JP2010529961A5 - - Google Patents
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- JP2010529961A5 JP2010529961A5 JP2010510954A JP2010510954A JP2010529961A5 JP 2010529961 A5 JP2010529961 A5 JP 2010529961A5 JP 2010510954 A JP2010510954 A JP 2010510954A JP 2010510954 A JP2010510954 A JP 2010510954A JP 2010529961 A5 JP2010529961 A5 JP 2010529961A5
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- JP
- Japan
- Prior art keywords
- compound
- formula
- represented
- group
- haloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 21
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000002877 alkyl aryl group Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000001188 haloalkyl group Chemical group 0.000 claims 3
- 125000003106 haloaryl group Chemical group 0.000 claims 3
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 125000005213 alkyl heteroaryl group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- -1 hydrate Chemical class 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Natural products C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 2
- 150000001204 N-oxides Chemical class 0.000 claims 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims 1
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 claims 1
- 229910052785 arsenic Inorganic materials 0.000 claims 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 claims 1
- 125000001769 aryl amino group Chemical group 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 125000004663 dialkyl amino group Chemical group 0.000 claims 1
- GLUUGHFHXGJENI-UHFFFAOYSA-N diethylenediamine Natural products C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 1
- 229910052732 germanium Inorganic materials 0.000 claims 1
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 claims 1
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 239000011574 phosphorus Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229910052710 silicon Inorganic materials 0.000 claims 1
- 239000010703 silicon Substances 0.000 claims 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 1
- FWODXGRCBRQTLP-UHFFFAOYSA-N CC(c(cc1CN2CCOCC2)cc(CN2CCOCC2)c1O)(c(cc1CN2CCOCC2)cc(CN2CCOCC2)c1O)c(cc1CN2CCOCC2)cc(CN2CCOCC2)c1O Chemical compound CC(c(cc1CN2CCOCC2)cc(CN2CCOCC2)c1O)(c(cc1CN2CCOCC2)cc(CN2CCOCC2)c1O)c(cc1CN2CCOCC2)cc(CN2CCOCC2)c1O FWODXGRCBRQTLP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92487507P | 2007-06-04 | 2007-06-04 | |
| US60/924,875 | 2007-06-04 | ||
| US92952507P | 2007-07-02 | 2007-07-02 | |
| US92952407P | 2007-07-02 | 2007-07-02 | |
| US60/929,525 | 2007-07-02 | ||
| US60/929,524 | 2007-07-02 | ||
| US692408P | 2008-02-06 | 2008-02-06 | |
| US61/006,924 | 2008-02-06 | ||
| PCT/IL2008/000747 WO2008149345A2 (en) | 2007-06-04 | 2008-06-03 | Tri-aryl compounds and compositions comprising the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010529961A JP2010529961A (ja) | 2010-09-02 |
| JP2010529961A5 true JP2010529961A5 (https=) | 2011-07-21 |
| JP5508258B2 JP5508258B2 (ja) | 2014-05-28 |
Family
ID=40094272
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010510954A Active JP5508258B2 (ja) | 2007-06-04 | 2008-06-03 | トリアリール化合物および前記化合物を含む組成物 |
| JP2010510957A Active JP5922328B2 (ja) | 2007-06-04 | 2008-06-04 | テロメラーゼ活性化化合物及びその使用方法 |
| JP2014158101A Expired - Fee Related JP5964898B2 (ja) | 2007-06-04 | 2014-08-01 | テロメラーゼ活性化化合物及びその使用方法 |
| JP2016013177A Expired - Fee Related JP6134824B2 (ja) | 2007-06-04 | 2016-01-27 | テロメラーゼ活性化化合物及びその使用方法 |
| JP2016130028A Pending JP2017019774A (ja) | 2007-06-04 | 2016-06-30 | テロメラーゼ活性化化合物及びその使用方法 |
| JP2017085145A Pending JP2017149762A (ja) | 2007-06-04 | 2017-04-24 | テロメラーゼ活性化化合物及びその使用方法 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010510957A Active JP5922328B2 (ja) | 2007-06-04 | 2008-06-04 | テロメラーゼ活性化化合物及びその使用方法 |
| JP2014158101A Expired - Fee Related JP5964898B2 (ja) | 2007-06-04 | 2014-08-01 | テロメラーゼ活性化化合物及びその使用方法 |
| JP2016013177A Expired - Fee Related JP6134824B2 (ja) | 2007-06-04 | 2016-01-27 | テロメラーゼ活性化化合物及びその使用方法 |
| JP2016130028A Pending JP2017019774A (ja) | 2007-06-04 | 2016-06-30 | テロメラーゼ活性化化合物及びその使用方法 |
| JP2017085145A Pending JP2017149762A (ja) | 2007-06-04 | 2017-04-24 | テロメラーゼ活性化化合物及びその使用方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (7) | US8604245B2 (https=) |
| EP (3) | EP2152663B1 (https=) |
| JP (6) | JP5508258B2 (https=) |
| KR (4) | KR101560844B1 (https=) |
| CN (4) | CN101742906A (https=) |
| AU (2) | AU2008259342B2 (https=) |
| CA (4) | CA2963857A1 (https=) |
| CY (1) | CY1115919T1 (https=) |
| DK (2) | DK2152663T3 (https=) |
| EA (4) | EA021544B1 (https=) |
| ES (2) | ES2465216T3 (https=) |
| HR (2) | HRP20140394T1 (https=) |
| IL (4) | IL202425A (https=) |
| MX (2) | MX2009013354A (https=) |
| PL (2) | PL2152663T3 (https=) |
| PT (2) | PT2152663E (https=) |
| SI (2) | SI2152663T1 (https=) |
| TW (1) | TWI430796B (https=) |
| WO (3) | WO2008149346A2 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
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| ES2465216T3 (es) * | 2007-06-04 | 2014-06-05 | Ben Gurion University Of The Negev Research And Development Authority | Compuestos de triarilo y composiciones que comprenden los mismos |
| SG171722A1 (en) * | 2008-12-22 | 2011-07-28 | Pola Chem Ind Inc | Melanin production inhibitor |
| CA2795981C (en) | 2009-05-18 | 2017-06-27 | Geron Corporation | Compositions and methods for increasing telomerase activity |
| CR20160207A (es) * | 2013-11-05 | 2016-08-10 | Ben Gurion Univ Of The Negev Res And Dev Authority | Compuestos para el tratamiento de la diabetes y las complicaciones que surgen de la misma enfermedad |
| US10898540B2 (en) | 2016-04-07 | 2021-01-26 | Gem Vax & KAEL Co., Ltd. | Peptide having effects of increasing telomerase activity and extending telomere, and composition containing same |
| IL257470B2 (en) * | 2018-02-11 | 2023-12-01 | Ben Gurion Univ Of The Negev Research And Development Authority | Telomerase activator compounds for use in fertility and related applications |
| EP3579824A1 (en) * | 2017-02-12 | 2019-12-18 | Ben-Gurion University Of The Negev Research And Development Authority | Telomerase activating compounds for use in fertility and related applications |
| KR102099335B1 (ko) | 2017-11-03 | 2020-04-09 | 한국과학기술연구원 | Prox1의 발현 또는 활성 조절제를 포함하는 텔로머라제 역전사효소의 발현 조절용 조성물 또는 텔로머라제 역전사효소 조절제의 스크리닝 방법 |
| US10098922B1 (en) * | 2017-11-30 | 2018-10-16 | Optigenex, Inc. | Increasing telomere length in a cell |
| EP3775258A4 (en) | 2018-03-28 | 2022-01-26 | Board of Regents, The University of Texas System | IDENTIFICATION OF EPIGENETIC ALTERATIONS IN DNA ISOLATED FROM EXOSOMES |
| CN112639020A (zh) * | 2018-08-24 | 2021-04-09 | 三菱瓦斯化学株式会社 | 化合物、包含其的组合物、以及抗蚀图案的形成方法和绝缘膜的形成方法 |
| KR20210049094A (ko) * | 2018-08-24 | 2021-05-04 | 미쯔비시 가스 케미칼 컴파니, 인코포레이티드 | 화합물, 및 그것을 포함하는 조성물, 그리고, 레지스트패턴의 형성방법 및 절연막의 형성방법 |
| US12422431B2 (en) * | 2018-12-31 | 2025-09-23 | B. G. Negev Technologies And Applications Ltd., At Ben-Gurion University | Capture flow assay device and methods |
| JP2022519718A (ja) * | 2019-02-08 | 2022-03-24 | ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム | 加齢および加齢性臓器不全に関連する疾患の処置のためのテロメラーゼ含有エキソソーム |
| KR102214612B1 (ko) | 2020-03-23 | 2021-02-15 | 한국과학기술연구원 | Prox1의 발현 또는 활성 조절제를 포함하는 텔로머라제 역전사효소의 발현 조절용 조성물 또는 텔로머라제 역전사효소 조절제의 스크리닝 방법 |
| US12305233B1 (en) | 2020-07-09 | 2025-05-20 | Arizona Board Of Regents On Behalf Of Arizona | Ultra-high-throughput assay for telomerase repeat addition processivity |
| KR102666470B1 (ko) | 2023-05-04 | 2024-05-17 | 주식회사 아리바이오 | 텔로머라제 활성화제와 나노 입자를 포함하는 약물 전달용 조성물 및 이를 포함하는 탈모 예방, 개선 또는 치료용 조성물 |
| KR102666469B1 (ko) * | 2023-05-04 | 2024-05-17 | 주식회사 아리바이오 | 텔로머라제 활성화제와 나노 입자를 포함하는 약물 전달용 조성물 및 이를 포함하는 탈모 예방, 개선 또는 치료용 조성물 |
| CN116850119B (zh) * | 2023-07-19 | 2024-10-22 | 上海联衡生物科技有限公司 | 端粒酶组合物的制备方法及在防脱发护发素中的应用 |
| TW202513555A (zh) * | 2023-07-20 | 2025-04-01 | 德商馬克專利公司 | 化合物、包含化合物之組合物及製造抗蝕膜之方法 |
| KR102647264B1 (ko) | 2023-11-01 | 2024-03-14 | 주식회사 아리바이오 | 텔로머라제 활성화제와 나노 입자를 포함하는 약물 전달용 조성물 및 이를 포함하는 탈모 예방, 개선 또는 치료용 조성물 |
| WO2026058262A1 (en) * | 2024-09-16 | 2026-03-19 | Esther Priel | Substituted tri-phenyl derivative compounds, compositions comprising same and applications of same |
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