AR043836A1 - Compuestos de pirazol - Google Patents
Compuestos de pirazolInfo
- Publication number
- AR043836A1 AR043836A1 ARP040101118A ARP040101118A AR043836A1 AR 043836 A1 AR043836 A1 AR 043836A1 AR P040101118 A ARP040101118 A AR P040101118A AR P040101118 A ARP040101118 A AR P040101118A AR 043836 A1 AR043836 A1 AR 043836A1
- Authority
- AR
- Argentina
- Prior art keywords
- hal
- het
- mono
- ch2ch2n
- coor5
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Anesthesiology (AREA)
- Psychology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Nutrition Science (AREA)
- Gynecology & Obstetrics (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Los compuestos de la fórmula (1) donde :R2, R4 son H, A, Hal, cicloalquilo C3-7, CF3, NO2,CN, OCF3, OA, NHA, NA2, NH2; R3, R6 son (CH2)nHet, (CH2)nAr; R1es H o un radical orgánico, en especial (CH2)nCO2R5, (CH2)nCOHet, CHO, (CH2)nOR5, (CH2)nHet, (CH2)nN(R5)2, CH=N-OA, CH2CH=N-OA, (CH2)nNHOA; (CH2)n(R5)Het, (CH2)nCH=N-Het, (CH2)nOCOR5, (CH2)nN(R5)CH2CH2OR5, (CH2)nN(R5)CH2CH2OCF3, (CH2)nN(R5)C(R5)COOR5, (CH2)nN(R5)CH2COHet, (CH2)nN(R5)CH2Het, (CH2)nN(R5)CH2CH2Het, (CH2)nN(R5)CH2CH2N(R5)CH2COOR5, (CH2)nN(R5)CH2CH2N(R5)2, CH=CHCOOR5, CH=CHCH2NR5Het, CH=CHCH2N(R5)2, CH=CHCH2OR5 o (CH2)nN(R5)Ar; R5 es H o A; A es alquilo o alcoxi lineal o ramificado C1-10, alquenilo o alqueniloxialquilo C2-10; Het es un radical heterocíclico, mono- o bicíclico insustituido o mono o polisustituido con A y/o Hal, saturado, insaturado o aromático o un radical orgánico lineal o ramificado que contiene uno o varios heteroátomos; Ar es un radical fenilo insustituido o mono o polisustituido con A y/o Hal, OR5, OOCR5, COOR5, CON(R5)2, CN, NO2, NH2, NHCOR5, CF3 o SO2CH3, n es 0,1 , 2, 3, 4, o 5 y Hal es F, Cl, Br o I donde, en el caso de que X presente el significado CH, R2 y R4 no sean al mismo tiempo H, así como sus sales y solvatos, enantiómeros, racematos y otras mezclas enantioméricas, en especial sus sales y solvatos de tolerancia fisiológica. Son apropiados como ligandos de receptores 5 HT.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2003115571 DE10315571A1 (de) | 2003-04-05 | 2003-04-05 | Pyrazolverbindungen |
Publications (1)
Publication Number | Publication Date |
---|---|
AR043836A1 true AR043836A1 (es) | 2005-08-17 |
Family
ID=32981072
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040101118A AR043836A1 (es) | 2003-04-05 | 2004-04-02 | Compuestos de pirazol |
Country Status (17)
Country | Link |
---|---|
US (1) | US7960413B2 (es) |
EP (1) | EP1611094B1 (es) |
JP (1) | JP4833832B2 (es) |
KR (1) | KR20050119195A (es) |
CN (1) | CN1768053A (es) |
AR (1) | AR043836A1 (es) |
AT (1) | ATE365161T1 (es) |
AU (1) | AU2004228119B2 (es) |
BR (1) | BRPI0409160A (es) |
CA (1) | CA2521199A1 (es) |
DE (2) | DE10315571A1 (es) |
ES (1) | ES2287707T3 (es) |
MX (1) | MXPA05010651A (es) |
PL (1) | PL377685A1 (es) |
RU (1) | RU2005133985A (es) |
WO (1) | WO2004089888A1 (es) |
ZA (1) | ZA200508946B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10315573A1 (de) | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Substituierte Pyrazole |
DE10315569A1 (de) * | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Substituierte Pyrazolverbindungen |
DE10315571A1 (de) | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Pyrazolverbindungen |
DE10315572A1 (de) * | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Substituierte Pyrazole |
CA2613517A1 (en) | 2005-06-27 | 2007-01-04 | Exelixis, Inc. | Pyrazole based lxr modulators |
JP2008169191A (ja) * | 2006-02-20 | 2008-07-24 | Eisai R & D Management Co Ltd | 運動ニューロン疾患治療剤 |
EP1989188B1 (en) | 2006-02-28 | 2015-07-22 | Dart Neuroscience (Cayman) Ltd | Therapeutic piperazines as pde4 inhibitors |
NZ595571A (en) | 2006-02-28 | 2013-04-26 | Helicon Therapeutics Inc | Pyrazole compounds and uses thereof |
JP5406018B2 (ja) | 2006-05-18 | 2014-02-05 | アリーナ ファーマシューティカルズ, インコーポレイテッド | 5−ht2aセロトニンレセプターに関連する障害の処置に有用な5−ht2aセロトニンレセプターのモジュレーターとしての1級アミン、およびその誘導体 |
US8148418B2 (en) | 2006-05-18 | 2012-04-03 | Arena Pharmaceuticals, Inc. | Ethers, secondary amines and derivatives thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto |
JP5399262B2 (ja) | 2006-12-08 | 2014-01-29 | エグゼリクシス パテント カンパニー エルエルシー | Lxrおよびfxrのモジュレーター |
MX2010002258A (es) | 2007-08-27 | 2010-04-22 | Helicon Therapeutics Inc | Compuestos terapeuticos de isoxazol. |
US8980891B2 (en) | 2009-12-18 | 2015-03-17 | Arena Pharmaceuticals, Inc. | Crystalline forms of certain 3-phenyl-pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto |
CA3121202A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4146721A (en) * | 1969-09-12 | 1979-03-27 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Pyrazol-4-acetic acid compounds |
CH518155A (de) | 1970-08-18 | 1972-01-31 | Schaerer Willy | Verfahren zur Erleichterung des Schleifens schraubenlinienförmiger Nuten, bei einer Serie von unter sich gleichen Werkstücken mit je mindestens einer schraubenlinienförmig eingefrästen Nut und Simuliergerät zur Durchführung des Verfahrens |
BE793955A (fr) | 1972-01-15 | 1973-07-12 | Merck Patent Gmbh | Arylpiperazines et leur procede de preparation |
DE2258033A1 (de) | 1972-11-27 | 1974-05-30 | Merck Patent Gmbh | Verfahren zur herstellung von pyrazolderivaten |
DE2906252A1 (de) * | 1979-02-19 | 1980-08-28 | Merck Patent Gmbh | Pyrazolderivate, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung |
US4631343A (en) * | 1983-11-07 | 1986-12-23 | Eli Lilly And Company | Cyanopyrazole intermediates |
EP0821674B1 (en) * | 1995-04-20 | 2003-08-06 | G.D. SEARLE & CO. | Cyclic amidino agents useful as nitric oxide synthase inhibitors |
CA2278307A1 (en) * | 1997-01-21 | 1998-07-23 | Siegfried Benjamin Christensen Iv | Novel cannabinoid receptor modulators |
US6150393A (en) | 1998-12-18 | 2000-11-21 | Arena Pharmaceuticals, Inc. | Small molecule modulators of non-endogenous, constitutively activated human serotonin receptors |
US20010044445A1 (en) * | 1999-04-08 | 2001-11-22 | Bamaung Nwe Y. | Azole inhibitors of cytokine production |
US6632815B2 (en) * | 1999-09-17 | 2003-10-14 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
JP4861585B2 (ja) | 1999-10-29 | 2012-01-25 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | 置換ピラゾールの合成方法 |
US6407238B1 (en) * | 1999-10-29 | 2002-06-18 | Boehringer Ingelheim Pharmaceuticals, Inc. | Process of making substituted pyrazoles |
ATE286883T1 (de) | 1999-11-05 | 2005-01-15 | Smithkline Beecham Plc | Isochinolin und chinazolinderivate mit kombinierter 5ht1a, 5ht1b und 5ht1d rezeptor aktivität |
KR100502330B1 (ko) * | 2000-04-29 | 2005-07-20 | 삼성에스디아이 주식회사 | 격벽이 마련된 기판 및 이를 이용한 플라즈마 표시장치 |
JP2005505506A (ja) * | 2001-06-12 | 2005-02-24 | イーラン ファーマスーティカルズ、インコーポレイテッド | アルツハイマー病の治療に有用な大環状分子 |
DE10149370A1 (de) * | 2001-10-06 | 2003-04-10 | Merck Patent Gmbh | Pyrazolderivate |
GR1004118B (el) * | 2001-10-11 | 2003-01-21 | Μαρκος Νινολακης | Ηλεκτροχημικη μεθοδος υγρης οξειδωσης-αποστειρωσης υγρων αποβλητων απο σφαγεια ψαριων |
AU2003223579A1 (en) * | 2002-04-18 | 2003-11-03 | Pharmacia Corporation | Combinations of cox-2 inhibitors and other agents for the treatment of parkinson's disease |
WO2003099793A1 (en) | 2002-05-24 | 2003-12-04 | Takeda Pharmaceutical Company Limited | 1,2-azole derivatives with hypoglycemic and hypolipidemic activity |
WO2004024705A1 (ja) | 2002-09-10 | 2004-03-25 | Takeda Pharmaceutical Company Limited | 5員複素環化合物 |
AU2003287965A1 (en) | 2002-10-24 | 2004-05-13 | Carex Sa | Modulation of peroxisome proliferator activated receptors activity |
DE10315572A1 (de) * | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Substituierte Pyrazole |
DE10315569A1 (de) * | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Substituierte Pyrazolverbindungen |
DE10315571A1 (de) | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Pyrazolverbindungen |
DE10315573A1 (de) * | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Substituierte Pyrazole |
US20070093492A1 (en) * | 2004-03-09 | 2007-04-26 | Weir-Torn Jiaang | Pyrrolidine derivatives |
-
2003
- 2003-04-05 DE DE2003115571 patent/DE10315571A1/de not_active Withdrawn
-
2004
- 2004-03-08 ES ES04718288T patent/ES2287707T3/es not_active Expired - Lifetime
- 2004-03-08 US US10/551,905 patent/US7960413B2/en not_active Expired - Fee Related
- 2004-03-08 KR KR1020057018899A patent/KR20050119195A/ko not_active Application Discontinuation
- 2004-03-08 JP JP2006504583A patent/JP4833832B2/ja not_active Expired - Fee Related
- 2004-03-08 BR BRPI0409160-4A patent/BRPI0409160A/pt not_active Application Discontinuation
- 2004-03-08 PL PL377685A patent/PL377685A1/pl unknown
- 2004-03-08 WO PCT/EP2004/002352 patent/WO2004089888A1/de active IP Right Grant
- 2004-03-08 CA CA002521199A patent/CA2521199A1/en not_active Abandoned
- 2004-03-08 AT AT04718288T patent/ATE365161T1/de not_active IP Right Cessation
- 2004-03-08 RU RU2005133985/04A patent/RU2005133985A/ru not_active Application Discontinuation
- 2004-03-08 DE DE502004004146T patent/DE502004004146D1/de not_active Expired - Lifetime
- 2004-03-08 AU AU2004228119A patent/AU2004228119B2/en not_active Ceased
- 2004-03-08 CN CNA2004800086045A patent/CN1768053A/zh active Pending
- 2004-03-08 EP EP04718288A patent/EP1611094B1/de not_active Expired - Lifetime
- 2004-03-08 MX MXPA05010651A patent/MXPA05010651A/es not_active Application Discontinuation
- 2004-04-02 AR ARP040101118A patent/AR043836A1/es unknown
-
2005
- 2005-11-04 ZA ZA200508946A patent/ZA200508946B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
KR20050119195A (ko) | 2005-12-20 |
JP4833832B2 (ja) | 2011-12-07 |
MXPA05010651A (es) | 2005-12-12 |
ATE365161T1 (de) | 2007-07-15 |
WO2004089888A1 (de) | 2004-10-21 |
CN1768053A (zh) | 2006-05-03 |
ZA200508946B (en) | 2007-02-28 |
AU2004228119A1 (en) | 2004-10-21 |
RU2005133985A (ru) | 2006-03-27 |
AU2004228119B2 (en) | 2010-09-02 |
ES2287707T3 (es) | 2007-12-16 |
BRPI0409160A (pt) | 2006-05-02 |
CA2521199A1 (en) | 2004-10-21 |
DE502004004146D1 (en) | 2007-08-02 |
US20060276650A1 (en) | 2006-12-07 |
DE10315571A1 (de) | 2004-10-14 |
EP1611094B1 (de) | 2007-06-20 |
JP2006523626A (ja) | 2006-10-19 |
EP1611094A1 (de) | 2006-01-04 |
PL377685A1 (pl) | 2006-02-06 |
US7960413B2 (en) | 2011-06-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR043837A1 (es) | Pirazoles sustituidos | |
AR043836A1 (es) | Compuestos de pirazol | |
AR043838A1 (es) | Pirazoles sustituidos | |
PE20221283A1 (es) | Compuestos triciclicos sustituidos | |
PE20091952A1 (es) | Compuestos de tiazole y oxazole de sulfonamida de benzeno | |
CO5690642A2 (es) | Compuestos de pirazolo[3,4-b]piridina, y su uso como inhibi- dores de fosfodiesterasa | |
AR055150A1 (es) | Compuestos de isoindol - imido y composiciones que los comprenden y sus metodos de uso | |
ECSP045276A (es) | O-ciclopropil-carboxanilidas y su uso como fungicidas | |
AR061642A1 (es) | Derivados de ureas de tropano, su preparacion y su aplicacion en terapeu-tica, procesos de obtencion y composiciones farmaceuticas | |
ECSP088431A (es) | Derivados de pirazolo | |
ES2536918T3 (es) | Compuestos de benzoilpirazol y herbicidas que los contienen | |
DE602004017087D1 (de) | Zusammensetzung für optische Filme enthaltend einen im Nah-Infrarotbereich absorbierenden Farbstoff und einen Löscher | |
CO5621366A2 (es) | Compuestos imidazoltionas como agonistas de los receptores adrenergicos alfa y 2b y/o alfa 2c para el tratamiento del dolor, alodinia y otras enfermedades relacionadas | |
CO4700453A1 (es) | N-(INDOL-2-CARBONIL)-beta-ALANILAMIDAS SUSTITUIDAS Y DERIVADOS COMO AGENTES ANTIDIABETICOS | |
AR078166A1 (es) | (heteroarilmetil) tiohidantoinas sustituidas | |
PE20070189A1 (es) | COMPUESTO DE AMINO-5-HETEROARILO (5 MIEMBROS) IMIDAZOLONA Y SU USO PARA MODULACION DE LA ß-SECRETASA | |
AR049543A1 (es) | Derivados de la 1-amino-ftalazina, su preparacion y su aplicacion en terapeutica | |
AR072166A1 (es) | Derivado de piperidina y su uso como inhibidor de renina superior | |
CO5721001A2 (es) | Derivados sustituidos de morfolina y tiomorfolina | |
AR053153A1 (es) | Derivados de pirazina -2- carboxamida como antagonistas de mglur5 | |
SV1999000119A (es) | Benzazoles consistentes en derivados de benzoxazol, benzthiazol y benzimidazol | |
RS52900B (en) | Benzoylpyrazole Compound, Process for Production and Production of Herbicides Containing Them | |
CO5720994A2 (es) | Derivados sustituidos del pirrol | |
AR061520A1 (es) | Derivados de cinamoil-piperazina | |
AR046745A1 (es) | Uso de derivados de amidrazonas para combatir pestes |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |