DK1602667T3 - Vandig formulering omfattende TFPI og solubiliseringsmidler - Google Patents
Vandig formulering omfattende TFPI og solubiliseringsmidlerInfo
- Publication number
- DK1602667T3 DK1602667T3 DK05076848T DK05076848T DK1602667T3 DK 1602667 T3 DK1602667 T3 DK 1602667T3 DK 05076848 T DK05076848 T DK 05076848T DK 05076848 T DK05076848 T DK 05076848T DK 1602667 T3 DK1602667 T3 DK 1602667T3
- Authority
- DK
- Denmark
- Prior art keywords
- ion
- tfpi
- solubilizers
- aqueous formulation
- sulfate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/09—Mashed or comminuted products, e.g. pulp, purée, sauce, or products made therefrom, e.g. snacks
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/10—Products from fruits or vegetables; Preparation or treatment thereof of tuberous or like starch containing root crops
- A23L19/12—Products from fruits or vegetables; Preparation or treatment thereof of tuberous or like starch containing root crops of potatoes
- A23L19/18—Roasted or fried products, e.g. snacks or chips
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L21/00—Marmalades, jams, jellies or the like; Products from apiculture; Preparation or treatment thereof
- A23L21/10—Marmalades; Jams; Jellies; Other similar fruit or vegetable compositions; Simulated fruit products
- A23L21/15—Marmalades; Jams; Jellies; Other similar fruit or vegetable compositions; Simulated fruit products derived from fruit or vegetable juices
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
- A23L29/212—Starch; Modified starch; Starch derivatives, e.g. esters or ethers
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
- A23L29/212—Starch; Modified starch; Starch derivatives, e.g. esters or ethers
- A23L29/219—Chemically modified starch; Reaction or complexation products of starch with other chemicals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L7/00—Cereal-derived products; Malt products; Preparation or treatment thereof
- A23L7/10—Cereal-derived products
- A23L7/109—Types of pasta, e.g. macaroni or noodles
- A23L7/111—Semi-moist pasta, i.e. containing about 20% of moist; Moist packaged or frozen pasta; Pasta fried or pre-fried in a non-aqueous frying medium, e.g. oil; Packaged pasta to be cooked directly in the package
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L7/00—Cereal-derived products; Malt products; Preparation or treatment thereof
- A23L7/10—Cereal-derived products
- A23L7/161—Puffed cereals, e.g. popcorn or puffed rice
- A23L7/165—Preparation of puffed cereals involving preparation of meal or dough as an intermediate step
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L9/00—Puddings; Cream substitutes; Preparation or treatment thereof
- A23L9/10—Puddings; Dry powder puddings
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L9/00—Puddings; Cream substitutes; Preparation or treatment thereof
- A23L9/20—Cream substitutes
- A23L9/22—Cream substitutes containing non-milk fats but no proteins other than milk proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P20/00—Coating of foodstuffs; Coatings therefor; Making laminated, multi-layered, stuffed or hollow foodstuffs
- A23P20/10—Coating with edible coatings, e.g. with oils or fats
- A23P20/12—Apparatus or processes for applying powders or particles to foodstuffs, e.g. for breading; Such apparatus combined with means for pre-moistening or battering
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47767795A | 1995-06-07 | 1995-06-07 | |
US47366895A | 1995-06-07 | 1995-06-07 | |
PCT/US1996/009980 WO1996040784A2 (en) | 1995-06-07 | 1996-06-07 | Method of solubilizing, purifying, and refolding protein |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1602667T3 true DK1602667T3 (da) | 2007-07-23 |
Family
ID=27044215
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK96924269T DK0837883T3 (da) | 1995-06-07 | 1996-06-07 | Fremgangsmåde til oplösning, oprensning og genfoldning af protein |
DK05076848T DK1602667T3 (da) | 1995-06-07 | 1996-06-07 | Vandig formulering omfattende TFPI og solubiliseringsmidler |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK96924269T DK0837883T3 (da) | 1995-06-07 | 1996-06-07 | Fremgangsmåde til oplösning, oprensning og genfoldning af protein |
Country Status (10)
Country | Link |
---|---|
US (5) | US6323326B1 (da) |
EP (2) | EP0837883B1 (da) |
JP (4) | JPH11514334A (da) |
AT (2) | ATE358684T1 (da) |
CA (1) | CA2223745C (da) |
DE (2) | DE69635051T2 (da) |
DK (2) | DK0837883T3 (da) |
ES (2) | ES2248818T3 (da) |
PT (1) | PT1602667E (da) |
WO (1) | WO1996040784A2 (da) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH11514334A (ja) * | 1995-06-07 | 1999-12-07 | チロン コーポレーション | タンパク質の可溶化、精製、および再生の方法 |
US5914390A (en) * | 1997-05-12 | 1999-06-22 | Celtrix Pharmaceuticals, Inc. | Methods for increasing yields of recombinant proteins |
BR0014486A (pt) | 1999-10-04 | 2002-09-17 | Chiron Corp | Composições farmacêuticas contendo polipeptìdeo lìquido estabilizado |
WO2003014736A1 (en) * | 2001-08-10 | 2003-02-20 | Meditech Reserach Limited | Biological molecules comprising glycosaminoglycans |
US7186539B1 (en) | 2001-08-31 | 2007-03-06 | Pharmacia & Upjohn Company | Method for refolding enzymes |
AU2002365131B2 (en) * | 2001-10-15 | 2007-03-01 | Novartis Vaccines And Diagnostics, Inc. | Treatment of sepsis by low dose administration of tissue factor pathway inhibitor (TFPI) |
EP1314739A1 (en) * | 2001-11-22 | 2003-05-28 | Bayer Ag | Process for renaturation of recombinant, disulfide containing proteins at high protein concentrations in the presence of amines |
EP1572904B1 (en) * | 2002-02-21 | 2009-04-15 | Pharmacia & Upjohn Company LLC | Modified bace |
CA2512680A1 (en) * | 2003-01-08 | 2004-07-29 | Chiron Corporation | Stabilized lyophilized compositions comprising tissue factor pathway inhibitor or tissue factor pathway inhibitor variants |
AU2004204720B2 (en) * | 2003-01-08 | 2009-08-06 | Novartis Vaccines And Diagnostics, Inc. | Stabilized aqueous compositions comprising tissue factor pathway inhibitor (TFPI) or tissue factor pathway inhibitor variant |
EP1803445A3 (en) * | 2003-01-08 | 2007-11-21 | Novartis Vaccines and Diagnostics, Inc. | Stabilized lyophilized compositions comprising tissue factor pathway inhibitor or tissue factor pathway inhibitor variants |
DE10333317A1 (de) * | 2003-07-22 | 2005-02-17 | Biotecon Therapeutics Gmbh | Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA) |
CA2535562A1 (en) * | 2003-08-13 | 2005-03-03 | Chiron Corporation | Improved method of purifying tfpi and tfpi analogs |
BRPI0508992A (pt) * | 2004-03-17 | 2007-09-04 | Chiron Corp | tratamento de pneumonia severa pela administração de tfpi |
US7148067B2 (en) * | 2004-08-31 | 2006-12-12 | The Board Of Trustees Of The University Of Illinois | Thromboplastin reagents |
JP2008530208A (ja) * | 2005-02-16 | 2008-08-07 | ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ | 万能前凝固薬 |
DE602006021290D1 (de) * | 2005-03-04 | 2011-05-26 | Univ Illinois | Modulator von coagulationskaskaden und fibrinolytischen kaskaden |
US20070021591A1 (en) * | 2005-07-25 | 2007-01-25 | Trubion Pharmaceuticals, Inc. | Compositions and methods for protein deaggregation |
WO2007081534A2 (en) * | 2005-12-22 | 2007-07-19 | Pfizer Products Inc | Method of producing catalytically active bace2 enzymes |
JP5274795B2 (ja) * | 2006-07-27 | 2013-08-28 | 三洋化成工業株式会社 | タンパク質のリフォールディング方法 |
US20080083672A1 (en) * | 2006-10-10 | 2008-04-10 | Xing Dong | Adsorbent composition and method of making same |
WO2008124134A2 (en) * | 2007-04-05 | 2008-10-16 | Barofold, Inc. | High-pressure refolding of proteins in the presence of binding partners |
US8821861B2 (en) * | 2007-10-05 | 2014-09-02 | The Board Of Trustees Of The University Of Illinois | Fibrin sealant |
WO2009061697A1 (en) * | 2007-11-09 | 2009-05-14 | The Board Of Trustees Of The University Of Illinois | Anticoagulant antagonist and hemophilia procoagulant |
WO2010150708A1 (ja) * | 2009-06-22 | 2010-12-29 | 株式会社メディネット | 蛋白質の修飾剤 |
EP2935323A4 (en) * | 2012-12-21 | 2016-05-25 | Merck Sharp & Dohme | COLLAR FILLING AND PURIFICATION OF LIPOPROTEINS |
WO2018181876A1 (ja) | 2017-03-31 | 2018-10-04 | Meiji Seikaファルマ株式会社 | 水性製剤及び注射器入り水性製剤、並びに、抗体タンパク脱凝集剤及び抗体タンパク脱凝集方法 |
JP2021080169A (ja) * | 2018-02-09 | 2021-05-27 | Spiber株式会社 | 組換えタンパク質の製造方法 |
CN108373494A (zh) * | 2018-02-27 | 2018-08-07 | 武汉伊艾博科技有限公司 | 一种防止重组蛋白质降解的保护技术 |
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DE3325223A1 (de) | 1983-07-13 | 1985-01-24 | Hoechst Ag, 6230 Frankfurt | Gegen denaturierung bestaendige, waessrige proteinloesungen, verfahren zu ihrer herstellung und ihre verwendung |
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DE4126983A1 (de) | 1991-08-15 | 1993-02-18 | Boehringer Mannheim Gmbh | Verfahren zur herstellung von humanprotein-enthaltenden, konservierten arzneimitteln fuer infusions- oder injektionszwecke |
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US5276015A (en) | 1992-03-18 | 1994-01-04 | Washington University | Method of inhibiting microvascular thrombosis |
KR950701820A (ko) | 1992-06-11 | 1995-05-17 | 로저 에이. 윌리암스 | 패혈증 및 패혈증-연관 옹고장애의 예방 및 치료(prophylaxs and treatment of sepsis and sepsis-associated coagulation disorders) |
US5358708A (en) | 1993-01-29 | 1994-10-25 | Schering Corporation | Stabilization of protein formulations |
JP3428687B2 (ja) * | 1993-06-30 | 2003-07-22 | 財団法人化学及血清療法研究所 | 組織因子凝固系インヒビターの調製法 |
US5407810A (en) * | 1993-08-20 | 1995-04-18 | Genentech, Inc. | Aqueous multiple-phase isolation of polypeptide |
WO1996001649A1 (en) | 1994-07-07 | 1996-01-25 | Washington University | Method of attenuating arterial stenosis |
AU707762B2 (en) * | 1994-08-05 | 1999-07-22 | Novartis Vaccines And Diagnostics, Inc. | Production of tissue factor pathway inhibitor |
JPH11514334A (ja) * | 1995-06-07 | 1999-12-07 | チロン コーポレーション | タンパク質の可溶化、精製、および再生の方法 |
CA2535562A1 (en) * | 2003-08-13 | 2005-03-03 | Chiron Corporation | Improved method of purifying tfpi and tfpi analogs |
-
1996
- 1996-06-07 JP JP9502126A patent/JPH11514334A/ja active Pending
- 1996-06-07 WO PCT/US1996/009980 patent/WO1996040784A2/en active IP Right Grant
- 1996-06-07 DK DK96924269T patent/DK0837883T3/da active
- 1996-06-07 CA CA002223745A patent/CA2223745C/en not_active Expired - Fee Related
- 1996-06-07 DE DE69635051T patent/DE69635051T2/de not_active Expired - Lifetime
- 1996-06-07 ES ES96924269T patent/ES2248818T3/es not_active Expired - Lifetime
- 1996-06-07 EP EP96924269A patent/EP0837883B1/en not_active Expired - Lifetime
- 1996-06-07 AT AT05076848T patent/ATE358684T1/de not_active IP Right Cessation
- 1996-06-07 ES ES05076848T patent/ES2285632T3/es not_active Expired - Lifetime
- 1996-06-07 DK DK05076848T patent/DK1602667T3/da active
- 1996-06-07 US US08/973,211 patent/US6323326B1/en not_active Expired - Fee Related
- 1996-06-07 EP EP05076848A patent/EP1602667B1/en not_active Expired - Lifetime
- 1996-06-07 PT PT05076848T patent/PT1602667E/pt unknown
- 1996-06-07 DE DE69637012T patent/DE69637012T2/de not_active Expired - Lifetime
- 1996-06-07 AT AT96924269T patent/ATE301675T1/de not_active IP Right Cessation
-
1999
- 1999-11-18 US US09/443,098 patent/US6319896B1/en not_active Expired - Fee Related
-
2001
- 2001-11-30 US US09/996,588 patent/US7022672B2/en not_active Expired - Fee Related
-
2003
- 2003-09-18 JP JP2003326585A patent/JP2004083591A/ja not_active Withdrawn
-
2004
- 2004-06-23 JP JP2004184539A patent/JP2004315541A/ja not_active Withdrawn
-
2006
- 2006-01-24 US US11/337,518 patent/US7226757B2/en not_active Expired - Fee Related
-
2007
- 2007-04-05 US US11/697,188 patent/US20080281084A1/en not_active Abandoned
- 2007-10-25 JP JP2007277137A patent/JP2008115176A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US6323326B1 (en) | 2001-11-27 |
CA2223745A1 (en) | 1996-12-19 |
PT1602667E (pt) | 2007-07-13 |
JP2004083591A (ja) | 2004-03-18 |
ATE358684T1 (de) | 2007-04-15 |
EP0837883A2 (en) | 1998-04-29 |
JP2004315541A (ja) | 2004-11-11 |
WO1996040784A3 (en) | 1997-03-13 |
US6319896B1 (en) | 2001-11-20 |
JPH11514334A (ja) | 1999-12-07 |
WO1996040784A2 (en) | 1996-12-19 |
US20080281084A1 (en) | 2008-11-13 |
US7022672B2 (en) | 2006-04-04 |
US20060128947A1 (en) | 2006-06-15 |
DK0837883T3 (da) | 2005-12-19 |
JP2008115176A (ja) | 2008-05-22 |
CA2223745C (en) | 2004-03-16 |
DE69635051D1 (de) | 2005-09-15 |
US7226757B2 (en) | 2007-06-05 |
ATE301675T1 (de) | 2005-08-15 |
DE69637012D1 (de) | 2007-05-16 |
US20020137884A1 (en) | 2002-09-26 |
EP1602667A1 (en) | 2005-12-07 |
EP0837883B1 (en) | 2005-08-10 |
ES2248818T3 (es) | 2006-03-16 |
EP1602667B1 (en) | 2007-04-04 |
DE69635051T2 (de) | 2006-06-14 |
DE69637012T2 (de) | 2009-01-08 |
ES2285632T3 (es) | 2007-11-16 |
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