. D. Searle & Co. | Amino benzenepropanoic acid compounds and derivatives thereof |
CN1085980C (zh) * | 1995-08-30 | 2002-06-05 | G·D·瑟尔公司 | 间-胍基、脲基、硫脲基或氮杂环氨基苯甲酸衍生物用作整合素拮抗剂 |
WO1997024343A1 (en) | 1995-12-29 | 1997-07-10 | Boehringer Ingelheim Pharmaceuticals, Inc. | Phenyl thiazole derivatives with anti herpes virus properties |
US6288091B1 (en) | 1995-12-29 | 2001-09-11 | Boehringer Ingelheim Ltd. | Antiherpes virus compounds and methods for their preparation and use |
ZA972195B (en) * | 1996-03-15 | 1998-09-14 | Du Pont Merck Pharma | Spirocycle integrin inhibitors |
ES2171768T3 (es) | 1996-03-20 | 2002-09-16 | Hoechst Ag | Inhibidores de la resorcion osea y antagonistas de receptores de vitronectina. |
DK0894084T3 (da) * | 1996-03-29 | 2002-10-14 | Searle & Co | Kanelsyrederivater og deres anvendelse som integrinantagonister |
JP2000507952A (ja) * | 1996-03-29 | 2000-06-27 | ジー.ディー.サール アンド カンパニー | meta―置換フェニレンスルホンアミド誘導体 |
PT889877E (pt) * | 1996-03-29 | 2002-02-28 | Searle & Co | Derivados fenileno meta substituidos e sua utilizacao como antagonitas ou inibidores integrina alfa v beta3 |
ATE202337T1 (de) * | 1996-03-29 | 2001-07-15 | Searle & Co | Cyclopropylalkansäurederivate |
ATE212978T1 (de) * | 1996-03-29 | 2002-02-15 | Searle & Co | Para-substituierte phenylpropansäure derivate als integrin-antagonisten |
EP0907637A1 (de) * | 1996-06-28 | 1999-04-14 | MERCK PATENT GmbH | Phenylalanin-derivate als integrin-inhibitoren |
US7094782B1 (en) | 1996-07-24 | 2006-08-22 | Bristol-Myers Squibb Company | Azolo triazines and pyrimidines |
DE19629816A1 (de) * | 1996-07-24 | 1998-01-29 | Hoechst Ag | Neue Cycloalkyl-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten |
US6191131B1 (en) | 1997-07-23 | 2001-02-20 | Dupont Pharmaceuticals Company | Azolo triazines and pyrimidines |
DE19629817A1 (de) * | 1996-07-24 | 1998-01-29 | Hoechst Ag | Neue Imino-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten |
US6124289A (en) * | 1996-07-24 | 2000-09-26 | Dupont Pharmaceuticals Co. | Azolo triazines and pyrimidines |
US6313124B1 (en) | 1997-07-23 | 2001-11-06 | Dupont Pharmaceuticals Company | Tetrazine bicyclic compounds |
US6060478A (en) * | 1996-07-24 | 2000-05-09 | Dupont Pharmaceuticals | Azolo triazines and pyrimidines |
US5981546A (en) * | 1996-08-29 | 1999-11-09 | Merck & Co., Inc. | Integrin antagonists |
US6211184B1 (en) | 1996-08-29 | 2001-04-03 | Merck & Co., Inc. | Integrin antagonists |
EP0934305A4 (en) * | 1996-08-29 | 2001-04-11 | Merck & Co Inc | INTEGRINE ANTAGONISTS |
AU717283B2 (en) * | 1996-10-30 | 2000-03-23 | Merck & Co., Inc. | Integrin antagonists |
US5952341A (en) * | 1996-10-30 | 1999-09-14 | Merck & Co., Inc. | Integrin antagonists |
US5919792A (en) * | 1996-10-30 | 1999-07-06 | Merck & Co., Inc. | Integrin antagonists |
US6482821B2 (en) | 1996-12-20 | 2002-11-19 | Hoechst Aktiengellschaft | Vitronectin receptor antagonists, their preparation and their use |
DE19653645A1 (de) * | 1996-12-20 | 1998-06-25 | Hoechst Ag | Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung |
US6218387B1 (en) | 1996-12-20 | 2001-04-17 | Hoechst Aktiengesellschaft | Vitronectin receptor anatagonists, their preparation and their use |
DE19653647A1 (de) | 1996-12-20 | 1998-06-25 | Hoechst Ag | Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung |
US6017925A (en) * | 1997-01-17 | 2000-01-25 | Merck & Co., Inc. | Integrin antagonists |
AU729869B2 (en) * | 1997-01-17 | 2001-02-15 | Merck & Co., Inc. | Integrin antagonists |
US6559144B2 (en) | 1997-02-13 | 2003-05-06 | Merck Patent Gesellschaft Mit | Bicyclic amino acids |
DE19705450A1 (de) * | 1997-02-13 | 1998-08-20 | Merck Patent Gmbh | Bicyclische aromatische Aminosäuren |
US6048861A (en) | 1997-12-17 | 2000-04-11 | Merck & Co., Inc. | Integrin receptor antagonists |
AU736026B2 (en) * | 1997-12-17 | 2001-07-26 | Merck & Co., Inc. | Integrin receptor antagonists |
TR200001752T2 (tr) * | 1997-12-17 | 2000-12-21 | Merck & Co., Inc. | Entegrin reseptör antagonistleri |
US6066648A (en) * | 1997-12-17 | 2000-05-23 | Merck & Co., Inc. | Integrin receptor antagonists |
HUP0100397A3 (en) * | 1997-12-17 | 2002-10-28 | Merck & Co Inc | Tetrahydro- or octahydrobenzonaphtyridin and quinolin derivatives, pharmaceutical compositions thereof and process for their preparation |
US6017926A (en) * | 1997-12-17 | 2000-01-25 | Merck & Co., Inc. | Integrin receptor antagonists |
US6211191B1 (en) | 1997-12-17 | 2001-04-03 | Merck & Co., Inc. | Integrin receptor antagonists |
WO1999037621A1 (en) * | 1998-01-23 | 1999-07-29 | Aventis Pharma Deutschland Gmbh | Novel sulfonamide derivatives as inhibitors of bone resorption and as inhibitors of cell adhesion |
US6313119B1 (en) | 1998-01-23 | 2001-11-06 | Adventis Pharma Deutschland Gmbh | Sulfonamide derivatives as inhibitors of bone resorption and as inhibitors of cell adhesion |
AU3213799A (en) * | 1998-04-01 | 1999-10-18 | Du Pont Pharmaceuticals Company | Integrin antagonists |
NZ507222A (en) * | 1998-04-09 | 2003-05-30 | Meiji Seika Kaisha | Aminopiperidine derivatives useful as integrin antagonists |
AU3561099A (en) * | 1998-04-14 | 1999-11-01 | American Home Products Corporation | Acylresorcinol derivatives as selective vitronectin receptor inhibitors |
EP0960882A1 (en) * | 1998-05-19 | 1999-12-01 | Hoechst Marion Roussel Deutschland GmbH | Thienyl substituted acylguanidines as inhibitors of bone resorption and vitronectin receptor antagonists |
US6417185B1 (en) | 1998-06-19 | 2002-07-09 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
US7045519B2 (en) | 1998-06-19 | 2006-05-16 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
SK242001A3 (en) * | 1998-07-06 | 2001-10-08 | Merck Patent Gmbh | Rdg mimetic compound, method for their producing and method for differentiation inhibiting of cell adhesion |
DE19831710A1 (de) | 1998-07-15 | 2000-01-20 | Merck Patent Gmbh | Diacylhydrazinderivate |
AU747784B2 (en) * | 1998-07-29 | 2002-05-23 | Merck & Co., Inc. | Integrin receptor antagonists |
DE19842415A1 (de) | 1998-09-16 | 2000-03-23 | Merck Patent Gmbh | Pharmazeutische Zubereitung |
FR2786184B1 (fr) * | 1998-11-24 | 2002-09-20 | Hoechst Marion Roussel Inc | Nouveaux derives du benzofurane, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
US6204282B1 (en) * | 1998-11-30 | 2001-03-20 | Schering Corporation | Benzimidazole compounds that are vitronectin receptor antagonists |
CN1161340C (zh) * | 1998-11-30 | 2004-08-11 | 先灵公司 | 为玻连蛋白受体拮抗剂的苯并咪唑化合物 |
WO2000038730A2 (en) | 1998-12-23 | 2000-07-06 | G.D. Searle & Co. | Use of a cyclooxygenase-2 inhibitor and one or more antineoplastic agents for combination therapy in neoplasia |
US6344484B1 (en) | 1999-02-12 | 2002-02-05 | 3-Dimensional Pharmaceuticals, Inc. | Tyrosine alkoxyguanidines as integrin inhibitors |
EP1028114A1 (en) | 1999-02-13 | 2000-08-16 | Aventis Pharma Deutschland GmbH | Novel guanidine derivatives as inhibitors of cell adhesion |
CN1208323C (zh) | 1999-04-06 | 2005-06-29 | 三共株式会社 | α-取代羧酸衍生物 |
US6586187B1 (en) | 1999-04-14 | 2003-07-01 | Wyeth | Methods for solid phase combinatorial synthesis of integrin inhibitors |
DE60035779T2 (de) | 1999-06-02 | 2008-04-30 | Merck & Co., Inc. | Alpha v integrin-rezeptor antagonisten |
GB2351082A (en) * | 1999-06-18 | 2000-12-20 | Lilly Forschung Gmbh | Synthesis of Cyclic Substituted Amidines |
EP1065207A1 (en) | 1999-07-02 | 2001-01-03 | Aventis Pharma Deutschland GmbH | Naphthyridine derivatives, processes for their preparation, their use, and pharmaceutical compositions comprising them |
EP1065208A1 (en) | 1999-07-02 | 2001-01-03 | Aventis Pharma Deutschland GmbH | Substituted purine derivatives as inhibitors of cell adhesion |
EP1070707A1 (en) * | 1999-07-21 | 2001-01-24 | Aventis Pharma Deutschland GmbH | 1,4,5,6-tetrahydropyrimidine derivative as a vitronectin inhibitor |
EP1198231A1 (en) | 1999-07-21 | 2002-04-24 | American Home Products Corporation | Bicyclic antagonists selective for the(alpha)v(beta)3 integrin |
WO2001010844A1 (en) | 1999-08-05 | 2001-02-15 | Meiji Seika Kaisha, Ltd. | φ-AMINO-α-HYDROXYCARBOXYLIC ACID DERIVATIVES HAVING INTEGRIN αvβ3 ANTAGONISM |
CZ20011872A3 (cs) | 1999-09-29 | 2002-03-13 | Ortho-Mcneil Pharmaceutical, Inc. | Isonipekotamidy pro léčbu onemocnění zprostředkovaných integriny |
EP1235807A1 (en) * | 1999-11-24 | 2002-09-04 | Millennium Pharmaceuticals, Inc. | B-amino acid-, aspartic acid- and diaminopropionic-based inhibitors of factor xa |
EP1108721A1 (en) * | 1999-12-15 | 2001-06-20 | Aventis Pharma Deutschland GmbH | Thienylalanine derivatives as inhibitors of cell adhesion |
US20030040531A1 (en) * | 2000-01-25 | 2003-02-27 | Kazuyuki Fujishima | Remedies for reperfusion injury containing integrin alphanubeta 3 antagonist |
AU2001269821A1 (en) | 2000-06-15 | 2001-12-24 | Barbara Chen | Cycloalkyl alkanoic acids as integrin receptor antagonists |
US6486174B2 (en) | 2000-08-07 | 2002-11-26 | 3-Dimensional Pharmaceuticals, Inc. | Tetrahydroisoquinoline-3-carboxylic acid alkoxyguanidines as integrin antagonists |
US6531494B1 (en) | 2001-08-29 | 2003-03-11 | Pharmacia Corporation | Gem-substituted αvβ3 antagonists |
KR100860827B1 (ko) * | 2000-09-06 | 2008-09-30 | 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 | 글리코겐 합성효소 키나아제 3의 억제제 |
EP1341497A4 (en) * | 2000-11-02 | 2005-10-19 | Smithkline Beecham Corp | RECEPTOR-LIPID ANTAGONIST CONJUGATES AND DELIVERY VEHICLES CONTAINING THE SAME |
US20030027331A1 (en) * | 2000-11-30 | 2003-02-06 | Yan Wen Liang | Isolated homozygous stem cells, differentiated cells derived therefrom, and materials and methods for making and using same |
CA2436130A1 (en) | 2001-01-29 | 2002-08-08 | 3-Dimensional Pharmaceuticals, Inc. | Substituted indoles and their use as integrin antagonists |
JP2004529918A (ja) | 2001-04-09 | 2004-09-30 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | インテグリンに由来する疾患の治療のためのキナゾリンおよびキナゾリン類似化合物 |
RU2316337C2 (ru) | 2001-04-24 | 2008-02-10 | Мерк Патент Гмбх | КОМБИНИРОВАННАЯ ТЕРАПИЯ, ИСПОЛЬЗУЮЩАЯ АНТИАНГИОГЕННЫЕ СРЕДСТВА И TNF-α |
US6872730B2 (en) * | 2001-04-27 | 2005-03-29 | 3-Dimensional Pharmaceuticals, Inc. | Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists |
CA2449054C (en) * | 2001-05-30 | 2011-01-04 | The Scripps Research Institute | Integrin targeting liposome for nucleic acid delivery |
US20040043988A1 (en) * | 2001-06-15 | 2004-03-04 | Khanna Ish Kurmar | Cycloalkyl alkanoic acids as intergrin receptor antagonists |
KR100454767B1 (ko) * | 2001-07-19 | 2004-11-03 | 동화약품공업주식회사 | 4-[(4-티아졸릴)페녹시]알콕시-벤즈아미딘 유도체의골다공증 예방 및 치료제로서의 용도 |
PL372695A1 (en) * | 2002-06-19 | 2005-07-25 | Solvay Pharmaceuticals Gmbh | Medicament for the treatment of diseases requiring inhibition or a reduction in the activity of ph value-regulating bicarbonate transporter proteins |
AU2003248861B2 (en) * | 2002-07-09 | 2009-01-22 | Bristol-Myers Squibb Company | Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method |
FR2847254B1 (fr) | 2002-11-19 | 2005-01-28 | Aventis Pharma Sa | Nouveaux derives antagonistes du recepteur de la vitronectine, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les refermant |
BRPI0409957A (pt) * | 2003-05-01 | 2006-04-25 | Hoffmann La Roche | imidazolin-2-ilaminofenil amidas |
JP2007502300A (ja) * | 2003-08-13 | 2007-02-08 | カイロン コーポレイション | Gsk−3インヒビターおよびその使用 |
FR2870541B1 (fr) | 2004-05-18 | 2006-07-14 | Proskelia Sas | Derives de pyrimidines antigonistes du recepteur de la vitronectine |
UA87854C2 (en) | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7300940B2 (en) * | 2004-08-04 | 2007-11-27 | The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Integrin α-v β-3 antagonists for use in imaging and therapy |
ES2401138T3 (es) * | 2004-08-13 | 2013-04-17 | Genentech, Inc. | Inhibidores basados en tiazol de enzimas que usan ATP |
KR101250889B1 (ko) | 2004-12-24 | 2013-04-04 | 도레이 카부시키가이샤 | 글리신 유도체 및 그 용도 |
TW200640887A (en) * | 2005-01-27 | 2006-12-01 | Kowa Co | PPAR-activating compound |
US7301033B2 (en) | 2005-01-27 | 2007-11-27 | Kowa Co., Ltd. | PPAR-activating compound |
EP1739078A1 (de) | 2005-05-30 | 2007-01-03 | Jerini AG | C5a-Rezeptor-Antagonisten |
CN101360736A (zh) * | 2005-11-23 | 2009-02-04 | 阿斯利康(瑞典)有限公司 | L-丙氨酸衍生物 |
EP1973569B1 (en) | 2006-01-18 | 2013-05-22 | Merck Patent GmbH | Specific therapy using integrin ligands for treating cancer |
WO2007141473A1 (en) * | 2006-06-09 | 2007-12-13 | Astrazeneca Ab | N-(benzoyl)-o- [2- (pyridin- 2 -ylamino) ethyl] -l-tyrosine derivatives and related compounds as a5b1 antagonists for the treatment of solid tumors |
CN101472580B (zh) * | 2006-06-14 | 2011-08-24 | 东丽株式会社 | 过敏性皮炎的治疗或预防药 |
CN101472900B (zh) | 2006-06-19 | 2011-07-27 | 东丽株式会社 | 多发性硬化症的治疗或预防药 |
DE602007012435D1 (de) | 2006-06-20 | 2011-03-24 | Toray Industries | Leukämie |
AU2007326395B2 (en) | 2006-12-01 | 2012-10-11 | Msd K.K. | Novel phenyl-isoxazol-3-ol derivative |
PL2101805T3 (pl) | 2007-01-18 | 2013-04-30 | Merck Patent Gmbh | Ligandy integryn do stosowania w leczeniu nowotworów |
WO2008093065A1 (en) * | 2007-01-29 | 2008-08-07 | Astrazeneca Ab | L-ALANINE DERIVATIVES AS α5βL ANTAGONISTS |
WO2008125811A1 (en) * | 2007-04-11 | 2008-10-23 | Astrazeneca Ab | N-[HETEROARYLCARBONYL]-S-THIENYL-L-ALANINE DERIVATIVES AS α5β1 ANTAGONISTS |
EP2167474A1 (en) * | 2007-06-11 | 2010-03-31 | Valletta Health IP EE B.V. | Urocanic acid derivatives useful for the treatment of immune-related and inflammatory diseases |
US8354446B2 (en) * | 2007-12-21 | 2013-01-15 | Ligand Pharmaceuticals Incorporated | Selective androgen receptor modulators (SARMs) and uses thereof |
EP2421559B1 (en) | 2009-04-24 | 2016-07-20 | Vanderbilt University | Anti-tgf-beta induction of bone growth |
WO2010136168A2 (en) | 2009-05-25 | 2010-12-02 | Merck Patent Gmbh | Continuous administration of integrin ligands for treating cancer |
CN101967209B (zh) * | 2010-10-20 | 2012-11-07 | 南京大学 | 一种n-乙酰基乙二胺螯合树脂及其制备方法 |
WO2014015157A2 (en) | 2012-07-19 | 2014-01-23 | Philadelphia Health & Education Corporation | Novel sigma receptor ligands and methods of modulating cellular protein homeostasis using same |
KR102301867B1 (ko) | 2013-12-18 | 2021-09-15 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | Nrf2 조절제 |
WO2015181676A1 (en) | 2014-05-30 | 2015-12-03 | Pfizer Inc. | Carbonitrile derivatives as selective androgen receptor modulators |
MY187540A (en) | 2014-08-01 | 2021-09-28 | Nuevolution As | Compounds active towards bromodomains |
WO2016172026A1 (en) | 2015-04-20 | 2016-10-27 | The Board Of Regents Of The University Of Texas System | Clec11a is a bone growth agent |
PE20180799A1 (es) | 2015-06-15 | 2018-05-09 | Glaxosmithkline Ip Dev Ltd | Reguladores de nrf2 |
AU2016280236B2 (en) | 2015-06-15 | 2019-02-07 | Astex Therapeutics Limited | Nrf2 regulators |
US10364256B2 (en) | 2015-10-06 | 2019-07-30 | Glaxosmithkline Intellectual Property Development Limited | Biaryl pyrazoles as NRF2 regulators |
EP3509590A4 (en) | 2016-09-07 | 2020-12-02 | Pliant Therapeutics, Inc. | N-ACYL AMINO ACID COMPOUNDS AND METHOD OF USING |
WO2019089902A1 (en) | 2017-11-01 | 2019-05-09 | Drexel University | Compounds, compositions, and methods for treating diseases |
WO2023275715A1 (en) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Metabolites of selective androgen receptor modulators |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL99537A (en) * | 1990-09-27 | 1995-11-27 | Merck & Co Inc | Fibrinogen receptor antagonists and pharmaceutical preparations containing them |
NZ239846A (en) * | 1990-09-27 | 1994-11-25 | Merck & Co Inc | Sulphonamide derivatives and pharmaceutical compositions thereof |
US5204350A (en) * | 1991-08-09 | 1993-04-20 | Merck & Co., Inc. | Method of inhibiting osteoclast-mediated bone resorption by administration of n-heterocyclicalkyl-substituted phenyl derivatives |
US5217994A (en) * | 1991-08-09 | 1993-06-08 | Merck & Co., Inc. | Method of inhibiting osteoclast-mediated bone resorption by administration of aminoalkyl-substituted phenyl derivatives |
DE69327536T2 (de) * | 1992-10-14 | 2000-07-06 | Merck & Co Inc | Fibrinogenrezeptor-antagonisten |
WO1994008577A1 (en) * | 1992-10-14 | 1994-04-28 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
CA2150550A1 (en) * | 1992-12-01 | 1994-06-09 | Melissa S. Egbertson | Fibrinogen receptor antagonists |
-
1995
- 1995-05-12 US US08/714,097 patent/US5741796A/en not_active Expired - Fee Related
- 1995-05-12 WO PCT/US1995/005938 patent/WO1995032710A1/en active IP Right Grant
- 1995-05-12 CA CA002190870A patent/CA2190870A1/en not_active Abandoned
- 1995-05-12 AU AU25868/95A patent/AU701776B2/en not_active Ceased
- 1995-05-12 EP EP95920409A patent/EP0760658B1/en not_active Expired - Lifetime
- 1995-05-12 JP JP8500899A patent/JPH10501222A/ja active Pending
- 1995-05-12 DE DE69528829T patent/DE69528829T2/de not_active Expired - Fee Related
- 1995-05-12 ES ES95920409T patent/ES2186720T3/es not_active Expired - Lifetime
- 1995-05-12 AT AT95920409T patent/ATE227567T1/de not_active IP Right Cessation
-
1998
- 1998-01-30 US US09/015,982 patent/US5929120A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2190870A1 (en) | 1995-12-07 |
JPH10501222A (ja) | 1998-02-03 |
US5741796A (en) | 1998-04-21 |
EP0760658A4 (en) | 1997-09-17 |
ATE227567T1 (de) | 2002-11-15 |
AU2586895A (en) | 1995-12-21 |
AU701776B2 (en) | 1999-02-04 |
US5929120A (en) | 1999-07-27 |
DE69528829D1 (de) | 2002-12-19 |
EP0760658A1 (en) | 1997-03-12 |
EP0760658B1 (en) | 2002-11-13 |
WO1995032710A1 (en) | 1995-12-07 |
DE69528829T2 (de) | 2003-08-07 |
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