JP2005515214A5 - - Google Patents
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- JP2005515214A5 JP2005515214A5 JP2003556020A JP2003556020A JP2005515214A5 JP 2005515214 A5 JP2005515214 A5 JP 2005515214A5 JP 2003556020 A JP2003556020 A JP 2003556020A JP 2003556020 A JP2003556020 A JP 2003556020A JP 2005515214 A5 JP2005515214 A5 JP 2005515214A5
- Authority
- JP
- Japan
- Prior art keywords
- tfpi
- pharmaceutical composition
- analog
- ala
- glycosylated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 239000008194 pharmaceutical composition Substances 0.000 claims 64
- 102100030951 Tissue factor pathway inhibitor Human genes 0.000 claims 57
- 108010013555 lipoprotein-associated coagulation inhibitor Proteins 0.000 claims 57
- 239000000203 mixture Substances 0.000 claims 12
- 229940024606 amino acid Drugs 0.000 claims 8
- 150000001413 amino acids Chemical class 0.000 claims 8
- 238000001802 infusion Methods 0.000 claims 4
- 238000001990 intravenous administration Methods 0.000 claims 4
- 102000004889 Interleukin-6 Human genes 0.000 claims 3
- 108090001005 Interleukin-6 Proteins 0.000 claims 3
- 206010040047 Sepsis Diseases 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 108090000695 Cytokines Proteins 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 2
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 claims 2
- 108010002352 Interleukin-1 Proteins 0.000 claims 2
- 102000002262 Thromboplastin Human genes 0.000 claims 2
- 108010000499 Thromboplastin Proteins 0.000 claims 2
- 102100040247 Tumor necrosis factor Human genes 0.000 claims 2
- 208000038016 acute inflammation Diseases 0.000 claims 2
- 230000006022 acute inflammation Effects 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 229940088710 antibiotic agent Drugs 0.000 claims 2
- 239000004074 complement inhibitor Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- 229940124073 Complement inhibitor Drugs 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- 229940124790 IL-6 inhibitor Drugs 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims 1
- 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 102100028123 Macrophage colony-stimulating factor 1 Human genes 0.000 claims 1
- 208000034486 Multi-organ failure Diseases 0.000 claims 1
- 208000010718 Multiple Organ Failure Diseases 0.000 claims 1
- 206010040070 Septic Shock Diseases 0.000 claims 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 1
- -1 antibodies Substances 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 229960003121 arginine Drugs 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 229960003589 arginine hydrochloride Drugs 0.000 claims 1
- 102000052586 bactericidal permeability increasing protein Human genes 0.000 claims 1
- 108010032816 bactericidal permeability increasing protein Proteins 0.000 claims 1
- 230000021164 cell adhesion Effects 0.000 claims 1
- 208000037976 chronic inflammation Diseases 0.000 claims 1
- 230000006020 chronic inflammation Effects 0.000 claims 1
- 238000011260 co-administration Methods 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 239000002158 endotoxin Substances 0.000 claims 1
- 229960002897 heparin Drugs 0.000 claims 1
- 229920000669 heparin Polymers 0.000 claims 1
- 229960001438 immunostimulant agent Drugs 0.000 claims 1
- 239000003022 immunostimulating agent Substances 0.000 claims 1
- 230000003308 immunostimulating effect Effects 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 208000029744 multiple organ dysfunction syndrome Diseases 0.000 claims 1
- 230000014508 negative regulation of coagulation Effects 0.000 claims 1
- 230000036470 plasma concentration Effects 0.000 claims 1
- 230000036303 septic shock Effects 0.000 claims 1
- 230000035939 shock Effects 0.000 claims 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims 1
- 239000001509 sodium citrate Substances 0.000 claims 1
- 229940046728 tumor necrosis factor alpha inhibitor Drugs 0.000 claims 1
- 239000002451 tumor necrosis factor inhibitor Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32880601P | 2001-10-15 | 2001-10-15 | |
| PCT/US2002/032625 WO2003055442A2 (en) | 2001-10-15 | 2002-10-15 | Treatment of sepsis by low dose administration of tissue factor pathway inhibitor (tfpi) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005271191A Division JP2006008704A (ja) | 2001-10-15 | 2005-09-16 | 組織因子経路インヒビター（ｔｆｐｉ）の低量投与による敗血症の処置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005515214A JP2005515214A (ja) | 2005-05-26 |
| JP2005515214A5 true JP2005515214A5 (enExample) | 2006-01-05 |
Family
ID=23282520
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003556020A Withdrawn JP2005515214A (ja) | 2001-10-15 | 2002-10-15 | 組織因子経路インヒビター（ｔｆｐｉ）の低量投与による敗血症の処置 |
| JP2003535710A Withdrawn JP2005506345A (ja) | 2001-10-15 | 2002-10-15 | 組織因子経路インヒビター（ｔｆｐｉ）の投与による重症な肺炎の処置 |
| JP2005271191A Withdrawn JP2006008704A (ja) | 2001-10-15 | 2005-09-16 | 組織因子経路インヒビター（ｔｆｐｉ）の低量投与による敗血症の処置 |
| JP2005271219A Pending JP2006008706A (ja) | 2001-10-15 | 2005-09-16 | 組織因子経路インヒビター（ｔｆｐｉ）の投与による重症な肺炎の処置 |
| JP2009235793A Withdrawn JP2010006839A (ja) | 2001-10-15 | 2009-10-09 | 組織因子経路インヒビター（ｔｆｐｉ）の低量投与による敗血症の処置 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003535710A Withdrawn JP2005506345A (ja) | 2001-10-15 | 2002-10-15 | 組織因子経路インヒビター（ｔｆｐｉ）の投与による重症な肺炎の処置 |
| JP2005271191A Withdrawn JP2006008704A (ja) | 2001-10-15 | 2005-09-16 | 組織因子経路インヒビター（ｔｆｐｉ）の低量投与による敗血症の処置 |
| JP2005271219A Pending JP2006008706A (ja) | 2001-10-15 | 2005-09-16 | 組織因子経路インヒビター（ｔｆｐｉ）の投与による重症な肺炎の処置 |
| JP2009235793A Withdrawn JP2010006839A (ja) | 2001-10-15 | 2009-10-09 | 組織因子経路インヒビター（ｔｆｐｉ）の低量投与による敗血症の処置 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7674769B2 (enExample) |
| EP (2) | EP1446140A4 (enExample) |
| JP (5) | JP2005515214A (enExample) |
| KR (2) | KR20050036867A (enExample) |
| CN (2) | CN1604787A (enExample) |
| AU (2) | AU2002365131B2 (enExample) |
| BR (2) | BR0213292A (enExample) |
| CA (2) | CA2463738A1 (enExample) |
| EA (2) | EA200400548A1 (enExample) |
| HU (2) | HUP0500472A2 (enExample) |
| IL (2) | IL161407A0 (enExample) |
| IS (2) | IS7224A (enExample) |
| MX (2) | MXPA04003547A (enExample) |
| NO (2) | NO20041996D0 (enExample) |
| PL (2) | PL374506A1 (enExample) |
| WO (2) | WO2003055442A2 (enExample) |
| ZA (2) | ZA200403601B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL374506A1 (en) | 2001-10-15 | 2005-10-31 | Chiron Corporation | Treatment of severe pneumonia by administration of tissue factor pathway inhibitor (tfpi) |
| CA2512680A1 (en) * | 2003-01-08 | 2004-07-29 | Chiron Corporation | Stabilized lyophilized compositions comprising tissue factor pathway inhibitor or tissue factor pathway inhibitor variants |
| JP4522997B2 (ja) * | 2003-08-13 | 2010-08-11 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | Ｔｆｐｉおよびｔｆｐｉアナログを精製するための改良された方法 |
| CN101426520A (zh) * | 2004-03-17 | 2009-05-06 | 诺华疫苗和诊断公司 | 通过给予组织因子途径抑制剂（tfpi）治疗社区获得性重症肺炎 |
| CN101180074A (zh) * | 2005-04-15 | 2008-05-14 | 诺华疫苗和诊断公司 | 通过施用组织因子通路抑制剂(tfpi)治疗严重社区获得性肺炎 |
| CA2607293A1 (en) * | 2005-05-06 | 2006-11-16 | Novartis Ag | Use of tfpi to treat severe bacterial infections |
| MX2007014440A (es) | 2005-05-16 | 2008-02-11 | Abbott Biotech Ltd | Uso de inhibidor de tnf para tratamiento de poliartritis erosiva. |
| DK1896059T3 (da) * | 2005-06-24 | 2013-04-08 | Drugrecure Aps | Luftvejsadministration af Tissue Factor Pathway Inhibitor ved inflammatoriske tilstande, der påvirker luftvejene |
| BRPI0613676A2 (pt) * | 2005-07-22 | 2011-01-25 | Novartis Ag | polipeptìdeo, seu uso e composição farmacêutica compreendendo o mesmo |
| EP2007426A4 (en) | 2006-04-10 | 2010-06-16 | Abbott Biotech Ltd | COMPOSITIONS FOR THE TREATMENT OF PSORIASTIC POLYARTHRITIS AND THEIR APPLICATIONS |
| US20110142837A1 (en) * | 2007-07-20 | 2011-06-16 | Trustees Of The University Of Pennsylvania | Method Of Treating Acute Respiratory Distress Syndrome |
| WO2009129164A1 (en) * | 2008-04-15 | 2009-10-22 | Novartis Ag | Pharmaceutical combinations of tfpi-fragments and an antibiotic |
| UA112050C2 (uk) * | 2008-08-04 | 2016-07-25 | БАЄР ХЕЛСКЕР ЛЛСі | Терапевтична композиція, що містить моноклональне антитіло проти інгібітора шляху тканинного фактора (tfpi) |
| WO2012078968A2 (en) | 2010-12-10 | 2012-06-14 | Lifeline Scientific, Inc. | Machine perfusion with complement inhibitors |
| JP2014520873A (ja) | 2011-07-18 | 2014-08-25 | ザ ユニバーシティ オブ メルボルン | ｃ−Ｆｍｓアンタゴニストの使用 |
| KR101672108B1 (ko) * | 2011-11-15 | 2016-11-02 | 아사히 가세이 파마 가부시키가이샤 | 패혈증의 치료 및/또는 개선을 위한 의약 |
| US9856316B2 (en) | 2013-04-12 | 2018-01-02 | Morphosys Ag | Antibodies targeting M-CSF |
| US11504071B2 (en) | 2018-04-10 | 2022-11-22 | Hill-Rom Services, Inc. | Patient risk assessment based on data from multiple sources in a healthcare facility |
| US11908581B2 (en) | 2018-04-10 | 2024-02-20 | Hill-Rom Services, Inc. | Patient risk assessment based on data from multiple sources in a healthcare facility |
| CN113301907A (zh) | 2018-10-22 | 2021-08-24 | 旭化成制药株式会社 | 用于治疗和/或改善伴有凝血障碍的败血症的药物 |
| WO2023142096A1 (en) * | 2022-01-30 | 2023-08-03 | Westlake University | Composition and method for preventing and/or treating clostridioides difficile infections caused by clade 2 strains |
Family Cites Families (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4399216A (en) * | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4603106A (en) * | 1982-02-22 | 1986-07-29 | The Rockefeller University | Lipoprotein lipase suppression by endotoxin-induced mediator (shock assay) |
| JPS5896026A (ja) * | 1981-10-30 | 1983-06-07 | Nippon Chemiphar Co Ltd | 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤 |
| DE3219248A1 (de) | 1982-05-21 | 1983-11-24 | Solco Basel AG, Birsfelden | Verfahren zur gewinnung zellatmungsfoerdernder wirkstoffe aus kaelberblut |
| US4609546A (en) * | 1982-06-24 | 1986-09-02 | Japan Chemical Research Co., Ltd. | Long-acting composition |
| US4511502A (en) * | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
| US4620948A (en) * | 1982-12-22 | 1986-11-04 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
| US4711845A (en) * | 1984-08-31 | 1987-12-08 | Cetus Corporation | Portable temperature-sensitive control cassette |
| US4530787A (en) * | 1984-03-28 | 1985-07-23 | Cetus Corporation | Controlled oxidation of microbially produced cysteine-containing proteins |
| US4569790A (en) * | 1984-03-28 | 1986-02-11 | Cetus Corporation | Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions |
| WO1985004899A1 (en) | 1984-04-19 | 1985-11-07 | Agracetus | Methods and vectors for transformation of plant cells |
| US4572798A (en) * | 1984-12-06 | 1986-02-25 | Cetus Corporation | Method for promoting disulfide bond formation in recombinant proteins |
| US4847201A (en) * | 1985-02-05 | 1989-07-11 | Cetus Corporation | DNA encoding for CSF-1 and accompanying recombinant systems |
| US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4766106A (en) * | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
| US4748234A (en) * | 1985-06-26 | 1988-05-31 | Cetus Corporation | Process for recovering refractile bodies containing heterologous proteins from microbial hosts |
| CA1294215C (en) | 1986-10-27 | 1992-01-14 | Ze'ev Shaked | Pharmaceutical compositions of recombinant beta-interferon and formulation processes |
| CA1292686C (en) | 1986-10-27 | 1991-12-03 | Ze'ev Shaked | Pharmaceutical compositions of recombinant interleukin-2 and formulation process |
| US5223427A (en) * | 1987-03-31 | 1993-06-29 | The Scripps Research Institute | Hybridomas producing monoclonal antibodies reactive with human tissue-factor glycoprotein heavy chain |
| US5110730A (en) * | 1987-03-31 | 1992-05-05 | The Scripps Research Institute | Human tissue factor related DNA segments |
| US4929700A (en) * | 1987-04-16 | 1990-05-29 | Cetus Corporation | Production of purified, biologically active, bacterially produced recombinant human CSF-1 |
| US5106833A (en) * | 1987-07-23 | 1992-04-21 | Washington University | Coagulation inhibitors |
| US4966852A (en) * | 1987-07-23 | 1990-10-30 | Monsanto Company | DNA clone of human tissue factor inhibitor |
| IL87171A (en) | 1987-11-23 | 1995-08-31 | Monsanto Co | cDNA of human tissue factor inhibitor |
| US5219994A (en) * | 1988-11-08 | 1993-06-15 | W. Alton Jones Cell Science Center, Inc. | Inhibitor of tissue factor activity |
| DK412389D0 (da) | 1989-01-19 | 1989-01-19 | Novo Nordisk As | Fremgangsmaade til udvinding af oprenset epi protein fra en fermenteringsoploesning |
| DK408089D0 (da) | 1989-08-18 | 1989-08-18 | Novo Nordisk As | Proteiner |
| DK148890D0 (da) | 1990-06-19 | 1990-06-19 | Novo Nordisk As | Farmaceutisk praeparat |
| IE913004A1 (en) | 1990-08-27 | 1992-03-11 | Monsanto Co | Anticoagulant combination of laci and sulfated¹polysaccharides |
| US5506134A (en) | 1990-10-22 | 1996-04-09 | Corvas International, Inc. | Hypridoma and monoclonal antibody which inhibits blood coagulation tissue factor/factor VIIa complex |
| DK261490D0 (da) | 1990-10-31 | 1990-10-31 | Novo Nordisk As | New pharmaceutical compound |
| US5212091A (en) * | 1992-03-02 | 1993-05-18 | Monsanto Company | Method of producing tissue factor pathway inhibitor |
| US5276015A (en) | 1992-03-18 | 1994-01-04 | Washington University | Method of inhibiting microvascular thrombosis |
| USRE36476E (en) | 1992-03-18 | 1999-12-28 | Washington University | Method of inhibiting microvascular thrombosis |
| US6063764A (en) * | 1992-06-01 | 2000-05-16 | Washington University & Chiron Corp. | Method for using lipoprotein associated coagulation inhibitor to treat sepsis |
| PT643585E (pt) | 1992-06-01 | 2000-05-31 | Chiron Corp | Utilizacao de inibidor da coagulacao associado a lipoproteinas (laci) para a preparacao de um medicamento para o tratamento de inflamacao aguda ou cronica |
| AU4408493A (en) | 1992-06-11 | 1994-01-04 | Washington University | Prophylaxis and treatment of sepsis and sepsis-associated coagulation disorders |
| US5589359A (en) | 1994-08-05 | 1996-12-31 | Chiron Corporation | Chimeric proteins |
| JP3571378B2 (ja) * | 1994-09-30 | 2004-09-29 | 扶桑薬品工業株式会社 | 感染症診断用プローブ |
| JP3761914B2 (ja) * | 1994-11-17 | 2006-03-29 | 財団法人化学及血清療法研究所 | アンチトロンビンｉｉｉ及び組織因子凝固系インヒビター含有血栓症治療剤 |
| US5914316A (en) | 1994-12-16 | 1999-06-22 | Washington University | Method of inhibiting intimal hyperplasia |
| US5612363A (en) | 1995-06-02 | 1997-03-18 | Berlex Laboratories, Inc. | N,N-di(aryl) cyclic urea derivatives as anti-coagulants |
| US5885781A (en) | 1995-06-07 | 1999-03-23 | Chiron Corporation | Regulation of cytokine synthesis and release |
| US5888968A (en) | 1995-06-07 | 1999-03-30 | Chiron Corporation | TFPI formulation |
| DE69635051T2 (de) | 1995-06-07 | 2006-06-14 | Chiron Corp | Methode zur lösung, reinigung und rückfaltung von protein |
| US6242414B1 (en) | 1995-06-07 | 2001-06-05 | Chiron Corporation | Regulation of cytokine synthesis and release |
| US5902582A (en) | 1995-09-05 | 1999-05-11 | Chiron Corporation | Use of TFPI inhibitor for treatment of cancer |
| US5772629A (en) * | 1995-10-23 | 1998-06-30 | Localmed, Inc. | Localized intravascular delivery of TFPI for inhibition of restenosis in recanalized blood vessels |
| US5736364A (en) | 1995-12-04 | 1998-04-07 | Genentech, Inc. | Factor viia inhibitors |
| JP4129994B2 (ja) | 1996-03-25 | 2008-08-06 | 財団法人化学及血清療法研究所 | 組織因子凝固系インヒビター含有血管新生阻害剤 |
| US5977057A (en) * | 1996-05-08 | 1999-11-02 | The University Of Vermont And State Agricultural College | Thrombosis prophylaxis for factor VLEIDEN carriers |
| AU6042298A (en) * | 1997-01-31 | 1998-08-25 | Human Genome Sciences, Inc. | Tissue factor pathway inhibitor-3 |
| US5981471A (en) * | 1997-02-06 | 1999-11-09 | Entremed, Inc. | Compositions and methods for inhibiting cellular proliferation |
| US6162629A (en) | 1997-04-28 | 2000-12-19 | Eli Lilly And Company | Methods for processing activated protein C |
| IL121191A0 (en) | 1997-06-29 | 1997-11-20 | Yeda Res & Dev | Synthetic peptides and pharmaceutical compositions comprising them |
| HUP0001237A3 (en) | 1997-10-20 | 2002-01-28 | Lilly Co Eli | Methods for treating vascular disorders |
| US6824997B1 (en) * | 1998-09-18 | 2004-11-30 | Binax, Inc. | Process and materials for the rapid detection of streptococcus pneumoniae employing purified antigen-specific antibodies |
| EP1124573A1 (en) | 1998-10-22 | 2001-08-22 | Eli Lilly And Company | Methods for treating sepsis |
| ES2195655T3 (es) | 1998-11-20 | 2003-12-01 | Lilly Co Eli | Procedimiento para tratar fiebre hemorragica virica con proteina c. |
| AU4683299A (en) * | 1999-06-11 | 2001-01-02 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Detection of streptococcus pneumoniae and immunization against streptococcus pneumoniae infection |
| AU5062100A (en) | 1999-06-14 | 2001-01-02 | Novo Nordisk A/S | Fviia/tf activity inhibiting compounds |
| US6294648B1 (en) | 1999-07-20 | 2001-09-25 | Bayer Corporation | Protein having proteinase inhibitor activity |
| US6180607B1 (en) | 1999-08-05 | 2001-01-30 | Christopher Davies | Protein having proteinase inhibitor activity |
| CN100389821C (zh) | 1999-10-04 | 2008-05-28 | 希龙公司 | 稳定化的含多肽的液体药物组合物 |
| JP2003519196A (ja) | 2000-01-06 | 2003-06-17 | イーライ・リリー・アンド・カンパニー | 炎症性疾患および呼吸器疾患を処置するための併用療法 |
| JP2003521938A (ja) | 2000-02-11 | 2003-07-22 | イーライ・リリー・アンド・カンパニー | プロテインｃ誘導体 |
| HK1053972A1 (zh) | 2000-02-16 | 2003-11-14 | Northwestern University | 聚甘氨酸胺基取代的阳离子寡聚合物肺表面活性剂 |
| DE10022092A1 (de) | 2000-05-08 | 2001-11-15 | Aventis Behring Gmbh | Stabilisiertes Protein-Präparat und Verfahren zu seiner Herstellung |
| US7015194B2 (en) | 2000-05-10 | 2006-03-21 | Novo Nordisk A/S | Pharmaceutical composition comprising factor VIIa and anti-TFPI |
| ATE352309T1 (de) | 2001-02-28 | 2007-02-15 | John H Griffin | Plasmaglucosylceramiddefizienz als risikofaktor für thrombose und modulator von anticoagulant protein c |
| EP1383885A4 (en) | 2001-04-04 | 2005-11-30 | American Diagnostica Inc | METHOD FOR PRODUCING A STABILIZED THROMBIN-ACTIVATED FIBRINOLYSE INHIBITOR (TAFI) AND METHOD FOR THE USE THEREOF |
| DE10132307A1 (de) | 2001-07-06 | 2003-01-30 | Aventis Behring Gmbh | Arzneizubereitung zur Inhalation von Antithrombin bei entzündlichen Lungenerkrankungen und ARDS |
| PL374506A1 (en) * | 2001-10-15 | 2005-10-31 | Chiron Corporation | Treatment of severe pneumonia by administration of tissue factor pathway inhibitor (tfpi) |
| US20020198138A1 (en) | 2002-06-07 | 2002-12-26 | Macias William Louis | Combination therapy for the treatment of inflammatory and respiratory diseases |
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2002
- 2002-10-15 PL PL02374506A patent/PL374506A1/xx not_active Application Discontinuation
- 2002-10-15 CA CA002463738A patent/CA2463738A1/en not_active Abandoned
- 2002-10-15 HU HU0500472A patent/HUP0500472A2/hu unknown
- 2002-10-15 US US10/270,478 patent/US7674769B2/en not_active Expired - Fee Related
- 2002-10-15 IL IL16140702A patent/IL161407A0/xx unknown
- 2002-10-15 JP JP2003556020A patent/JP2005515214A/ja not_active Withdrawn
- 2002-10-15 JP JP2003535710A patent/JP2005506345A/ja not_active Withdrawn
- 2002-10-15 HU HU0501111A patent/HUP0501111A2/hu unknown
- 2002-10-15 AU AU2002365131A patent/AU2002365131B2/en not_active Ceased
- 2002-10-15 BR BRPI0213292-3A patent/BR0213292A/pt unknown
- 2002-10-15 EA EA200400548A patent/EA200400548A1/ru unknown
- 2002-10-15 CN CNA028250648A patent/CN1604787A/zh active Pending
- 2002-10-15 EP EP02778529A patent/EP1446140A4/en not_active Withdrawn
- 2002-10-15 WO PCT/US2002/032625 patent/WO2003055442A2/en not_active Ceased
- 2002-10-15 IL IL16140802A patent/IL161408A0/xx unknown
- 2002-10-15 KR KR1020047005618A patent/KR20050036867A/ko not_active Withdrawn
- 2002-10-15 PL PL02372138A patent/PL372138A1/xx not_active Application Discontinuation
- 2002-10-15 CN CNA028249003A patent/CN1604790A/zh active Pending
- 2002-10-15 CA CA002463655A patent/CA2463655A1/en not_active Abandoned
- 2002-10-15 EA EA200400549A patent/EA200400549A1/ru unknown
- 2002-10-15 AU AU2002340183A patent/AU2002340183B2/en not_active Ceased
- 2002-10-15 BR BR0213293-1A patent/BR0213293A/pt not_active Application Discontinuation
- 2002-10-15 WO PCT/US2002/032624 patent/WO2003032904A2/en not_active Ceased
- 2002-10-15 EP EP02803284A patent/EP1446138A4/en not_active Withdrawn
- 2002-10-15 MX MXPA04003547A patent/MXPA04003547A/es unknown
- 2002-10-15 KR KR10-2004-7005632A patent/KR20040040489A/ko not_active Withdrawn
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2003
- 2003-02-04 US US10/270,479 patent/US20030139340A1/en not_active Abandoned
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2004
- 2004-04-15 IS IS7224A patent/IS7224A/is unknown
- 2004-04-15 MX MXPA04003548A patent/MXPA04003548A/es not_active Application Discontinuation
- 2004-04-15 IS IS7223A patent/IS7223A/is unknown
- 2004-05-11 ZA ZA200403601A patent/ZA200403601B/en unknown
- 2004-05-13 ZA ZA200403690A patent/ZA200403690B/xx unknown
- 2004-05-14 NO NO20041996A patent/NO20041996D0/no not_active Application Discontinuation
- 2004-05-14 NO NO20041997A patent/NO20041997D0/no not_active Application Discontinuation
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2005
- 2005-09-16 JP JP2005271191A patent/JP2006008704A/ja not_active Withdrawn
- 2005-09-16 JP JP2005271219A patent/JP2006008706A/ja active Pending
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2009
- 2009-10-09 JP JP2009235793A patent/JP2010006839A/ja not_active Withdrawn
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