CO5621366A2 - Compuestos imidazoltionas como agonistas de los receptores adrenergicos alfa y 2b y/o alfa 2c para el tratamiento del dolor, alodinia y otras enfermedades relacionadas - Google Patents

Compuestos imidazoltionas como agonistas de los receptores adrenergicos alfa y 2b y/o alfa 2c para el tratamiento del dolor, alodinia y otras enfermedades relacionadas

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Publication number
CO5621366A2
CO5621366A2 CO04124455A CO04124455A CO5621366A2 CO 5621366 A2 CO5621366 A2 CO 5621366A2 CO 04124455 A CO04124455 A CO 04124455A CO 04124455 A CO04124455 A CO 04124455A CO 5621366 A2 CO5621366 A2 CO 5621366A2
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Prior art keywords
alfa
carbons
ring
independently
integer
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CO04124455A
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English (en)
Inventor
Daniel W Gil
Michael E Garst
Larry A Wheeler
Phong X Nguyen
Dario G Gomez
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Allergan Inc
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Publication of CO5621366A2 publication Critical patent/CO5621366A2/es

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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D409/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings

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Abstract

1.- Los Compuestos de la fórmula donde la variable Y en el anillo es opcional y representa un heteroátomo seleccionado de N, O y S con la condición que el átomo de N es trivalente y los átomos de O ó S son divalentes;k es un entero que tiene los valores de 0 ó 1;n es un entero que tiene los valores de 0, 1 ó 2;p es un entero que tiene los valores de 0, 1 ó 2;X es O ó S;Las líneas entrecortadas representan un enlace, o ausencia de enlace con la condición que únicamente un doble enlace está presente en el anillo y que dos líneas entrecortadas adyacentes, ambas no representan un enlace;R1, R2, R3 y R4 son independientemente H, fenilo, dicho grupo fenilo está opcionalmente sustituido independientemente con uno, dos o tres grupos alquiloC1-6, SO3H, N3, halógeno, CN, NO2, NH2, alcoxiloC1-6, tioalcoxiloC1-6, alquilarninoC1-6, dialquilaminoC1-6, alquiniloC2-6, alqueniloC2-6, heteroarilo de 5 ó 6 miembros que tiene 1 a 3 heteroátomos seleccionados de O, S y N, dichos grupos heteroarilos están opcionalmente sustituidos independientemente con uno, dos o tres grupos alquiloC1-6, SO3H, N3, halógeno, CN, NO2, NH2, alcoxiloC1-6, tioalcoxiloC1-6, tioalcoxiloC1-6, alquilaminoC1-6, dialquilaminoC1-6, alquiniloC2-6, alqueniloC2-6, ó dichos grupos R1, R2, R3 y R4 son independientemente alquilo de 1 a 4 átomos, cicloalquilo de 3 a 5 carbonos, CH2CN, CH2SR5, CH2NR6R6, COR5, CH2OR5, OR6, SR6, NR6R6, alquenilo que tiene 1 a 4 carbonos, alquinilo que tiene 1 a 4 carbonos, cicloalquilo que tiene 3 a 6 carbonos, F, CI, Br, I, CF3 ó CN, un oxígeno doblemente unido al carbono del anillo con la condición que la línea entrecortada adyacente dentro del anillo representa la ausencia de un enlace; ...
CO04124455A 2002-05-21 2004-12-13 Compuestos imidazoltionas como agonistas de los receptores adrenergicos alfa y 2b y/o alfa 2c para el tratamiento del dolor, alodinia y otras enfermedades relacionadas CO5621366A2 (es)

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US15332802A 2002-05-21 2002-05-21

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CO5621366A2 true CO5621366A2 (es) 2006-03-31

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CO04124455A CO5621366A2 (es) 2002-05-21 2004-12-13 Compuestos imidazoltionas como agonistas de los receptores adrenergicos alfa y 2b y/o alfa 2c para el tratamiento del dolor, alodinia y otras enfermedades relacionadas

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US (5) US7091232B2 (es)
EP (1) EP1507767A1 (es)
JP (2) JP2005531581A (es)
KR (1) KR101016151B1 (es)
CN (1) CN1332952C (es)
AU (2) AU2003245286A1 (es)
BR (1) BR0311326A (es)
CA (1) CA2486537C (es)
CO (1) CO5621366A2 (es)
IL (1) IL165280A (es)
MX (1) MXPA04011546A (es)
NO (1) NO330692B1 (es)
NZ (1) NZ536626A (es)
PL (1) PL213028B1 (es)
RU (1) RU2318816C2 (es)
WO (1) WO2003099795A1 (es)
ZA (1) ZA200409333B (es)

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