JP2006523626A5 - - Google Patents
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- Publication number
- JP2006523626A5 JP2006523626A5 JP2006504583A JP2006504583A JP2006523626A5 JP 2006523626 A5 JP2006523626 A5 JP 2006523626A5 JP 2006504583 A JP2006504583 A JP 2006504583A JP 2006504583 A JP2006504583 A JP 2006504583A JP 2006523626 A5 JP2006523626 A5 JP 2006523626A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- solvate
- salt
- medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 18
- 150000003839 salts Chemical class 0.000 claims description 17
- 239000012453 solvate Substances 0.000 claims description 12
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 239000002253 acid Substances 0.000 claims description 6
- 125000004432 carbon atom Chemical group C* 0.000 claims description 6
- 150000007514 bases Chemical class 0.000 claims description 4
- 125000000962 organic group Chemical group 0.000 claims description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 2
- 125000003342 alkenyl group Chemical group 0.000 claims description 2
- 125000005452 alkenyloxyalkyl group Chemical group 0.000 claims description 2
- 125000003545 alkoxy group Chemical group 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 2
- 125000005842 heteroatom Chemical group 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 229920006395 saturated elastomer Polymers 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 5
- 108091032151 5-hydroxytryptamine receptor family Proteins 0.000 claims 2
- 102000014630 G protein-coupled serotonin receptor activity proteins Human genes 0.000 claims 2
- 230000003042 antagnostic effect Effects 0.000 claims 2
- 102000049773 5-HT2A Serotonin Receptor Human genes 0.000 claims 1
- 108010072564 5-HT2A Serotonin Receptor Proteins 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 2
- 0 CC(*)(C=C(*)C=*1)C=C1[n]1ncc(C(*)=O)c1* Chemical compound CC(*)(C=C(*)C=*1)C=C1[n]1ncc(C(*)=O)c1* 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10315571.6 | 2003-04-05 | ||
| DE2003115571 DE10315571A1 (de) | 2003-04-05 | 2003-04-05 | Pyrazolverbindungen |
| PCT/EP2004/002352 WO2004089888A1 (de) | 2003-04-05 | 2004-03-08 | Pyrazolverbindungen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006523626A JP2006523626A (ja) | 2006-10-19 |
| JP2006523626A5 true JP2006523626A5 (https=) | 2007-04-26 |
| JP4833832B2 JP4833832B2 (ja) | 2011-12-07 |
Family
ID=32981072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006504583A Expired - Fee Related JP4833832B2 (ja) | 2003-04-05 | 2004-03-08 | ピラゾール化合物 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7960413B2 (https=) |
| EP (1) | EP1611094B1 (https=) |
| JP (1) | JP4833832B2 (https=) |
| KR (1) | KR20050119195A (https=) |
| CN (1) | CN1768053A (https=) |
| AR (1) | AR043836A1 (https=) |
| AT (1) | ATE365161T1 (https=) |
| AU (1) | AU2004228119B2 (https=) |
| BR (1) | BRPI0409160A (https=) |
| CA (1) | CA2521199A1 (https=) |
| DE (2) | DE10315571A1 (https=) |
| ES (1) | ES2287707T3 (https=) |
| MX (1) | MXPA05010651A (https=) |
| PL (1) | PL377685A1 (https=) |
| RU (1) | RU2005133985A (https=) |
| WO (1) | WO2004089888A1 (https=) |
| ZA (1) | ZA200508946B (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10315571A1 (de) | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Pyrazolverbindungen |
| DE10315573A1 (de) | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Substituierte Pyrazole |
| DE10315569A1 (de) * | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Substituierte Pyrazolverbindungen |
| DE10315572A1 (de) * | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Substituierte Pyrazole |
| US8703805B2 (en) | 2005-06-27 | 2014-04-22 | Exelixis Patent Company Llc | Modulators of LXR |
| JP2008169191A (ja) * | 2006-02-20 | 2008-07-24 | Eisai R & D Management Co Ltd | 運動ニューロン疾患治療剤 |
| CN101484424B (zh) * | 2006-02-28 | 2014-05-14 | 达特神经科学(开曼)有限公司 | 治疗化合物 |
| EP2562168B1 (en) | 2006-02-28 | 2014-04-16 | Dart Neuroscience (Cayman) Ltd | Therapeutic piperazines as pde4 inhibitors |
| ES2536762T3 (es) | 2006-05-18 | 2015-05-28 | Arena Pharmaceuticals, Inc. | Aminas primarias y sus derivados como moduladores del receptor de la serotonina 5-HT2A útiles para el tratamiento de trastornos relacionados con este |
| CA2646076C (en) | 2006-05-18 | 2015-06-30 | Arena Pharmaceuticals, Inc. | Ethers, secondary amines and derivatives thereof as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto |
| KR20090094125A (ko) | 2006-12-08 | 2009-09-03 | 엑셀리시스, 인코포레이티드 | Ｌｘｒ 및 ｆｘｒ 조절자 |
| AU2008293542B9 (en) | 2007-08-27 | 2014-08-07 | Dart Neuroscience (Cayman) Ltd. | Therapeutic isoxazole compounds |
| WO2011075596A1 (en) | 2009-12-18 | 2011-06-23 | Arena Pharmaceuticals, Inc. | Crystalline forms of certain 3-phenyl-pyrazole derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto |
| WO2020113094A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4146721A (en) * | 1969-09-12 | 1979-03-27 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Pyrazol-4-acetic acid compounds |
| CH518155A (de) | 1970-08-18 | 1972-01-31 | Schaerer Willy | Verfahren zur Erleichterung des Schleifens schraubenlinienförmiger Nuten, bei einer Serie von unter sich gleichen Werkstücken mit je mindestens einer schraubenlinienförmig eingefrästen Nut und Simuliergerät zur Durchführung des Verfahrens |
| BE793955A (fr) * | 1972-01-15 | 1973-07-12 | Merck Patent Gmbh | Arylpiperazines et leur procede de preparation |
| DE2258033A1 (de) | 1972-11-27 | 1974-05-30 | Merck Patent Gmbh | Verfahren zur herstellung von pyrazolderivaten |
| DE2906252A1 (de) * | 1979-02-19 | 1980-08-28 | Merck Patent Gmbh | Pyrazolderivate, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung |
| US4631343A (en) * | 1983-11-07 | 1986-12-23 | Eli Lilly And Company | Cyanopyrazole intermediates |
| WO1996033175A1 (en) * | 1995-04-20 | 1996-10-24 | G.D. Searle & Co. | Cyclic amidino agents useful as nitric oxide synthase inhibitors |
| DE69822449T2 (de) * | 1997-01-21 | 2005-01-27 | Smithkline Beecham Corp. | Neue cannabinoidrezeptor-modulatoren |
| US6150393A (en) * | 1998-12-18 | 2000-11-21 | Arena Pharmaceuticals, Inc. | Small molecule modulators of non-endogenous, constitutively activated human serotonin receptors |
| US20010044445A1 (en) * | 1999-04-08 | 2001-11-22 | Bamaung Nwe Y. | Azole inhibitors of cytokine production |
| US6632815B2 (en) * | 1999-09-17 | 2003-10-14 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
| JP4861585B2 (ja) | 1999-10-29 | 2012-01-25 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | 置換ピラゾールの合成方法 |
| US6407238B1 (en) * | 1999-10-29 | 2002-06-18 | Boehringer Ingelheim Pharmaceuticals, Inc. | Process of making substituted pyrazoles |
| AU1028601A (en) | 1999-11-05 | 2001-05-14 | Smithkline Beecham Plc | Isoquinoline and quinazoline derivatives having a combined 5ht1a, 5ht1b and 5ht1d receptor activity |
| KR100502330B1 (ko) * | 2000-04-29 | 2005-07-20 | 삼성에스디아이 주식회사 | 격벽이 마련된 기판 및 이를 이용한 플라즈마 표시장치 |
| BR0210391A (pt) * | 2001-06-12 | 2004-06-15 | Elan Pharm Inc | Composto, métodos de tratar um paciente que tenha ou de prevenir um paciente de contrair uma doença ou condição e de preparar um composto, e, uso de um composto |
| DE10149370A1 (de) | 2001-10-06 | 2003-04-10 | Merck Patent Gmbh | Pyrazolderivate |
| GR1004118B (el) * | 2001-10-11 | 2003-01-21 | Ηλεκτροχημικη μεθοδος υγρης οξειδωσης-αποστειρωσης υγρων αποβλητων απο σφαγεια ψαριων | |
| EP1494664A2 (en) * | 2002-04-18 | 2005-01-12 | Pharmacia Corporation | Combinations of cox-2 inhibitors and other agents for the treatment of parkinson's disease |
| EP1513817A1 (en) | 2002-05-24 | 2005-03-16 | Takeda Pharmaceutical Company Limited | 1, 2-azole derivatives with hypoglycemic and hypolipidemic activity |
| US7368578B2 (en) * | 2002-09-10 | 2008-05-06 | Takeda Pharmaceutical Company Limited | Five-membered heterocyclic compounds |
| AU2003287965A1 (en) | 2002-10-24 | 2004-05-13 | Carex Sa | Modulation of peroxisome proliferator activated receptors activity |
| DE10315571A1 (de) | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Pyrazolverbindungen |
| DE10315572A1 (de) * | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Substituierte Pyrazole |
| DE10315573A1 (de) * | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Substituierte Pyrazole |
| DE10315569A1 (de) * | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Substituierte Pyrazolverbindungen |
| US20070093492A1 (en) * | 2004-03-09 | 2007-04-26 | Weir-Torn Jiaang | Pyrrolidine derivatives |
-
2003
- 2003-04-05 DE DE2003115571 patent/DE10315571A1/de not_active Withdrawn
-
2004
- 2004-03-08 CA CA002521199A patent/CA2521199A1/en not_active Abandoned
- 2004-03-08 RU RU2005133985/04A patent/RU2005133985A/ru not_active Application Discontinuation
- 2004-03-08 PL PL377685A patent/PL377685A1/pl unknown
- 2004-03-08 DE DE502004004146T patent/DE502004004146D1/de not_active Expired - Lifetime
- 2004-03-08 MX MXPA05010651A patent/MXPA05010651A/es not_active Application Discontinuation
- 2004-03-08 ES ES04718288T patent/ES2287707T3/es not_active Expired - Lifetime
- 2004-03-08 AU AU2004228119A patent/AU2004228119B2/en not_active Ceased
- 2004-03-08 AT AT04718288T patent/ATE365161T1/de not_active IP Right Cessation
- 2004-03-08 WO PCT/EP2004/002352 patent/WO2004089888A1/de not_active Ceased
- 2004-03-08 BR BRPI0409160-4A patent/BRPI0409160A/pt not_active Application Discontinuation
- 2004-03-08 US US10/551,905 patent/US7960413B2/en not_active Expired - Fee Related
- 2004-03-08 CN CNA2004800086045A patent/CN1768053A/zh active Pending
- 2004-03-08 JP JP2006504583A patent/JP4833832B2/ja not_active Expired - Fee Related
- 2004-03-08 KR KR1020057018899A patent/KR20050119195A/ko not_active Withdrawn
- 2004-03-08 EP EP04718288A patent/EP1611094B1/de not_active Expired - Lifetime
- 2004-04-02 AR ARP040101118A patent/AR043836A1/es unknown
-
2005
- 2005-11-04 ZA ZA200508946A patent/ZA200508946B/xx unknown
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