JP2005535731A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005535731A5 JP2005535731A5 JP2004549842A JP2004549842A JP2005535731A5 JP 2005535731 A5 JP2005535731 A5 JP 2005535731A5 JP 2004549842 A JP2004549842 A JP 2004549842A JP 2004549842 A JP2004549842 A JP 2004549842A JP 2005535731 A5 JP2005535731 A5 JP 2005535731A5
- Authority
- JP
- Japan
- Prior art keywords
- halo
- alkyl
- alkenyl
- phenyl
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000005843 halogen group Chemical group 0.000 claims 113
- 150000001875 compounds Chemical class 0.000 claims 96
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 89
- 125000000623 heterocyclic group Chemical group 0.000 claims 86
- 125000001475 halogen functional group Chemical group 0.000 claims 78
- 125000006370 trihalo methyl group Chemical group 0.000 claims 47
- 125000003118 aryl group Chemical group 0.000 claims 40
- 125000000217 alkyl group Chemical group 0.000 claims 39
- 125000001072 heteroaryl group Chemical group 0.000 claims 38
- -1 -OH Chemical group 0.000 claims 34
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 33
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 29
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 29
- 125000006375 C2-C10 alkynyl group Chemical group 0.000 claims 29
- 125000003342 alkenyl group Chemical group 0.000 claims 29
- 150000001602 bicycloalkyls Chemical group 0.000 claims 29
- 150000003839 salts Chemical class 0.000 claims 21
- 125000001309 chloro group Chemical group Cl* 0.000 claims 18
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 10
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 4
- 125000003373 pyrazinyl group Chemical group 0.000 claims 4
- 125000002098 pyridazinyl group Chemical group 0.000 claims 4
- 125000004076 pyridyl group Chemical group 0.000 claims 4
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 2
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 2
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 2
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 2
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 2
- 125000000259 cinnolinyl group Chemical group N1=NC(=CC2=CC=CC=C12)* 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 125000002883 imidazolyl group Chemical group 0.000 claims 2
- 125000001041 indolyl group Chemical group 0.000 claims 2
- 125000001786 isothiazolyl group Chemical group 0.000 claims 2
- 125000000842 isoxazolyl group Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000002971 oxazolyl group Chemical group 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 125000004592 phthalazinyl group Chemical group C1(=NN=CC2=CC=CC=C12)* 0.000 claims 2
- 125000003226 pyrazolyl group Chemical group 0.000 claims 2
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 claims 2
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 2
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- 125000004306 triazinyl group Chemical group 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 claims 1
- 206010046543 Urinary incontinence Diseases 0.000 claims 1
- 230000001668 ameliorated effect Effects 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 231100000397 ulcer Toxicity 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39196202P | 2002-06-28 | 2002-06-28 | |
| US41103002P | 2002-09-17 | 2002-09-17 | |
| US41314802P | 2002-09-25 | 2002-09-25 | |
| US41658202P | 2002-10-08 | 2002-10-08 | |
| PCT/US2003/020509 WO2004002983A2 (en) | 2002-06-28 | 2003-06-27 | Therapeutic piperazine derivatives useful for treating pain |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005535731A JP2005535731A (ja) | 2005-11-24 |
| JP2005535731A5 true JP2005535731A5 (enExample) | 2006-03-09 |
| JP4621502B2 JP4621502B2 (ja) | 2011-01-26 |
Family
ID=30003987
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004549842A Expired - Fee Related JP4621502B2 (ja) | 2002-06-28 | 2003-06-27 | 疼痛の治療に有用な治療剤 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US7279493B2 (enExample) |
| EP (1) | EP1556354B1 (enExample) |
| JP (1) | JP4621502B2 (enExample) |
| CN (1) | CN100457735C (enExample) |
| AT (1) | ATE384698T1 (enExample) |
| AU (1) | AU2003247829A1 (enExample) |
| BR (1) | BR0312322A (enExample) |
| CA (1) | CA2491079C (enExample) |
| CY (1) | CY1107411T1 (enExample) |
| DE (1) | DE60318875T2 (enExample) |
| DK (1) | DK1556354T3 (enExample) |
| EA (1) | EA200500114A1 (enExample) |
| ES (1) | ES2300613T3 (enExample) |
| IL (1) | IL165862A0 (enExample) |
| MX (1) | MXPA04012748A (enExample) |
| NO (1) | NO20050371L (enExample) |
| NZ (1) | NZ537292A (enExample) |
| PT (1) | PT1556354E (enExample) |
| RS (1) | RS114804A (enExample) |
| WO (1) | WO2004002983A2 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60234812D1 (de) | 2001-01-29 | 2010-02-04 | Shionogi & Co | Arzneipräparat, das als wirkstoff 5-methyl-1-phenyl-2-(1h)-pyridon enthält |
| IL165862A0 (en) | 2002-06-28 | 2006-01-15 | Euro Celtique Sa | Therapeutic piperazine derivatives useful for tre ating pain |
| US7262194B2 (en) * | 2002-07-26 | 2007-08-28 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
| US7157462B2 (en) * | 2002-09-24 | 2007-01-02 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
| US7582635B2 (en) | 2002-12-24 | 2009-09-01 | Purdue Pharma, L.P. | Therapeutic agents useful for treating pain |
| ITMI20030151A1 (it) * | 2003-01-30 | 2004-07-31 | Recordati Ind Chimica E Farma Ceutica S P A | Uso di antagonisti selettivi del recettore mglu5 per il trattamento di disfunzioni neuromuscolari del tratto urinario inferiore. |
| SI1641775T1 (sl) * | 2003-07-03 | 2009-08-31 | Euro Celtique Sa | 2-piridin alkinski derivati, uporabni za zdravljenje bolečine |
| UA84710C2 (ru) * | 2003-07-24 | 2008-11-25 | Евро-Селтик С.А. | Пиперидиновые производные, фармацевтическая композиция, которая их содержит, и способ лечения |
| PL1867644T3 (pl) * | 2003-07-24 | 2009-10-30 | Euro Celtique Sa | Związki heteroarylo-tetrahydropiperydylowe przydatne w leczeniu lub zapobieganiu bólu |
| SI1867644T1 (sl) | 2003-07-24 | 2009-10-31 | Euro Celtique Sa | Heteroaril-tetrahidropiperidilne spojine, koristne za zdravljenje ali preprečevanje bolečine |
| WO2005012287A1 (en) | 2003-08-01 | 2005-02-10 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
| CN1902178A (zh) * | 2003-12-30 | 2007-01-24 | 欧洲凯尔特公司 | 用于治疗疼痛的哌嗪 |
| KR20060087386A (ko) | 2005-01-28 | 2006-08-02 | 주식회사 대웅제약 | 신규 벤조이미다졸 유도체 및 이를 함유하는 약제학적조성물 |
| US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
| AU2011226773C1 (en) * | 2007-04-27 | 2012-07-26 | Purdue Pharma L.P. | TRPV1 antagonists and uses thereof |
| DK2142529T3 (da) * | 2007-04-27 | 2014-02-10 | Purdue Pharma Lp | Trpv1-antagonister og anvendelser deraf |
| US8362012B2 (en) | 2008-04-18 | 2013-01-29 | Daewoong Pharmaceutical Co., Ltd. | Benzoxazine benzimidazole derivative, a pharmaceutical composition comprising the same, and a use thereof |
| ES2550667T3 (es) | 2010-02-18 | 2015-11-11 | Vtv Therapeutics Llc | Derivados de fenilheteroarilo y métodos de uso de los mismos |
| JP5876423B2 (ja) | 2010-06-22 | 2016-03-02 | 塩野義製薬株式会社 | Ｔｒｐｖ１阻害活性を有する化合物とその使用 |
| KR101293384B1 (ko) | 2010-10-13 | 2013-08-05 | 주식회사 대웅제약 | 신규 피리딜 벤조옥사진 유도체, 이를 포함하는 약학 조성물 및 이의 용도 |
| EP2709609B1 (en) | 2011-05-17 | 2017-10-04 | Shionogi & Co., Ltd. | Heterocyclic compounds |
| SG10201605163PA (en) | 2011-06-22 | 2016-08-30 | Purdue Pharma Lp | Trpv1 antagonists including dihydroxy substituent and uses thereof |
| MX2014015648A (es) | 2012-06-28 | 2015-08-05 | Abbvie Inc | Cianoguanidinas y usos de las mismas. |
| CA2937365C (en) | 2016-03-29 | 2018-09-18 | F. Hoffmann-La Roche Ag | Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same |
| CN105944083A (zh) * | 2016-05-03 | 2016-09-21 | 董桂芬 | 一种用于治疗纤维肌痛综合症的复方护理剂及其制备方法 |
| MX2019001224A (es) | 2016-07-29 | 2019-06-03 | Janssen Pharmaceutica Nv | Metodos para tratar el cancer de prostata. |
| CN112716979B (zh) * | 2021-01-26 | 2022-11-04 | 上海优祺生物医药科技有限公司 | 羊膜上皮细胞条件培养基的制药用途 |
| DE102022104759A1 (de) | 2022-02-28 | 2023-08-31 | SCi Kontor GmbH | Co-Kristall-Screening Verfahren, insbesondere zur Herstellung von Co-Kristallen |
| WO2023239415A1 (en) * | 2022-06-08 | 2023-12-14 | Angrow Company Limited | Compositions including cannabinoid and use thereof in the manufacture of a medicament for the treatment of inflammation in a subject |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI56836C (fi) * | 1977-10-25 | 1980-04-10 | Fermion Oy | 4-substituerade piperazin-1-(n-aryl-n'-cyano)-karboximidamider som aer mellanprodukter vid framstaellningen av farmakologiskt vaerdefulla 6,7-dimetoxi- eller 6,7,8-trimetoxi-4-amino-2-(4-substituerade-piperazin-1-yl)-kinazoliner |
| US4450272A (en) | 1982-05-06 | 1984-05-22 | American Cyanamid Company | Antiatherosclerotic 1-piperazine-thicarboxamides |
| US4439606A (en) | 1982-05-06 | 1984-03-27 | American Cyanamid Company | Antiatherosclerotic 1-piperazinecarbonyl compounds |
| US5316759A (en) | 1986-03-17 | 1994-05-31 | Robert J. Schaap | Agonist-antagonist combination to reduce the use of nicotine and other drugs |
| US5198459A (en) | 1987-07-11 | 1993-03-30 | Sandoz Ltd. | Use of 5HT-3 antagonists in preventing or reducing dependency on dependency-inducing agents |
| DE3822792C2 (de) | 1987-07-11 | 1997-11-27 | Sandoz Ag | Neue Verwendung von 5HT¶3¶-Antagonisten |
| US5075341A (en) | 1989-12-01 | 1991-12-24 | The Mclean Hospital Corporation | Treatment for cocaine abuse |
| US6204284B1 (en) | 1991-12-20 | 2001-03-20 | American Cyanamid Company | Use of 1-(substitutedphenyl)-3-azabicyclo[3.1.0]hexanes for the treatment of chemical dependencies |
| US5232934A (en) | 1992-07-17 | 1993-08-03 | Warner-Lambert Co. | Method for the treatment of psychomotor stimulant addiction |
| DE4234295A1 (de) | 1992-10-12 | 1994-04-14 | Thomae Gmbh Dr K | Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| US5321012A (en) | 1993-01-28 | 1994-06-14 | Virginia Commonwealth University Medical College | Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance |
| GB9306578D0 (en) | 1993-03-30 | 1993-05-26 | Merck Sharp & Dohme | Therapeutic agents |
| GB9308725D0 (en) | 1993-04-27 | 1993-06-09 | Wyeth John & Brother Ltd | Piperazine derivatives |
| US5461047A (en) | 1993-06-16 | 1995-10-24 | G. D. Searle & Co. | 2-,3-,4-,5-,6-,7-,8-,9- and/or 10-substituted dibenzoxazepine and dibenzthiazepine compounds, pharmaceutical compositions and methods of use |
| US5464788A (en) | 1994-03-24 | 1995-11-07 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
| FR2722788B1 (fr) | 1994-07-20 | 1996-10-04 | Pf Medicament | Nouvelles piperazides derivees d'aryl piperazine, leurs procedes de preparation, leur utilisation a titre de medicament et les compositions pharmaceutiques les comprenant |
| US5556837A (en) | 1994-08-01 | 1996-09-17 | Regeneron Pharmaceuticals Inc. | Methods for treating addictive disorders |
| US5762925A (en) | 1994-11-03 | 1998-06-09 | Sagen; Jacqueline | Preventing opiate tolerance by cellular implantation |
| US5780472A (en) | 1995-01-11 | 1998-07-14 | Samjin Pharmaceuticazl Co., Ltd. | Piperazine derivatives and methods for the preparation thereof and compositions containing the same |
| US5792769A (en) | 1995-09-29 | 1998-08-11 | 3-Dimensional Pharmaceuticals, Inc. | Guanidino protease inhibitors |
| DE69722360T2 (de) | 1996-06-29 | 2003-11-27 | Samjin Pharm, Co. | Piperazin-derivate und verfahren zu ihrer herstellung |
| JP2001502712A (ja) | 1996-10-31 | 2001-02-27 | ノボ ノルディスク アクティーゼルスカブ | 束縛されたソマトスタチン・アゴニスト及びアンタゴニスト |
| WO1999007672A1 (en) | 1997-08-05 | 1999-02-18 | Novo Nordisk A/S | Derivatives of 2,5- and 3,5-disubstituted anilines, their preparation and use |
| ES2356886T3 (es) * | 1998-03-31 | 2011-04-14 | Kyowa Hakko Kirin Co., Ltd. | Compuestos heterocíclicos nitrogenados. |
| US6329395B1 (en) | 1998-06-08 | 2001-12-11 | Schering Corporation | Neuropeptide Y5 receptor antagonists |
| US6673799B1 (en) | 1998-09-22 | 2004-01-06 | Yamanouchi Pharmaceutical Co. Ltd. | Cyanophenyl derivative |
| EP1424072A1 (en) | 1999-03-03 | 2004-06-02 | Samjin Pharmaceutical Co., Ltd. | N'-(pyridin-3-yl)-(4-phenylpiperazin-1-yl)-carboxyimidamide and -iminothiolate derivatives for the treatment of tumors |
| US6109269A (en) | 1999-04-30 | 2000-08-29 | Medtronic, Inc. | Method of treating addiction by brain infusion |
| WO2001095856A2 (en) * | 2000-06-15 | 2001-12-20 | Chaconne Nsi Co., Ltd. | Urea derivative useful as an anti-cancer agent and process for preparing same |
| AU2001280599A1 (en) | 2000-07-15 | 2002-01-30 | Smith Kline Beecham Corporation | Compounds and methods |
| KR100564902B1 (ko) * | 2000-08-21 | 2006-03-30 | 주식회사 태평양 | 신규 티오우레아 유도체 및 이를 함유하는 약제학적 조성물 |
| JP2004506714A (ja) | 2000-08-21 | 2004-03-04 | パシフィック コーポレーション | 新規チオ尿素化合物及びこれを含有する薬学的組成物 |
| AU2001280187A1 (en) | 2000-08-28 | 2002-03-13 | Toray Industries, Inc. | Cyclic amine derivatives |
| PE20030417A1 (es) | 2001-09-13 | 2003-08-06 | Smithkline Beecham Plc | Derivados de urea como antagonistas del receptor vainilloide |
| RS63204A (sr) | 2002-01-17 | 2006-10-27 | Neurogen Corporation | Supstituisani analozi hinazolin-4-ilamina kao modulatori kapsaicina |
| WO2003068749A1 (en) | 2002-02-15 | 2003-08-21 | Glaxo Group Limited | Vanilloid receptor modulators |
| US7074805B2 (en) | 2002-02-20 | 2006-07-11 | Abbott Laboratories | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
| US20030158188A1 (en) | 2002-02-20 | 2003-08-21 | Chih-Hung Lee | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
| KR20040099449A (ko) | 2002-04-18 | 2004-11-26 | 쉐링 코포레이션 | 히스타민 ｈ3 길항제로서의1-(4-피페리디닐)벤즈이미다졸론 |
| US7105505B2 (en) | 2002-04-18 | 2006-09-12 | Schering Corporation | Benzimidazole derivatives useful as histamine H3 antagonists |
| US7220862B2 (en) | 2002-06-05 | 2007-05-22 | Bristol-Myers Squibb Company | Calcitonin gene related peptide receptor antagonists |
| EP1539742B1 (en) | 2002-06-24 | 2006-11-08 | Schering Corporation | Indole derivatives useful as histamine h3 antagonists |
| IL165862A0 (en) * | 2002-06-28 | 2006-01-15 | Euro Celtique Sa | Therapeutic piperazine derivatives useful for tre ating pain |
| ES2298545T3 (es) | 2002-08-21 | 2008-05-16 | Astrazeneca Ab | Compuestos de tieno-pirrol como antagonistas de la hormona liberadora de gonadotropina. |
| TW200418835A (en) | 2003-01-24 | 2004-10-01 | Tanabe Seiyaku Co | A pyrazolopyrimidine compound and a process for preparing the same |
-
2003
- 2003-06-27 IL IL16586203A patent/IL165862A0/xx unknown
- 2003-06-27 DK DK03762220T patent/DK1556354T3/da active
- 2003-06-27 EA EA200500114A patent/EA200500114A1/ru unknown
- 2003-06-27 US US10/607,563 patent/US7279493B2/en not_active Expired - Lifetime
- 2003-06-27 WO PCT/US2003/020509 patent/WO2004002983A2/en not_active Ceased
- 2003-06-27 RS YU114804A patent/RS114804A/sr unknown
- 2003-06-27 ES ES03762220T patent/ES2300613T3/es not_active Expired - Lifetime
- 2003-06-27 JP JP2004549842A patent/JP4621502B2/ja not_active Expired - Fee Related
- 2003-06-27 PT PT03762220T patent/PT1556354E/pt unknown
- 2003-06-27 EP EP03762220A patent/EP1556354B1/en not_active Expired - Lifetime
- 2003-06-27 CN CNB038201372A patent/CN100457735C/zh not_active Expired - Fee Related
- 2003-06-27 AT AT03762220T patent/ATE384698T1/de active
- 2003-06-27 AU AU2003247829A patent/AU2003247829A1/en not_active Abandoned
- 2003-06-27 BR BR0312322-7A patent/BR0312322A/pt not_active Application Discontinuation
- 2003-06-27 CA CA2491079A patent/CA2491079C/en not_active Expired - Fee Related
- 2003-06-27 MX MXPA04012748A patent/MXPA04012748A/es active IP Right Grant
- 2003-06-27 DE DE60318875T patent/DE60318875T2/de not_active Expired - Lifetime
- 2003-06-27 NZ NZ537292A patent/NZ537292A/en not_active IP Right Cessation
-
2005
- 2005-01-24 NO NO20050371A patent/NO20050371L/no unknown
-
2007
- 2007-09-04 US US11/899,379 patent/US7799786B2/en not_active Expired - Lifetime
-
2008
- 2008-04-15 CY CY20081100417T patent/CY1107411T1/el unknown
-
2010
- 2010-09-10 US US12/879,885 patent/US20110281885A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005535731A5 (enExample) | ||
| TW199156B (enExample) | ||
| Diana et al. | Oxadiazoles as ester bioisosteric replacements in compounds related to disoxaril. Antirhinovirus activity | |
| ES2316818T3 (es) | Nuevos derivados de glicosido de tiofeno, procedimiento para su preparacion, medicamentos que contienen a estos compuestos y su uso. | |
| JP2007504284A5 (enExample) | ||
| RU2733750C2 (ru) | Производные карбоксизамещенных (гетеро)ароматических колец, способ их получения и применение | |
| CA2513081A1 (en) | Pyrrolopyridazine derivatives | |
| JP2005525291A5 (enExample) | ||
| JP2002523371A (ja) | ウイルス感染および関連疾患を治療または予防するための化合物、組成物および方法 | |
| EP2310010A2 (en) | Chemical compounds 251 | |
| RU2002107975A (ru) | Глюкопиранозилоксипиразольные производные, лекарственные композиции, содержащие эти производные, и промежуточные соединения для их получения | |
| CA2505368A1 (en) | Trans-9,10-dehydroepothilone c and d, analogs thereof and methods of making the same | |
| HRP20110252T1 (hr) | Fenil-karboksamidni spojevi korisni za liječenje boli | |
| JPH0283384A (ja) | 新規化合物、その製法及びそれを含む医薬組成物 | |
| KR20080034436A (ko) | 암 치료에 사용되는 티아졸 유도체 및 유사체 | |
| JP2006507220A5 (enExample) | ||
| FR2663633A1 (fr) | Nouvelles chalcones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. | |
| KR100608416B1 (ko) | 2-(ｎ-시아노이미노)티아졸리딘-4-온 유도체 | |
| CN102584690A (zh) | 吡啶-2-酮类化合物，其制备方法以及所述吡啶-2-酮类化合物的应用 | |
| KR900004126B1 (ko) | 아릴피페라지닐-에틸(또는 부틸)-페닐-헤테로시클릭 화합물 | |
| FR2965262A1 (fr) | Derives de nicotinamide, leur preparation et leur application en therapeutique | |
| KR20020002394A (ko) | 비만증 예방 또는 치료용 약제를 제조하기 위한,폴리사이클릭 2-아미노-티아졸계의 용도 | |
| EP0321115A1 (en) | Carboxamide derivatives having tetrazole and thiazole rings and their use | |
| KR20010102390A (ko) | 폴리사이클릭 2-아미노-티아졸 시스템, 이의 제조방법 및이를 함유하는 약제 | |
| CN115515603A (zh) | 用于治疗戊型肝炎的双环和单环核苷类似物 |