CN100546977C - 抑制旋转异构酶的新化合物及其应用 - Google Patents
抑制旋转异构酶的新化合物及其应用 Download PDFInfo
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- CN100546977C CN100546977C CNB038252651A CN03825265A CN100546977C CN 100546977 C CN100546977 C CN 100546977C CN B038252651 A CNB038252651 A CN B038252651A CN 03825265 A CN03825265 A CN 03825265A CN 100546977 C CN100546977 C CN 100546977C
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- phenyl
- hydroxyl
- chloro
- urea
- thiocarbamide
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- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02020987.0 | 2002-09-18 | ||
| EP20020020987 EP1402888A1 (en) | 2002-09-18 | 2002-09-18 | The use of substituted carbocyclic compounds as rotamases inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1701061A CN1701061A (zh) | 2005-11-23 |
| CN100546977C true CN100546977C (zh) | 2009-10-07 |
Family
ID=31970282
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB038252651A Expired - Fee Related CN100546977C (zh) | 2002-09-18 | 2003-09-18 | 抑制旋转异构酶的新化合物及其应用 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20070054904A1 (https=) |
| EP (3) | EP1402888A1 (https=) |
| JP (2) | JP2005539072A (https=) |
| KR (1) | KR20050053673A (https=) |
| CN (1) | CN100546977C (https=) |
| AU (1) | AU2003271619A1 (https=) |
| BR (1) | BR0314544A (https=) |
| CA (1) | CA2498662A1 (https=) |
| MX (1) | MXPA05003084A (https=) |
| PL (1) | PL374846A1 (https=) |
| RU (2) | RU2005111256A (https=) |
| SG (1) | SG165995A1 (https=) |
| WO (1) | WO2004026815A2 (https=) |
| ZA (1) | ZA200501913B (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107417578A (zh) * | 2017-08-23 | 2017-12-01 | 沈阳海诺威医药科技有限公司 | N‑(3,5‑二甲基金刚烷‑1‑基)‑n’‑取代苯基脲类化合物及其制备方法和用途 |
| CN111233692A (zh) * | 2020-01-19 | 2020-06-05 | 江西农业大学 | 一种香茅酸酰胺类衍生物及其制备方法与应用 |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006518738A (ja) * | 2003-02-12 | 2006-08-17 | トランス テック ファーマ,インコーポレイテッド | 治療薬としての置換アゾール誘導体 |
| CA2520763A1 (en) * | 2003-04-03 | 2004-10-21 | The Regents Of The University Of California | Improved inhibitors for the soluble epoxide hydrolase |
| RS50589B (sr) * | 2003-12-23 | 2010-05-07 | H. Lundbeck A/S. | 2-(1h-indolilsulfanil)-benzil amin derivati kao ssri |
| US7304086B2 (en) * | 2004-02-05 | 2007-12-04 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| EP1765311A4 (en) | 2004-03-16 | 2009-04-29 | Univ California | REDUCTION OF NEPHROPATHY WITH INHIBITORS OF SOLUBLE EPOXY HYDROLASE AND EPOXYEICOSANOIDS |
| US7550499B2 (en) | 2004-05-12 | 2009-06-23 | Bristol-Myers Squibb Company | Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
| WO2005113534A2 (en) * | 2004-05-12 | 2005-12-01 | Schering Corporation | Cxcr1 and cxcr2 chemokine antagonists |
| AR052308A1 (es) * | 2004-07-16 | 2007-03-14 | Lundbeck & Co As H | Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto |
| US7662910B2 (en) * | 2004-10-20 | 2010-02-16 | The Regents Of The University Of California | Inhibitors for the soluble epoxide hydrolase |
| EP1954696B1 (en) | 2005-01-19 | 2011-02-23 | Bristol-Myers Squibb Company | 2-phenoxy-n-(1,3,4-thiadizol-2-yl)pyridin-3-amine derivatives and related compounds as p2y1 receptor inhibitors for the treatment of thromboembolic disorders |
| JP2008540571A (ja) * | 2005-05-12 | 2008-11-20 | ウィスコンシン・アルムニ・リサーチ・ファウンデーション | Pin1の遮断は活性化した免疫細胞によるサイトカイン産生を防ぐ |
| AR054393A1 (es) * | 2005-06-17 | 2007-06-20 | Lundbeck & Co As H | Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos. |
| US7629473B2 (en) * | 2005-06-17 | 2009-12-08 | H. Lundbeck A/S | 2-(1H-indolylsulfanyl)-aryl amine derivatives |
| EP1899299B1 (en) | 2005-06-27 | 2010-10-20 | Bristol-Myers Squibb Company | C-linked cyclic antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
| AR056867A1 (es) | 2005-06-27 | 2007-10-31 | Bristol Myers Squibb Co | Antagonistas heterociclicos n- enlazados del receptor de p2y1 utiles en el tratamiento de condiciones tromboticas. composiciones farmaceuticas. |
| DE602006020871D1 (de) | 2005-06-27 | 2011-05-05 | Bristol Myers Squibb Co | Lineare harnstoffmimetika-antagonisten des p2y1-rezeptors zur behandlung von thromboseleiden |
| WO2007002634A1 (en) | 2005-06-27 | 2007-01-04 | Bristol-Myers Squibb Company | Carbocycle and heterocycle antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
| BRPI0707338A2 (pt) | 2006-01-30 | 2011-05-03 | Transtech Pharma Inc | derivados de imidazol, composições, e métodos substituìdos de uso como inibidores de ptpase |
| US20080081913A1 (en) * | 2006-09-29 | 2008-04-03 | General Electric Company | Benzoxazole and benzothiazole compounds and methods therefor |
| US20080081210A1 (en) | 2006-09-29 | 2008-04-03 | General Electric Company | Authenticatable articles and methods therefor |
| US7960569B2 (en) | 2006-10-17 | 2011-06-14 | Bristol-Myers Squibb Company | Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
| KR20090117950A (ko) * | 2007-03-08 | 2009-11-16 | 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 | 미토콘드리아 알데히드 탈수소효소-2 조절자 및 그것의 사용 방법 |
| US20110110958A1 (en) * | 2007-09-11 | 2011-05-12 | University Of Florida Research Foundation | Compositions and methods for the treatment of neoplasia |
| EP2062578A1 (en) * | 2007-11-12 | 2009-05-27 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Novel use of chemical compounds for the treatment of AIDS |
| EP2337563B1 (en) | 2008-09-08 | 2014-04-09 | The Board of Trustees of The Leland Stanford Junior University | Modulators of aldehyde dehydrogenase activity and methods of use thereof |
| KR20110082180A (ko) | 2008-10-28 | 2011-07-18 | 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 | 알데히드 탈수소효소의 조절자 및 그것의 사용방법 |
| WO2010057101A2 (en) * | 2008-11-17 | 2010-05-20 | Schering Corporation | Compounds useful as hiv blockers |
| MX2011010058A (es) * | 2009-03-25 | 2011-10-11 | Abbott Lab | Compuestos antivirales y usos de los mismos. |
| AU2010235334A1 (en) * | 2009-04-06 | 2011-11-24 | Neurotech Pharmaceuticals Co., Ltd. | Pharmaceutical composition for treating or preventing burn injuries |
| EP2701699B1 (en) * | 2011-04-28 | 2019-10-16 | The Broad Institute, Inc. | Inhibitors of histone deacetylase |
| WO2012149106A1 (en) | 2011-04-29 | 2012-11-01 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for increasing proliferation of adult salivary stem cells |
| US20140296255A1 (en) * | 2011-05-19 | 2014-10-02 | Oryzong Genomics, S.A. | Lysine demethylase inhibitors for thrombosis and cardiovascular diseases |
| EP2741741A2 (en) * | 2011-05-19 | 2014-06-18 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for inflammatory diseases or conditions |
| CA2867175A1 (en) * | 2012-03-28 | 2013-10-03 | Neuropore Therapies, Inc. | Phenyl-urea and phenyl-carbamate derivatives as inhibitors of protein aggregation |
| KR20130118612A (ko) * | 2012-04-20 | 2013-10-30 | (주)네오믹스 | 신규한 아미노피리딘 유도체 및 이의 용도 |
| JP6337255B2 (ja) | 2012-07-27 | 2018-06-06 | ザ ブロード インスティテュート, インコーポレーテッドThe Broad Institute, Inc. | ヒストンデアセチラーゼの阻害剤 |
| US9914717B2 (en) | 2012-12-20 | 2018-03-13 | The Broad Institute, Inc. | Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors |
| JP6410790B2 (ja) | 2013-03-14 | 2018-10-24 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | ミトコンドリアアルデヒドデヒドロゲナーゼ−2調節因子およびその使用方法 |
| WO2016049774A1 (en) * | 2014-10-03 | 2016-04-07 | The Royal Institution For The Advancement Of Learning/Mcgill University | Urea and bis-urea based compounds and analogues thereof useful in the treatment of androgen receptor mediated diseases or disorders |
| JP6917974B2 (ja) | 2015-07-06 | 2021-08-11 | ターニング・ポイント・セラピューティクス・インコーポレイテッドTurning Point Therapeutics,Inc. | ジアリール大環状多形 |
| CA3125731A1 (en) | 2018-01-12 | 2019-07-18 | KDAc Therapeutics, Inc. | Combination of a selective histone deacetylase 3 (hdac3) inhibitor and an immunotherapy agent for the treatment of cancer |
| WO2023003468A1 (en) | 2021-07-23 | 2023-01-26 | Rijksuniversiteit Groningen | Novel inhibitors of histone deacetylase (hdac), and methods, compositions and uses related thereto. |
| CN117682973B (zh) * | 2022-09-26 | 2026-03-20 | 中国药科大学 | 磺酰胺类化合物及其医药用途 |
| CN116942649B (zh) * | 2023-08-01 | 2025-09-16 | 华中农业大学 | 一种苯基脲类化合物作为巴贝斯虫生长抑制剂的应用 |
| CN117224515A (zh) * | 2023-10-31 | 2023-12-15 | 首都医科大学附属北京朝阳医院 | Coh-sr4在制备预防和/或治疗缺血性心脏病的药物中的应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001017953A1 (en) * | 1999-09-08 | 2001-03-15 | Guilford Pharmaceuticals Inc. | Non-peptidic cyclophilin binding compounds and their use |
| WO2002059080A2 (en) * | 2001-01-25 | 2002-08-01 | Guilford Pharmaceuticals Inc. | Trisubstituted carbocyclic cyclophilin binding compounds and their use |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK41193D0 (da) * | 1993-04-07 | 1993-04-07 | Neurosearch As | Ionkanalaabnere |
| US5744485A (en) * | 1994-03-25 | 1998-04-28 | Vertex Pharmaceuticals Incorporated | Carbamates and ureas as modifiers of multi-drug resistance |
| US5696135A (en) * | 1995-06-07 | 1997-12-09 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth |
| SK57899A3 (en) * | 1996-12-31 | 2000-05-16 | Guilford Pharm Inc | N-linked ureas and carbamates of heterocyclic thioesters |
| US6242468B1 (en) * | 1997-02-27 | 2001-06-05 | Jia-He Li | Carbamate and urea compositions and neurotrophic uses |
| ZA98825B (en) * | 1997-02-27 | 1998-10-19 | Guilford Pharm Inc | Method of using neurotrophic carbamates and ureas |
| US6093742A (en) * | 1997-06-27 | 2000-07-25 | Vertex Pharmaceuticals, Inc. | Inhibitors of p38 |
| CA2430409A1 (en) * | 2000-11-28 | 2002-06-06 | Guilford Pharmaceuticals Inc. | Bisubstituted carbocyclic cyclophilin binding compounds and their use |
| JP2002241273A (ja) * | 2001-02-13 | 2002-08-28 | Sumitomo Pharmaceut Co Ltd | ベンズアミド誘導体およびその利用 |
| EP1361874A1 (en) * | 2001-02-15 | 2003-11-19 | Neurosearch A/S | Treatment of diseases characterized by excessive or insufficient cell death |
| JP2004523543A (ja) * | 2001-02-15 | 2004-08-05 | ニューロサーチ、アクティーゼルスカブ | 神経栄養活性を有する化合物とドパミン活性を増加させる化合物の組み合わせ作用によるパーキンソン病の治療法 |
-
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- 2003-09-18 SG SG200702382-3A patent/SG165995A1/en unknown
- 2003-09-18 US US10/528,139 patent/US20070054904A1/en not_active Abandoned
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- 2010-09-02 RU RU2010136779/04A patent/RU2010136779A/ru not_active Application Discontinuation
- 2010-09-29 JP JP2010219856A patent/JP2011037869A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001017953A1 (en) * | 1999-09-08 | 2001-03-15 | Guilford Pharmaceuticals Inc. | Non-peptidic cyclophilin binding compounds and their use |
| WO2002059080A2 (en) * | 2001-01-25 | 2002-08-01 | Guilford Pharmaceuticals Inc. | Trisubstituted carbocyclic cyclophilin binding compounds and their use |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107417578A (zh) * | 2017-08-23 | 2017-12-01 | 沈阳海诺威医药科技有限公司 | N‑(3,5‑二甲基金刚烷‑1‑基)‑n’‑取代苯基脲类化合物及其制备方法和用途 |
| CN107417578B (zh) * | 2017-08-23 | 2020-02-07 | 沈阳海诺威医药科技有限公司 | N-(3,5-二甲基金刚烷-1-基)-n’-取代苯基脲类化合物及其制备方法和用途 |
| CN111233692A (zh) * | 2020-01-19 | 2020-06-05 | 江西农业大学 | 一种香茅酸酰胺类衍生物及其制备方法与应用 |
Also Published As
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| KR20050053673A (ko) | 2005-06-08 |
| EP1402888A1 (en) | 2004-03-31 |
| JP2011037869A (ja) | 2011-02-24 |
| PL374846A1 (en) | 2005-11-14 |
| CA2498662A1 (en) | 2004-04-01 |
| AU2003271619A1 (en) | 2004-04-08 |
| WO2004026815A3 (en) | 2004-12-02 |
| EP2100876A3 (en) | 2010-02-24 |
| BR0314544A (pt) | 2005-08-16 |
| MXPA05003084A (es) | 2005-11-17 |
| US20110065760A1 (en) | 2011-03-17 |
| RU2005111256A (ru) | 2006-10-27 |
| EP1539683A2 (en) | 2005-06-15 |
| EP2100876A2 (en) | 2009-09-16 |
| WO2004026815A2 (en) | 2004-04-01 |
| ZA200501913B (en) | 2005-07-27 |
| SG165995A1 (en) | 2010-11-29 |
| RU2010136779A (ru) | 2012-03-10 |
| JP2005539072A (ja) | 2005-12-22 |
| CN1701061A (zh) | 2005-11-23 |
| US20070054904A1 (en) | 2007-03-08 |
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