CA2498662A1 - Phenol derivatives and their use as rotamase inhibitors - Google Patents

Phenol derivatives and their use as rotamase inhibitors Download PDF

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Publication number
CA2498662A1
CA2498662A1 CA002498662A CA2498662A CA2498662A1 CA 2498662 A1 CA2498662 A1 CA 2498662A1 CA 002498662 A CA002498662 A CA 002498662A CA 2498662 A CA2498662 A CA 2498662A CA 2498662 A1 CA2498662 A1 CA 2498662A1
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CA
Canada
Prior art keywords
phenyl
hydroxy
chloro
benzylamino
phenol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002498662A
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English (en)
French (fr)
Inventor
Jochen Knolle
Mike Schutkowski
Gerd Hummel
Thomas Tradler
Laurence Jobron
Claudia Christner
Dirk Scharn
Roland Stragies
Christoph Gibson
Frank Osterkamp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jerini AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2498662A1 publication Critical patent/CA2498662A1/en
Abandoned legal-status Critical Current

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    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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  • Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
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  • Biomedical Technology (AREA)
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  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Biotechnology (AREA)
  • Ophthalmology & Optometry (AREA)
CA002498662A 2002-09-18 2003-09-18 Phenol derivatives and their use as rotamase inhibitors Abandoned CA2498662A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20020020987 EP1402888A1 (en) 2002-09-18 2002-09-18 The use of substituted carbocyclic compounds as rotamases inhibitors
EP02020987.0 2002-09-18
PCT/EP2003/010406 WO2004026815A2 (en) 2002-09-18 2003-09-18 Phenol derivatives and their use as rotamase inhibitors

Publications (1)

Publication Number Publication Date
CA2498662A1 true CA2498662A1 (en) 2004-04-01

Family

ID=31970282

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002498662A Abandoned CA2498662A1 (en) 2002-09-18 2003-09-18 Phenol derivatives and their use as rotamase inhibitors

Country Status (14)

Country Link
US (2) US20070054904A1 (https=)
EP (3) EP1402888A1 (https=)
JP (2) JP2005539072A (https=)
KR (1) KR20050053673A (https=)
CN (1) CN100546977C (https=)
AU (1) AU2003271619A1 (https=)
BR (1) BR0314544A (https=)
CA (1) CA2498662A1 (https=)
MX (1) MXPA05003084A (https=)
PL (1) PL374846A1 (https=)
RU (2) RU2005111256A (https=)
SG (1) SG165995A1 (https=)
WO (1) WO2004026815A2 (https=)
ZA (1) ZA200501913B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016049774A1 (en) * 2014-10-03 2016-04-07 The Royal Institution For The Advancement Of Learning/Mcgill University Urea and bis-urea based compounds and analogues thereof useful in the treatment of androgen receptor mediated diseases or disorders

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* Cited by examiner, † Cited by third party
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CA2514363A1 (en) * 2003-02-12 2004-08-26 Transtech Pharma, Inc. Substituted azole derivatives as therapeutic agents
US20050026844A1 (en) 2003-04-03 2005-02-03 Regents Of The University Of California Inhibitors for the soluble epoxide hydrolase
WO2005089380A2 (en) 2004-03-16 2005-09-29 The Regents Of The University Of California Reducing nephropathy with inhibitors of soluble epoxide hydrolase and epoxyeicosanoids
PL1701940T3 (pl) * 2003-12-23 2008-11-28 H Lundbeck As Pochodne 2-(1H-indolilosulfanylo)benzyloaminy jako SSRI
CA2554809C (en) * 2004-02-05 2014-04-29 Probiodrug Ag Novel n-alkyl thiourea- and thioamide-substituted imidazolyl inhibitors of glutaminyl cyclase
US7550499B2 (en) 2004-05-12 2009-06-23 Bristol-Myers Squibb Company Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
CN1984899B (zh) * 2004-05-12 2011-07-27 先灵公司 Cxcr1和cxcr2趋化因子拮抗剂
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