JP2005539072A5 - - Google Patents
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- Publication number
- JP2005539072A5 JP2005539072A5 JP2004537125A JP2004537125A JP2005539072A5 JP 2005539072 A5 JP2005539072 A5 JP 2005539072A5 JP 2004537125 A JP2004537125 A JP 2004537125A JP 2004537125 A JP2004537125 A JP 2004537125A JP 2005539072 A5 JP2005539072 A5 JP 2005539072A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- heterocycle
- group
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000000623 heterocyclic group Chemical group 0.000 claims 62
- 125000000217 alkyl group Chemical group 0.000 claims 51
- 125000001072 heteroaryl group Chemical group 0.000 claims 37
- 150000001875 compounds Chemical class 0.000 claims 31
- 125000003118 aryl group Chemical group 0.000 claims 27
- 125000000547 substituted alkyl group Chemical group 0.000 claims 27
- 125000003342 alkenyl group Chemical group 0.000 claims 24
- 125000002877 alkyl aryl group Chemical group 0.000 claims 24
- 125000000304 alkynyl group Chemical group 0.000 claims 24
- 125000003107 substituted aryl group Chemical group 0.000 claims 21
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 claims 20
- 125000005213 alkyl heteroaryl group Chemical group 0.000 claims 20
- 125000000753 cycloalkyl group Chemical group 0.000 claims 17
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 17
- 125000005843 halogen group Chemical group 0.000 claims 11
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 10
- 125000003282 alkyl amino group Chemical group 0.000 claims 8
- 125000001769 aryl amino group Chemical group 0.000 claims 8
- 125000004104 aryloxy group Chemical group 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 125000006850 spacer group Chemical group 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 125000006727 (C1-C6) alkenyl group Chemical group 0.000 claims 4
- 125000006728 (C1-C6) alkynyl group Chemical group 0.000 claims 4
- -1 OR 16 Chemical group 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 4
- 125000002924 primary amino group Chemical class [H]N([H])* 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 125000005415 substituted alkoxy group Chemical group 0.000 claims 4
- 230000002159 abnormal effect Effects 0.000 claims 2
- 230000004663 cell proliferation Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000011278 mitosis Effects 0.000 claims 2
- 101710103508 FK506-binding protein Proteins 0.000 claims 1
- 101710104425 FK506-binding protein 2 Proteins 0.000 claims 1
- 101710104423 FK506-binding protein 3 Proteins 0.000 claims 1
- 101710104333 FK506-binding protein 4 Proteins 0.000 claims 1
- 101710104342 FK506-binding protein 5 Proteins 0.000 claims 1
- 101710149710 FKBP-type 16 kDa peptidyl-prolyl cis-trans isomerase Proteins 0.000 claims 1
- 101710121306 FKBP-type 22 kDa peptidyl-prolyl cis-trans isomerase Proteins 0.000 claims 1
- 101710180800 FKBP-type peptidyl-prolyl cis-trans isomerase FkpA Proteins 0.000 claims 1
- 101710104030 Long-type peptidyl-prolyl cis-trans isomerase Proteins 0.000 claims 1
- 101710114693 Outer membrane protein MIP Proteins 0.000 claims 1
- 101710116692 Peptidyl-prolyl cis-trans isomerase Proteins 0.000 claims 1
- 101710111764 Peptidyl-prolyl cis-trans isomerase FKBP10 Proteins 0.000 claims 1
- 101710111749 Peptidyl-prolyl cis-trans isomerase FKBP11 Proteins 0.000 claims 1
- 101710111747 Peptidyl-prolyl cis-trans isomerase FKBP12 Proteins 0.000 claims 1
- 101710111757 Peptidyl-prolyl cis-trans isomerase FKBP14 Proteins 0.000 claims 1
- 101710111682 Peptidyl-prolyl cis-trans isomerase FKBP1A Proteins 0.000 claims 1
- 101710111689 Peptidyl-prolyl cis-trans isomerase FKBP1B Proteins 0.000 claims 1
- 101710147154 Peptidyl-prolyl cis-trans isomerase FKBP2 Proteins 0.000 claims 1
- 101710147149 Peptidyl-prolyl cis-trans isomerase FKBP3 Proteins 0.000 claims 1
- 101710147152 Peptidyl-prolyl cis-trans isomerase FKBP4 Proteins 0.000 claims 1
- 101710147150 Peptidyl-prolyl cis-trans isomerase FKBP5 Proteins 0.000 claims 1
- 101710147138 Peptidyl-prolyl cis-trans isomerase FKBP7 Proteins 0.000 claims 1
- 101710147137 Peptidyl-prolyl cis-trans isomerase FKBP8 Proteins 0.000 claims 1
- 101710147136 Peptidyl-prolyl cis-trans isomerase FKBP9 Proteins 0.000 claims 1
- 102100038809 Peptidyl-prolyl cis-trans isomerase FKBP9 Human genes 0.000 claims 1
- 101710174853 Peptidyl-prolyl cis-trans isomerase Mip Proteins 0.000 claims 1
- 101710200991 Peptidyl-prolyl cis-trans isomerase, rhodopsin-specific isozyme Proteins 0.000 claims 1
- 101710092145 Peptidyl-prolyl cis-trans isomerase-like 1 Proteins 0.000 claims 1
- 101710092146 Peptidyl-prolyl cis-trans isomerase-like 2 Proteins 0.000 claims 1
- 101710092148 Peptidyl-prolyl cis-trans isomerase-like 3 Proteins 0.000 claims 1
- 101710092149 Peptidyl-prolyl cis-trans isomerase-like 4 Proteins 0.000 claims 1
- 101710113444 Probable parvulin-type peptidyl-prolyl cis-trans isomerase Proteins 0.000 claims 1
- 101710090737 Probable peptidyl-prolyl cis-trans isomerase Proteins 0.000 claims 1
- 101710133309 Putative peptidyl-prolyl cis-trans isomerase Proteins 0.000 claims 1
- 101710124237 Short-type peptidyl-prolyl cis-trans isomerase Proteins 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 0 CC(C)(*)*C(C)(C)c1c(*)c(*)c(*)c(**)c1* Chemical compound CC(C)(*)*C(C)(C)c1c(*)c(*)c(*)c(**)c1* 0.000 description 5
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20020020987 EP1402888A1 (en) | 2002-09-18 | 2002-09-18 | The use of substituted carbocyclic compounds as rotamases inhibitors |
| PCT/EP2003/010406 WO2004026815A2 (en) | 2002-09-18 | 2003-09-18 | Phenol derivatives and their use as rotamase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010219856A Division JP2011037869A (ja) | 2002-09-18 | 2010-09-29 | ロタマーゼの阻害のための新規化合物およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005539072A JP2005539072A (ja) | 2005-12-22 |
| JP2005539072A5 true JP2005539072A5 (https=) | 2006-08-24 |
Family
ID=31970282
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004537125A Withdrawn JP2005539072A (ja) | 2002-09-18 | 2003-09-18 | ロタマーゼの阻害のための新規化合物およびその使用 |
| JP2010219856A Pending JP2011037869A (ja) | 2002-09-18 | 2010-09-29 | ロタマーゼの阻害のための新規化合物およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010219856A Pending JP2011037869A (ja) | 2002-09-18 | 2010-09-29 | ロタマーゼの阻害のための新規化合物およびその使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20070054904A1 (https=) |
| EP (3) | EP1402888A1 (https=) |
| JP (2) | JP2005539072A (https=) |
| KR (1) | KR20050053673A (https=) |
| CN (1) | CN100546977C (https=) |
| AU (1) | AU2003271619A1 (https=) |
| BR (1) | BR0314544A (https=) |
| CA (1) | CA2498662A1 (https=) |
| MX (1) | MXPA05003084A (https=) |
| PL (1) | PL374846A1 (https=) |
| RU (2) | RU2005111256A (https=) |
| SG (1) | SG165995A1 (https=) |
| WO (1) | WO2004026815A2 (https=) |
| ZA (1) | ZA200501913B (https=) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006518738A (ja) * | 2003-02-12 | 2006-08-17 | トランス テック ファーマ，インコーポレイテッド | 治療薬としての置換アゾール誘導体 |
| CA2520763A1 (en) * | 2003-04-03 | 2004-10-21 | The Regents Of The University Of California | Improved inhibitors for the soluble epoxide hydrolase |
| RS50589B (sr) * | 2003-12-23 | 2010-05-07 | H. Lundbeck A/S. | 2-(1h-indolilsulfanil)-benzil amin derivati kao ssri |
| US7304086B2 (en) * | 2004-02-05 | 2007-12-04 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| EP1765311A4 (en) | 2004-03-16 | 2009-04-29 | Univ California | REDUCTION OF NEPHROPATHY WITH INHIBITORS OF SOLUBLE EPOXY HYDROLASE AND EPOXYEICOSANOIDS |
| US7550499B2 (en) | 2004-05-12 | 2009-06-23 | Bristol-Myers Squibb Company | Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
| WO2005113534A2 (en) * | 2004-05-12 | 2005-12-01 | Schering Corporation | Cxcr1 and cxcr2 chemokine antagonists |
| AR052308A1 (es) * | 2004-07-16 | 2007-03-14 | Lundbeck & Co As H | Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto |
| US7662910B2 (en) * | 2004-10-20 | 2010-02-16 | The Regents Of The University Of California | Inhibitors for the soluble epoxide hydrolase |
| EP1954696B1 (en) | 2005-01-19 | 2011-02-23 | Bristol-Myers Squibb Company | 2-phenoxy-n-(1,3,4-thiadizol-2-yl)pyridin-3-amine derivatives and related compounds as p2y1 receptor inhibitors for the treatment of thromboembolic disorders |
| JP2008540571A (ja) * | 2005-05-12 | 2008-11-20 | ウィスコンシン・アルムニ・リサーチ・ファウンデーション | Ｐｉｎ１の遮断は活性化した免疫細胞によるサイトカイン産生を防ぐ |
| AR054393A1 (es) * | 2005-06-17 | 2007-06-20 | Lundbeck & Co As H | Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos. |
| US7629473B2 (en) * | 2005-06-17 | 2009-12-08 | H. Lundbeck A/S | 2-(1H-indolylsulfanyl)-aryl amine derivatives |
| EP1899299B1 (en) | 2005-06-27 | 2010-10-20 | Bristol-Myers Squibb Company | C-linked cyclic antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
| AR056867A1 (es) | 2005-06-27 | 2007-10-31 | Bristol Myers Squibb Co | Antagonistas heterociclicos n- enlazados del receptor de p2y1 utiles en el tratamiento de condiciones tromboticas. composiciones farmaceuticas. |
| DE602006020871D1 (de) | 2005-06-27 | 2011-05-05 | Bristol Myers Squibb Co | Lineare harnstoffmimetika-antagonisten des p2y1-rezeptors zur behandlung von thromboseleiden |
| WO2007002634A1 (en) | 2005-06-27 | 2007-01-04 | Bristol-Myers Squibb Company | Carbocycle and heterocycle antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
| BRPI0707338A2 (pt) | 2006-01-30 | 2011-05-03 | Transtech Pharma Inc | derivados de imidazol, composições, e métodos substituìdos de uso como inibidores de ptpase |
| US20080081913A1 (en) * | 2006-09-29 | 2008-04-03 | General Electric Company | Benzoxazole and benzothiazole compounds and methods therefor |
| US20080081210A1 (en) | 2006-09-29 | 2008-04-03 | General Electric Company | Authenticatable articles and methods therefor |
| US7960569B2 (en) | 2006-10-17 | 2011-06-14 | Bristol-Myers Squibb Company | Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
| KR20090117950A (ko) * | 2007-03-08 | 2009-11-16 | 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 | 미토콘드리아 알데히드 탈수소효소-2 조절자 및 그것의 사용 방법 |
| US20110110958A1 (en) * | 2007-09-11 | 2011-05-12 | University Of Florida Research Foundation | Compositions and methods for the treatment of neoplasia |
| EP2062578A1 (en) * | 2007-11-12 | 2009-05-27 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Novel use of chemical compounds for the treatment of AIDS |
| EP2337563B1 (en) | 2008-09-08 | 2014-04-09 | The Board of Trustees of The Leland Stanford Junior University | Modulators of aldehyde dehydrogenase activity and methods of use thereof |
| KR20110082180A (ko) | 2008-10-28 | 2011-07-18 | 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 | 알데히드 탈수소효소의 조절자 및 그것의 사용방법 |
| WO2010057101A2 (en) * | 2008-11-17 | 2010-05-20 | Schering Corporation | Compounds useful as hiv blockers |
| MX2011010058A (es) * | 2009-03-25 | 2011-10-11 | Abbott Lab | Compuestos antivirales y usos de los mismos. |
| AU2010235334A1 (en) * | 2009-04-06 | 2011-11-24 | Neurotech Pharmaceuticals Co., Ltd. | Pharmaceutical composition for treating or preventing burn injuries |
| EP2701699B1 (en) * | 2011-04-28 | 2019-10-16 | The Broad Institute, Inc. | Inhibitors of histone deacetylase |
| WO2012149106A1 (en) | 2011-04-29 | 2012-11-01 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for increasing proliferation of adult salivary stem cells |
| US20140296255A1 (en) * | 2011-05-19 | 2014-10-02 | Oryzong Genomics, S.A. | Lysine demethylase inhibitors for thrombosis and cardiovascular diseases |
| EP2741741A2 (en) * | 2011-05-19 | 2014-06-18 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for inflammatory diseases or conditions |
| CA2867175A1 (en) * | 2012-03-28 | 2013-10-03 | Neuropore Therapies, Inc. | Phenyl-urea and phenyl-carbamate derivatives as inhibitors of protein aggregation |
| KR20130118612A (ko) * | 2012-04-20 | 2013-10-30 | (주)네오믹스 | 신규한 아미노피리딘 유도체 및 이의 용도 |
| JP6337255B2 (ja) | 2012-07-27 | 2018-06-06 | ザ ブロード インスティテュート, インコーポレーテッドThe Broad Institute, Inc. | ヒストンデアセチラーゼの阻害剤 |
| US9914717B2 (en) | 2012-12-20 | 2018-03-13 | The Broad Institute, Inc. | Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors |
| JP6410790B2 (ja) | 2013-03-14 | 2018-10-24 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | ミトコンドリアアルデヒドデヒドロゲナーゼ−２調節因子およびその使用方法 |
| WO2016049774A1 (en) * | 2014-10-03 | 2016-04-07 | The Royal Institution For The Advancement Of Learning/Mcgill University | Urea and bis-urea based compounds and analogues thereof useful in the treatment of androgen receptor mediated diseases or disorders |
| JP6917974B2 (ja) | 2015-07-06 | 2021-08-11 | ターニング・ポイント・セラピューティクス・インコーポレイテッドＴｕｒｎｉｎｇ Ｐｏｉｎｔ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | ジアリール大環状多形 |
| CN107417578B (zh) * | 2017-08-23 | 2020-02-07 | 沈阳海诺威医药科技有限公司 | N-(3,5-二甲基金刚烷-1-基)-n’-取代苯基脲类化合物及其制备方法和用途 |
| CA3125731A1 (en) | 2018-01-12 | 2019-07-18 | KDAc Therapeutics, Inc. | Combination of a selective histone deacetylase 3 (hdac3) inhibitor and an immunotherapy agent for the treatment of cancer |
| CN111233692A (zh) * | 2020-01-19 | 2020-06-05 | 江西农业大学 | 一种香茅酸酰胺类衍生物及其制备方法与应用 |
| WO2023003468A1 (en) | 2021-07-23 | 2023-01-26 | Rijksuniversiteit Groningen | Novel inhibitors of histone deacetylase (hdac), and methods, compositions and uses related thereto. |
| CN117682973B (zh) * | 2022-09-26 | 2026-03-20 | 中国药科大学 | 磺酰胺类化合物及其医药用途 |
| CN116942649B (zh) * | 2023-08-01 | 2025-09-16 | 华中农业大学 | 一种苯基脲类化合物作为巴贝斯虫生长抑制剂的应用 |
| CN117224515A (zh) * | 2023-10-31 | 2023-12-15 | 首都医科大学附属北京朝阳医院 | Coh-sr4在制备预防和/或治疗缺血性心脏病的药物中的应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK41193D0 (da) * | 1993-04-07 | 1993-04-07 | Neurosearch As | Ionkanalaabnere |
| US5744485A (en) * | 1994-03-25 | 1998-04-28 | Vertex Pharmaceuticals Incorporated | Carbamates and ureas as modifiers of multi-drug resistance |
| US5696135A (en) * | 1995-06-07 | 1997-12-09 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth |
| SK57899A3 (en) * | 1996-12-31 | 2000-05-16 | Guilford Pharm Inc | N-linked ureas and carbamates of heterocyclic thioesters |
| US6242468B1 (en) * | 1997-02-27 | 2001-06-05 | Jia-He Li | Carbamate and urea compositions and neurotrophic uses |
| ZA98825B (en) * | 1997-02-27 | 1998-10-19 | Guilford Pharm Inc | Method of using neurotrophic carbamates and ureas |
| US6093742A (en) * | 1997-06-27 | 2000-07-25 | Vertex Pharmaceuticals, Inc. | Inhibitors of p38 |
| WO2001017953A1 (en) * | 1999-09-08 | 2001-03-15 | Guilford Pharmaceuticals Inc. | Non-peptidic cyclophilin binding compounds and their use |
| CA2430409A1 (en) * | 2000-11-28 | 2002-06-06 | Guilford Pharmaceuticals Inc. | Bisubstituted carbocyclic cyclophilin binding compounds and their use |
| JP2004532187A (ja) * | 2001-01-25 | 2004-10-21 | ギルフォード ファーマシュウティカルズ インコーポレイテッド | 三置換カルボサイクリックサイクロフィリン結合化合物とその用途 |
| JP2002241273A (ja) * | 2001-02-13 | 2002-08-28 | Sumitomo Pharmaceut Co Ltd | ベンズアミド誘導体およびその利用 |
| EP1361874A1 (en) * | 2001-02-15 | 2003-11-19 | Neurosearch A/S | Treatment of diseases characterized by excessive or insufficient cell death |
| JP2004523543A (ja) * | 2001-02-15 | 2004-08-05 | ニューロサーチ、アクティーゼルスカブ | 神経栄養活性を有する化合物とドパミン活性を増加させる化合物の組み合わせ作用によるパーキンソン病の治療法 |
-
2002
- 2002-09-18 EP EP20020020987 patent/EP1402888A1/en not_active Withdrawn
-
2003
- 2003-09-18 BR BR0314544-1A patent/BR0314544A/pt not_active IP Right Cessation
- 2003-09-18 SG SG200702382-3A patent/SG165995A1/en unknown
- 2003-09-18 US US10/528,139 patent/US20070054904A1/en not_active Abandoned
- 2003-09-18 MX MXPA05003084A patent/MXPA05003084A/es not_active Application Discontinuation
- 2003-09-18 JP JP2004537125A patent/JP2005539072A/ja not_active Withdrawn
- 2003-09-18 AU AU2003271619A patent/AU2003271619A1/en not_active Abandoned
- 2003-09-18 CA CA002498662A patent/CA2498662A1/en not_active Abandoned
- 2003-09-18 PL PL03374846A patent/PL374846A1/xx not_active Application Discontinuation
- 2003-09-18 WO PCT/EP2003/010406 patent/WO2004026815A2/en not_active Ceased
- 2003-09-18 RU RU2005111256/04A patent/RU2005111256A/ru not_active Application Discontinuation
- 2003-09-18 KR KR1020057004693A patent/KR20050053673A/ko not_active Ceased
- 2003-09-18 EP EP09007837A patent/EP2100876A3/en not_active Withdrawn
- 2003-09-18 EP EP03753427A patent/EP1539683A2/en not_active Ceased
- 2003-09-18 CN CNB038252651A patent/CN100546977C/zh not_active Expired - Fee Related
-
2005
- 2005-03-07 ZA ZA2005/01913A patent/ZA200501913B/en unknown
-
2009
- 2009-11-23 US US12/624,308 patent/US20110065760A1/en not_active Abandoned
-
2010
- 2010-09-02 RU RU2010136779/04A patent/RU2010136779A/ru not_active Application Discontinuation
- 2010-09-29 JP JP2010219856A patent/JP2011037869A/ja active Pending
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