JP2007532486A5 - - Google Patents

Info

Publication number

JP2007532486A5

JP2007532486A5 JP2007504145A JP2007504145A JP2007532486A5 JP 2007532486 A5 JP2007532486 A5 JP 2007532486A5 JP 2007504145 A JP2007504145 A JP 2007504145A JP 2007504145 A JP2007504145 A JP 2007504145A JP 2007532486 A5 JP2007532486 A5 JP 2007532486A5

Authority

JP

Japan

Prior art keywords

tfpi

composition

analog

administration

ala

Prior art date

2005-03-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000000203 mixture Substances 0.000 claims 58
• 102100030951 Tissue factor pathway inhibitor Human genes 0.000 claims 53
• 108010013555 lipoprotein-associated coagulation inhibitor Proteins 0.000 claims 53
• 239000003146 anticoagulant agent Substances 0.000 claims 7
• 229940127219 anticoagulant drug Drugs 0.000 claims 7
• 238000009472 formulation Methods 0.000 claims 7
• ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims 6
• FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 6
• 206010035664 Pneumonia Diseases 0.000 claims 6
• 229930182817 methionine Natural products 0.000 claims 6
• NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims 6
• 239000001509 sodium citrate Substances 0.000 claims 6
• 150000001413 amino acids Chemical class 0.000 claims 5
• 229930064664 L-arginine Natural products 0.000 claims 4
• 235000014852 L-arginine Nutrition 0.000 claims 4
• 229940024606 amino acid Drugs 0.000 claims 4
• 235000001014 amino acid Nutrition 0.000 claims 4
• 238000001802 infusion Methods 0.000 claims 4
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 2
• 239000005557 antagonist Substances 0.000 claims 2
• 229960003589 arginine hydrochloride Drugs 0.000 claims 2
• 239000000872 buffer Substances 0.000 claims 2
• 229920000669 heparin Polymers 0.000 claims 2
• 239000003112 inhibitor Substances 0.000 claims 2
• 238000001990 intravenous administration Methods 0.000 claims 2
• 239000000126 substance Substances 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 239000004475 Arginine Substances 0.000 claims 1
• KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
• 108090000695 Cytokines Proteins 0.000 claims 1
• 102000004127 Cytokines Human genes 0.000 claims 1
• 229940124790 IL-6 inhibitor Drugs 0.000 claims 1
• 108010002352 Interleukin-1 Proteins 0.000 claims 1
• 108090001005 Interleukin-6 Proteins 0.000 claims 1
• 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
• 102100028123 Macrophage colony-stimulating factor 1 Human genes 0.000 claims 1
• 101710190786 PI protein Proteins 0.000 claims 1
• 102000002262 Thromboplastin Human genes 0.000 claims 1
• 108010000499 Thromboplastin Proteins 0.000 claims 1
• 239000003242 anti bacterial agent Substances 0.000 claims 1
• 229940088710 antibiotic agent Drugs 0.000 claims 1
• -1 antibodies Substances 0.000 claims 1
• 239000000427 antigen Substances 0.000 claims 1
• 102000036639 antigens Human genes 0.000 claims 1
• 108091007433 antigens Proteins 0.000 claims 1
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
• 235000009697 arginine Nutrition 0.000 claims 1
• 229960003121 arginine Drugs 0.000 claims 1
• 230000003115 biocidal effect Effects 0.000 claims 1
• 230000021164 cell adhesion Effects 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 230000000295 complement effect Effects 0.000 claims 1
• 239000004074 complement inhibitor Substances 0.000 claims 1
• 239000002158 endotoxin Substances 0.000 claims 1
• 239000002532 enzyme inhibitor Substances 0.000 claims 1
• 229940125532 enzyme inhibitor Drugs 0.000 claims 1
• 229960002897 heparin Drugs 0.000 claims 1
• 229960001438 immunostimulant agent Drugs 0.000 claims 1
• 239000003022 immunostimulating agent Substances 0.000 claims 1
• 230000003308 immunostimulating effect Effects 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 238000010253 intravenous injection Methods 0.000 claims 1
• 230000014508 negative regulation of coagulation Effects 0.000 claims 1
• 208000026425 severe pneumonia Diseases 0.000 claims 1
• 229940046728 tumor necrosis factor alpha inhibitor Drugs 0.000 claims 1
• 239000002451 tumor necrosis factor inhibitor Substances 0.000 claims 1