BR0311326A - Imidazol-2-tionas de 4-(substituìda cicloalquilmetila), imidazol-2-tionas de 4-(substituìda cicloalquenilmetila), imidazol-2-onas de 4-(substituìda cicloalquilmetila) e imidazol-2-onas de 4-(substituìda cicloalquenilmetil) e compostos relacionados - Google Patents
Imidazol-2-tionas de 4-(substituìda cicloalquilmetila), imidazol-2-tionas de 4-(substituìda cicloalquenilmetila), imidazol-2-onas de 4-(substituìda cicloalquilmetila) e imidazol-2-onas de 4-(substituìda cicloalquenilmetil) e compostos relacionadosInfo
- Publication number
- BR0311326A BR0311326A BR0311326-4A BR0311326A BR0311326A BR 0311326 A BR0311326 A BR 0311326A BR 0311326 A BR0311326 A BR 0311326A BR 0311326 A BR0311326 A BR 0311326A
- Authority
- BR
- Brazil
- Prior art keywords
- imidazole
- substituted
- cycloalkylmethyl
- thione
- ones
- Prior art date
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
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- Health & Medical Sciences (AREA)
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- Orthopedic Medicine & Surgery (AREA)
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- Urology & Nephrology (AREA)
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- Vascular Medicine (AREA)
- Transplantation (AREA)
- Otolaryngology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"IMIDAZOL-2-TIONAS DE 4-(SUBSTITUìDA CICLOALQUILMETILA), IMIDAZOL-2-TIONAS DE 4-(SUBSTITUìDA CICLOALQUENILMETILA), IMIDAZOL-2-ONAS DE 4-(SUBSTITUìDA CICLOALQUILMETILA) E IMIDAZOL-2-ONAS DE 4-(SUBSTITUìDA CICLOALQUENILMETIL) E COMPOSTOS RELACIONADOS". Compostos de Fórmula (I): onde X é S e as variáveis têm o significado definido na especificação, são específicos ou seletivos para receptores adrenérgicos alfa~ 2B~ e/ou alfa~ 2C~ em preferência sobre os receptores adrenérgicos alfa~ 2A~, e como tal não têm nenhuma ou apenas mínima atividade cardiovascular e/ou sedativa. Estes compostos de Fórmula (I) são úteis como medicamentos em mamíferos, incluindo humanos, para o tratamento de doenças e/ou alívios de condições que são sensíveis ao tratamento por agonistas de receptores adrenérgicos alfa~ 2B~. Os compostos de Fórmula (I) onde X é O também têm a propriedade vantajosa de que eles não têm nenhuma ou apenas mínima atividade cardiovascular e/ou sedativa e são úteis para tratar dor e outras condições com nenhuma ou apenas mínima atividade cardiovascular e/ou sedativa.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15332802A | 2002-05-21 | 2002-05-21 | |
PCT/US2003/015441 WO2003099795A1 (en) | 2002-05-21 | 2003-05-16 | 4-substituted imidazole-2-thiones and imidazol-2-ones as agonists of the alpha-2b and alpha-2c adrenergic receptors |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0311326A true BR0311326A (pt) | 2005-02-22 |
Family
ID=29582081
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0311326-4A BR0311326A (pt) | 2002-05-21 | 2003-05-16 | Imidazol-2-tionas de 4-(substituìda cicloalquilmetila), imidazol-2-tionas de 4-(substituìda cicloalquenilmetila), imidazol-2-onas de 4-(substituìda cicloalquilmetila) e imidazol-2-onas de 4-(substituìda cicloalquenilmetil) e compostos relacionados |
Country Status (17)
Country | Link |
---|---|
US (5) | US7091232B2 (pt) |
EP (1) | EP1507767A1 (pt) |
JP (2) | JP2005531581A (pt) |
KR (1) | KR101016151B1 (pt) |
CN (1) | CN1332952C (pt) |
AU (2) | AU2003245286A1 (pt) |
BR (1) | BR0311326A (pt) |
CA (1) | CA2486537C (pt) |
CO (1) | CO5621366A2 (pt) |
IL (1) | IL165280A (pt) |
MX (1) | MXPA04011546A (pt) |
NO (1) | NO330692B1 (pt) |
NZ (1) | NZ536626A (pt) |
PL (1) | PL213028B1 (pt) |
RU (1) | RU2318816C2 (pt) |
WO (1) | WO2003099795A1 (pt) |
ZA (1) | ZA200409333B (pt) |
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IL148921A0 (en) * | 2002-03-26 | 2002-09-12 | Peptor Ltd | Photo active backbone cyclized somatostatin analogs for optical imaging and photodynamic therapy |
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