JP2010524435A5 - - Google Patents
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- Publication number
- JP2010524435A5 JP2010524435A5 JP2010501433A JP2010501433A JP2010524435A5 JP 2010524435 A5 JP2010524435 A5 JP 2010524435A5 JP 2010501433 A JP2010501433 A JP 2010501433A JP 2010501433 A JP2010501433 A JP 2010501433A JP 2010524435 A5 JP2010524435 A5 JP 2010524435A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- cdr
- set forth
- region
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Revoked
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 21
- 229920001184 polypeptide Polymers 0.000 claims 20
- 102000004196 processed proteins & peptides Human genes 0.000 claims 20
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 150000007523 nucleic acids Chemical group 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 101150029707 ERBB2 gene Proteins 0.000 claims 1
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 241000282577 Pan troglodytes Species 0.000 claims 1
- 241000288959 Saguinus Species 0.000 claims 1
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims 1
- 230000009831 antigen interaction Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
- 230000001613 neoplastic effect Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07006990 | 2007-04-03 | ||
| EP07006988 | 2007-04-03 | ||
| US91366807P | 2007-04-24 | 2007-04-24 | |
| EP07020646 | 2007-10-22 | ||
| EP07020641 | 2007-10-22 | ||
| EP07020640 | 2007-10-22 | ||
| EP08004741 | 2008-03-13 | ||
| PCT/EP2008/002663 WO2008119566A2 (en) | 2007-04-03 | 2008-04-03 | Cross-species-specific bispecific binders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013218769A Division JP6016747B2 (ja) | 2007-04-03 | 2013-10-22 | 種間特異的二重特異性バインダー |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010524435A JP2010524435A (ja) | 2010-07-22 |
| JP2010524435A5 true JP2010524435A5 (https=) | 2011-05-19 |
Family
ID=42582614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010501433A Revoked JP2010524435A (ja) | 2007-04-03 | 2008-04-03 | 種間特異的二重特異性バインダー |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JP2010524435A (https=) |
| DK (1) | DK2155788T3 (https=) |
| ES (1) | ES2390243T3 (https=) |
| NZ (1) | NZ580746A (https=) |
| PT (1) | PT2155788E (https=) |
| RS (1) | RS52492B (https=) |
| RU (1) | RU2535992C2 (https=) |
| SI (1) | SI2155788T1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2009010611A (es) * | 2007-04-03 | 2010-03-26 | Micromet Ag | Enlazadores biespecificos, especificos para especies. |
| RU2769948C2 (ru) * | 2007-04-03 | 2022-04-11 | Эмджен Рисерч (Мьюник) Гмбх | CD3-Эпсилон-связывающий домен с межвидовой специфичностью |
| EP3974453A3 (en) * | 2010-11-16 | 2022-08-03 | Amgen Inc. | Agents and methods for treating diseases that correlate with bcma expression |
| WO2012158818A2 (en) * | 2011-05-16 | 2012-11-22 | Fabion Pharmaceuticals, Inc. | Multi-specific fab fusion proteins and methods of use |
| KR102060389B1 (ko) * | 2011-05-21 | 2019-12-31 | 마크로제닉스, 인크. | 사람 및 비-사람 cd3에 결합할 수 있는 cd3-결합 분자 |
| IL263466B2 (en) | 2013-12-17 | 2023-10-01 | Genentech Inc | Anti-CD3 antibodies and methods of using them |
| CN106459201A (zh) * | 2014-05-28 | 2017-02-22 | 豪夫迈·罗氏有限公司 | 结合人和食蟹猴CD3ε的抗体 |
| CA2955947A1 (en) * | 2014-07-25 | 2016-01-28 | Cytomx Therapeutics, Inc. | Anti-cd3 antibodies, activatable anti-cd3 antibodies, multispecific anti-cd3 antibodies, multispecific activatable anti-cd3 antibodies, and methods of using the same |
| MX384418B (es) * | 2014-07-31 | 2025-03-14 | Amgen Res Munich Gmbh | Constructo de anticuerpo de cadena individual biespecífico con distribución mejorada de tejido. |
| EP3288981A1 (en) * | 2015-05-01 | 2018-03-07 | Genentech, Inc. | Masked anti-cd3 antibodies and methods of use |
| EP3430058A4 (en) | 2016-03-15 | 2019-10-23 | Generon (Shanghai) Corporation Ltd. | MULTISPECIFIC FAB FUSION PROTEINS AND USES THEREOF |
| JP7784795B2 (ja) | 2016-11-15 | 2025-12-12 | ジェネンテック， インコーポレイテッド | 抗ｃｄ２０／抗ｃｄ３二重特異性抗体による処置のための投与 |
| US10426424B2 (en) | 2017-11-21 | 2019-10-01 | General Electric Company | System and method for generating and performing imaging protocol simulations |
| IL325995A (en) | 2018-02-08 | 2026-03-01 | Genentech Inc | Bispecific antigen binding molecules and methods of use |
| EP3847196A4 (en) | 2018-09-07 | 2023-01-04 | ITabMed (HK) Limited | BISPECIFIC ANTIGEN BINDING PROTEINS AND USES THEREOF |
| WO2020132810A1 (en) | 2018-12-24 | 2020-07-02 | Generon (Shanghai) Corporation Ltd. | Multispecific antigen binding proteins capable of binding cd19 and cd3, and use thereof |
| US20230067182A1 (en) * | 2019-11-29 | 2023-03-02 | Boe Technology Group Co., Ltd. | Data Processing Device and Method, and Computer Readable Storage Medium |
| WO2021119505A1 (en) | 2019-12-13 | 2021-06-17 | Genentech, Inc. | Anti-ly6g6d antibodies and methods of use |
| JP2022087602A (ja) * | 2020-12-01 | 2022-06-13 | 株式会社バイオピーク | 組換え大腸菌による有用タンパク質の生産性を向上するための培養方法 |
| EP4337330A1 (en) | 2021-05-14 | 2024-03-20 | Genentech, Inc. | Methods for treatment of cd20-positive proliferative disorder with mosunetuzumab and polatuzumab vedotin |
| CN115932808B (zh) * | 2022-11-04 | 2025-05-27 | 四川九洲电器集团有限责任公司 | 一种基于多特征融合的被动声纳智能探测方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2179862C1 (ru) * | 2000-12-26 | 2002-02-27 | Общество с ограниченной ответственностью Научно-производственный центр "МедБиоСпектр" | Лекарственное средство для предотвращения отторжения трансплантата, моноклональное антитело к cd3-антигену т-лимфоцитов человека, гибридома и способ лечения больных, имеющих реакцию острого отторжения трансплантата после пересадки почки |
| RU2005137325A (ru) * | 2003-05-31 | 2006-09-10 | Микромет Аг (De) | Фармацевтическая композиция, содержащая конструкт, специфичный к ерсам |
| US7235641B2 (en) * | 2003-12-22 | 2007-06-26 | Micromet Ag | Bispecific antibodies |
| CA2569509C (en) * | 2004-06-03 | 2014-08-12 | Novimmune S.A. | Anti-cd3 antibodies and methods of use thereof |
| CN101309703A (zh) * | 2005-09-12 | 2008-11-19 | 诺维莫尼公司 | 抗cd3抗体组合物 |
| EP1940881B1 (en) * | 2005-10-11 | 2016-11-30 | Amgen Research (Munich) GmbH | Compositions comprising cross-species-specific antibodies and uses thereof |
-
2008
- 2008-04-03 RS RS20120412A patent/RS52492B/sr unknown
- 2008-04-03 JP JP2010501433A patent/JP2010524435A/ja not_active Revoked
- 2008-04-03 DK DK08735000.5T patent/DK2155788T3/da active
- 2008-04-03 NZ NZ580746A patent/NZ580746A/en unknown
- 2008-04-03 RU RU2009136913/10A patent/RU2535992C2/ru active
- 2008-04-03 ES ES08735000T patent/ES2390243T3/es active Active
- 2008-04-03 PT PT08735000T patent/PT2155788E/pt unknown
- 2008-04-03 SI SI200830762T patent/SI2155788T1/sl unknown
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