RU2535992C2 - Биспецифические связывающие агенты с межвидовой специфичностью - Google Patents

Биспецифические связывающие агенты с межвидовой специфичностью Download PDF

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Publication number
RU2535992C2
RU2535992C2 RU2009136913/10A RU2009136913A RU2535992C2 RU 2535992 C2 RU2535992 C2 RU 2535992C2 RU 2009136913/10 A RU2009136913/10 A RU 2009136913/10A RU 2009136913 A RU2009136913 A RU 2009136913A RU 2535992 C2 RU2535992 C2 RU 2535992C2
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Russia
Prior art keywords
seq
cdr
presented
region
human
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RU2009136913/10A
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English (en)
Russian (ru)
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RU2009136913A (ru
Inventor
Маттиас КЛИНГЕР
Тобиас Раум
Дорис РАУ
Сюзанна МАНГОЛЬД
Роман КИШЕЛЬ
Ральф ЛУТТЕРБЮЗЕ
Патрик Хоффманн
Петер КУФЕР
Original Assignee
Эмджен Рисерч (Мьюник) Гмбх
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Application filed by Эмджен Рисерч (Мьюник) Гмбх filed Critical Эмджен Рисерч (Мьюник) Гмбх
Priority claimed from PCT/EP2008/002663 external-priority patent/WO2008119566A2/en
Publication of RU2009136913A publication Critical patent/RU2009136913A/ru
Application granted granted Critical
Publication of RU2535992C2 publication Critical patent/RU2535992C2/ru

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  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
RU2009136913/10A 2007-04-03 2008-04-03 Биспецифические связывающие агенты с межвидовой специфичностью RU2535992C2 (ru)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
EP07006988 2007-04-03
EP07006988.5 2007-04-03
EP07006990.1 2007-04-03
EP07006990 2007-04-03
US91366807P 2007-04-24 2007-04-24
US60/913,668 2007-04-24
EP07020641 2007-10-22
EP07020646.1 2007-10-22
EP07020641.2 2007-10-22
EP07020646 2007-10-22
EP07020640 2007-10-22
EP07020640.4 2007-10-22
EP08004741.8 2008-03-13
EP08004741 2008-03-13
PCT/EP2008/002663 WO2008119566A2 (en) 2007-04-03 2008-04-03 Cross-species-specific bispecific binders

Publications (2)

Publication Number Publication Date
RU2009136913A RU2009136913A (ru) 2011-06-20
RU2535992C2 true RU2535992C2 (ru) 2014-12-20

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RU2009136913/10A RU2535992C2 (ru) 2007-04-03 2008-04-03 Биспецифические связывающие агенты с межвидовой специфичностью

Country Status (8)

Country Link
JP (1) JP2010524435A (https=)
DK (1) DK2155788T3 (https=)
ES (1) ES2390243T3 (https=)
NZ (1) NZ580746A (https=)
PT (1) PT2155788E (https=)
RS (1) RS52492B (https=)
RU (1) RU2535992C2 (https=)
SI (1) SI2155788T1 (https=)

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MX2009010611A (es) * 2007-04-03 2010-03-26 Micromet Ag Enlazadores biespecificos, especificos para especies.
RU2769948C2 (ru) * 2007-04-03 2022-04-11 Эмджен Рисерч (Мьюник) Гмбх CD3-Эпсилон-связывающий домен с межвидовой специфичностью
EP3974453A3 (en) * 2010-11-16 2022-08-03 Amgen Inc. Agents and methods for treating diseases that correlate with bcma expression
WO2012158818A2 (en) * 2011-05-16 2012-11-22 Fabion Pharmaceuticals, Inc. Multi-specific fab fusion proteins and methods of use
KR102060389B1 (ko) * 2011-05-21 2019-12-31 마크로제닉스, 인크. 사람 및 비-사람 cd3에 결합할 수 있는 cd3-결합 분자
IL263466B2 (en) 2013-12-17 2023-10-01 Genentech Inc Anti-CD3 antibodies and methods of using them
CN106459201A (zh) * 2014-05-28 2017-02-22 豪夫迈·罗氏有限公司 结合人和食蟹猴CD3ε的抗体
CA2955947A1 (en) * 2014-07-25 2016-01-28 Cytomx Therapeutics, Inc. Anti-cd3 antibodies, activatable anti-cd3 antibodies, multispecific anti-cd3 antibodies, multispecific activatable anti-cd3 antibodies, and methods of using the same
MX384418B (es) * 2014-07-31 2025-03-14 Amgen Res Munich Gmbh Constructo de anticuerpo de cadena individual biespecífico con distribución mejorada de tejido.
EP3288981A1 (en) * 2015-05-01 2018-03-07 Genentech, Inc. Masked anti-cd3 antibodies and methods of use
EP3430058A4 (en) 2016-03-15 2019-10-23 Generon (Shanghai) Corporation Ltd. MULTISPECIFIC FAB FUSION PROTEINS AND USES THEREOF
JP7784795B2 (ja) 2016-11-15 2025-12-12 ジェネンテック， インコーポレイテッド 抗ｃｄ２０／抗ｃｄ３二重特異性抗体による処置のための投与
US10426424B2 (en) 2017-11-21 2019-10-01 General Electric Company System and method for generating and performing imaging protocol simulations
IL325995A (en) 2018-02-08 2026-03-01 Genentech Inc Bispecific antigen binding molecules and methods of use
EP3847196A4 (en) 2018-09-07 2023-01-04 ITabMed (HK) Limited BISPECIFIC ANTIGEN BINDING PROTEINS AND USES THEREOF
WO2020132810A1 (en) 2018-12-24 2020-07-02 Generon (Shanghai) Corporation Ltd. Multispecific antigen binding proteins capable of binding cd19 and cd3, and use thereof
US20230067182A1 (en) * 2019-11-29 2023-03-02 Boe Technology Group Co., Ltd. Data Processing Device and Method, and Computer Readable Storage Medium
WO2021119505A1 (en) 2019-12-13 2021-06-17 Genentech, Inc. Anti-ly6g6d antibodies and methods of use
JP2022087602A (ja) * 2020-12-01 2022-06-13 株式会社バイオピーク 組換え大腸菌による有用タンパク質の生産性を向上するための培養方法
EP4337330A1 (en) 2021-05-14 2024-03-20 Genentech, Inc. Methods for treatment of cd20-positive proliferative disorder with mosunetuzumab and polatuzumab vedotin
CN115932808B (zh) * 2022-11-04 2025-05-27 四川九洲电器集团有限责任公司 一种基于多特征融合的被动声纳智能探测方法

Citations (5)

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RU2179862C1 (ru) * 2000-12-26 2002-02-27 Общество с ограниченной ответственностью Научно-производственный центр "МедБиоСпектр" Лекарственное средство для предотвращения отторжения трансплантата, моноклональное антитело к cd3-антигену т-лимфоцитов человека, гибридома и способ лечения больных, имеющих реакцию острого отторжения трансплантата после пересадки почки
WO2004106383A1 (en) * 2003-05-31 2004-12-09 Micromet Ag Pharmaceutical composition comprising a bispecific antibody for epcam
WO2005118635A2 (en) * 2004-06-03 2005-12-15 Novimmune S.A. Anti-cd3 antibodies and methods of use thereof
WO2007033230A2 (en) * 2005-09-12 2007-03-22 Novimmune S.A. Anti-cd3 antibody formulations
WO2007042261A2 (en) * 2005-10-11 2007-04-19 Micromet Ag Compositions comprising cross-species-specific antibodies and uses thereof

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Patent Citations (5)

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RU2179862C1 (ru) * 2000-12-26 2002-02-27 Общество с ограниченной ответственностью Научно-производственный центр "МедБиоСпектр" Лекарственное средство для предотвращения отторжения трансплантата, моноклональное антитело к cd3-антигену т-лимфоцитов человека, гибридома и способ лечения больных, имеющих реакцию острого отторжения трансплантата после пересадки почки
WO2004106383A1 (en) * 2003-05-31 2004-12-09 Micromet Ag Pharmaceutical composition comprising a bispecific antibody for epcam
WO2005118635A2 (en) * 2004-06-03 2005-12-15 Novimmune S.A. Anti-cd3 antibodies and methods of use thereof
WO2007033230A2 (en) * 2005-09-12 2007-03-22 Novimmune S.A. Anti-cd3 antibody formulations
WO2007042261A2 (en) * 2005-10-11 2007-04-19 Micromet Ag Compositions comprising cross-species-specific antibodies and uses thereof

Non-Patent Citations (1)

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Title
REUSCH U. et al., "Anti-CD3 x anti-epidermal growth factor receptor (EGFR) bispecific antibody redirects T-cell cytolytic activity to EGFR-positive cancers in vitro and in an animal model." Clin Cancer Res. (2006); 12(1):183-90. SEN M. et al., "Use of anti-CD3 x anti-HER2/neu bispecific antibody for redirecting cytotoxicity of activated T cells toward HER2/neu+ tumors." J Hematother Stem Cell Res. (2001);10(2):247-60. PORTOLES P. et al., "Monoclonal antibodies to murine CD3[epsilon] define distinct epitopes, one of which may interact with CD4 during T cell activation", J Immunology (1989); 142(12): 4169-4175. *

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Publication number Publication date
RS52492B (sr) 2013-02-28
DK2155788T3 (da) 2012-10-08
RU2009136913A (ru) 2011-06-20
NZ580746A (en) 2012-05-25
JP2010524435A (ja) 2010-07-22
PT2155788E (pt) 2012-09-25
ES2390243T3 (es) 2012-11-07
SI2155788T1 (sl) 2012-11-30

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