BR9914735A - Processo para tratamento de sépsia - Google Patents
Processo para tratamento de sépsiaInfo
- Publication number
- BR9914735A BR9914735A BR9914735-1A BR9914735A BR9914735A BR 9914735 A BR9914735 A BR 9914735A BR 9914735 A BR9914735 A BR 9914735A BR 9914735 A BR9914735 A BR 9914735A
- Authority
- BR
- Brazil
- Prior art keywords
- protein
- sepsis
- treatment
- bpi
- provides
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A61K38/1751—Bactericidal/permeability-increasing protein [BPI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4866—Protein C (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Marine Sciences & Fisheries (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Patente de Invenção: <B>"PROCESSO PARA TRATAMENTO DE SEPSIA"<D>. A presente invenção proporciona um processo de tratamento para pacientes com sepsia. O tratamento reivindicado é uma terapia de combinação com proteína C e proteína BPI. Combinando proteína C com suas propriedades anticoagulante/antiinflamatórias e BPI com atividades neutralizantes bactericidas e endotoxinas, proporciona uma terapia eficaz, sinérgica para sepsia que reduzirá ou melhorará os eventos adversos e melhorará o resultado clínico dos pacientes sépticos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10523998P | 1998-10-22 | 1998-10-22 | |
PCT/US1999/024409 WO2000023101A1 (en) | 1998-10-22 | 1999-10-15 | Methods for treating sepsis |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9914735A true BR9914735A (pt) | 2001-07-03 |
Family
ID=22304754
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9914735-1A BR9914735A (pt) | 1998-10-22 | 1999-10-15 | Processo para tratamento de sépsia |
Country Status (9)
Country | Link |
---|---|
US (2) | US6344197B2 (pt) |
EP (1) | EP1124573A1 (pt) |
JP (1) | JP2002527490A (pt) |
CN (1) | CN1324244A (pt) |
AU (1) | AU768075B2 (pt) |
BR (1) | BR9914735A (pt) |
CA (1) | CA2347250A1 (pt) |
IL (1) | IL142248A0 (pt) |
WO (1) | WO2000023101A1 (pt) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4746741B2 (ja) * | 2000-12-14 | 2011-08-10 | キヤノン株式会社 | 放射線撮像装置及びシステム |
US7605130B2 (en) * | 2002-03-26 | 2009-10-20 | Medical College Of Ohio | Albumin-based colloid composition and method of use in treating hypovolemia and multiorgan dysfunction |
US7037895B2 (en) * | 2001-03-27 | 2006-05-02 | Medical College Of Ohio | Albumin-based colloid composition and method of use in treating hypovolemia and multiorgan dysfunction |
US20040198652A1 (en) * | 2001-04-24 | 2004-10-07 | Carter J. Paul | Methods and compositions for preventing and treating septic shock and endotoxemia |
US20030055003A1 (en) * | 2001-07-19 | 2003-03-20 | David Bar-Or | Use of copper chelators to inhibit the inactivation of protein C |
US6838432B2 (en) * | 2001-09-19 | 2005-01-04 | Oklahoma Medical Research Foundation | Treatment of sepsis with TAFI |
BR0213292A (pt) | 2001-10-15 | 2006-05-23 | Chiron Corp | tratamento de pneumonia severa por administração de inibidor da via de fator tecidual (tfpi) |
US7345150B2 (en) * | 2002-03-26 | 2008-03-18 | Medical University Of Toledo | Albumin-based colloid composition having at least one protected thiol region, methods of making, and methods of use |
US7884068B2 (en) * | 2002-03-26 | 2011-02-08 | Assaly Ragheb A | Albumin-based colloid composition having at least one protected thiol region, methods of making, and methods of use |
US20070142272A1 (en) * | 2003-01-24 | 2007-06-21 | Zlokovic Berislav V | Neuroprotective activity of activated protein c independent of its anticoagulant activity |
JP4607010B2 (ja) * | 2003-02-28 | 2011-01-05 | 中外製薬株式会社 | タンパク質含有安定化製剤 |
JP4768620B2 (ja) * | 2003-05-15 | 2011-09-07 | ジェネンテック, インコーポレイテッド | 敗血症の予防及び治療のための方法及び組成物 |
EP1673465A4 (en) * | 2003-09-29 | 2008-04-30 | Biosite Inc | PROCESS AND COMPOSITIONS FOR SEPSIS DIAGNOSIS |
US20050148029A1 (en) * | 2003-09-29 | 2005-07-07 | Biosite, Inc. | Methods and compositions for determining treatment regimens in systemic inflammatory response syndromes |
CA2560103A1 (en) * | 2004-03-17 | 2005-11-24 | Chiron Corporation | Treatment of severe community-acquired pneumonia by administration of tissue factor pathway inhibitor (tfpi) |
CA2574598A1 (en) * | 2004-07-23 | 2006-02-09 | The University Of Rochester | Activated protein c inhibits undesirable effects of plasminogen activator in the brain |
US20100284997A1 (en) * | 2006-10-31 | 2010-11-11 | Griffin John H | Dosing regimen of activated protein c and variants having reduced anticoagulant activity |
JP5583575B2 (ja) * | 2007-03-28 | 2014-09-03 | ユニベルシダード デ バルセロナ | 感染症と関連炎症過程の治療のためのタンパク質生成物 |
US20090270497A1 (en) * | 2008-04-24 | 2009-10-29 | Pharmacyclics, Inc. | Treatment of Non-Localized Inflammation with pan-HDAC Inhibitors |
WO2013151910A1 (en) * | 2012-04-02 | 2013-10-10 | Saint Louis University | Methods and compositions for reducing the incidence of post-surgical adhesions |
CA3044334A1 (en) | 2016-11-18 | 2018-05-24 | Institut D'investigacions Biomediques August Pi I Sunyer- Idibaps | Combined cd6 and imipenem therapy for treatment of infectious diseases and related inflammatory processes |
EP4201420A1 (en) * | 2021-12-21 | 2023-06-28 | Universität Regensburg | Non-human bactericidal/permeability-increasing protein (bpi) for therapy of infections |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4775624A (en) | 1985-02-08 | 1988-10-04 | Eli Lilly And Company | Vectors and compounds for expression of human protein C |
US5516650A (en) | 1985-06-27 | 1996-05-14 | Zymogenetics, Inc. | Production of activated protein C |
US5550036A (en) | 1986-04-09 | 1996-08-27 | Eli Lilly And Company | Method for co-amplification of human protein C genes in human cells |
US5198541A (en) | 1987-08-11 | 1993-03-30 | New York University | Dna encoding bactericidal/permeability-increasing proteins |
US4992373A (en) | 1987-12-04 | 1991-02-12 | Eli Lilly And Company | Vectors and compounds for direct expression of activated human protein C |
US5009889A (en) * | 1987-12-31 | 1991-04-23 | Oklahoma Medical Research Foundation | Treatment of dysfunctional vascular endothelium using activated protein C |
US4981952A (en) | 1988-10-04 | 1991-01-01 | Eli Lilly And Company | Method for the purification of vitamin K-dependent proteins |
US5093117A (en) * | 1989-01-24 | 1992-03-03 | Baxter International Inc. | Compositions and method for the treatment or prophylaxis of sepsis or septic shock |
US5308834A (en) | 1989-02-14 | 1994-05-03 | Incyte Pharmaceuticals, Inc. | Treatment of endotoxin-associated shock and prevention thereof using a BPI protein |
US5089274A (en) * | 1989-02-14 | 1992-02-18 | Incyte Pharmaceuticals, Inc. | Use of bactericidal/permeability increasing protein or biologically active analogs thereof to treat endotoxin-related disorders |
US5171739A (en) | 1989-02-14 | 1992-12-15 | Incyte Pharmaceuticals, Inc. | Treatment of endotoxin-associated shock and preventation thereof using a BPI protein |
US5627262A (en) | 1989-07-05 | 1997-05-06 | The Board Of Regents Of The University Of Oklahoma | Method and composition for the treatment of septic shock |
US5607916A (en) | 1989-07-05 | 1997-03-04 | The Board Of Regents Of The University Of Oklahoma | Method and composition for the treatment of septic shock |
IL97312A (en) | 1990-02-23 | 1999-01-26 | Lilly Co Eli | A method of generating a polypeptide in an eukaryotic vector AND recombinant surrogate cell containing an enhanced transcriptional control unit based on the primary late adenovirus coefficient |
AT402262B (de) | 1991-06-20 | 1997-03-25 | Immuno Ag | Arzneimittel enthaltend aktiviertes protein c |
MY110664A (en) | 1992-05-21 | 1999-01-30 | Lilly Co Eli | Protein c derivatives |
US5733872A (en) | 1993-03-12 | 1998-03-31 | Xoma Corporation | Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof |
US5643875A (en) | 1994-01-24 | 1997-07-01 | Friedmann; Nadav | Human therapeutic uses of bactericidal/permeability increasing (BPI) protein products |
WO1997020043A1 (en) | 1995-11-30 | 1997-06-05 | Zymogenetics, Inc. | Protein c production in transgenic animals |
CA2255539C (en) | 1996-05-23 | 2005-09-27 | Xoma Corporation | Therapeutic uses of bpi protein products in humans with hemorrhage due to trauma |
HUP0001237A3 (en) | 1997-10-20 | 2002-01-28 | Lilly Co Eli | Methods for treating vascular disorders |
-
1999
- 1999-10-15 CN CN99812519A patent/CN1324244A/zh active Pending
- 1999-10-15 CA CA002347250A patent/CA2347250A1/en not_active Abandoned
- 1999-10-15 EP EP99970606A patent/EP1124573A1/en not_active Withdrawn
- 1999-10-15 AU AU12117/00A patent/AU768075B2/en not_active Ceased
- 1999-10-15 WO PCT/US1999/024409 patent/WO2000023101A1/en active IP Right Grant
- 1999-10-15 BR BR9914735-1A patent/BR9914735A/pt not_active IP Right Cessation
- 1999-10-15 JP JP2000576874A patent/JP2002527490A/ja not_active Withdrawn
- 1999-10-15 IL IL14224899A patent/IL142248A0/xx unknown
- 1999-10-22 US US09/425,181 patent/US6344197B2/en not_active Expired - Fee Related
-
2001
- 2001-11-02 US US09/998,393 patent/US20020044929A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20020044929A1 (en) | 2002-04-18 |
AU768075B2 (en) | 2003-12-04 |
JP2002527490A (ja) | 2002-08-27 |
US6344197B2 (en) | 2002-02-05 |
CA2347250A1 (en) | 2000-04-27 |
US20010006806A1 (en) | 2001-07-05 |
WO2000023101A1 (en) | 2000-04-27 |
EP1124573A1 (en) | 2001-08-22 |
CN1324244A (zh) | 2001-11-28 |
IL142248A0 (en) | 2002-03-10 |
AU1211700A (en) | 2000-05-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A, 7A E 8A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1913 DE 04/09/2007. |