JP2003527861A5 - - Google Patents
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- JP2003527861A5 JP2003527861A5 JP2001569367A JP2001569367A JP2003527861A5 JP 2003527861 A5 JP2003527861 A5 JP 2003527861A5 JP 2001569367 A JP2001569367 A JP 2001569367A JP 2001569367 A JP2001569367 A JP 2001569367A JP 2003527861 A5 JP2003527861 A5 JP 2003527861A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- sequence
- cdr
- variable domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108091007491 NSP3 Papain-like protease domains Proteins 0.000 description 10
- 125000003275 alpha amino acid group Chemical group 0.000 description 8
- 150000007523 nucleic acids Chemical class 0.000 description 8
- 102000039446 nucleic acids Human genes 0.000 description 8
- 108020004707 nucleic acids Proteins 0.000 description 8
- 238000000034 method Methods 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 208000035475 disorder Diseases 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 description 2
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 description 2
- 208000007536 Thrombosis Diseases 0.000 description 2
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 description 2
- 201000000028 adult respiratory distress syndrome Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 206010003178 Arterial thrombosis Diseases 0.000 description 1
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010040070 Septic Shock Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 238000002399 angioplasty Methods 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- 208000015294 blood coagulation disease Diseases 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000009852 coagulant defect Effects 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000036543 hypotension Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 208000037803 restenosis Diseases 0.000 description 1
- 230000036303 septic shock Effects 0.000 description 1
- 230000002537 thrombolytic effect Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18977500P | 2000-03-16 | 2000-03-16 | |
| US60/189,775 | 2000-03-16 | ||
| PCT/US2001/007501 WO2001070984A2 (en) | 2000-03-16 | 2001-03-08 | Anti-tissue factor antibodies with enhanced anticoagulant potency |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003527861A JP2003527861A (ja) | 2003-09-24 |
| JP2003527861A5 true JP2003527861A5 (https=) | 2008-05-01 |
Family
ID=22698717
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001569367A Pending JP2003527861A (ja) | 2000-03-16 | 2001-03-08 | 増強した抗血液凝固能を持つ抗組織因子抗体 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1263960A2 (https=) |
| JP (1) | JP2003527861A (https=) |
| AU (2) | AU2001250814B2 (https=) |
| CA (1) | CA2402596A1 (https=) |
| HK (1) | HK1049184A1 (https=) |
| WO (1) | WO2001070984A2 (https=) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT833911E (pt) | 1995-06-07 | 2004-09-30 | Ortho Mcneil Pharm Inc | Anticorpos anti-factor tecidular enxertados com cdr e metodos para a sua utilizacao |
| US20030109680A1 (en) | 2001-11-21 | 2003-06-12 | Sunol Molecular Corporation | Antibodies for inhibiting blood coagulation and methods of use thereof |
| US5986065A (en) | 1997-03-10 | 1999-11-16 | Sunol Molecular Corporation | Antibodies for inhibiting blood coagulation and methods of use thereof |
| US20060235209A9 (en) | 1997-03-10 | 2006-10-19 | Jin-An Jiao | Use of anti-tissue factor antibodies for treating thromboses |
| US7749498B2 (en) | 1997-03-10 | 2010-07-06 | Genentech, Inc. | Antibodies for inhibiting blood coagulation and methods of use thereof |
| US6703494B2 (en) | 2000-03-16 | 2004-03-09 | Genentech, Inc. | Anti-tissue factor antibodies with enhanced anticoagulant potency |
| GB0027750D0 (en) | 2000-11-14 | 2000-12-27 | Trisport Ltd | Studded footwear |
| US20040180051A1 (en) * | 2001-03-26 | 2004-09-16 | Koji Suzuki | Blood rheology improving agents |
| KR20040045478A (ko) * | 2001-10-02 | 2004-06-01 | 노보 노르디스크 에이/에스 | 인간 조직인자 항체 |
| TWI338009B (en) * | 2001-10-29 | 2011-03-01 | Genentech Inc | Antibodies for inhibiting blood coagulation and methods of use thereof |
| AP2004003113A0 (en) * | 2002-02-22 | 2004-09-30 | Prophy Med Ab | Use of an inhibitor or antagonist against tissue factor |
| US7579000B2 (en) | 2002-05-01 | 2009-08-25 | Bayer Schering Pharma Ag | Tissue factor targeted antibodies as anticoagulants |
| HK1080372A1 (zh) * | 2002-05-01 | 2006-04-28 | Schering Aktiengesellschaft | 作为抗凝剂的新型组织因子目标抗体 |
| AU2003277832A1 (en) * | 2002-10-31 | 2004-05-25 | Novo Nordisk A/S | Humanized tissue factor antibodies |
| WO2004041302A1 (en) * | 2002-11-06 | 2004-05-21 | Novo Nordisk A/S | Pharmaceutical composition comprising a tissue factor antagonist and a blood glucose regulator |
| EP1585768A2 (en) | 2003-01-23 | 2005-10-19 | Genentech, Inc. | Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture |
| US7223393B2 (en) | 2003-02-07 | 2007-05-29 | Pdl Biopharma, Inc | Amphiregulin antibodies and their use to treat cancer and psoriasis |
| KR101235507B1 (ko) | 2003-02-28 | 2013-02-20 | 추가이 세이야쿠 가부시키가이샤 | 단백질을 함유하는 안정화 제제 |
| US7425328B2 (en) | 2003-04-22 | 2008-09-16 | Purdue Pharma L.P. | Tissue factor antibodies and uses thereof |
| US7605235B2 (en) | 2003-05-30 | 2009-10-20 | Centocor, Inc. | Anti-tissue factor antibodies and compositions |
| US9708410B2 (en) | 2003-05-30 | 2017-07-18 | Janssen Biotech, Inc. | Anti-tissue factor antibodies and compositions |
| WO2005000896A2 (en) * | 2003-05-30 | 2005-01-06 | Genentech, Inc. | Polypeptides that bind an anti-tissue factor antibody and uses thereof |
| US20050031615A1 (en) * | 2003-05-30 | 2005-02-10 | Anderson G. Mark | Method of inhibiting tumor growth with anti-tissue factor antibodies |
| CA2530980A1 (en) * | 2003-06-19 | 2005-01-20 | Tanox, Inc. | Tissue factor-specific antibodies for preventing or treating acute lung injury or acute respiratory distress syndrome |
| US6904707B2 (en) | 2003-07-01 | 2005-06-14 | Softspikes, Llc | Indexable shoe cleat with improved traction |
| ITRM20030601A1 (it) * | 2003-12-24 | 2005-06-25 | Lay Line Genomics Spa | Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti. |
| US8303955B2 (en) | 2005-05-26 | 2012-11-06 | Seattle Genetics, Inc. | Humanized anti-CD40 antibodies and their methods of use |
| ITRM20050290A1 (it) | 2005-06-07 | 2006-12-08 | Lay Line Genomics Spa | Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato. |
| WO2009113083A1 (en) | 2008-03-14 | 2009-09-17 | Biocon Limited | A monoclonal antibody and a method thereof |
| UA109633C2 (uk) | 2008-12-09 | 2015-09-25 | Антитіло людини проти тканинного фактора | |
| BR112012031727B1 (pt) | 2010-06-15 | 2022-03-29 | Genmab A/S | Conjugado de droga-anticorpo, composição farmacêutica, e, uso do conjugado de droga- anticorpo |
| US8722044B2 (en) | 2011-03-15 | 2014-05-13 | Janssen Biotech, Inc. | Human tissue factor antibody and uses thereof |
| US20140296139A1 (en) | 2013-03-15 | 2014-10-02 | The Regents Of The University Of California | Mitochondrial-derived peptide mots3 regulates metabolism and cell survival |
| EP3024485B1 (en) | 2013-07-23 | 2020-11-18 | Biocon Limited | Use of a cd6 binding partner and method based thereon |
| MX2016009690A (es) | 2014-02-03 | 2017-03-03 | Nat Cancer Ct | Anticuerpos monoclonal anti-factor de tejido. |
| ES2991182T3 (es) | 2016-10-21 | 2024-12-02 | Biocon Ltd | Un anticuerpo monoclonal y un método de uso para el tratamiento del lupus |
| TW201922796A (zh) * | 2017-10-30 | 2019-06-16 | 國立研究開發法人國立癌症研究中心 | 可用於實體腫瘤治療之抗體及其抗體－藥物共軛物以及含其之抗癌劑 |
| MX2020007077A (es) | 2018-01-04 | 2020-10-28 | Iconic Therapeutics Inc | Anticuerpos anti-factor tisular, conjugados anticuerpo-farmaco y metodos relacionados. |
| TWI841554B (zh) | 2018-03-21 | 2024-05-11 | 丹麥商珍美寶股份有限公司 | 以鉑為主之劑與抗組織因子抗體－藥物共軛物的組合治療癌症之方法 |
| TW202506732A (zh) | 2018-05-07 | 2025-02-16 | 丹麥商珍美寶股份有限公司 | 使用抗ｐｄ－１抗體與抗組織因子抗體－藥物共軛體之組合以治療癌症之方法 |
| TWI844571B (zh) | 2018-10-30 | 2024-06-11 | 丹麥商珍美寶股份有限公司 | 使用抗血管內皮生長因子（ｖｅｇｆ）抗體與抗組織因子（ｔｆ）抗體－藥物共軛體之組合以治療癌症之方法 |
| BR112023000455A2 (pt) * | 2020-07-10 | 2023-03-28 | Iconic Therapeutics Inc | Tratamento de doença inflamatória que usa anticorpos de fator antitecidual |
| WO2024102818A1 (en) * | 2022-11-09 | 2024-05-16 | Wisconsin Alumni Research Foundation | Combination tumor therapy with thrombosis initiation and platelet recruitment |
| CN119454938B (zh) * | 2024-11-15 | 2025-07-25 | 广州骐骥生物科技有限公司 | 一种枸橼酸透析浓缩液及其制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US596065A (en) * | 1897-12-28 | Ejector for ashes | ||
| DE3237880A1 (de) * | 1982-10-13 | 1984-04-19 | Robert Bosch Gmbh, 7000 Stuttgart | Kodierspeicher, insbesondere fuer werkstuecktraeger in der fliessfertigung |
| JPS60188045A (ja) * | 1984-03-08 | 1985-09-25 | リサーチ・コーポレイシヨン | 保存安定性魚肉ベース製品 |
| US5811248A (en) * | 1986-03-31 | 1998-09-22 | Charter Ventures | Atherosclerotic plaque specific antigens, antibodies thereto, and uses thereof |
| US5986065A (en) * | 1997-03-10 | 1999-11-16 | Sunol Molecular Corporation | Antibodies for inhibiting blood coagulation and methods of use thereof |
| DK1069185T3 (da) * | 1998-04-03 | 2011-06-27 | Chugai Pharmaceutical Co Ltd | Humaniseret antistof mod human vævsfaktor (TF) og fremgangsmåde til at konstruere humaniseret antistof |
-
2001
- 2001-03-08 WO PCT/US2001/007501 patent/WO2001070984A2/en not_active Ceased
- 2001-03-08 AU AU2001250814A patent/AU2001250814B2/en not_active Expired
- 2001-03-08 AU AU5081401A patent/AU5081401A/xx active Pending
- 2001-03-08 HK HK03101227.0A patent/HK1049184A1/zh unknown
- 2001-03-08 CA CA002402596A patent/CA2402596A1/en not_active Abandoned
- 2001-03-08 EP EP01924131A patent/EP1263960A2/en not_active Withdrawn
- 2001-03-08 JP JP2001569367A patent/JP2003527861A/ja active Pending