HUP0002852A2 - Eljárás ösztrogén-dependens betegségek és rendellenességek megelőzésére vagy kezelésére trifenil-etilén-származékokkal - Google Patents

Eljárás ösztrogén-dependens betegségek és rendellenességek megelőzésére vagy kezelésére trifenil-etilén-származékokkal

Info

Publication number
HUP0002852A2
HUP0002852A2 HU0002852A HUP0002852A HUP0002852A2 HU P0002852 A2 HUP0002852 A2 HU P0002852A2 HU 0002852 A HU0002852 A HU 0002852A HU P0002852 A HUP0002852 A HU P0002852A HU P0002852 A2 HUP0002852 A2 HU P0002852A2
Authority
HU
Hungary
Prior art keywords
disorders
triphenil
preventing
dependent diseases
estrogen
Prior art date
Application number
HU0002852A
Other languages
English (en)
Inventor
Caroline Connor
Donald P. Mcdonnell
John Norris
Ashini Wijayaratne
Original Assignee
Duke University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duke University filed Critical Duke University
Publication of HUP0002852A2 publication Critical patent/HUP0002852A2/hu
Publication of HUP0002852A3 publication Critical patent/HUP0002852A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Above=83;BrkLine=&;KeepPrev=Y;>(57) A találmány tárgyát az ösztrogén-dependens betegségek és rendellenességek kezelése képezi, pontosabban,a találmány tárgyát ösztrogén-dependens rákok, főleg emlőrákantiösztrogénekkel való kezelése képezi, oly módon, hogy emlősnek az(I) általános képletű vegyület megfelelő mennyiségét adják be, ahol isR1 jelentése -(CH2)n CR5=CR6R7, -(CH2)mC(X)NR8R9; vagy a (II)általános képletű csoport; R4 jelentése -CN, -NO2, -CH3, -CH2CH3, -CH2CH2-Y vagy Y; R2 és R3 jelentése egymástól függetlenülhidrogénatom, -CH3, -OH, -OCH3, -OCH2CH3 vagy -CH(CH3)2. Ó
HU0002852A 1997-08-15 1998-08-14 A method of preventing or treating estrogen-dependent diseases and disorders using triphenil-ethylene derivatives HUP0002852A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5588197P 1997-08-15 1997-08-15
PCT/US1998/016864 WO1999008682A1 (en) 1997-08-15 1998-08-14 A method of preventing or treating estrogen-dependent diseases and disorders

Publications (2)

Publication Number Publication Date
HUP0002852A2 true HUP0002852A2 (hu) 2001-10-28
HUP0002852A3 HUP0002852A3 (en) 2001-11-28

Family

ID=22000784

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0002852A HUP0002852A3 (en) 1997-08-15 1998-08-14 A method of preventing or treating estrogen-dependent diseases and disorders using triphenil-ethylene derivatives

Country Status (21)

Country Link
US (1) US7307102B2 (hu)
EP (1) EP1019057B1 (hu)
JP (1) JP2001515038A (hu)
KR (1) KR20010022956A (hu)
CN (1) CN1275911A (hu)
AT (1) ATE411016T1 (hu)
AU (1) AU757206B2 (hu)
BR (1) BR9811946A (hu)
CA (1) CA2301032C (hu)
CZ (1) CZ300929B6 (hu)
DE (1) DE69840126D1 (hu)
EE (1) EE200000077A (hu)
ES (1) ES2312189T3 (hu)
HU (1) HUP0002852A3 (hu)
IL (1) IL134445A0 (hu)
NO (1) NO20000752L (hu)
NZ (1) NZ502738A (hu)
PL (1) PL338555A1 (hu)
RU (1) RU2214236C2 (hu)
UA (1) UA70925C2 (hu)
WO (1) WO1999008682A1 (hu)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6413533B1 (en) * 1998-05-07 2002-07-02 The University Of Tennessee Research Corporation Method for chemoprevention of prostate cancer
WO1999063980A1 (en) * 1998-06-12 1999-12-16 Ligand Pharmaceuticals Inc. Treatment of anti-estrogen resistant breast cancer using rxr modulators
GB9824207D0 (en) * 1998-11-04 1998-12-30 Zeneca Ltd Neurological disorders
AU5957500A (en) * 1999-07-06 2001-01-22 Endorecherche Inc. Methods of treating and/or suppressing weight gain
CO5271709A1 (es) 2000-01-12 2003-04-30 Pfizer Prod Inc Composiciones y procedimientos para el y tratamiento de afecciones que responden a estrogenos
US6417394B2 (en) * 2000-04-05 2002-07-09 Bristol Myers Squibb Pharma Company Specific salt forms of triphenylethylene derivatives as selective estrogen receptor modulators
US6528681B2 (en) * 2000-04-05 2003-03-04 Bristol-Meyers Squibb Pharma Company Halogenated triphenylethylene derivatives as selective estrogen receptor modulators
AU2001272249A1 (en) * 2000-07-05 2002-01-14 Andrew J. E. Seely Method and apparatus for multiple patient parameter variability analysis and display
DE60230017D1 (de) * 2001-02-15 2009-01-08 Janssen Pharmaceutica Nv Farnesyl-protein-transferase hemmer in kombination mit antiöstrogenen
US20020164581A1 (en) * 2001-03-12 2002-11-07 Chawnshang Chang Methods for identifying compounds that do not attenuate the protective effects of estrogen
EP1417169A2 (en) * 2001-08-11 2004-05-12 Bristol-Myers Squibb Pharma Company Selective estrogen receptor modulators
EP1768657B1 (en) 2004-06-23 2008-08-13 Sirion Therapeutics, Inc. Methods and compositions for treating ophthalmic conditions with retinyl derivates
EP1807103A4 (en) 2004-11-04 2009-02-11 Sirion Therapeutics Inc MODULATORS OF A COMPLEX RETINOL-RETINOL-BINDING PROTEIN-TRANSTHYRETINE FORMATION
EA011154B1 (ru) * 2004-12-08 2009-02-27 Сирион Терапьютикс, Инк. Композиции для лечения ретинол-ассоциированных заболеваний
US20060264413A1 (en) * 2005-04-18 2006-11-23 Sri International Method and composition for inhibiting cell proliferation and angiogenesis
UA81382C2 (en) * 2005-07-11 2007-12-25 Composition for treating retinol-related diseases by modulation of retinol binding
JP2010540127A (ja) 2007-10-03 2010-12-24 オタワ ヘルス リサーチ インスティチュート １つ以上の臓器の経時的生理的パラメータ変動を監視するための方法および装置
US8232402B2 (en) 2008-03-12 2012-07-31 Link Medicine Corporation Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
EP2370436A1 (en) 2008-11-13 2011-10-05 Link Medicine Corporation Azaquinolinone derivatives and uses thereof
EP3205648A1 (en) 2010-06-10 2017-08-16 Seragon Pharmaceuticals, Inc. Estrogen receptor modulators and uses thereof
WO2011159769A2 (en) 2010-06-17 2011-12-22 Aragon Pharmaceuticals, Inc. Indane estrogen receptor modulators and uses thereof
GB2483736B (en) 2010-09-16 2012-08-29 Aragon Pharmaceuticals Inc Estrogen receptor modulators and uses thereof
WO2013090829A1 (en) 2011-12-14 2013-06-20 Aragon Pharmaceuticals, Inc. Estrogen receptor modulators and uses thereof
CN102532073A (zh) * 2011-12-30 2012-07-04 北京赛林泰医药技术有限公司 作为选择性雌激素受体调节剂的乙烯衍生物
CN102584687A (zh) * 2011-12-30 2012-07-18 北京赛林泰医药技术有限公司 作为选择性雌激素受体调节剂的乙烯衍生物
SG11201405918XA (en) 2012-03-20 2014-10-30 Seragon Pharmaceuticals Inc Estrogen receptor modulators and uses thereof
EP3386500B1 (en) * 2015-12-09 2022-09-07 The Board of Trustees of the University of Illinois Benzothiophene-based selective estrogen receptor downregulators
WO2019023481A1 (en) * 2017-07-28 2019-01-31 Zeno Royalties & Milestones, LLC ANALOGUES OF ACRYLIC ACID

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE637389A (hu) 1962-09-13
GB1029221A (en) 1963-09-02 1966-05-11 Ici Ltd Triarylalkane derivatives
GB1079747A (en) 1965-07-07 1967-08-16 Ici Ltd Alkene derivatives
US3637856A (en) 1965-07-12 1972-01-25 Ici Ltd Trans-1-p-(dialkylaminoalkyl) phenyl-1 2-diphenyl-alk-1-enes and salts thereof
GB1128379A (en) 1966-06-20 1968-09-25 Ici Ltd Novel alkene derivatives, process for the preparation thereof and compositions containing the same
GB1560274A (en) 1977-02-28 1980-02-06 Ici Ltd Phenylbut 1-ene derivatives having antiostrogenicactivity
DE2860900D1 (en) 1977-08-22 1981-11-05 Ici Plc Triphenylalkene derivatives, process for their preparation and pharmaceutical compositions containing them
US4206234A (en) 1977-08-22 1980-06-03 Imperial Chemical Industries Limited Triphenylbut-1-ene derivatives and pharmaceutical compositions and uses thereof
DE3060722D1 (en) 1979-05-15 1982-09-30 Ici Plc 1-hydrocarbyloxyphenyl-1,2-diphenylalkene derivatives, their manufacture and a pharmaceutical composition containing them
HU178253B (en) 1979-08-15 1982-04-28 Gyogyszerkutato Intezet Process for preparing 1,1,2-triphenyl-propane and -propane derivatives
DE3046719C2 (de) 1980-12-11 1983-02-17 Klinge Pharma GmbH, 8000 München 1,1,2-Triphenyl-but-1-en-Derivate, Verfahren zu ihrer Herstellung und Arzneimittel
FI77839C (fi) 1982-05-27 1989-05-10 Farmos Oy Foerfarande foer framstaellning av nya terapeutiskt effektiva trifenylalkan- och alkenderivat.
US5491173A (en) * 1982-06-25 1996-02-13 Orion-Yhtyma Oy Tri-phenyl alkene derivatives and their preparation and use
CA1229604A (en) 1984-02-14 1987-11-24 Lorne J. Brandes Aminoalkyl ethers of phenols as antiproliferative anticancer agents
US4760053A (en) 1984-08-02 1988-07-26 Fernand Labrie Combination therapy for selected sex steroid dependent cancers
US4729999A (en) 1984-10-12 1988-03-08 Bcm Technologies Antiestrogen therapy for symptoms of estrogen deficiency
GB8604528D0 (en) 1986-02-24 1986-04-03 Ici Plc Therapeutic agents
US4859695A (en) 1986-06-10 1989-08-22 Merck & Co., Inc. Antiestrogen agents having anabolic activity in animals
CA1289570C (en) 1986-06-16 1991-09-24 Tetsuji Asao 1,1,2-triaryl-1-alkene derivatives
DE3736682A1 (de) 1987-10-29 1989-05-11 Klinge Co Chem Pharm Fab Verfahren zur herstellung von trans-1,1,2-triphenyl-but-1-en-derivaten
US5393785A (en) 1988-10-31 1995-02-28 Endorecherche, Inc. Therapeutic antiestrogens
US5119827A (en) 1990-09-05 1992-06-09 Board Of Regents, The University Of Texas System Mechanisms of antiestrogen resistance in breast cancer
US5189212A (en) 1990-09-07 1993-02-23 University Of Georgia Research Foundation, Inc. Triarylethylene carboxylic acids with estrogenic activity
JPH06504522A (ja) 1990-10-01 1994-05-26 ボード　オブ　リージェンツ，　ザ　ユニバーシティ　オブ　テキサス　システム 高親和性タモキシフェン誘導体とその使用
WO1992019585A1 (fr) 1991-04-30 1992-11-12 Asahi Kasei Kogyo Kabushiki Kaisha Derive de triphenylethylene et preparation pharmaceutique contenant celui-ci
CA2143000C (en) 1992-09-15 2000-03-28 Alan J. Bitonti Non-metabolizable clomiphene analogs for treatment of tamoxifen-resistant tumors
DE4311870C2 (de) * 1993-04-10 1998-07-30 Altramed Holdings Ltd Verwendung eines Anti-Östrigens zur Therapie und Prophylaxe von Demenz-Erkrankungen
US5681835A (en) * 1994-04-25 1997-10-28 Glaxo Wellcome Inc. Non-steroidal ligands for the estrogen receptor
US5455275A (en) * 1994-05-11 1995-10-03 Eli Lilly And Company Methods for inhibiting endometriosis and uterine fibroid disease with 1,1,2-triphenylbut-1-ene derivatives

Also Published As

Publication number Publication date
NO20000752D0 (no) 2000-02-15
JP2001515038A (ja) 2001-09-18
RU2214236C2 (ru) 2003-10-20
NO20000752L (no) 2000-02-15
PL338555A1 (en) 2000-11-06
KR20010022956A (ko) 2001-03-26
UA70925C2 (uk) 2004-11-15
ES2312189T3 (es) 2009-02-16
US20030232795A1 (en) 2003-12-18
EP1019057A4 (en) 2006-06-14
CZ2000531A3 (en) 2001-05-16
HUP0002852A3 (en) 2001-11-28
CZ300929B6 (cs) 2009-09-16
ATE411016T1 (de) 2008-10-15
CA2301032A1 (en) 1999-02-25
EP1019057A1 (en) 2000-07-19
CN1275911A (zh) 2000-12-06
AU8906398A (en) 1999-03-08
EE200000077A (et) 2000-12-15
DE69840126D1 (de) 2008-11-27
NZ502738A (en) 2002-06-28
AU757206B2 (en) 2003-02-06
WO1999008682A1 (en) 1999-02-25
IL134445A0 (en) 2001-04-30
US7307102B2 (en) 2007-12-11
BR9811946A (pt) 2000-08-22
EP1019057B1 (en) 2008-10-15
CA2301032C (en) 2009-01-13

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