JP2005538046A5 - - Google Patents

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Publication number
JP2005538046A5
JP2005538046A5 JP2004500787A JP2004500787A JP2005538046A5 JP 2005538046 A5 JP2005538046 A5 JP 2005538046A5 JP 2004500787 A JP2004500787 A JP 2004500787A JP 2004500787 A JP2004500787 A JP 2004500787A JP 2005538046 A5 JP2005538046 A5 JP 2005538046A5
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JP
Japan
Prior art keywords
fusion protein
domain
antibody
monoclonal antibody
protein according
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JP2004500787A
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English (en)
Japanese (ja)
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JP4567437B2 (ja
JP2005538046A (ja
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Priority claimed from PCT/US2003/013522 external-priority patent/WO2003092602A2/en
Publication of JP2005538046A publication Critical patent/JP2005538046A/ja
Publication of JP2005538046A5 publication Critical patent/JP2005538046A5/ja
Application granted granted Critical
Publication of JP4567437B2 publication Critical patent/JP4567437B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2004500787A 2002-05-01 2003-04-30 抗凝固剤としての新規組織因子標的化されたトロンボモジュリン融合タンパク質 Expired - Fee Related JP4567437B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37656602P 2002-05-01 2002-05-01
PCT/US2003/013522 WO2003092602A2 (en) 2002-05-01 2003-04-30 Novel tissue factor targeted thrombomodulin fusion proteins as anticoagulants

Publications (3)

Publication Number Publication Date
JP2005538046A JP2005538046A (ja) 2005-12-15
JP2005538046A5 true JP2005538046A5 (https=) 2006-06-22
JP4567437B2 JP4567437B2 (ja) 2010-10-20

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Family Applications (2)

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JP2004500787A Expired - Fee Related JP4567437B2 (ja) 2002-05-01 2003-04-30 抗凝固剤としての新規組織因子標的化されたトロンボモジュリン融合タンパク質
JP2004501558A Expired - Fee Related JP4460443B2 (ja) 2002-05-01 2003-04-30 抗凝固剤としての新規組織因子標的化された抗体

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JP2004501558A Expired - Fee Related JP4460443B2 (ja) 2002-05-01 2003-04-30 抗凝固剤としての新規組織因子標的化された抗体

Country Status (29)

Country Link
US (3) US7250168B2 (https=)
EP (2) EP1503785B1 (https=)
JP (2) JP4567437B2 (https=)
KR (2) KR101013697B1 (https=)
CN (2) CN100563709C (https=)
AR (1) AR039515A1 (https=)
AT (2) ATE427121T1 (https=)
AU (2) AU2003225255B2 (https=)
BR (2) BR0304659A (https=)
CA (2) CA2483910A1 (https=)
CR (1) CR7584A (https=)
DE (2) DE60334538D1 (https=)
DK (2) DK1549341T3 (https=)
EC (2) ECSP045468A (https=)
ES (2) ES2354419T3 (https=)
HK (1) HK1080372A1 (https=)
IL (3) IL164733A0 (https=)
MX (2) MXPA04010851A (https=)
NO (2) NO20035848L (https=)
NZ (2) NZ536243A (https=)
PE (1) PE20040597A1 (https=)
PL (2) PL373945A1 (https=)
PT (2) PT1549341E (https=)
RS (2) RS102404A (https=)
RU (2) RU2345789C2 (https=)
TW (1) TWI343388B (https=)
UA (2) UA81114C2 (https=)
WO (2) WO2003092602A2 (https=)
ZA (2) ZA200409694B (https=)

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CN104162155A (zh) 2007-12-05 2014-11-26 中外制药株式会社 搔痒症治疗药
US8333973B2 (en) * 2008-01-02 2012-12-18 The Trustees Of The University Of Pennsylvania Targeting recombinant therapeutics to circulating red blood cells
UA112050C2 (uk) * 2008-08-04 2016-07-25 БАЄР ХЕЛСКЕР ЛЛСі Терапевтична композиція, що містить моноклональне антитіло проти інгібітора шляху тканинного фактора (tfpi)
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WO2010045518A1 (en) * 2008-10-16 2010-04-22 The Trustees Of The University Of Pennsylvania Compositions containing thrombomodulin domains and uses thereof
US20120165244A1 (en) * 2008-10-30 2012-06-28 Hua-Lin Wu Methods for binding lewis y antigen
UA109633C2 (uk) 2008-12-09 2015-09-25 Антитіло людини проти тканинного фактора
EP2230251A1 (en) * 2009-03-19 2010-09-22 Bracco Imaging S.p.A Antibodies specifically active in the coronary plaque and method for their identification
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JP6055404B2 (ja) 2010-06-15 2016-12-27 ゲンマブ エー／エス 組織因子に対するヒト抗体薬物結合体
US9150844B2 (en) * 2010-08-05 2015-10-06 Neeraj Maheshwari Protein fusion constructs possessing thrombolytic and anticoagulant properties
RU2445365C1 (ru) * 2010-11-03 2012-03-20 Общество с ограниченной ответственностью "Инновационный Центр "Новые Технологии и Материалы" (ООО "ИЦ Новтехмат") Штамм гибридных культивируемых клеток mus musculus - продуцент моноклональных антител, специфичных к протеину с человека (варианты)
KR20170134748A (ko) 2015-04-14 2017-12-06 추가이 세이야쿠 가부시키가이샤 Il-31 안타고니스트를 유효 성분으로서 함유하는 아토피성 피부염의 예방용 및/또는 치료용 의약 조성물
WO2016176440A2 (en) * 2015-04-28 2016-11-03 Saint Louis University Thrombin-thrombomodulin fusion proteins as protein c activators
US11085031B2 (en) 2016-04-28 2021-08-10 Saint Louis University Thrombin-thrombomodulin fusion proteins as a powerful anticoagulant
AR110079A1 (es) * 2016-11-16 2019-02-20 Bayer Healthcare Llc Factor viii direccionado a los glóbulos rojos y método para su uso
BR102017005783A2 (pt) * 2017-03-21 2018-10-02 Fund Butantan processo de obtenção de esculptina e seus fragmentos, esculptina recombinante e seus usos
TWI841554B (zh) 2018-03-21 2024-05-11 丹麥商珍美寶股份有限公司 以鉑為主之劑與抗組織因子抗體－藥物共軛物的組合治療癌症之方法
WO2019217455A1 (en) 2018-05-07 2019-11-14 Genmab A/S Methods of treating cancer with a combination of an anti-pd-1 antibody and an anti-tissue factor antibody-drug conjugate
WO2020070237A1 (en) * 2018-10-04 2020-04-09 Thrombosis And Coagulation Ab Method for the determination of protein s levels
TWI844571B (zh) 2018-10-30 2024-06-11 丹麥商珍美寶股份有限公司 使用抗血管內皮生長因子（ｖｅｇｆ）抗體與抗組織因子（ｔｆ）抗體－藥物共軛體之組合以治療癌症之方法
CN114728064B (zh) 2019-11-20 2025-05-06 中外制药株式会社 含抗体制剂
CN114686443B (zh) * 2020-12-31 2023-11-03 广州万孚生物技术股份有限公司 杂交瘤细胞、抗血栓调节蛋白单克隆抗体及其制备方法和应用
CN114686444B (zh) * 2020-12-31 2024-05-31 广州万孚生物技术股份有限公司 杂交瘤细胞、抗血栓调节蛋白单克隆抗体及其制备方法和应用

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