JP2005526723A5 - - Google Patents
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- Publication number
- JP2005526723A5 JP2005526723A5 JP2003567880A JP2003567880A JP2005526723A5 JP 2005526723 A5 JP2005526723 A5 JP 2005526723A5 JP 2003567880 A JP2003567880 A JP 2003567880A JP 2003567880 A JP2003567880 A JP 2003567880A JP 2005526723 A5 JP2005526723 A5 JP 2005526723A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- alkyl
- phenyl
- carboxamide
- pyrazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000000217 alkyl group Chemical group 0.000 claims 30
- 125000003545 alkoxy group Chemical group 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 18
- -1 aralkoxy Chemical group 0.000 claims 15
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 14
- 125000004076 pyridyl group Chemical group 0.000 claims 11
- 125000003710 aryl alkyl group Chemical group 0.000 claims 10
- 125000000753 cycloalkyl group Chemical group 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 9
- 239000011780 sodium chloride Substances 0.000 claims 9
- 239000012453 solvate Substances 0.000 claims 9
- 125000003386 piperidinyl group Chemical group 0.000 claims 7
- 125000003373 pyrazinyl group Chemical group 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000002541 furyl group Chemical group 0.000 claims 6
- 125000005843 halogen group Chemical group 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 125000000623 heterocyclic group Chemical group 0.000 claims 6
- 125000002883 imidazolyl group Chemical group 0.000 claims 6
- 125000000842 isoxazolyl group Chemical group 0.000 claims 6
- 125000002757 morpholinyl group Chemical group 0.000 claims 6
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 6
- 125000002971 oxazolyl group Chemical group 0.000 claims 6
- 125000003226 pyrazolyl group Chemical group 0.000 claims 6
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 6
- 125000000168 pyrrolyl group Chemical group 0.000 claims 6
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 6
- 125000000335 thiazolyl group Chemical group 0.000 claims 6
- 125000001544 thienyl group Chemical group 0.000 claims 6
- 125000001425 triazolyl group Chemical group 0.000 claims 6
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 5
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 5
- 125000001786 isothiazolyl group Chemical group 0.000 claims 5
- 125000004193 piperazinyl group Chemical group 0.000 claims 5
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims 4
- 125000005418 aryl aryl group Chemical group 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 125000005112 cycloalkylalkoxy group Chemical group 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000004433 nitrogen atoms Chemical group N* 0.000 claims 3
- 229920000728 polyester Polymers 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- ZBNXLNQOZROTKK-UHFFFAOYSA-N 1-(3-chlorophenyl)-N-isoquinolin-5-yl-5-methylpyrazole-3-carboxamide Chemical compound CC1=CC(C(=O)NC=2C3=CC=NC=C3C=CC=2)=NN1C1=CC=CC(Cl)=C1 ZBNXLNQOZROTKK-UHFFFAOYSA-N 0.000 claims 2
- BJIGPOHHQXLJJG-UHFFFAOYSA-N 1-(3-fluorophenyl)-N-isoquinolin-5-yl-5-methylpyrazole-3-carboxamide Chemical compound CC1=CC(C(=O)NC=2C3=CC=NC=C3C=CC=2)=NN1C1=CC=CC(F)=C1 BJIGPOHHQXLJJG-UHFFFAOYSA-N 0.000 claims 2
- JXZCRDUDHXLHSO-UHFFFAOYSA-N 1-[2-chloro-5-(trifluoromethyl)phenyl]-N-isoquinolin-5-yl-5-methylpyrazole-3-carboxamide Chemical compound CC1=CC(C(=O)NC=2C3=CC=NC=C3C=CC=2)=NN1C1=CC(C(F)(F)F)=CC=C1Cl JXZCRDUDHXLHSO-UHFFFAOYSA-N 0.000 claims 2
- DZXOOWSJLLMRJJ-UHFFFAOYSA-N 5-amino-N-isoquinolin-5-yl-1-[3-(trifluoromethyl)phenyl]pyrazole-3-carboxamide Chemical compound NC1=CC(C(=O)NC=2C3=CC=NC=C3C=CC=2)=NN1C1=CC=CC(C(F)(F)F)=C1 DZXOOWSJLLMRJJ-UHFFFAOYSA-N 0.000 claims 2
- HESDFBZNGHRRPM-UHFFFAOYSA-N 5-methyl-N-(3-methylisoquinolin-5-yl)-1-[3-(trifluoromethyl)phenyl]pyrazole-3-carboxamide Chemical compound CC1=CC(C(=O)NC=2C3=CC(C)=NC=C3C=CC=2)=NN1C1=CC=CC(C(F)(F)F)=C1 HESDFBZNGHRRPM-UHFFFAOYSA-N 0.000 claims 2
- FRCOEAAEFSEYPE-UHFFFAOYSA-N 5-methyl-N-quinolin-3-yl-1-[3-(trifluoromethyl)phenyl]pyrazole-3-carboxamide Chemical compound CC1=CC(C(=O)NC=2C=C3C=CC=CC3=NC=2)=NN1C1=CC=CC(C(F)(F)F)=C1 FRCOEAAEFSEYPE-UHFFFAOYSA-N 0.000 claims 2
- QKBBWAFNMUOVAZ-UHFFFAOYSA-N 5-methyl-N-quinolin-5-yl-1-[3-(trifluoromethyl)phenyl]pyrazole-3-carboxamide Chemical compound CC1=CC(C(=O)NC=2C3=CC=CN=C3C=CC=2)=NN1C1=CC=CC(C(F)(F)F)=C1 QKBBWAFNMUOVAZ-UHFFFAOYSA-N 0.000 claims 2
- RNFRFPSSWGWDKI-UHFFFAOYSA-N Benzoquinuclidine Chemical group C12=CC=CC=C2N2CCC1CC2 RNFRFPSSWGWDKI-UHFFFAOYSA-N 0.000 claims 2
- WEKSTRYBSSDRRD-UHFFFAOYSA-N N-[1-acetyl-3-[(dimethylamino)methyl]-3,4-dihydro-2H-quinolin-7-yl]-4-phenylbenzamide Chemical compound C=1C=C2CC(CN(C)C)CN(C(C)=O)C2=CC=1NC(=O)C(C=C1)=CC=C1C1=CC=CC=C1 WEKSTRYBSSDRRD-UHFFFAOYSA-N 0.000 claims 2
- RLUXNAPFXSKUES-UHFFFAOYSA-N N-[3-[(dimethylamino)methyl]-1,2,3,4-tetrahydroquinolin-7-yl]-4-phenylbenzamide Chemical compound C=1C=C2CC(CN(C)C)CNC2=CC=1NC(=O)C(C=C1)=CC=C1C1=CC=CC=C1 RLUXNAPFXSKUES-UHFFFAOYSA-N 0.000 claims 2
- XIROUHIROZWIGD-UHFFFAOYSA-N N-[3-[(dimethylamino)methyl]-1-formyl-3,4-dihydro-2H-quinolin-7-yl]-4-phenylbenzamide Chemical compound C=1C=C2CC(CN(C)C)CN(C=O)C2=CC=1NC(=O)C(C=C1)=CC=C1C1=CC=CC=C1 XIROUHIROZWIGD-UHFFFAOYSA-N 0.000 claims 2
- OXKVEIRVLVYRGP-UHFFFAOYSA-N N-[3-[(dimethylamino)methyl]-1-methylsulfonyl-3,4-dihydro-2H-quinolin-7-yl]-4-phenylbenzamide Chemical compound C=1C=C2CC(CN(C)C)CN(S(C)(=O)=O)C2=CC=1NC(=O)C(C=C1)=CC=C1C1=CC=CC=C1 OXKVEIRVLVYRGP-UHFFFAOYSA-N 0.000 claims 2
- ULGJQTZESNGVFR-UHFFFAOYSA-N N-isoquinolin-5-yl-1-(3-methoxyphenyl)-5-methylpyrazole-3-carboxamide Chemical compound COC1=CC=CC(N2C(=CC(=N2)C(=O)NC=2C3=CC=NC=C3C=CC=2)C)=C1 ULGJQTZESNGVFR-UHFFFAOYSA-N 0.000 claims 2
- CPNKPIYIMJJWTI-UHFFFAOYSA-N N-isoquinolin-5-yl-5-methyl-1-[3-(trifluoromethyl)phenyl]pyrazole-3-carboxamide Chemical compound CC1=CC(C(=O)NC=2C3=CC=NC=C3C=CC=2)=NN1C1=CC=CC(C(F)(F)F)=C1 CPNKPIYIMJJWTI-UHFFFAOYSA-N 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
- BUZFNXOUWRSUBK-UHFFFAOYSA-N 5-methyl-N-quinolin-8-yl-1-[3-(trifluoromethyl)phenyl]pyrazole-3-carboxamide Chemical compound CC1=CC(C(=O)NC=2C3=NC=CC=C3C=CC=2)=NN1C1=CC=CC(C(F)(F)F)=C1 BUZFNXOUWRSUBK-UHFFFAOYSA-N 0.000 claims 1
- SJDMUMDEWSBHIX-UHFFFAOYSA-N N-[3-[2-(diethylamino)ethyl]-4-methyl-2-oxo-1H-quinolin-7-yl]-4-phenylpiperazine-1-carboxamide Chemical compound C1=C2NC(=O)C(CCN(CC)CC)=C(C)C2=CC=C1NC(=O)N(CC1)CCN1C1=CC=CC=C1 SJDMUMDEWSBHIX-UHFFFAOYSA-N 0.000 claims 1
- 230000003042 antagnostic Effects 0.000 claims 1
- 150000003857 carboxamides Chemical class 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000546 pharmaceutic aid Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000001225 therapeutic Effects 0.000 claims 1
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0203677A GB0203677D0 (en) | 2002-02-15 | 2002-02-15 | Novel compounds |
| GB0203673A GB0203673D0 (en) | 2002-02-15 | 2002-02-15 | Novel compounds |
| GB0203680A GB0203680D0 (en) | 2002-02-15 | 2002-02-15 | Novel compounds |
| GB0209035A GB0209035D0 (en) | 2002-04-19 | 2002-04-19 | Novel compounds |
| GB0209003A GB0209003D0 (en) | 2002-04-19 | 2002-04-19 | Novel compounds |
| GB0209032A GB0209032D0 (en) | 2002-04-19 | 2002-04-19 | Novel compounds |
| GB0221318A GB0221318D0 (en) | 2002-09-13 | 2002-09-13 | Novel compounds |
| PCT/GB2003/000608 WO2003068749A1 (en) | 2002-02-15 | 2003-02-13 | Vanilloid receptor modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005526723A JP2005526723A (ja) | 2005-09-08 |
| JP2005526723A5 true JP2005526723A5 (US07928230-20110419-C00107.png) | 2006-03-09 |
Family
ID=27739514
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003567880A Pending JP2005526723A (ja) | 2002-02-15 | 2003-02-13 | バニロイド受容体モジュレーター |
Country Status (10)
Families Citing this family (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4583760B2 (ja) | 2002-02-01 | 2010-11-17 | ユーロ−セルティーク エス．エイ． | 疼痛の治療に有用な治療薬 |
| US6974818B2 (en) | 2002-03-01 | 2005-12-13 | Euro-Celtique S.A. | 1,2,5-thiadiazol-3-YL-piperazine therapeutic agents useful for treating pain |
| ATE533743T1 (de) | 2002-05-17 | 2011-12-15 | Janssen Pharmaceutica Nv | Harnstoffderivate von aminotetralin als modulatoren des vanilloid-rezeptors vr1 |
| JP4621502B2 (ja) | 2002-06-28 | 2011-01-26 | ユーロ−セルティーク エス．エイ． | 疼痛の治療に有用な治療剤 |
| US7262194B2 (en) | 2002-07-26 | 2007-08-28 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
| GB0221157D0 (en) * | 2002-09-12 | 2002-10-23 | Glaxo Group Ltd | Novel treatment |
| US7157462B2 (en) | 2002-09-24 | 2007-01-02 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
| GB0226724D0 (en) * | 2002-11-15 | 2002-12-24 | Merck Sharp & Dohme | Therapeutic agents |
| ES2291725T3 (es) * | 2002-12-06 | 2008-03-01 | Xention Limited | Derivados de tetrahidro-naftaleno. |
| JP4440113B2 (ja) * | 2002-12-09 | 2010-03-24 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | バニロイド受容体アンタゴニストとしてのテトラヒドロ−ナフタレン誘導体 |
| EP1575918A2 (en) * | 2002-12-19 | 2005-09-21 | Neurogen Corporation | Substituted biaryl-4-carboxylic acid arylamide analogues as capsaicin receptor modulators |
| SE0301446D0 (sv) | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | New Compounds |
| WO2004103954A1 (ja) * | 2003-05-20 | 2004-12-02 | Ajinomoto Co., Inc. | アミド誘導体 |
| PT1632477T (pt) | 2003-06-12 | 2017-04-04 | Astellas Pharma Inc | Derivado de benzamida ou seu sal |
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| KR20080092473A (ko) * | 2003-07-24 | 2008-10-15 | 유로-셀띠끄 소시에떼 아노님 | 통증 치료 또는 예방에 유용한 헤테로아릴-테트라하이드로피페리딜 화합물 |
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| GB0319151D0 (en) * | 2003-08-14 | 2003-09-17 | Glaxo Group Ltd | Novel compounds |
| EP1664016B9 (en) * | 2003-09-22 | 2009-07-08 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
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- 2003-02-13 ES ES03739564T patent/ES2316777T3/es not_active Expired - Lifetime
- 2003-02-13 AT AT03739564T patent/ATE416168T1/de not_active IP Right Cessation
- 2003-02-13 TW TW092102941A patent/TW200403223A/zh unknown
- 2003-02-13 AR ARP030100474A patent/AR038420A1/es unknown
- 2003-02-13 EP EP08170191A patent/EP2033953A1/en not_active Withdrawn
- 2003-02-13 WO PCT/GB2003/000608 patent/WO2003068749A1/en active Application Filing
- 2003-02-13 US US10/503,648 patent/US7538121B2/en not_active Expired - Fee Related
- 2003-02-13 AU AU2003245773A patent/AU2003245773A1/en not_active Abandoned
- 2003-02-13 JP JP2003567880A patent/JP2005526723A/ja active Pending
- 2003-02-13 DE DE60325025T patent/DE60325025D1/de not_active Expired - Lifetime
- 2003-02-13 EP EP03739564A patent/EP1480954B1/en not_active Expired - Lifetime
