BR9811946A - Método para prevenção ou tratamento de distúrbios e doenças dependentes de estrogênio - Google Patents
Método para prevenção ou tratamento de distúrbios e doenças dependentes de estrogênioInfo
- Publication number
- BR9811946A BR9811946A BR9811946-0A BR9811946A BR9811946A BR 9811946 A BR9811946 A BR 9811946A BR 9811946 A BR9811946 A BR 9811946A BR 9811946 A BR9811946 A BR 9811946A
- Authority
- BR
- Brazil
- Prior art keywords
- diseases
- preventing
- estrogen
- dependent disorders
- treating estrogen
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 4
- 230000001419 dependent effect Effects 0.000 title abstract 3
- 229940011871 estrogen Drugs 0.000 title abstract 3
- 239000000262 estrogen Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000035475 disorder Diseases 0.000 title 1
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 229940046836 anti-estrogen Drugs 0.000 abstract 1
- 230000001833 anti-estrogenic effect Effects 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 239000000328 estrogen antagonist Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Patente de Invenção: <B>"MéTODO PARA PREVENçãO OU TRATAMENTO DE DISTúRBIOS E DOENçAS DEPENDENTES DE ESTROGêNIO"<D>. A presente invenção refere-se, em geral, ao tratamento do doenças e distúrbios dependentes de estrogênio e, em particular, a um método para tratamento de cânceres dependentes de estrogênio, particularmente câncer de mama, com antiestrogênios.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5588197P | 1997-08-15 | 1997-08-15 | |
PCT/US1998/016864 WO1999008682A1 (en) | 1997-08-15 | 1998-08-14 | A method of preventing or treating estrogen-dependent diseases and disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9811946A true BR9811946A (pt) | 2000-08-22 |
Family
ID=22000784
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9811946-0A BR9811946A (pt) | 1997-08-15 | 1998-08-14 | Método para prevenção ou tratamento de distúrbios e doenças dependentes de estrogênio |
Country Status (21)
Country | Link |
---|---|
US (1) | US7307102B2 (pt) |
EP (1) | EP1019057B1 (pt) |
JP (1) | JP2001515038A (pt) |
KR (1) | KR20010022956A (pt) |
CN (1) | CN1275911A (pt) |
AT (1) | ATE411016T1 (pt) |
AU (1) | AU757206B2 (pt) |
BR (1) | BR9811946A (pt) |
CA (1) | CA2301032C (pt) |
CZ (1) | CZ300929B6 (pt) |
DE (1) | DE69840126D1 (pt) |
EE (1) | EE200000077A (pt) |
ES (1) | ES2312189T3 (pt) |
HU (1) | HUP0002852A3 (pt) |
IL (1) | IL134445A0 (pt) |
NO (1) | NO20000752L (pt) |
NZ (1) | NZ502738A (pt) |
PL (1) | PL338555A1 (pt) |
RU (1) | RU2214236C2 (pt) |
UA (1) | UA70925C2 (pt) |
WO (1) | WO1999008682A1 (pt) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6413533B1 (en) * | 1998-05-07 | 2002-07-02 | The University Of Tennessee Research Corporation | Method for chemoprevention of prostate cancer |
CA2334545A1 (en) * | 1998-06-12 | 1999-12-16 | Ligand Pharmaceuticals Incorporated | Treatment of anti-estrogen resistant breast cancer using rxr modulators |
GB9824207D0 (en) * | 1998-11-04 | 1998-12-30 | Zeneca Ltd | Neurological disorders |
TWI359015B (en) * | 1999-07-06 | 2012-03-01 | Endorech Inc | Pharmaceutical composition for treatment or preve |
CO5271709A1 (es) | 2000-01-12 | 2003-04-30 | Pfizer Prod Inc | Composiciones y procedimientos para el y tratamiento de afecciones que responden a estrogenos |
US6417394B2 (en) * | 2000-04-05 | 2002-07-09 | Bristol Myers Squibb Pharma Company | Specific salt forms of triphenylethylene derivatives as selective estrogen receptor modulators |
US6528681B2 (en) * | 2000-04-05 | 2003-03-04 | Bristol-Meyers Squibb Pharma Company | Halogenated triphenylethylene derivatives as selective estrogen receptor modulators |
AU2001272249A1 (en) * | 2000-07-05 | 2002-01-14 | Andrew J. E. Seely | Method and apparatus for multiple patient parameter variability analysis and display |
ATE415161T1 (de) * | 2001-02-15 | 2008-12-15 | Janssen Pharmaceutica Nv | Farnesyl-protein-transferase hemmer in kombination mit antiöstrogenen |
US20020164581A1 (en) * | 2001-03-12 | 2002-11-07 | Chawnshang Chang | Methods for identifying compounds that do not attenuate the protective effects of estrogen |
WO2003016270A2 (en) | 2001-08-11 | 2003-02-27 | Bristol-Myers Squibb Pharma Company | Selective estrogen receptor modulators |
KR100862930B1 (ko) | 2004-06-23 | 2008-10-13 | 시리온 테라퓨틱스, 인크. | 레티닐 유도체를 사용하여 안 증상을 치료하기 위한 방법및 조성물 |
JP2008519054A (ja) | 2004-11-04 | 2008-06-05 | シリオン セラピューティクス, インコーポレイテッド | レチノール−レチノール結合タンパク質(rbp)−トランスチレチン(ttr)複合体の形成のモジュレーター |
SG144145A1 (en) * | 2004-12-08 | 2008-07-29 | Sirion Therapeutics Inc | Methods, assays and compositions for treating retinol-related diseases |
US20060264413A1 (en) * | 2005-04-18 | 2006-11-23 | Sri International | Method and composition for inhibiting cell proliferation and angiogenesis |
UA81382C2 (en) * | 2005-07-11 | 2007-12-25 | Composition for treating retinol-related diseases by modulation of retinol binding | |
JP2010540127A (ja) * | 2007-10-03 | 2010-12-24 | オタワ ヘルス リサーチ インスティチュート | 1つ以上の臓器の経時的生理的パラメータ変動を監視するための方法および装置 |
WO2009151683A2 (en) | 2008-03-12 | 2009-12-17 | Link Medicine Corporation | Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications |
BRPI0920927A2 (pt) | 2008-11-13 | 2019-09-24 | Link Medicine Corp | derivados de azaquinolinona e usos dos mesmos |
CA2800673A1 (en) | 2010-06-10 | 2011-12-15 | Aragon Pharmaceuticals, Inc. | Estrogen receptor modulators and uses thereof |
WO2011159769A2 (en) | 2010-06-17 | 2011-12-22 | Aragon Pharmaceuticals, Inc. | Indane estrogen receptor modulators and uses thereof |
GB2483736B (en) | 2010-09-16 | 2012-08-29 | Aragon Pharmaceuticals Inc | Estrogen receptor modulators and uses thereof |
WO2013090836A1 (en) | 2011-12-14 | 2013-06-20 | Aragon Pharmaceuticals, Inc. | Fluorinated estrogen receptor modulators and uses thereof |
CN102584687A (zh) * | 2011-12-30 | 2012-07-18 | 北京赛林泰医药技术有限公司 | 作为选择性雌激素受体调节剂的乙烯衍生物 |
CN102532073A (zh) * | 2011-12-30 | 2012-07-04 | 北京赛林泰医药技术有限公司 | 作为选择性雌激素受体调节剂的乙烯衍生物 |
EA201491530A1 (ru) | 2012-03-20 | 2015-07-30 | Серагон Фармасьютикалс, Инк. | Модуляторы рецепторов эстрогенов и их применение |
RU2747802C2 (ru) * | 2015-12-09 | 2021-05-14 | Зе Боард Оф Трастис Оф Зе Юниверсити Оф Иллинойс | Бензотиофеновые селективные блокаторы эстрогеновых рецепторов |
EP3658527A4 (en) * | 2017-07-28 | 2021-04-07 | Recurium IP Holdings, LLC | ACRYLIC ACID ANALOGUES |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE637389A (pt) | 1962-09-13 | |||
GB1029221A (en) | 1963-09-02 | 1966-05-11 | Ici Ltd | Triarylalkane derivatives |
GB1079747A (en) | 1965-07-07 | 1967-08-16 | Ici Ltd | Alkene derivatives |
US3637856A (en) | 1965-07-12 | 1972-01-25 | Ici Ltd | Trans-1-p-(dialkylaminoalkyl) phenyl-1 2-diphenyl-alk-1-enes and salts thereof |
GB1128379A (en) | 1966-06-20 | 1968-09-25 | Ici Ltd | Novel alkene derivatives, process for the preparation thereof and compositions containing the same |
GB1560274A (en) | 1977-02-28 | 1980-02-06 | Ici Ltd | Phenylbut 1-ene derivatives having antiostrogenicactivity |
EP0002097B1 (en) | 1977-08-22 | 1981-08-05 | Imperial Chemical Industries Plc | Triphenylalkene derivatives, process for their preparation and pharmaceutical compositions containing them |
US4206234A (en) | 1977-08-22 | 1980-06-03 | Imperial Chemical Industries Limited | Triphenylbut-1-ene derivatives and pharmaceutical compositions and uses thereof |
ATE1418T1 (de) | 1979-05-15 | 1982-08-15 | Imperial Chemical Industries Plc | 1-hydrocarbyloxyphenyl-1.2-diphenylalkenderivate, ihre herstellung und sie enthaltende pharmazeutische zusammensetzung. |
HU178253B (en) | 1979-08-15 | 1982-04-28 | Gyogyszerkutato Intezet | Process for preparing 1,1,2-triphenyl-propane and -propane derivatives |
DE3046719C2 (de) | 1980-12-11 | 1983-02-17 | Klinge Pharma GmbH, 8000 München | 1,1,2-Triphenyl-but-1-en-Derivate, Verfahren zu ihrer Herstellung und Arzneimittel |
FI77839C (fi) | 1982-05-27 | 1989-05-10 | Farmos Oy | Foerfarande foer framstaellning av nya terapeutiskt effektiva trifenylalkan- och alkenderivat. |
US5491173A (en) * | 1982-06-25 | 1996-02-13 | Orion-Yhtyma Oy | Tri-phenyl alkene derivatives and their preparation and use |
CA1229604A (en) | 1984-02-14 | 1987-11-24 | Lorne J. Brandes | Aminoalkyl ethers of phenols as antiproliferative anticancer agents |
US4760053A (en) | 1984-08-02 | 1988-07-26 | Fernand Labrie | Combination therapy for selected sex steroid dependent cancers |
US4729999A (en) | 1984-10-12 | 1988-03-08 | Bcm Technologies | Antiestrogen therapy for symptoms of estrogen deficiency |
GB8604528D0 (en) | 1986-02-24 | 1986-04-03 | Ici Plc | Therapeutic agents |
US4859695A (en) | 1986-06-10 | 1989-08-22 | Merck & Co., Inc. | Antiestrogen agents having anabolic activity in animals |
CA1289570C (en) | 1986-06-16 | 1991-09-24 | Tetsuji Asao | 1,1,2-triaryl-1-alkene derivatives |
DE3736682A1 (de) | 1987-10-29 | 1989-05-11 | Klinge Co Chem Pharm Fab | Verfahren zur herstellung von trans-1,1,2-triphenyl-but-1-en-derivaten |
US5393785A (en) | 1988-10-31 | 1995-02-28 | Endorecherche, Inc. | Therapeutic antiestrogens |
US5119827A (en) | 1990-09-05 | 1992-06-09 | Board Of Regents, The University Of Texas System | Mechanisms of antiestrogen resistance in breast cancer |
US5189212A (en) | 1990-09-07 | 1993-02-23 | University Of Georgia Research Foundation, Inc. | Triarylethylene carboxylic acids with estrogenic activity |
EP0551434B1 (en) | 1990-10-01 | 1995-11-15 | The Board Of Regents, The University Of Texas System | High affinity tamoxifen derivatives and uses thereof |
EP0589039A1 (en) | 1991-04-30 | 1994-03-30 | Asahi Kasei Kogyo Kabushiki Kaisha | Triphenylethylene derivative and pharmaceutical preparation containing the same |
HUT71244A (en) | 1992-09-15 | 1995-11-28 | Merrell Dow Pharma | Non-metabolizable clomiphene analogs for treatment of tamoxifen-resistant tumors |
DE4311870C2 (de) * | 1993-04-10 | 1998-07-30 | Altramed Holdings Ltd | Verwendung eines Anti-Östrigens zur Therapie und Prophylaxe von Demenz-Erkrankungen |
US5681835A (en) * | 1994-04-25 | 1997-10-28 | Glaxo Wellcome Inc. | Non-steroidal ligands for the estrogen receptor |
US5455275A (en) * | 1994-05-11 | 1995-10-03 | Eli Lilly And Company | Methods for inhibiting endometriosis and uterine fibroid disease with 1,1,2-triphenylbut-1-ene derivatives |
-
1998
- 1998-08-14 EP EP98940886A patent/EP1019057B1/en not_active Expired - Lifetime
- 1998-08-14 UA UA2000020847A patent/UA70925C2/uk unknown
- 1998-08-14 HU HU0002852A patent/HUP0002852A3/hu unknown
- 1998-08-14 CA CA002301032A patent/CA2301032C/en not_active Expired - Fee Related
- 1998-08-14 DE DE69840126T patent/DE69840126D1/de not_active Expired - Fee Related
- 1998-08-14 JP JP2000509421A patent/JP2001515038A/ja active Pending
- 1998-08-14 EE EEP200000077A patent/EE200000077A/xx unknown
- 1998-08-14 CZ CZ20000531A patent/CZ300929B6/cs not_active IP Right Cessation
- 1998-08-14 ES ES98940886T patent/ES2312189T3/es not_active Expired - Lifetime
- 1998-08-14 NZ NZ502738A patent/NZ502738A/en unknown
- 1998-08-14 AU AU89063/98A patent/AU757206B2/en not_active Ceased
- 1998-08-14 AT AT98940886T patent/ATE411016T1/de not_active IP Right Cessation
- 1998-08-14 BR BR9811946-0A patent/BR9811946A/pt not_active IP Right Cessation
- 1998-08-14 IL IL13444598A patent/IL134445A0/xx not_active IP Right Cessation
- 1998-08-14 KR KR1020007001564A patent/KR20010022956A/ko active Search and Examination
- 1998-08-14 WO PCT/US1998/016864 patent/WO1999008682A1/en not_active Application Discontinuation
- 1998-08-14 RU RU2000106448/14A patent/RU2214236C2/ru not_active IP Right Cessation
- 1998-08-14 PL PL98338555A patent/PL338555A1/xx unknown
- 1998-08-14 CN CN98810214A patent/CN1275911A/zh active Pending
-
2000
- 2000-02-15 NO NO20000752A patent/NO20000752L/no not_active Application Discontinuation
-
2003
- 2003-03-18 US US10/390,032 patent/US7307102B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1999008682A1 (en) | 1999-02-25 |
ES2312189T3 (es) | 2009-02-16 |
NZ502738A (en) | 2002-06-28 |
HUP0002852A3 (en) | 2001-11-28 |
PL338555A1 (en) | 2000-11-06 |
NO20000752D0 (no) | 2000-02-15 |
HUP0002852A2 (hu) | 2001-10-28 |
JP2001515038A (ja) | 2001-09-18 |
AU8906398A (en) | 1999-03-08 |
CN1275911A (zh) | 2000-12-06 |
EP1019057B1 (en) | 2008-10-15 |
CZ300929B6 (cs) | 2009-09-16 |
ATE411016T1 (de) | 2008-10-15 |
CA2301032A1 (en) | 1999-02-25 |
EP1019057A4 (en) | 2006-06-14 |
UA70925C2 (uk) | 2004-11-15 |
EP1019057A1 (en) | 2000-07-19 |
KR20010022956A (ko) | 2001-03-26 |
AU757206B2 (en) | 2003-02-06 |
CZ2000531A3 (en) | 2001-05-16 |
CA2301032C (en) | 2009-01-13 |
IL134445A0 (en) | 2001-04-30 |
EE200000077A (et) | 2000-12-15 |
DE69840126D1 (de) | 2008-11-27 |
NO20000752L (no) | 2000-02-15 |
RU2214236C2 (ru) | 2003-10-20 |
US7307102B2 (en) | 2007-12-11 |
US20030232795A1 (en) | 2003-12-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR9811946A (pt) | Método para prevenção ou tratamento de distúrbios e doenças dependentes de estrogênio | |
PT1955700E (pt) | Tratamento terap?utico de doen?as associadas ao receptor de androg?nios | |
BE2012C005I2 (pt) | ||
PT768885E (pt) | Metodo para inibir a metastizacao do cancro por administracao oral de pectina citrica modificada soluvel | |
AU1770299A (en) | Nitric oxide releasing chelating agents and their therapeutic use | |
BR9916879A (pt) | Composição e método para tratamento do câncer utilizando óleos essenciais vegetais naturais | |
MY155218A (en) | Small molecules useful in the treatment of inflammatory disease | |
BR9709942A (pt) | Uso de um composto composição farmacêutica embalagem e processo de tratamento de organismo de animal humano ou não humano para combater ou prevenircondições associadas com a presença de radicais livres no organismo | |
BR0209269A (pt) | Terapia de combinação antiangiogênica para o tratamento de câncer | |
BR9814923A (pt) | Método para tratamento de doença de alzheimer | |
PL330496A1 (en) | Methods of and compositions for treating and preventing tumours, disorders associated with tumours as well as cachexy | |
BRPI0313792B8 (pt) | utilização de proteína de eritropoetina, método para tratamento de distúrbios de distribuição de ferro em diabetes e medicamento para o seu tratamento | |
GB8628398D0 (en) | Pharmaceutically-active conjugates | |
TW200640944A (en) | VGF polypeptides and methods of treating VGF-related disorders | |
BR9814419A (pt) | "combinação de compostos de benzociclo-heptapiridina e drogas antineopláticas para tratamento de doenças proliferativas" | |
HK1020867A1 (en) | The topical use of kappa opioid agonists to treat ocular pain k | |
BR9706966A (pt) | Utilização do enanciômero-l de um composto e processo para tratamento ou profilaxia de câncer da mama | |
MXPA02000680A (es) | Polipeptidos vgf y metodos para tratar desordenes relacionados con vgf. | |
AU3600199A (en) | A pharmaceutical composition containing ezrin mutated on tyrosine 353 | |
BR0212446A (pt) | Uso de 4-piridilmetilftalazinas para tratamento de câncer | |
BRPI0417371A (pt) | enoxaparina para o tratamento de cáncer | |
DE60006284D1 (de) | Arzneimittel zur behandlung konvulsivischer zustände | |
BR9801839A (pt) | Medicamento analgésico e aplicação de (+) -0-demetiltramadol. | |
DK0465512T3 (da) | Regional kemoterapi med 4-hydroperoxycyclophosphamid | |
BR0008606A (pt) | Uso de triazóis fluorados para tratamento de dor e distúrbios afetivos ou de atenção |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A E 8A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1890 DE 27/03/2007. |